In vivo evaluation of ethanolic extract of Zingiber officinale rhizomes for its protective effect against liver cirrhosis

BioMed Research International

Volumn 2013, Issue , 2013, Pages

  Abdulaziz Bardi, Daleya ^a   Halabi, Mohammed Farouq ^a   Abdullah, Nor Azizan ^a   Rouhollahi, Elham ^a   Hajrezaie, Maryam ^a   Abdulla, Mahmood Ameen ^a  

^a UNIVERSITY OF MALAYA   (Malaysia)

Author keywords

[No Author keywords available]

Indexed keywords

ALCOHOL; CYCLINE; PLANT EXTRACT; SILYMARIN; THIOACETAMIDE;

ANIMAL; ARTICLE; CELL PROLIFERATION; CHEMICALLY INDUCED DISORDER; CHEMISTRY; DRUG EFFECT; EXPERIMENTAL LIVER CIRRHOSIS; GINGER; HEPG2 CELL LINE; HUMAN; MALE; MEDICINAL PLANT; METABOLISM; PATHOLOGY; RAT; RHIZOME; SPRAGUE DAWLEY RAT;

ANIMALS; CELL PROLIFERATION; ETHANOL; GINGER; HEP G2 CELLS; HUMANS; LIVER CIRRHOSIS, EXPERIMENTAL; MALE; PLANT EXTRACTS; PLANTS, MEDICINAL; PROLIFERATING CELL NUCLEAR ANTIGEN; RATS; RATS, SPRAGUE-DAWLEY; RHIZOME; SILYMARIN; THIOACETAMIDE;

EID: 84893761965     PISSN: 23146133     EISSN: 23146141     Source Type: Journal    
DOI: 10.1155/2013/918460     Document Type: Article

References (59)

