Loss of the tumour-suppressor genes CHK2 and BRCA1 results in chromosomal instability

Biochemical Society Transactions

Volumn 38, Issue 6, 2010, Pages 1704-1708

  Stolz, Ailine ^a   Ertych, Norman ^a   Bastians, Holger ^a,b  

^a PHILIPPS UNIVERSITY MARBURG   (Germany)

^b UNIVERSITY MEDICAL CENTER GÖTTINGEN   (Germany)

Author keywords

Chromosomal instability; Lung adenocarcinoma; Mitosis; Tumour suppressor gene

Indexed keywords

BRCA1 PROTEIN; CHECKPOINT KINASE 2;

ANEUPLOIDY; CELL ADHESION; CENTROMERE; CHROMOSOMAL INSTABILITY; CONFERENCE PAPER; GENE INACTIVATION; GENE LOSS; GENE TARGETING; HUMAN; LUNG ADENOCARCINOMA; MICROTUBULE; MITOSIS SPINDLE; NONHUMAN; PATHOPHYSIOLOGY; PRIORITY JOURNAL; PROTEIN PHOSPHORYLATION; TUMOR SUPPRESSOR GENE;

ANEUPLOIDY; ANIMALS; BRCA1 PROTEIN; CHROMOSOMAL INSTABILITY; DNA DAMAGE; HUMANS; LUNG NEOPLASMS; MICE; MICE, KNOCKOUT; MITOSIS; MITOTIC SPINDLE APPARATUS; PROTEIN-SERINE-THREONINE KINASES;

MUS;

EID: 78649739186     PISSN: 03005127     EISSN: 14708752     Source Type: Journal    
DOI: 10.1042/BST0381704     Document Type: Conference Paper

References (35)

