Global virulence regulation in Staphylococcus aureus: Pinpointing the roles of C1pP and C1pX in the sar/agr regulatory network

Infection and Immunity

Volumn 73, Issue 12, 2005, Pages 8100-8108

  Frees, Dorte ^a   Sørensen, Karen ^a   Ingmer, Hanne ^a  

^a UNIVERSITY OF COPENHAGEN   (Denmark)

Author keywords

[No Author keywords available]

Indexed keywords

BACTERIAL PROTEIN; ENDOPEPTIDASE CLP; ENDOPEPTIDASE CLPX; FIBRINOGEN; FIBRONECTIN; PROTEIN A; PROTEIN CLPXP; PROTEIN ROT; RNA; UNCLASSIFIED DRUG;

AGR GENE; ANIMAL CELL; ARTICLE; BACTERIAL CELL WALL; BACTERIAL VIRULENCE; CONTROLLED STUDY; GENE DELETION; GENE LOCUS; GENE MUTATION; GROWTH REGULATION; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; REGULATOR GENE; REGULATORY MECHANISM; REPRESSOR GENE; SAR GENE; SSPA GENE; STAPHYLOCOCCUS AUREUS; STRAIN IDENTIFICATION; SYSTEMIC DISEASE; TRANSCRIPTION REGULATION; WOUND INFECTION;

BACTERIAL PROTEINS; CELL WALL; ENDOPEPTIDASE CLP; EPISTASIS, GENETIC; GENE DELETION; GENE EXPRESSION REGULATION, BACTERIAL; MUTATION; REPRESSOR PROTEINS; RNA, ANTISENSE; RNA, BACTERIAL; SERINE ENDOPEPTIDASES; STAPHYLOCOCCAL PROTEIN A; STAPHYLOCOCCUS AUREUS; TRANS-ACTIVATORS; TRANSCRIPTION, GENETIC; VIRULENCE;

EID: 28444470162     PISSN: 00199567     EISSN: None     Source Type: Journal    
DOI: 10.1128/IAI.73.12.8100-8108.2005     Document Type: Article

References (45)

