Restriction of the conformational dynamics of the cyclic acyldepsipeptide antibiotics improves their antibacterial activity

Journal of the American Chemical Society

Volumn 136, Issue 5, 2014, Pages 1922-1929

  Carney, Daniel W ^a   Schmitz, Karl R ^b   Truong, Jonathan V ^a   Sauer, Robert T ^b   Sello, Jason K ^a  

^a BROWN UNIVERSITY   (United States)

^b MASSACHUSETTS INSTITUTE OF TECHNOLOGY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ANTI-BACTERIAL ACTIVITY; ANTI-BACTERIAL AGENTS; ANTIBACTERIAL DRUGS; BIOACTIVE CONFORMERS; CONFORMATIONAL DYNAMICS; MEASUREMENTS OF; MEDICINAL CHEMISTRY; NATURAL PRODUCTS;

AMINO ACIDS; ANTIBIOTICS; CRYSTAL STRUCTURE; HYDROGEN BONDS; MOLECULES;

CONFORMATIONS;

AMINO ACID; ANTIBIOTIC AGENT; CYCLIC ACYLDEPSIPEPTIDE ANTIBIOTIC; METHYL GROUP; UNCLASSIFIED DRUG;

AMINO ACID SUBSTITUTION; ANTIBACTERIAL ACTIVITY; ARTICLE; BIOLOGICAL ACTIVITY; CRYSTAL STRUCTURE; DRUG BIOAVAILABILITY; DRUG CONFORMATION; HYDROGEN BOND; PROTON NUCLEAR MAGNETIC RESONANCE; RECEPTOR BINDING;

ANTI-BACTERIAL AGENTS; CRYSTALLOGRAPHY, X-RAY; DEPSIPEPTIDES; ENTEROCOCCUS FAECALIS; HYDROGEN BONDING; MICROBIAL SENSITIVITY TESTS; PROTEIN CONFORMATION; STAPHYLOCOCCUS AUREUS; STREPTOCOCCUS PNEUMONIAE; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 84893790296     PISSN: 00027863     EISSN: 15205126     Source Type: Journal    
DOI: 10.1021/ja410385c     Document Type: Article

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