1. Watt J. M., Breyer-Brandwijk M. G., The Medicinal and Poisonous Plants of Southern and Eastern Africa 1962 2nd
2. Dedov V. N., Tran V. H., Duke C. C., Connor M., Christie M. J., Mandadi S., Roufogalis B. D., Gingerols: a novel class of vanilloid receptor (VR1) agonists. British Journal of Pharmacology 2009 137 6 793 798 2-s2.0-0036856241 10.1038/sj.bjp.0704925
3. Govindarajan V. S., Connell D. W., Ginger-chemistry, technology, and quality evaluation: part 1. Critical Reviews in Food Science and Nutrition 1983 17 1 1 96 2-s2.0-0020011597
4. Govindarajan V. S., Connell D. W., Ginger-chemistry, technology, and quality evaluation: part 2. Critical Reviews in Food Science and Nutrition 1983 17 3 189 258 2-s2.0-0020448351
5. 4 induced toxicityand comparison of the extract's fraction D hepatoprotective capacity. Research Journal of Medical Sciences 2011 5 2 102 107 2-s2.0-79952130808 10.3923/rjmsci.2011.102.107
6. Forouzan S., Bahmani M., Parsaei P., Anti-parasitic activites of Zingiber officinale methanolic extract on Limnatis nilotica. Global Veterinaria 2012 9 2 144 148
7. Mostafa O. M. S., Eid R. A., Adly M. A., Antischistosomal activity of ginger (Zingiber officinale) against Schistosoma mansoni harbored in C57BL/6 mice. Parasitology Research 2011 109 2 395 403 2-s2.0-80052334637 10.1007/s00436-011-2267-x
8. Karuppiah P., Rajaram S., Antibacterial effect of Allium sativum cloves and Zingiber officinale rhizomes against multiple-drug resistant clinical pathogens. Asian Pacific Journal of Tropical Biomedicine 2012 2 8 597 601 2-s2.0-84860632228 10.1016/S2221-1691(12)60104-X
9. Al-Amin Z. M., Thomson M., Al-Qattan K. K., Ali M., Anti-diabetic and hypolipidaemic properties of ginger (Zingiber officina (Pubitemid 46470189)
10. Baliga M. S., Haniadka R., Pereira M. M., Thilakchand K. R., Rao S., Arora R., Radioprotective effects of Zingiber officinale Roscoe (ginger): past, present and future. Food & Function 2012 3 7 714 723
11. Nicoll R., Henein M. Y., Ginger (Zingiber officinale Roscoe): a hot remedy for cardiovascular disease? International Journal of Cardiology 2009 131 3 408 409 2-s2.0-58149204183 10.1016/j.ijcard.2007.07.107
12. Darvishzadeh-Mahani F., Esmaeili-Mahani S., Komeili G., Sheibani V., Zare L., Ginger (Zingiber officinale Roscoe) prevents the development of morphine analgesic tolerance and physical dependence in rats. Journal of Ethnopharmacology 2012 141 3 901 907 2-s2.0-84859541965 10.1016/j.jep.2012.03. 030
13. Ghasemzadeh A., Jaafar H. Z. E., Rahmat A., Antioxidant activities, total phenolics and flavonoids content in two varieties of Malaysia young ginger (Zingiber officinale Roscoe). Molecules 2010 15 6 4324 4333 2-s2.0-77954266959 10.3390/molecules15064324
14. Chrubasik S., Pittler M. H., Roufogalis B. D., Zingiberis rhizoma: a comprehensive review on the ginger effect and efficacy profiles. Phytomedicine 2005 12 9 684 701 2-s2.0-23844530273 10.1016/j.phymed.2004.07.009 (Pubitemid 41169818)
15. Ali B. H., Blunden G., Tanira M. O., Nemmar A., Some phytochemical, pharmacological and toxicological properties of ginger (Zingiber officinale Roscoe): a review of recent research. Food and Chemical Toxicology 2008 46 2 409 420 2-s2.0-37349127807 10.1016/j.fct.2007.09.085 (Pubitemid 350297543)
16. Koek G. H., Bast A., Driessen A., Watson R. R., Liver cirrhosis and vitamin E status. The Encyclopedia of Vitamin E 2007 CABI Publishing
17. Ueki T., Kaneda Y., Tsutsui H., Nakanishi K., Sawa Y., Morishita R., Matsumoto K., Nakamura T., Takahashi H., Okamoto E., Fujimoto J., Hepatocyte growth factor gene therapy of liver cirrhosis in rats. Nature Medicine 1999 5 2 226 230 2-s2.0-0032903634 10.1038/5593 (Pubitemid 29068532)
18. Pinzani M., Liver fibrosis. Springer Seminars in Immunopathology 2000 21 Springer 475 490 (Pubitemid 30433753)
19. Cruz-Pamplona M., Margaix-Munoz M., Sarrión-Pérez M. G., Dental considerations in patients with liver disease. Journal of Clinical and Experimental Dentistry 2011 3 2 127 134
20. Kadir F. A., Othman F., Abdulla M. A., Hussan F., Hassandarvish P., Effect of Tinospora crispa on thioacetamide-induced liver cirrhosis in rats. Indian Journal of Pharmacology 2011 43 1 64 68 2-s2.0-78951481366 10.4103/0253-7613.75673
21. Salama S. M., Bilgen M., Al Rashdi A. S., Abdulla M. A., Efficacy of Boesenbergia rotunda treatment against thioacetamide-induced liver cirrhosis in a rat model. Evidence-Based Complementary and Alternative Medicine 2012 2012 12 137083 10.1155/2012/137083
