Diversity-oriented synthesis of cyclic acyldepsipeptides leads to the discovery of a potent antibacterial agent

Bioorganic and Medicinal Chemistry

Volumn 18, Issue 20, 2010, Pages 7193-7202

  Socha, Aaron M ^a   Tan, Nicholas Y ^a   Laplante, Kerry L ^b   Sello, Jason K ^a  

^a BROWN UNIVERSITY   (United States)

^b UNIVERSITY OF RHODE ISLAND   (United States)

Author keywords

Antibacterial agent; Clinical pathogens; ClpP; Cyclic acyldepsipeptide; MRSA; Multicomponent reactions; Ugi; VRE

Indexed keywords

ACYLDPESIPEPTIDE 4 DERIVATIVE; POLYPEPTIDE ANTIBIOTIC AGENT; UNCLASSIFIED DRUG;

ANTIBACTERIAL ACTIVITY; ARTICLE; CONTROLLED STUDY; DRUG STRUCTURE; DRUG SYNTHESIS; METHICILLIN RESISTANT STAPHYLOCOCCUS AUREUS; MINIMUM INHIBITORY CONCENTRATION; NONHUMAN; STAPHYLOCOCCUS AUREUS; VANCOMYCIN RESISTANT ENTEROCOCCUS;

ANIMALS; ANTI-BACTERIAL AGENTS; BACTERIAL INFECTIONS; BACTERIAL PROTEINS; DEPSIPEPTIDES; DRUG EVALUATION, PRECLINICAL; DRUG RESISTANCE, BACTERIAL; ENTEROCOCCUS; METHICILLIN-RESISTANT STAPHYLOCOCCUS AUREUS; MICE; MICROBIAL SENSITIVITY TESTS;

BACTERIA (MICROORGANISMS); ENTEROCOCCUS FAECALIS; METHICILLIN RESISTANT STAPHYLOCOCCUS AUREUS; STAPHYLOCOCCUS;

EID: 77957570418     PISSN: 09680896     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmc.2010.08.032     Document Type: Article

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