-
1
-
-
34547129074
-
Molecular approaches to target discovery: evaluating targets for anti-tuberculosis drug discovery programmes
-
Balganesh TS, Furr NJ. 2007. Molecular approaches to target discovery: evaluating targets for anti-tuberculosis drug discovery programmes. Infect. Disord. Drug Targets 7:120-126.
-
(2007)
Infect. Disord. Drug Targets
, vol.7
, pp. 120-126
-
-
Balganesh, T.S.1
Furr, N.J.2
-
2
-
-
75149132523
-
RseA, the SigE specific anti-sigma factor of Mycobacterium tuberculosis, is inactivated by phosphorylation-dependent ClpC1P2 proteolysis
-
Barik S, Sureka K, Mukherjee K, Basu J, Kundu M. 2010. RseA, the SigE specific anti-sigma factor of Mycobacterium tuberculosis, is inactivated by phosphorylation-dependent ClpC1P2 proteolysis. Mol. Microbiol. 75: 592-606.
-
(2010)
Mol. Microbiol.
, vol.75
, pp. 592-606
-
-
Barik, S.1
Sureka, K.2
Mukherjee, K.3
Basu, J.4
Kundu, M.5
-
3
-
-
0036270739
-
Evaluation of a nutrient starvation model of Mycobacterium tuberculosis persistence by gene and protein expression profiling
-
Betts JC, Lukey PT, Robb LC, McAdam RA, Duncan K. 2002. Evaluation of a nutrient starvation model of Mycobacterium tuberculosis persistence by gene and protein expression profiling. Mol. Microbiol. 43: 717-731.
-
(2002)
Mol. Microbiol.
, vol.43
, pp. 717-731
-
-
Betts, J.C.1
Lukey, P.T.2
Robb, L.C.3
McAdam, R.A.4
Duncan, K.5
-
4
-
-
27144460621
-
Dysregulation of bacterial proteolytic machinery by a new class of antibiotics
-
Brötz-Oesterhelt H, et al. 2005. Dysregulation of bacterial proteolytic machinery by a new class of antibiotics. Nat. Med. 11:1082-1087.
-
(2005)
Nat. Med.
, vol.11
, pp. 1082-1087
-
-
Brötz-Oesterhelt, H.1
-
5
-
-
34547561306
-
Discovery of antibacterial cyclic peptides that inhibit the ClpXP protease
-
Cheng L, et al. 2007. Discovery of antibacterial cyclic peptides that inhibit the ClpXP protease. Protein Sci. 16:1535-1542.
-
(2007)
Protein Sci
, vol.16
, pp. 1535-1542
-
-
Cheng, L.1
-
6
-
-
0032508046
-
Deciphering the biology of Mycobacterium tuberculosis from the complete genome sequence
-
Cole ST, et al. 1998. Deciphering the biology of Mycobacterium tuberculosis from the complete genome sequence. Nature 393:537-544.
-
(1998)
Nature
, vol.393
, pp. 537-544
-
-
Cole, S.T.1
-
7
-
-
0038519673
-
Progress in TB drug development and what is still needed
-
Duncan K. 2003. Progress in TB drug development and what is still needed. Tuberculosis 83:201-207.
-
(2003)
Tuberculosis
, vol.83
, pp. 201-207
-
-
Duncan, K.1
-
8
-
-
1942519868
-
clpC and clpP1P2 gene expression in Corynebacterium glutamicum is controlled by a regulatory network involving the transcriptional regulators ClgR and HspR as well as the ECF sigma factor sigma(H)
-
Engels S, Schweitzer JE, Ludwig C, Bott M, Schaffer S. 2004. clpC and clpP1P2 gene expression in Corynebacterium glutamicum is controlled by a regulatory network involving the transcriptional regulators ClgR and HspR as well as the ECF sigma factor sigma(H). Mol. Microbiol. 52: 285-302.
-
(2004)
Mol. Microbiol.
, vol.52
, pp. 285-302
-
-
Engels, S.1
Schweitzer, J.E.2
Ludwig, C.3
Bott, M.4
Schaffer, S.5
-
9
-
-
78049498592
-
ClgR regulation of chaperone and protease systems is essential for Mycobacterium tuberculosis parasitism of the macrophage
-
Estorninho M, et al. 2010. ClgR regulation of chaperone and protease systems is essential for Mycobacterium tuberculosis parasitism of the macrophage. Microbiology 156:3445-3455.
-
(2010)
Microbiology
, vol.156
, pp. 3445-3455
-
-
Estorninho, M.1
-
10
-
-
0036786322
-
Distinct clpP genes control specific adaptive responses in Bacillus thuringiensis
-
Fedhila S, Msadek T, Nel P, Lereclus D. 2002. Distinct clpP genes control specific adaptive responses in Bacillus thuringiensis. J. Bacteriol. 184: 5554-5562.