22. Amin Z. A., Bilgen M., Alshawsh M.A., Ali H. M., Hadi A. H. A., Abdulla M. A., Protective role of Phyllanthus niruri extract against thioacetamide-induced liver cirrhosis in rat model. Evidence-Based Complementary and Alternative Medicine 2012 2012 9 241583 10.1155/2012/241583
23. Alkiyumi S. S., Abdullah M. A., Alrashdi A. S., Salama S. M., Abdelwahab S. I., Hadi A. H., Ipomoea aquatica extract shows protective action against thioacetamide-induced hepatotoxicity. Molecules 2012 17 5 6146 6155
24. Alshawsh M. A., Abdulla M. A., Ismail S., Amin Z. A., Hepatoprotective effects of Orthosiphon stamineus extract on thioacetamide-induced liver cirrhosis in rats. Evidence-Based Complementary and Alternative Medicine 2011 2011 6 2-s2.0-79959241786 10.1155/2011/103039 103039
25. Miliauskas G., Venskutonis P., van Beek T., Screening of radical scavenging activity of some medicinal and aromatic plant extracts. Food Chemistry 2004 85 2 231 237 2-s2.0-0346849967 10.1016/j.foodchem.2003.05.007 (Pubitemid 37532696)
26. Rafat A., Philip K., Muniandy S., Antioxidant potential and content of phenolic compounds in ethanolic extracts of selected parts of Andrographis paniculata. Journal of Medicinal Plant Research 2010 4 3 197 202 2-s2.0-77649126555
27. Stoilova I., Krastanov A., Stoyanova A., Denev P., Gargova S., Antioxidant activity of a ginger extract (Zingiber officinale). Food Chemistry 2007 102 3 764 770 2-s2.0-33846223213 10.1016/j.foodchem.2006.06.023 (Pubitemid 46108279)
28. Kim N. H., Hyun S. H., Jin C. H., Pretreatment with 1,8-cineole potentiates thioacetamide-induced hepatotoxicity and immunosuppression. Archives of Pharmacal Research 2004 27 7 781 789 2-s2.0-16644375320 10.1007/BF02980149 (Pubitemid 43086224)
29. Tayal V., Kalra B. S., Agarwal S., Khurana N., Gupta U., Hepatoprotective effect of tocopherol against isoniazid and rifampicin induced hepatotoxicity in albino rabbits. Indian Journal of Experimental Biology 2007 45 12 1031 1036 2-s2.0-39649102578
30. Hassan M. H., Edfawy M., Mansour A., Hamed A. A., Antioxidant and antiapoptotic effects of capsaicin against carbon tetrachloride-induced hepatotoxicity in rats. Toxicology and Industrial Health 2012 28 5 428 438
31. Hor S. Y., Ahmad M., Farsi E., Lim C. P., Asmawi M. Z., Yam M. F., Acute and subchronic oral toxicity of Coriolus versicolor standardized water extract in Sprague-Dawley rats. Journal of Ethnopharmacology 2011 137 3 1067 1076 2-s2.0-80054923481 10.1016/j.jep.2011.07.007
32. Ljubuncic P., Song H., Cogan U., Azaizeh H., Bomzon A., The effects of aqueous extracts prepared from the leaves of Pistacia lentiscus in experimental liver disease. Journal of Ethnopharmacology 2005 100 1-2 198 204 2-s2.0-23044465135 10.1016/j.jep.2005.03.006 (Pubitemid 41073546)
33. Selzner M., Clavien P.-A., Failure of regeneration of the steatotic rat liver: disruption at two different levels in the regeneration pathway. Hepatology 2000 31 1 35 42 2-s2.0-0033985856 (Pubitemid 30033686)
34. Sartor R., Thomas C., Natural S., Some anti-thyroidand related substances, nitrofurans and industrial chemicals 1974 Geneva, Switzerland World Health Organisation
35. Ramya M., Ashok Kumar C. K., Teja Sree M., Revathi K., A review on hepatoprotective plants. International Journal of Phytopharmacy Research 2012 3 2 83 86
36. Chilakapati J., Shankar K., Korrapati M. C., Hill R. A., Mehendale H. M., Saturation toxicokinetics of thioacetamide: role in initiation of liver injury. Drug Metabolism and Disposition 2005 33 12 1877 1885 2-s2.0-28144443116 10.1124/dmd.105.005520 (Pubitemid 41697274)
37. Staňková P., Kučera O., Lotková H., Roušar T., Endlicher R., Červinková Z., The toxic effect of thioacetamide on rat liver in vitro. Toxicology in Vitro 2010 24 8 2097 2103 2-s2.0-78449306226 10.1016/j.tiv.2010.06.011
38. Natarajan S. K., Thomas S., Ramamoorthy P., Basivireddy J., Pulimood A. B., Ramachandran A., Balasubramanian K. A., Oxidative stress in the development of liver cirrhosis: a comparison of two different experimental models. Journal of Gastroenterology and Hepatology 2006 21 6 947 957 2-s2.0-33744770685 10.1111/j.1440-1746.2006.04231.x (Pubitemid 43823277)
39. Balkan J., Dogru-Abbasoglu S., Kanbagli O., Taurine has a protective effect against thioacetamide-induced liver cirrhosis by decreasing oxidative stress. Human and Experimental Toxicology 2001 20 5 251 254 2-s2.0-20644461914 10.1191/096032701678227758 (Pubitemid 32684850)
40. Srivastava K., Mustafa T., Ginger (Zingiber officinale) in rheumatism and musculoskeletal disorders. Medical Hypotheses 1992 39 4 342 348 2-s2.0-0027051053 10.1016/0306-9877(92)90059-L (Pubitemid 23010771)