1. Arnau, J., K. I. Sorensen, K. F Appel, F. K. Vogensen, and K. Hammer. 1996. Analysis of heat shock gene expression in Lactococcus lactis MG1363. Microbiology 142:1685-1691.
2. Arvidson, S., and K. Tegmark. 2001. Regulation of virulence determinants in Staphylococcus aureus. Int. J. Med. Microbiol. 291:159-170.
3. Balaban, N., and R. P. Novick. 1995. Translation of RNAHI, the Staphylococcus aureus agr regulatory RNA can be activated by a 3′-end deletion. FEMS Microbiol. Lett. 133:155-161.
4. Benito, Y., F. A. Kolb, P. Romby, G. Lina, J. Etienne, and F. Vandenesch. 2000. Probing the structure of RNAIII, the Staphylococcus aureus agr regulatory RNA, and identification of the RNA domain involved in repression of protein A expression. RNA 6:668-679.
5. Chan, P. F., and S. J. Foster. 1998. Role of SarA in virulence determinant production and environmental signal transduction in Staphylococcus aureus. J. Bacteriol. 180:6232-6241.
6. Cheung, A. L., and V. Fischetti. 1988. Variation in the expression of cell wall proteins of Staphylococcus aureus grown on solid and liquid media. Infect. Immun. 56:1061-1065.
7. Cheung, A. L., and S. J. Projan. 1994. Cloning and sequencing of sarA of Staphylococcus aureus, a gene required for the expression of agr. J. Bacteriol. 176:4168-4172.
8. Cheung, A. L., K. Schmidt, B. Bateman, and A. C. Manna. 2001. SarS, a SarA homolog repressible by agr, is an activator of protein A synthesis in Staphylococcus aureus. Infect. Immun. 69:2448-2455.
9. Cheung, A. L., and G. Zhang. 2002. Global regulation of virulence determinants in Staphylococcus aureus by the SarA protein family. Front. Biosci. 7:1825-1842.
10. Chien, Y.-T., A. C. Manna, S. J. Projan, and A. L. Cheung. 1999. SarA, a global regulator of virulence determinants in Staphylococcus aureus, binds to a conserved motif essential forsar-dependent gene regulation. J. Biol. Chem. 274:37169-37176.
11. Frees, D., S. Qazi, P. Hill, and H. Ingmer. 2003. Alternative roles of ClpX and ClpP in Staphylococcus aureus stress tolerance and virulence. Mol. Microbiol. 48:1565-1578.
12. Gerth, U., J. Kirstein, J. Mosterz, T. Waldminghaus, M. Mielthke, H. Kock, and M. Hecker. 2004. Fine-tuning in regulation of Clp protein content in Bacillus subtilis. J. Bacteriol. 186:179-191.
13. Gottesman, S. 1999. Regulation by proteolysis: developmental switches. Curr. Opin. Microbiol. 2:142-147.
14. Heinrichs, J. H., M. G. Bayer, and A. L. Cheung. 1996. Characterization of the sar locus and its interaction with agr in Staphylococcus aureus. J. Bacteriol. 178:418-423.
15. Höök M., and T. J. Foster. 2000. Staphylococcal surface proteins, p. 386-391. In V. A. Fischetti, R. P. Novick, J. J. Ferretti, D. A. Portnoy, and J. I. Rood (ed.), Gram-positive pathogens. ASM Press, Washington, D.C.
16. B modulates virulence determinant expression and stress resistance: characterization of a functional rsbU strain derived from Staphylococcus aureus 8325-4. J. Bacteriol. 184:5457-5467.
17. Ingavale, S., W. van Wamel, T. T. Luong, C. Y. Lee, and A. L. Cheung. 2005. Rat/MgrA, a regulator of autolysis, is a regulator of virulence genes in Staphylococcus aureus. Infect. Immun. 73:1423-1431.
18. Janzon, L., and S. Arvidson. 1990. The role of the delta-lysin gene (hld) in the regulation of virulence genes by the accessory gene regulator (agr) in Staphylococcus aureus. EMBO J. 9:1391-1399.
19. Ji, G., R. C. Beavis, and R. P. Novick. 1995. Cell density control of Staphylococcal virulence mediated by an octapeptide pheromone. Proc. Natl. Acad. Sci. USA 92:12055-12059.
20. Karlsson, A., P. Saravia-Otten, K. Tegmark, E. Morfeldt, and S. Arvidson. 2001. Decreased amounts of cell wall-associated protein A and fibronectin-binding proteins in Staphylococcus aureus sarA mutants due to up-regulation of extracellular proteases. Infect. Immun. 69:4742-4748.
21. Kessel, M., M. R. Maurizi, B. Kim, E. Kocsis, B. L. Trus, S. K. Singh, and A. C. Steven. 1995. Homology in structural organization between the E. coli ClpAP pratease and the eukaryotic 26 S proteasome. J. Mol. Biol. 250:587-594.
22. Kornblum, J., B. Kreiswirth, S. J. Projan, H. Ross, and R. P. Novick. 1990. agr: a polycistronic locus regulating exoprotein synthesis in Staphylococcus aureus, p. 373-402. In R. P. Novick (ed.), Molecular biology of the staphylococci. VCH Publishers, New York, N.Y.
23. B in Staphylococcus aureus reveals its function as a global regulator of virulence genes. J. Bacteriol. 180:4814-4820.
