P53/p21 pathway involved in mediating cellular senescence of bone marrow-derived mesenchymal stem cells from systemic lupus erythematosus patients

Clinical and Developmental Immunology

Volumn 2013, Issue , 2013, Pages

  Gu, Zhifeng ^a   Jiang, Jinxia ^a   Tan, Wei ^a   Xia, Yunfei ^a   Cao, Haixia ^a   Meng, Yan ^a   Da, Zhanyun ^a   Liu, Hong ^a   Cheng, Chun ^b  

^a NANTONG UNIVERSITY   (China)

^b NANTONG MEDICAL COLLEGE   (China)

Author keywords

[No Author keywords available]

Indexed keywords

CYCLIN DEPENDENT KINASE 2; CYCLIN E; PROTEIN P21; PROTEIN P53; RETINOBLASTOMA PROTEIN; SMALL INTERFERING RNA; CYCLIN DEPENDENT KINASE INHIBITOR 1A;

ADOLESCENT; ADULT; AGE DISTRIBUTION; ARTICLE; BONE MARROW CELL; BONE MARROW DERIVE MESENCHYMAL STEM CELL; CELL AGING; CELL COUNT; CELL PROLIFERATION; CELLULAR DISTRIBUTION; CLINICAL ARTICLE; COLONY FORMING UNIT; CONTROLLED STUDY; CYTOPLASM; DISEASE COURSE; DOWN REGULATION; FEMALE; GROWTH CURVE; HUMAN; HUMAN CELL; IMMUNOFLUORESCENCE; INTRACELLULAR SIGNALING; MESENCHYMAL STEM CELL; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN LOCALIZATION; PROTEIN PHOSPHORYLATION; SYSTEMIC LUPUS ERYTHEMATOSUS; CELL CULTURE; CELL NUCLEUS; GENE SILENCING; GENETICS; MESENCHYMAL STROMA CELL; METABOLISM; PROTEIN TRANSPORT; RNA INTERFERENCE; SIGNAL TRANSDUCTION; YOUNG ADULT;

ADOLESCENT; ADULT; CELL AGING; CELL NUCLEUS; CELLS, CULTURED; CYCLIN-DEPENDENT KINASE INHIBITOR P21; FEMALE; GENE KNOCKDOWN TECHNIQUES; HUMANS; LUPUS ERYTHEMATOSUS, SYSTEMIC; MESENCHYMAL STROMAL CELLS; PROTEIN TRANSPORT; RNA INTERFERENCE; SIGNAL TRANSDUCTION; TUMOR SUPPRESSOR PROTEIN P53; YOUNG ADULT;

EID: 84885666355     PISSN: 17402522     EISSN: 17402530     Source Type: Journal    
DOI: 10.1155/2013/134243     Document Type: Article

References (41)

