Hepatoprotective effect of methanol extracts of Zingiber officinale and Cichorium intybus

Indian Journal of Pharmaceutical Sciences

Volumn 72, Issue 5, 2010, Pages 564-570

  Atta, A J ^a   Elkoly, T A ^b   Mouneir, S M ^a   Kamel, Gehan ^a   Alwabel, N A ^c   Zaher, Shaimaa ^b  

^a Cairo University   (Egypt)

^b KING ABDULAZIZ UNIVERSITY   (Saudi Arabia)

^c QASSIM UNIVERSITY   (Saudi Arabia)

Author keywords

Carbon tetrachloride; chicory; cholesterol; creatinine; ginger; hepatotoprotective; histopathological; liver function; triglycerides

Indexed keywords

ALANINE AMINOTRANSFERASE; ALKALINE PHOSPHATASE; ALKALOID; ASPARTATE AMINOTRANSFERASE; CARBOHYDRATE; CARBON TETRACHLORIDE; CICHORIUM INTYBUS EXTRACT; FLAVONOID; GAMMA GLUTAMYLTRANSFERASE; GINGER EXTRACT; GLYCOSIDE; HEMOGLOBIN; LIVER PROTECTIVE AGENT; PHYTOSTEROL; PLANT EXTRACT; SAPONIN; SILYMARIN; TANNIN; TRIACYLGLYCEROL; TRITERPENE; UNCLASSIFIED DRUG;

ALANINE AMINOTRANSFERASE BLOOD LEVEL; ALKALINE PHOSPHATASE BLOOD LEVEL; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; ASPARTATE AMINOTRANSFERASE BLOOD LEVEL; BLOOD SAMPLING; CELL PROLIFERATION; CHICORY; CHOLESTEROL BLOOD LEVEL; CONTROLLED STUDY; DRUG EFFECT; ENZYME ACTIVITY; ERYTHROCYTE COUNT; FEMALE; GAMMA GLUTAMYL TRANSFERASE BLOOD LEVEL; GINGER; HISTOPATHOLOGY; INFLAMMATORY CELL; KUPFFER CELL; LEUKOCYTE COUNT; LIVER DYSFUNCTION; LIVER PROTECTION; MALE; NONHUMAN; RAT; THIN LAYER CHROMATOGRAPHY; THROMBOCYTE COUNT; THROMBOCYTE VOLUME; TOXICITY TESTING; TRIACYLGLYCEROL BLOOD LEVEL;

EID: 79955097107     PISSN: 0250474X     EISSN: 19983743     Source Type: Journal    
DOI: 10.4103/0250-474X.78521     Document Type: Article

References (41)