-
(2002)
J. Bacteriol.
, vol.184
, pp. 5554-5562
-
-
Fedhila, S.1
Msadek, T.2
Nel, P.3
Lereclus, D.4
-
11
-
-
0038236437
-
Alternative roles of ClpX and ClpP in Staphylococcus aureus stress tolerance and virulence
-
Frees D, Qazi SNA, Hill PJ, Ingmer H. 2003. Alternative roles of ClpX and ClpP in Staphylococcus aureus stress tolerance and virulence. Mol. Microbiol. 48:1565-1578.
-
(2003)
Mol. Microbiol.
, vol.48
, pp. 1565-1578
-
-
Frees, D.1
Qazi, S.N.A.2
Hill, P.J.3
Ingmer, H.4
-
12
-
-
0034103357
-
The ClpP serine protease is essential for the intracellular parasitism and virulence of Listeria monocytogenes
-
Gaillot O, Pellegrini E, Bregenholt S, Nair S, Berche P. 2000. The ClpP serine protease is essential for the intracellular parasitism and virulence of Listeria monocytogenes. Mol. Microbiol. 35:1286-1294.
-
(2000)
Mol. Microbiol.
, vol.35
, pp. 1286-1294
-
-
Gaillot, O.1
Pellegrini, E.2
Bregenholt, S.3
Nair, S.4
Berche, P.5
-
13
-
-
34347402468
-
Silencing essential protein secretion in Mycobacterium smegmatis by using tetracycline repressors
-
Guo XV, et al. 2007. Silencing essential protein secretion in Mycobacterium smegmatis by using tetracycline repressors. J. Bacteriol. 189: 4614-4623.
-
(2007)
J. Bacteriol.
, vol.189
, pp. 4614-4623
-
-
Guo, X.V.1
-
14
-
-
0033026248
-
Enhanced gene replacement in mycobacteria
-
Hinds J, et al. 1999. Enhanced gene replacement in mycobacteria. Microbiology 145:519-527.
-
(1999)
Microbiology
, vol.145
, pp. 519-527
-
-
Hinds, J.1
-
15
-
-
56849094648
-
Mycobacterium tuberculosis ClpC1: characterization and role of the N-terminal domain in its function
-
Kar NP, Sikriwal D, Rath P, Choudhary RK, Batra JK. 2008. Mycobacterium tuberculosis ClpC1: characterization and role of the N-terminal domain in its function. FEBS J. 275:6149-6158.
-
(2008)
FEBS J
, vol.275
, pp. 6149-6158
-
-
Kar, N.P.1
Sikriwal, D.2
Rath, P.3
Choudhary, R.K.4
Batra, J.K.5
-
16
-
-
66249146869
-
Stochasticity in protein levels drives colinearity of gene order in metabolic operons of Escherichia coli
-
Kovács K, Hurst LD, Papp B. 2009. Stochasticity in protein levels drives colinearity of gene order in metabolic operons of Escherichia coli. PLoS Biol. 7:e1000115.
-
(2009)
PLoS Biol
, vol.7
-
-
Kovács, K.1
Hurst, L.D.2
Papp, B.3
-
17
-
-
71749085013
-
Clp chaperone-proteases: structure and function
-
Kress W, Maglica Z, Weber-Ban E. 2009. Clp chaperone-proteases: structure and function. Res. Microbiol. 160:618-628.
-
(2009)
Res. Microbiol.
, vol.160
, pp. 618-628
-
-
Kress, W.1
Maglica, Z.2
Weber-Ban, E.3
-
18
-
-
4644372119
-
The ClpP protease of Streptococcus pneumoniae modulates virulence expression and protects against fatal pneumococcal challenge
-
Kwon HY, et al. 2004. The ClpP protease of Streptococcus pneumoniae modulates virulence expression and protects against fatal pneumococcal challenge. Infect. Immun. 72:5646-5653.
-
(2004)
Infect. Immun.
, vol.72
, pp. 5646-5653
-
-
Kwon, H.Y.1
-
19
-
-
77950519954
-
Structures of ClpP in complex with acyldepsipeptide antibiotics reveal its activation mechanism
-
Lee BG, et al. 2010. Structures of ClpP in complex with acyldepsipeptide antibiotics reveal its activation mechanism. Nat. Struct. Mol. Biol. 17: 471-478.
-
(2010)
Nat. Struct. Mol. Biol.