1. Rahman A., Isenberg D. A., Systemic lupus erythematosus. The New England Journal of Medicine 2008 358 9 929 939 2-s2.0-40049093765 10.1056/NEJMra071297 (Pubitemid 351397092)
2. Liang J., Zhang H., Hua B., Wang H., Lu L., Shi S., Hou Y., Zeng X., Gilkeson G. S., Sun L., Allogenic mesenchymal stem cells transplantation in refractory systemic lupus erythematosus: a pilot clinical study. Annals of the Rheumatic Diseases 2010 69 8 1423 1429
3. Gu Z., Akiyama K., Ma X., Zhang H., Feng X., Yao G., Hou Y., Lu L., Gilkeson G. S., Silver R. M., Zeng X., Shi S., Sun L., Transplantation of umbilical cord mesenchymal stem cells alleviates lupus nephritis in MRL/lpr mice. Lupus 2010 19 13 1502 1514 2-s2.0-78649245336 10.1177/0961203310373782
4. Sun L., Akiyama K., Zhang H., Yamaza T., Hou Y., Zhao S., Xu T., Le A., Shi S., Mesenchymal stem cell transplantation reverses multiorgan dysfunction in systemic lupus erythematosus mice and humans. Stem Cells 2009 27 6 1421 1432 2-s2.0-67649604299 10.1002/stem.68
5. Liang J., Gu F., Wang H., Hua B., Hou Y., Shi S., Lu L., Sun L., Mesenchymal stem cell transplantation for diffuse alveolar hemorrhage in SLE. Nature Reviews Rheumatology 2010 6 8 486 489 2-s2.0-77955320722 10.1038/nrrheum.2010.80
6. Zhou K., Zhang H., Jin O., Feng X., Yao G., Hou Y., Sun L., Transplantation of human bone marrow mesenchymal stem cell ameliorates the autoimmune pathogenesis in MRL/lpr mice. Cellular and Molecular Immunology 2008 5 6 417 424 2-s2.0-62449102751 10.1038/cmi.2008.52
7. Sun L., Wang D., Liang J., Zhang H., Feng X., Wang H., Hua B., Liu B., Ye S., Hu X., Xu W., Zeng X., Hou Y., Gilkeson G. S., Silver R. M., Lu L., Shi S., Umbilical cord mesenchymal stem cell transplantation in severe and refractory systemic lupus erythematosus. Arthritis and Rheumatism 2010 62 8 2467 2475 2-s2.0-77955361735 10.1002/art.27548
8. Carrion F., Nova E., Ruiz C., Diaz F., Inostroza C., Rojo D., MÖnckeberg G., Figueroa F. E., Autologous mesenchymal stem cell treatment increased T regulatory cells with no effect on disease activity in two systemic lupus erythematosus patients. Lupus 2010 19 3 317 322 2-s2.0-77749279645 10.1177/0961203309348983
9. Nie Y., Lau C. S., Lie A. K. W., Chan G. C. F., Mok M. Y., Defective phenotype of mesenchymal stem cells in patients with systemic lupus erythematosus. Lupus 2010 19 7 850 859 2-s2.0-77952921223 10.1177/ 0961203309361482
10. Sun L. Y., Zhang H. Y., Feng X. B., Hou Y. Y., Lu L. W., Fan L. M., Abnormality of bone marrow-derived mesenchymal stem cells in patients with systemic lupus erythematosus. Lupus 2007 16 2 121 128 2-s2.0-33847374613 10.1177/0961203306075793 (Pubitemid 46347934)
11. Li X., Liu L., Meng D., Wang D., Zhang J., Shi D., Liu H., Xu H., Lu L., Sun L., Enhanced apoptosis and senescence of bone-marrow-derived mesenchymal stem cells in patients with systemic lupus erythematosus. Stem Cells and Development 2012 21 13 2387 2394
12. Gu Z., Cao X., Jiang J., Li L., Da Z., Liu H., Cheng C., Upregulation of p1 6 INK4A promotes cellular senescence of bone marrow-derived mesenchymal stem cells from systemic lupus erythematosus patients. Cellular Signalling 2012 24 12 2307 2314
13. Berlanga-Acosta J., Mendoza-Mari Y., Martínez M. D., Valdés-Perez C., Ojalvo A. G., Armstrong D. G., Expression of cell proliferation cycle negative regulators in fibroblasts of an ischemic diabetic foot ulcer. A clinical case report. International Wound Journal 2013 10 2 232 236
14. Wilson A., Shehadeh L. A., Yu H., Webster K. A., Age-related molecular genetic changes of murine bone marrow mesenchymal stem cells. BMC Genomics 2010 11 1, article 229 2-s2.0-77950645030 10.1186/1471-2164-11-229