24. McAleese, F. M., E. J. Walsh, M. Sieprawska, J. Potempa, and T. J. Foster. 2001. Loss of clumping factor B fibrinogen binding activity by Staphylococcus aureus involves cessation of transcription, shedding and cleavage by metalloprotease. J. Biol. Chem. 276:29969-29978.
25. McNamara, P. J., K. C. Milligan-Monroe, S. Kbalili, and R. A. Proctor. 2000. Identification, cloning, and initial characterization of rot, a locus encoding a regulator of virulence factor expression in Staphylococcus aureus. J. Bacteriol. 182:3197-3203.
26. Morfeldt, E., L. Janzon, S. Arvidson, and S. Lofdahl. 1988. Cloning of a chromosomal locus (exp) which regulates the expression of several exoprotein genes in. Staphylococcus aureus. Mol. Gen. Genet. 211:435-440.
27. Novick, R. 1967. Properties of a cryptic high-frequency transducing phage in Staphylococcus aureus. Virology 33:155-166.
28. Novick, R. P. 2000. Pathogenicity factors and their regulation, p. 392-407. In V. A. Fischetti, R. P. Novick, J. J. Ferretti, D. A. Portnoy, and J. I. Rood (ed.), Gram-positive pathogens. ASM Press, Washington, D.C.
29. Novick, R. P. 2003. Autoinduction and signal transduction in the regulation of staphylococcal virulence. Mol. Microbiol. 48:1429-1449.
30. Novick, R. P., S. J. Projan, J. Kornblum, H. F. Ross, G. Ji, B. Kreiswirth, F. Vandenesch, and S. Moghazeh. 1995. The agr P2 operon: an autocatalytic sensory transduction system in Staphylococcus aureus. Mol. Gen. Genet. 248:445-446.
31. Novick, R. P., H. F. Ross, S. J. Projan, J. Kornblum, B. Kreiswirth, and S. Moghazeh. 1993. Synthesis of staphylococcal virulence factors is controlled by a regulatory RNA molecule. EMBO J. 12:3967-3975.
32. O'Brien, L., S. Kerrigan, G. Kaw, M. Hogan, J. Penades, D. Litt, D. J. Fitzgerald, T. J. Foster, and D. Cox. 2002. Multiple mechanisms for the activation of human platelet aggregation by Staphylococcus aureus: roles for the clumping factors ClfA and ClfB and the serine-aspartate repeat protein SdrE. Mol. Microbiol. 44:1033-1044.
33. Peacock, S. J., T. J. Foster, B. J. Cameron, and A. R. Berendt. 1999. Bacterial fibronectin-binding proteins and endothelial cell surface fibronectin mediate adherence of Staphylococcus aureus to resting human endothelial cells. Microbiology 145:3477-3486.
34. Pelle, R., and N. B. Murphy. 1993. Northern hybridization: rapid and simple electrophoretic conditions. Nucleic Acid Res. 21:2783-2784.
35. Recsei, P., B. Kreiswirth, M. O'Reilly, P. Schlievert, A. Gruss, and R. P. Novick. 1986. Regulation of exoprotein gene expression in Staphylococcus aureus by agr. Mol. Gen. Genet. 202:58-61.
36. Saïd-Salim, B., P. M. Dunman, F. M. McAleese, D. Macapagal, E. Murphy, P. J. McNamara, S. Arvidson, T. J. Foster, S. J. Projan, and B. N. Kreiswirth. 2003. Global regulation of Staphylococcus aureus genes by Rot. J. Bacteriol. 185:610-619.
37. Sambrook, J., E. F. Fritsch, and T. Maniatis. 1989. Molecular cloning: a laboratory manual, 2nd ed. Cold Spring Harbor Laboratory Press, Cold Spring Harbor, N.Y.
38. Schmidt, K. A., A. C. Manna, and A. L. Cheung. 2003. SarT influences sarS expression in Staphylococcus aureus. Infect. Immun. 71:5139-5148.
39. Tegmark, K., A. Karlsson, and S. Arvidson. 2000. Identification and characterization of SarH1, a new global regulator of virulence gene expression in Staphylococcus aureus. Mol. Microbiol. 37:398-409.
40. Turgay, K., J. Hahn, J. Burghoorn, and D. Dubnau. 1998. Competence in Bacillus subtilis is controlled by regulated proteolysis of a transcription factor. EMBO J. 17:6730-6738.
41. Wang, J., J. A. Hartling, and J. M. Flanagan. 1997. The structure of ClpP at 2.3 Å resolution suggests a model for ATP-dependent proteolysis. Cell 91: 447-456.
42. Wawrzynow, A., D. Wojtkowiak, J. Marszalek, B. Banecki, M. Jonsen, B. Graves, C. Georgopolous, and M. Zylicz. 1995. The ClpX heat shock protein of Escherichia coll, the ATP-dependent substrate specificity component of the ClpP-ClpX protease, is a novel molecular chaperone. EMBO J. 14:1867-1877.
43. Wickner, S., S. Gottesman, D. Skowyra, J. Hoskins, K. McKenney, and M. R. Maurizi. 1994. A molecular chaperone, ClpA, functions like DnaK and DnaJ. Proc. Natl. Acad. Sci. USA 91:12218-12222.
44. Wolz, C., C. Goerke, R. Landmann, W. Zimmerli, and U. Fluckiger. 2000. Transcription of clumping factor A in attached and unattached Staphylococcus aureus in vitro and during device-related infection. Infect. Immun. 70: 2758-2762.
45. Zhou, Y., S. Gottesman, J. R. Hoskins, M. R. Maurizi, and S. Wickner. 2001. The RssB response regulator directly targets sigma(S) for degradation by ClpXP. Genes Dev. 15:627-637.