, vol.17
, pp. 471-478
-
-
Lee, B.G.1
-
20
-
-
0026323938
-
Site-specific integration of mycobacteriophage L5: integration-proficient vectors for Mycobacterium smegmatis, Mycobacterium tuberculosis, and bacille Calmette- Guérin
-
Lee MH, Pascopella L, Jacobs WR, Hatfull GF. 1991. Site-specific integration of mycobacteriophage L5: integration-proficient vectors for Mycobacterium smegmatis, Mycobacterium tuberculosis, and bacille Calmette- Guérin. Proc. Natl. Acad. Sci. U. S. A. 88:3111-3115.
-
(1991)
Proc. Natl. Acad. Sci. U. S. A.
, vol.88
, pp. 3111-3115
-
-
Lee, M.H.1
Pascopella, L.2
Jacobs, W.R.3
Hatfull, G.F.4
-
21
-
-
77956947687
-
Acyldepsipeptide antibiotics induce the formation of a structured axial channel in ClpP: a model for the ClpX/ClpA-bound state of ClpP
-
Li DHS, et al. 2010. Acyldepsipeptide antibiotics induce the formation of a structured axial channel in ClpP: a model for the ClpX/ClpA-bound state of ClpP. Chem. Biol. 17:959-969.
-
(2010)
Chem. Biol.
, vol.17
, pp. 959-969
-
-
Li, D.H.S.1
-
22
-
-
0031820470
-
Site-directed mutagenesis of the 19-kilodalton lipoprotein antigen reveals no essential role for the protein in the growth and virulence of Mycobacterium intracellulare
-
Mahenthiralingam E, et al. 1998. Site-directed mutagenesis of the 19-kilodalton lipoprotein antigen reveals no essential role for the protein in the growth and virulence of Mycobacterium intracellulare. Infect. Immun. 66:3626-3634.
-
(1998)
Infect. Immun.
, vol.66
, pp. 3626-3634
-
-
Mahenthiralingam, E.1
-
23
-
-
58149114923
-
Azole resistance in Mycobacterium tuberculosis is mediated by the MmpS5-MmpL5 efflux system
-
Milano A, et al. 2009. Azole resistance in Mycobacterium tuberculosis is mediated by the MmpS5-MmpL5 efflux system. Tuberculosis 89:84-90.
-
(2009)
Tuberculosis
, vol.89
, pp. 84-90
-
-
Milano, A.1
-
24
-
-
3042706671
-
Gene expression profile of Mycobacterium tuberculosis in a non-replicating state
-
Muttucumaru DGN, Roberts G, Hinds J, Stabler RA, Parish T. 2004. Gene expression profile of Mycobacterium tuberculosis in a non-replicating state. Tuberculosis 84:239-246.
-
(2004)
Tuberculosis
, vol.84
, pp. 239-246
-
-
Muttucumaru, D.G.N.1
Roberts, G.2
Hinds, J.3
Stabler, R.A.4
Parish, T.5
-
25
-
-
0033880508
-
Use of a flexible cassette method to generate a double unmarked Mycobacterium tuberculosis tlyA plcABC mutant by gene replacement
-
Parish T, Stoker NG. 2000. Use of a flexible cassette method to generate a double unmarked Mycobacterium tuberculosis tlyA plcABC mutant by gene replacement. Microbiology 146:1969-1975.
-
(2000)
Microbiology
, vol.146
, pp. 1969-1975
-
-
Parish, T.1
Stoker, N.G.2
-
26
-
-
0348110537
-
Efficient switching of mycobacteriophage L5-based integrating plasmids in Mycobacterium tuberculosis
-
Pashley CA, Parish T. 2003. Efficient switching of mycobacteriophage L5-based integrating plasmids in Mycobacterium tuberculosis. FEMS Microbiol. Lett. 229:211-215.
-
(2003)
FEMS Microbiol. Lett.
, vol.229
, pp. 211-215
-
-
Pashley, C.A.1
Parish, T.2
-
27
-
-
0036279922
-
Global transcriptional analysis of clpP mutations of type 2 Streptococcus pneumoniae and their effects on physiology and virulence
-
Robertson GT, Ng WL, Foley J, Gilmour R, Winkler ME. 2002. Global transcriptional analysis of clpP mutations of type 2 Streptococcus pneumoniae and their effects on physiology and virulence. J. Bacteriol. 184: 3508-3520.
-
(2002)
J. Bacteriol.
, vol.184
, pp. 3508-3520
-
-
Robertson, G.T.1
Ng, W.L.2
Foley, J.3
Gilmour, R.4
Winkler, M.E.5
-
28
-
-
0345701347
-
Genes required for mycobacterial growth defined by high density mutagenesis
-
Sassetti CM, Boyd DH, Rubin EJ. 2003. Genes required for mycobacterial growth defined by high density mutagenesis. Mol. Microbiol. 48: 77-84.