15. Hong H., Takahashi K., Ichisaka T., Aoi T., Kanagawa O., Nakagawa M., Okita K., Yamanaka S., Suppression of induced pluripotent stem cell generation by the p53-p21 pathway. Nature 2009 460 7259 1132 1135 2-s2.0-69349100179 10.1038/nature08235
16. Armesilla-Diaz A., Elvira G., Silva A., p53 regulates the proliferation, differentiation and spontaneous transformation of mesenchymal stem cells. Experimental Cell Research 2009 315 20 3598 3610 2-s2.0-70449521174 10.1016/j.yexcr.2009.08.004
17. Zhou S., Greenberger J. S., Epperly M. W., Goff J. P., Adler C., Leboff M. S., Glowacki J., Age-related intrinsic changes in human bone-marrow-derived mesenchymal stem cells and their differentiation to osteoblasts. Aging Cell 2008 7 3 335 343 2-s2.0-43049162965 10.1111/j.1474-9726.2008.00377.x (Pubitemid 351663902)
18. Hochberg M. C., Updating the American College of Rheumatology revised criteria for the classification of systemic lupus erythematosus. Arthritis and Rheumatism 1997 40 9 1725 2-s2.0-0031229830
19. Kim K.-W., Chung H.-N., Ha K.-Y., Lee J.-S., Kim Y.-Y., Senescence mechanisms of nucleus pulposus chondrocytes in human intervertebral discs. The Spine Journal 2009 9 8 658 666 2-s2.0-67651083411 10.1016/j.spinee.2009.04.018
20. Fenouille N., Robert G., Tichet M., Puissant A., Dufies M., Rocchi S., Ortonne J.-P., Deckert M., Ballotti R., Tartare-Deckert S., The p53/p21Cip1/Waf1 pathway mediates the effects of SPARC on melanoma cell cycle progression. Pigment Cell and Melanoma Research 2011 24 1 219 232 2-s2.0-78651454767 10.1111/j.1755-148X.2010.00790.x
21. Bartholomew J. N., Volonte D., Galbiati F., Caveolin-1 regulates the antagonistic pleiotropic properties of cellular senescence through a novel Mdm2/p53-mediated pathway. Cancer Research 2009 69 7 2878 2886 2-s2.0-66149127739 10.1158/0008-5472.CAN-08-2857
22. Rosso A., Balsamo A., Gambino R., Dentelli P., Falcioni R., Cassader M., Pegoraro L., Pagano G., Brizzi M. F., p53 mediates the accelerated onset of senescence of endothelial progenitor cells in diabetes. Journal of Biological Chemistry 2006 281 7 4339 4347 2-s2.0-33645224640 10.1074/jbc.M509293200 (Pubitemid 43847865)
23. Kunieda T., Minamino T., Nishi J.-I., Tateno K., Oyama T., Katsuno T., Miyauchi H., Orimo M., Okada S., Takamura M., Nagai T., Kaneko S., Komuro I., Angiotensin II induces premature senescence of vascular smooth muscle cells and accelerates the development of atherosclerosis via a p21-dependent pathway. Circulation 2006 114 9 953 960 2-s2.0-33748351173 10.1161/CIRCULATIONAHA.106. 626606 (Pubitemid 44337139)
24. Sherr C. J., G1 phase progression: cycling on cue. Cell 1994 79 4 551 555 2-s2.0-0028171292 10.1016/0092-8674(94)90540-1 (Pubitemid 24363798)
25. Elmore S., Apoptosis: a review of programmed cell death. Toxicologic Pathology 2007 35 4 495 516 2-s2.0-34250308322 10.1080/01926230701320337 (Pubitemid 46911891)
26. Bian T., Gibbs J. D., Örvell C., Imani F., Respiratory syncytial virus matrix protein induces lung epithelial cell cycle arrest through a p53 dependent pathway. PLoS One 2012 7 5 e38052
27. Stein G. H., Drullinger L. F., Soulard A., Dulić V., Differential roles for cyclin-dependent kinase inhibitors p21 and p16 in the mechanisms of senescence and differentiation in human fibroblasts. Molecular and Cellular Biology 1999 19 3 2109 2117 2-s2.0-0033013980 (Pubitemid 29098269)
28. Harper J. W., Adami G. R., Wei N., Keyomarsi K., Elledge S. J., The p21 Cdk-interacting protein Cip1 is a potent inhibitor of G1 cyclin- dependent kinases. Cell 1993 75 4 805 816 2-s2.0-0027496935 10.1016/0092-8674(93)90499-G (Pubitemid 23346377)