41. Atta A., Elkoly T. A., Mouneir S. M., Kamel G., Alwabel N. A., Zaher S., Hepatoprotective effect of methanol extracts of Zingiber officinale and Cichorium intybus. Indian Journal of Pharmaceutical Sciences 2010 72 5 564 570 2-s2.0-79955097107 10.4103/0250-474X.78521
42. Galisteo M., Suárez A., Montilla M. P., Fernandez M. I., Gil A., Navarro M. C., Protective effects of Rosmarinus tomentosus ethanol extract on thioacetamide-induced liver cirrhosis in rats. Phytomedicine 2006 13 1-2 101 108 2-s2.0-29144472081 10.1016/j.phymed.2004.06.024 (Pubitemid 41797597)
43. Kadnur S. V., Goyal R. K., Beneficial effects of Zingiber officinale Roscoe on fructose induced hyperlipidemia and hyperinsulinemia in rats. Indian Journal of Experimental Biology 2005 43 12 1161 1164 2-s2.0-28844458471 (Pubitemid 41769216)
44. Pal J., Singh S. P., Prakash O., Batra M., Pant A. K., Mathela C. S., Hepatoprotective and antioxidant activity of Zingiber chrysanthum Rosec. rhizomes. Asian Journal of Traditional Medicines 2011 6 6 242 251
45. Islam S., Antonsson L., Westin J., Lagging M., Cirrhosis in hepatitis C virus-infected patients can be excluded using an index of standard biochemical serum markers. Scandinavian Journal of Gastroenterology 2005 40 7 867 872 2-s2.0-22144498854 10.1080/00365520510015674 (Pubitemid 40978865)
46. Hasan F. A., Owyed S., Interpretation of liver chemistry tests. Bulletin of the Kuwait Institute for Medical Specialization 2003 2 1 27 31
47. Ajith T. A., Hema U., Aswathy M. S., Zingiber officinale Roscoe prevents acetaminophen-induced acute hepatotoxicity by enhancing hepatic antioxidant status. Food and Chemical Toxicology 2007 45 11 2267 2272 2-s2.0-34548819875 10.1016/j.fct.2007.06.001 (Pubitemid 47451580)
48. Yemitan O. K., Izegbu M. C., Protective effects of Zingiber officinale (Zingiberaceae) against carbon tetrachloride and acetaminophen-induced hepatotoxicity in rats. Phytotherapy Research 2006 20 11 997 1002 2-s2.0-33751097241 10.1002/ptr.1957 (Pubitemid 44763787)
49. Nagalekshmi R., Menon A., Chandrasekharan D. K., Nair C. K. K., Hepatoprotective activity of Andrographis paniculata and Swertia chirayita. Food and Chemical Toxicology 2011 49 12 3367 3373 2-s2.0-80055024594 10.1016/j.fct.2011.09.026
50. Suriyakalaa U., Antony J. J., Suganya S., Hepatocurative activity of biosynthesized silver nanoparticles fabricated using Andrographis paniculata. Colloids and Surfaces B 2013 102 189 194
51. Lee J. K., Kim J. H., Shin H. K., Therapeutic effects of the oriental herbal medicine Sho-saiko-to on liver cirrhosis and carcinoma. Hepatology Research 2011 41 9 825 837
52. Ng I. O. L., Lai E. C. S., Fan S. T., Ng M., Chan A. S. Y., So M. K. P., Prognostic significance of proliferating cell nuclear antigen expression in hepatocellular carcinoma. Cancer 1994 73 9 2268 2274 2-s2.0-0028271583 (Pubitemid 24129107)
53. Takasaki Y., Anti-proliferating cell nuclear antigen (PCNA) antibody. Japanese Journal of Clinical Medicine 2010 68 578 581 2-s2.0-79952108267
54. Waseem N. H., Lane D. P., Monoclonal antibody analysis of the proliferating cell nuclear antigen (PCNA). Structural conservation and the detection of a nucleolar form. Journal of Cell Science 1990 96 1 121 129 2-s2.0-0025275171
55. Taha M. M. E., Abdul A. B., Abdullah R., Ibrahim T. A. T., Abdelwahab S. I., Mohan S., Potential chemoprevention of diethylnitrosamine-initiated and 2-acetylaminofluorene-promoted hepatocarcinogenesis by zerumbone from the rhizomes of the subtropical ginger (Zingiber zerumbet). Chemico-Biological Interactions 2010 186 3 295 305 2-s2.0-77954427466 10.1016/j.cbi.2010.04.029
56. Wang J. H., Redmond H. P., Wu Q. D. I., Bouchier-Hayes D., Nitric oxide mediates hepatocyte injury. The American Journal of Physiology 1998 275 5 G1117 G1126 2-s2.0-0031793498
57. Sakr S. A., Mahran H. A., Lamfon H. A., Protective effect of ginger (Zingiber officinale) on adriamycin-induced hepatotoxicity in albino rats. Journal of Medicinal Plant Research 2011 5 1 133 140 2-s2.0-79551701170
58. Kim J.-K., Kim Y., Na K.-M., Surh Y.-J., Kim T.-Y., [6]-gingerol prevents UVB-induced ROS production and COX-2 expression in vitro and in vivo. Free Radical Research 2007 41 5 603 614 2-s2.0-34047135039 10.1080/10715760701209896 (Pubitemid 46511125)
59. Sivasothy Y., Chong W. K., Hamid A., Eldeen I. M., Sulaiman S. F., Awang K., Essential oils of Zingiber officinale var. rubrum Theilade and their antibacterial activities. Food Chemistry 2011 124 2 514 517 2-s2.0-77955772172 10.1016/j.foodchem.2010.06.062