-
(2003)
Mol. Microbiol.
, vol.48
, pp. 77-84
-
-
Sassetti, C.M.1
Boyd, D.H.2
Rubin, E.J.3
-
30
-
-
77955343540
-
Characterization of a Clp protease gene regulator and the reaeration response in Mycobacterium tuberculosis
-
Sherrid AM, Rustad TR, Cangelosi GA, Sherman DR. 2010. Characterization of a Clp protease gene regulator and the reaeration response in Mycobacterium tuberculosis. PLoS One 5:e11622.
-
(2010)
PLoS One
, vol.5
-
-
Sherrid, A.M.1
Rustad, T.R.2
Cangelosi, G.A.3
Sherman, D.R.4
-
31
-
-
33746622429
-
Dissecting virulence pathways of Mycobacterium tuberculosis through protein-protein association
-
Singh A, Mai D, Kumar A, Steyn AJC. 2006. Dissecting virulence pathways of Mycobacterium tuberculosis through protein-protein association. Proc. Natl. Acad. Sci. U. S. A. 103:11346-11351.
-
(2006)
Proc. Natl. Acad. Sci. U. S. A.
, vol.103
, pp. 11346-11351
-
-
Singh, A.1
Mai, D.2
Kumar, A.3
Steyn, A.J.C.4
-
32
-
-
77957570418
-
Diversity-oriented synthesis of cyclic acyldepsipeptides leads to the discovery of a potent antibacterial agent
-
Socha AM, Tan NY, LaPlante KL, Sello JK. 2010. Diversity-oriented synthesis of cyclic acyldepsipeptides leads to the discovery of a potent antibacterial agent. Bioorg. Med. Chem. 18:7193-7202.
-
(2010)
Bioorg. Med. Chem.
, vol.18
, pp. 7193-7202
-
-
Socha, A.M.1
Tan, N.Y.2
LaPlante, K.L.3
Sello, J.K.4
-
33
-
-
0242651822
-
In vitro model of hypoxically induced nonreplicating persistence of Mycobacterium tuberculosis
-
Parish T, Stoker NG (ed), Humana Press Inc, Totowa, NJ
-
Wayne LG. 2001. In vitro model of hypoxically induced nonreplicating persistence of Mycobacterium tuberculosis. In Parish T, Stoker NG (ed), Mycobacterium tuberculosis protocols. Humana Press Inc, Totowa, NJ.
-
(2001)
Mycobacterium tuberculosis protocols
-
-
Wayne, L.G.1
-
34
-
-
0029976980
-
An in vitro model for sequential study of shiftdown of Mycobacterium tuberculosis through two stages of nonreplicating persistence
-
Wayne LG, Hayes LG. 1996. An in vitro model for sequential study of shiftdown of Mycobacterium tuberculosis through two stages of nonreplicating persistence. Infect. Immun. 64:2062-2069.
-
(1996)
Infect. Immun.
, vol.64
, pp. 2062-2069
-
-
Wayne, L.G.1
Hayes, L.G.2
-
35
-
-
0034780485
-
Nonreplicating persistence of Mycobacterium tuberculosis
-
Wayne LG, Sohaskey CD. 2001. Nonreplicating persistence of Mycobacterium tuberculosis. Annu. Rev. Microbiol. 55:139-163.
-
(2001)
Annu. Rev. Microbiol.
, vol.55
, pp. 139-163
-
-
Wayne, L.G.1
Sohaskey, C.D.2
-
36
-
-
0037216549
-
Global role for ClpP-containing proteases in stationary-phase adaptation of Escherichia coli
-
Weichart D, Querfurth N, Dreger M, Hengge-Aronis R. 2003. Global role for ClpP-containing proteases in stationary-phase adaptation of Escherichia coli. J. Bacteriol. 185:115-125.
-
(2003)
J. Bacteriol.
, vol.185
, pp. 115-125
-
-
Weichart, D.1
Querfurth, N.2
Dreger, M.3
Hengge-Aronis, R.4
-
37
-
-
79955103273
-
-
W.H.O. World Health Organization, Geneva, Switzerland
-
WHO. 2010. Global tuberculosis control: WHO report 2010. World Health Organization, Geneva, Switzerland.
-
(2010)
Global tuberculosis control: WHO report 2010
-
-
-
39
-
-
34248636300
-
Current strategies for identifying and validating targets for new treatment-shortening drugs for TB
-
Williams KJ, Duncan K. 2007. Current strategies for identifying and validating targets for new treatment-shortening drugs for TB. Curr. Mol. Med. 7:297-307.
-
(2007)
Curr. Mol. Med.
, vol.7
, pp. 297-307
-
-
Williams, K.J.1
Duncan, K.2
|