1. Lengauer, C., Kinzler, K.W. and Vogelstein, B. (1998) Genetic instabilities in human cancers. Nature 396, 643-649
2. Holland, A.J. and Cleveland, D.W. (2009) Boveri revisited: chromosomal instability, aneuploidy and tumorigenesis. Nat. Rev. Mol. Cell. Biol. 10, 478-487
3. Ricke, R.M., van Ree, J.H. and van Deursen, J.M. (2008) Whole chromosome instability and cancer: a complex relationship. Trends Genet. 24, 457-466
4. Thompson, S.L., Bakhoum, S.F. and Compton, D.A. (2010) Mechanisms of chromosomal instability. Curr. Biol. 20, R285-R295
5. Barber, T.D., McManus, K., Yuen, K.W., Reis, M., Parmigiani, G., Shen, D., Barrett, I., Nouhi, Y., Spencer, F., Markowitz, S. et al. (2008) Chromatid cohesion defects may underlie chromosome instability in human colorectal cancers. Proc. Natl. Acad. Sci. U.S.A. 105, 3443-3448
6. Jallepalli, P.V., Waizenegger, I.C., Bunz, F., Langer, S., Speicher, M.R., Peters, J.M., Kinzler, K.W., Vogelstein, B. and Lengauer, C. (2001) Securin is required for chromosomal stability in human cells. Cell 105, 445-457 (Pubitemid 32520851)
7. Zhang, N., Ge, G., Meyer, R., Sethi, S., Basu, D., Pradhan, S., Zhao, Y.J., Li, X.N., Cai, W.W., El-Naggar, A.K. et al. (2008) Overexpression of separase induces aneuploidy and mammary tumorigenesis. Proc. Natl. Acad. Sci. U.S.A. 105, 13033-13038
8. Musacchio, A. and Salmon, E.D. (2007) The spindle-assembly checkpoint in space and time. Nat. Rev. Mol. Cell. Biol. 8, 379-393
9. Peters, J.M. (2006) The anaphase promoting complex/cyclosome: a machine designed to destroy. Nat. Rev. Mol. Cell. Biol. 7, 644-656
10. Cahill, D.P., Lengauer, C., Yu, J., Riggins, G.J., Willson, J.K., Markowitz, S.D., Kinzler, K.W. and Vogelstein, B. (1998) Mutations of mitotic checkpoint genes in human cancers. Nature 392, 300-303 (Pubitemid 28155105)
11. Tighe, A., Johnson, V.L., Albertella, M. and Taylor, S.S. (2001) Aneuploid colon cancer cells have a robust spindle checkpoint. EMBO Rep. 2, 609-614 (Pubitemid 32707708)
12. Thompson, S.L. and Compton, D.A. (2008) Examining the link between chromosomal instability and aneuploidy in human cells. J. Cell. Biol. 180, 665-672
13. Bakhoum, S.F., Thompson, S.L., Manning, A.L. and Compton, D.A. (2009) Genome stability is ensured by temporal control of kinetochore-microtubule dynamics. Nat. Cell Biol. 11, 27-35
14. Cimini, D. (2008) Merotelic kinetochore orientation, aneuploidy, and cancer. Biochim. Biophys. Acta 1786, 32-40
15. Andrews, P.D., Ovechkina, Y., Morrice, N., Wagenbach, M., Duncan, K., Wordeman, L. and Swedlow, J.R. (2004) Aurora B regulates MCAK at the mitotic centromere. Dev. Cell 6, 253-268 (Pubitemid 38190365)
16. Lan, W., Zhang, X., Kline-Smith, S.L., Rosasco, S.E., Barrett-Wilt, G.A., Shabanowitz, J., Hunt, D.F., Walczak, C.E. and Stukenberg, P.T. (2004) Aurora B phosphorylates centromeric MCAK and regulates its localization and microtubule depolymerization activity. Curr. Biol. 14, 273-286
17. Liu, D., Vader, G., Vromans, M.J., Lampson, M.A. and Lens, S.M. (2009) Sensing chromosome bi-orientation by spatial separation of aurora B kinase from kinetochore substrates. Science 323, 1350-1353
18. Bakhoum, S.F., Genovese, G. and Compton, D.A. (2009) Deviant kinetochore microtubule dynamics underlie chromosomal instability. Curr. Biol. 19, 1937-1942
19. Ganem, N.J., Godinho, S.A. and Pellman, D. (2009) A mechanism linking extra centrosomes to chromosomal instability. Nature 460, 278-282
20. Ahn, J., Urist, M. and Prives, C. (2004) The Chk2 protein kinase. DNA Repair 3, 1039-1047
21. Ahn, J., Urist, M. and Prives, C. (2003) Questioning the role of checkpoint kinase 2 in the p53 DNA damage response. J. Biol. Chem. 278, 20480-20489
22. Jallepalli, P.V., Lengauer, C., Vogelstein, B. and Bunz, F. (2003) The Chk2 tumor suppressor is not required for p53 responses in human cancer cells. J. Biol. Chem. 278, 20475-20479
23. Jin, J., Ang, X.L., Ye, X., Livingstone, M. and Harper, J.W. (2008) The Chk2 tumor suppressor is not required for p53 responses in human cancer cells. J. Biol. Chem. 283, 19322-19328
24. Stolz, A., Ertych, N., Kienitz, A., Vogel, C., Schneider, V., Fritz, B., Jacob, R., Dittmar, G., Weichert, W., Petersen, I. and Bastians, H. (2010) The CHK2-BRCA1 tumour suppressor pathway ensures chromosomal stability in human somatic cells. Nat. Cell Biol. 12, 492-499
25. Michel, L.S., Liberal, V., Chatterjee, A., Kirchwegger, R., Pasche, B., Gerald, W., Dobles, M., Sorger, P.K., Murty, V.V. and Benezra, R. (2001) MAD2 haplo-insufficiency causes premature anaphase and chromosome instability in mammalian cells. Nature 409, 355-359 (Pubitemid 32151241)
26. Antoni, L., Sodha, N., Collins, I. and Garrett, M.D. (2007) CHK2 kinase: cancer susceptibility and cancer therapy - two sides of the same coin? Nat. Rev. Cancer 7, 925-936 (Pubitemid 350165855)
27. Lee, J.S., Collins, K.M., Brown, A.L., Lee, C.H. and Chung, J.H. (2000) hCds1-mediated phosphorylation of BRCA1 regulates the DNA damage response. Nature 404, 201-204 (Pubitemid 30154490)
28. Joukov, V., Groen, A.C., Prokhorova, T., Gerson, R., White, E., Rodriguez, A., Walter, J.C. and Livingston, D.M. (2006) 1α,25- dihydroxyvitamin D3 inhibits matrix metalloproteinases induced by Mycobacterium tuberculosis infection. Cell 127, 539-552
29. Jin, S., Gao, H., Mazzacurati, L., Wang, Y., Fan, W., Chen, Q., Yu, W., Wang, M., Zhu, X., Zhang, C. and Zhan, Q. (2009) BRCA1 interaction of centrosomal protein Nlp is required for successful mitotic progression. J. Biol. Chem. 284, 22970-22977
30. Parvin, J.D. and Sankaran, S. (2006) The BRCA1 E3 ubiquitin ligase controls centrosome dynamics. Cell Cycle 5, 1946-1950 (Pubitemid 44435300)
31. Sankaran, S., Starita, L.M., Groen, A.C., Ko, M.J. and Parvin, J.D. (2005) Centrosomal microtubule nucleation activity is inhibited by BRCA1-dependent ubiquitination. Mol. Cell. Biol. 25, 8656-8668
32. Ouchi, M., Fujiuchi, N., Sasai, K., Katayama, H., Minamishima, Y.A., Ongusaha, P.P., Deng, C., Sen, S., Lee, S.W. and Ouchi, T. (2004) BRCA1 phosphorylation by Aurora-A in the regulation of G2 to M transition. J. Biol. Chem. 279, 19643-19648
33. Sankaran, S., Crone, D.E., Palazzo, R.E. and Parvin, J.D. (2007) Aurora-A kinase regulates breast cancer associated gene 1 inhibition of centrosome-dependent microtubule nucleation. Cancer Res. 67, 11186-11194 (Pubitemid 350248543)
34. Wei, J.H., Chou, Y.F., Ou, Y.H., Yeh, Y.H., Tyan, S.W., Sun, T.P., Shen, C.Y. and Shieh, S.Y. (2005) TTK/hMps1 participates in the regulation of DNA damage checkpoint response by phosphorylating CHK2 on threonine 68. J. Biol. Chem. 280, 7748-7757
35. Tsvetkov, L., Xu, X., Li, J. and Stern, D.F. (2003) Polo-like kinase 1 and Chk2 interact and co-localize to centrosomes and the midbody. J. Biol. Chem. 278, 8468-8475