1. Mitra SK, Venkataranganna MV, Sundaram R, Goupmadhavan S. Protective effect of HD-03, a herbal formulation, against various hepatotoxic agents in rats. J Ethnopharmacol 1998;63:181-6. (Pubitemid 29030285)
2. Bhandari U, Kanojia R, Pillai KK. Effect of ethanolic extract of Zingiber offi cinale on dyslipidaemia in diabetic rats. J Ethnopharmacol 2005;97:227-30. (Pubitemid 40222022)
3. Mallikarjuna K, Sahitya CP, Sathyavelu RK, Rajendra, W. Ethanol toxicity: Rehabilitation of hepatic antioxidant defense system with dietary ginger. Fitoterapia 2008;79:174-8.
4. Ghayur MN, Gilani AH. Ginger lowers blood pressure through blockade of voltage-dependent calcium channels. Dig Dis Sci 2005;50:1889-97.
5. Siddaraju MN, Dharmesh SM. Inhibition of gastric H+, K+-ATPase and Helicobacter pylori growth by phenolic antioxidants of Zingiber offi cinale. Mol Nutr Food Res 2007;51:324-32. (Pubitemid 47083667)
6. Liu H, Zhu Y. Effect of alcohol extract of Zingber officinale rose on immunologic function of mice with tumor. Wei Sheng Yan Jiu 2002;31:208-9.
7. Yemitan OK, Izegbu, MC. Protective effects of Zingiber officinale (Zingiberaceae) against carbon tetrachloride and acetaminophen-induced hepatotoxicity in rats. Phytother Res 2006;20:997-1002. (Pubitemid 44763787)
8. Manju V, Nalini N. Effect of ginger on bacterial enzymes in 1, 2-dimethylhydrazine induced experimental colon carcinogenesis. Eur J Cancer Prev 2006;15:377-83. (Pubitemid 44252908)
9. Ansari MN, Bhandari U, Pillai KK. Ethanolic Zingiber officinale R. extract pretreatment alleviates isoproterenol-induced oxidative myocardial necrosis in rats. Indian J Exp Biol 2006;44:892-7. (Pubitemid 44736228)
10. Kim M, Shin HK. The water-soluble extract of chicory influences serum and liver lipid concentrations, cecal short-chain fatty acid concentrations and fecal lipid excretion in rats. J Nutr 1998;128:1731-6. (Pubitemid 28452859)
11. Ahmed B, Al-Howiriny TA Siddiqui AB. Antihepatotoxic activity of seeds of Cichorium intybus. J Ethnopharmacol 2003;87:237-40. (Pubitemid 36809158)
12. Krylova SG, Efimova LA, Vymiatina, ZK, Zueva EP. The effect of cichorium root extract on the morphofunctional state of liver in rats with carbon tetrachloride induced hepatitis model. Eksp Klin Farmakol 2006;69:34-6.
13. Kery A, Blazovics A, Fejes S, Nagy E, Lugasi A, Kursinszki L, et al. Antioxidant activity of medicinal plants used in phytotherapy. Int J Hortcultural Sci 2001;7:28-35.
14. Rossetto M, Lante A, Vanzani P, Spettoli, P, Scarpa M, Rigo A. Red chicories as potent scavengers of highly reactive radicals: A study on their phenolic composition and peroxyl radical trapping capacity and effi ciency. J Agric Food Chem 2005;53:8169-75. (Pubitemid 41564623)
15. Petlevski R, Hadzija M, Slijepcevic, M, Juretic D, Petrik J. Glutathione S-transferases and malondialdehyde in the liver of NOD mice on shortterm treatment with plant mixture extract P-9801 091. Phytother Res 2003;17:311-4. (Pubitemid 36565332)
16. Kaur N, Gupta AK. Applications of inulin and oligofructose in health and nutrition. J Biosci 2002;27:703-14. (Pubitemid 36091305)
17. Chakraborti KK, Handa SS. Antihepatotoxic investigations on Boerhavia repanda Willd. Ind Drugs 1989;27:19-24.
18. Reitman S, Frankel S. Colorimetric determination of serum glutamic oxalactic and glutamic pyruvic transaminase. Am J Clin Path 1957;28:56-8.
19. Szasz G. A kinetic photometric method for serum gamma glutamyl transferase. Clin Chem 1969;15:124-36.
20. Trinder P. Enzymatic methods for glucose determination. Ann Clin Biochem 1969;6:24-8.
21. VanHendle E, Zilversmith, DB. Determination of serum triglycerides. J Lab Clin Med 1957;50:152-7.
22. Henary RJ, Cannon DC, Winkleman JW. Clinical Chemistry Principles and Techniques. 2nd ed. New York: Harper and Roe; 1974.
23. Husdan H, Rapoport A. Estimation of Creatinine by the Jaffe reaction. Clin Chem 1968;14:222-38.
24. Fredrikson DS, Levi RL, Less RS. Determination of cholesterol. N Engl J Med 1967;276:148-56.
25. Tanira MO, Shah AH, Mohsin A, Ageel AM, Qureshi S. Pharmacological and toxicological investigations on Foeniculum vulgare dried fruit extract in experimental animals. Phytother Res 1996;10:33-6. (Pubitemid 26056650)
26. Stahl E. Thin Layer Chromatography. 2nd ed. New York: Springer- Verlag; 1969.
27. Wagner H, Bladt S, Zgainski EM. Drogen Analyse. Heidelberg: Springer Verlag; 1983.
28. Buck WB, Osweiter GD, Van Gelder AG. In: Clinical and Diagnostic Veterinary Toxicology. 2nd ed. Iowa City: Kendall, Hunt Publishing Company; 1976.
29. Schmidt BM, Iliæ N, Poulev A, Raskin I. Toxicological evaluation of a chicory root extract. Food Chem Tox 2007;45:1131-9. (Pubitemid 46590554)
30. Jagetia GC, Baliga, MS Venkatesh P. Ginger (Zingiber offi cinale Rosc.), a dietary supplement, protects mice against radiation-induced lethality: Mechanism of action. Cancer Biother Radiopharm 2004;19:422-35. (Pubitemid 39281334)
31. Gergely J, Kulcsár A, Hársfalvi J. Changes in fat metabolism in acute carbon tetrachloride intoxication of rats. Acta Pharm Hung 1995;65:3-4.
32. Judah JD. Biochemical disturbances in liver injury. Br Med Bull 1969;25:274-7.
33. Ajith TA, Hema U, Aswathy MS. Zingiber offi cinale Roscoe prevents acetaminophen-induced acute hepatotoxicity by enhancing hepatic antioxidant status. Food Chem Toxicol 2007;45:2267-72. (Pubitemid 47451580)
34. Gilani AH, Janbaz KH. Preventive and curative effects of Artemisia absinthium on acetaminophen and CCl4-induced hepatotoxicity. Gen Pharmacol 1995;26:309-15.
35. Nicoll R, Henein MY. Ginger (Zingiber officinale Roscoe): A hot remedy for cardiovascular disease? Int J Cardiol 2009;131:408-9.
36. Islam MS, Choi H. Comparative effects of dietary ginger (Zingiber offi cinale) and garlic (Allium sativum) investigated in a type 2 diabetes model of rats. J Med Food 2008;11:152-9. (Pubitemid 351450508)
37. Thulasi GP, Dos PD. Prevention of radiation-induced chromosome damage in mouse bone marrow by aqueous leaf extract of Cichorium intybus. J Cell Mol Biol 2007;6:59-64.
38. Lantz RC, Chen GJ, Sarihan M, Sólyom AM, Jolad SD, Timmermann BN. The effect of extracts from ginger rhizome on inflammatory mediator production. Phytomedicine 2006;14:123-8.
39. Levy AS, Simon O, Shelly J, Gardener M. 6-Shogaol reduced chronic inflammatory response in the knees of rats treated with complete Freund's adjuvant. BMC Pharmacol 2006;1:6-12.
40. Grieshop CM, Flickinger EA, Bruce KJ, Patil AR, Czarecki-Maulden GL, Fahey GC. Gastrointestinal and immunological responses of senior dose to chicory and mannan-oligosaccharides. Arch Animal Nutr 2004;58:483-93. (Pubitemid 40126159)
41. Kim JH, Mun YJ, Woo WH, Jeon KS, An NH, Park JS. Effect of the ethanol extract of Cichorium intybus on the immunotoxicity by ethanol in mice. Int Immunopharmacol 2002;2:733-44.