29. Cmielová J., Rezáčová M., p21Cip1/Waf1 protein and its function based on a subcellular localization [corrected]. Journal of Cellular Biochemistry 2011 112 12 3502 3506
30. Han J., Yuan Z., Yan H., Inhibitory effect of adenoviral vector-mediated delivery of p21WAF1/CIP1 on retinal vascular endothelial cell proliferation and tube formation in cultured Rhesus monkey cells (RF/6A). Current Eye Research 2013 38 6 670 673 10.3109/02713683.2012.746992
31. Wang J., Zheng T., Chen X., Song X., Meng X., Bhatta N., Pan S., Jiang H., Liu L., MDM2 antagonist can inhibit tumor growth in hepatocellular carcinoma with different types of p53 in vitro. Journal of Gastroenterology and Hepatology 2011 26 2 371 377 2-s2.0-78851472178 10.1111/j.1440-1746.2010.06440.x
32. Solozobova V., Rolletschek A., Blattner C., Nuclear accumulation and activation of p53 in embryonic stem cells after DNA damage. BMC Cell Biology 2009 10 article 46 2-s2.0-67650261871 10.1186/1471-2121-10-46
33. Hiromura K., Pippin J. W., Blonski M. J., Roberts J. M., Shankland S. J., The subcellular localization of cyclin dependent kinase 2 determines the fate of mesangial cells: role in apoptosis and proliferation. Oncogene 2002 21 11 1750 1758 2-s2.0-0037034870 10.1038/sj/onc/1205238 (Pubitemid 34259038)
34. Aladjem M. I., Spike B. T., Rodewald L. W., Hope T. J., Klemm M., Jaenisch R., Wahl G. M., ES cells do not activate p53-dependent stress responses and undergo p53-independent apoptosis in response to DNA damage. Current Biology 1998 8 3 145 155 2-s2.0-0032576768 (Pubitemid 28091572)
35. Stolzing A., Jones E., McGonagle D., Scutt A., Age-related changes in human bone marrow-derived mesenchymal stem cells: consequences for cell therapies. Mechanisms of Ageing and Development 2008 129 3 163 173 2-s2.0-39149093357 10.1016/j.mad.2007.12.002
36. Zhang D.-Y., Wang H.-J., Tan Y.-Z., Wnt/ β -Catenin signaling induces the aging of Mesenchymal stem cells through the DNA damage response and the P53/P21 pathway. PLoS One 2011 6 6 2-s2.0-79959340540 10.1371/journal.pone. 0021397 e21397
37. Yu J. M., Wu X., Gimble J. M., Guan X., Freitas M. A., Bunnell B. A., Age-related changes in mesenchymal stem cells derived from rhesus macaque bone marrow. Aging Cell 2011 10 1 66 79 2-s2.0-78651278814 10.1111/j.1474-9726.2010. 00646.x
38. Yew T.-L., Chiu F.-Y., Tsai C.-C., Chen H.-L., Lee W.-P., Chen Y.-J., Chang M.-C., Hung S.-C., Knockdown of p21Cip1/Waf1 enhances proliferation, the expression of stemness markers, and osteogenic potential in human mesenchymal stem cells. Aging Cell 2011 10 2 349 361 2-s2.0-79952650332 10.1111/j.1474-9726. 2011.00676.x
39. Plasilova M., Schonmyer B., Fernandez J., Clavin N., Soares M., Mehrara B. J., Accelerating stem cell proliferation by down-regulation of cell cycle regulator p21. Plastic and Reconstructive Surgery 2009 123 2, supplement 149S 157S 2-s2.0-61749088477 10.1097/PRS.0b013e318191c82b
40. Ito T., Sawada R., Fujiwara Y., Seyama Y., Tsuchiya T., FGF-2 suppresses cellular senescence of human mesenchymal stem cells by down-regulation of TGF- β 2. Biochemical and Biophysical Research Communications 2007 359 1 108 114 2-s2.0-34249661093 10.1016/j.bbrc.2007.05.067 (Pubitemid 46836675)
41. Mehrara B. J., Avraham T., Soares M., Fernandez J. G., Yan A., Zampell J. C., Andrade V. P., Cordeiro A. P., Sorrento C. M., p21cip/WAF is a key regulator of long-term radiation damage in mesenchyme-derived tissues. The FASEB Journal 2010 24 12 4877 4888 2-s2.0-78649752486 10.1096/fj.10-155762