Antihepatotoxicity studies of crude extract of Zingiber officinale on CC14 induced toxicityand comparison of the extract's fraction D hepatoprotective capacity

Research Journal of Medical Sciences

Volumn 5, Issue 2, 2011, Pages 102-107

  Ezeonu, C S ^a   Egbuna, P A C ^b   Ezeanyika, L U S ^b   Nkwonta, C G ^b   Idoko, N D ^b  

^a GODFREY OKOYE UNIVERSITY   (Nigeria)

^b UNIVERSITY OF NIGERIA   (Nigeria)

Author keywords

CCl4; Ginger; Hepatoprotective; Intraperitoneal; Nigeria; SGOT; SGPT

Indexed keywords

ALANINE AMINOTRANSFERASE; ALCOHOL; ASPARTATE AMINOTRANSFERASE; CARBON TETRACHLORIDE; GINGER EXTRACT; PHOSPHATE;

ALANINE AMINOTRANSFERASE BLOOD LEVEL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; ASPARTATE AMINOTRANSFERASE BLOOD LEVEL; CONTROLLED STUDY; DRUG ACTIVITY; DRUG EFFECT; DRUG EFFICACY; ENZYME BLOOD LEVEL; FEMALE; LIPID PEROXIDATION; LIVER INJURY; LIVER PROTECTION; LIVER TOXICITY; MALE; NONHUMAN; PROTEIN BLOOD LEVEL; PROTEIN SYNTHESIS; RAT;

EID: 79952130808     PISSN: 18159346     EISSN: 19936095     Source Type: Journal    
DOI: 10.3923/rjmsci.2011.102.107     Document Type: Article

References (12)

1. Ahmed, R.S. and S.B. Sharma, 1997. Biochemical studies on combined effects of garlic (Allium sativum Linn.) and ginger (Zingiber officinale Rose.) in albino rats. Ind. J. Exp. Biol, 35: 841-843.
2. Bergmeyer, H.U., 1974. Methods of Enzymatic Analysis. 2nd Edn., Academic Press, New York, ISBN: 0895 732424, pp: 534.
3. Egbuna, P. A.C. and C.T. Echetabu, 1996. Antihepatotoxic effect of Nauclea diderrichii. Plant Prod. Res. Commun., 1: 1-4.
4. Elegbede, J. A., T.H. Maltzman, C.E. Eison and M.N. Gould, 1993. Effects of anticarcinogenic monoterpenes on phase II hepatic metabolizing enzymes. Carcluogenesb, 14: 1221-1223.
5. Gomeri, G., 1942. Determination of inorganic phosphate in serum and plasma. J. Labs. Clin. Med., 29: 955-956.
6. International Programme on Chemical Safety (IPCS), 1999. Environmental health criteria 208: Carbon tetrachloride. World Health Organization, Geneva. http://whqhbdoc.who.int/ehcAVHO_EHC_208.pdf.
7. Lehninger, A.L., D.L. Nelson and M.M Cox, 2000. Priniple of Biochemistry. 3rd Edn., Worth Publishers, New York.
8. Leung, A. Y. and S. Foster, 1996. Encyclopedia of Common Natural Ingredients used in Foods, Drugs and Cosmetics. 2nd Edn., John Willy and Sons, New York, ISBN-13: 9780471508267, pp: 649.
9. Reitman, S. and S. Frankel, 1957. Colorimetric method for the determination of SGOT and SGPT. Am. J. Clin. Path., 33: 97-97.
10. Wagner, H., 1981. Plant Constituents with Antihepatotoxic Activity. In: Natural Products as Medicinal Agents, Beal, J.L. and E. Reinhard (Eds.). Hippokrates-Verlang, Stuttgart.
11. Wallin, B., B. Rosengren, H.G. Shertzer and G. Camejo, 1993. Lipoprotein oxidation and measurement of thiobarbituric acid reacting substances formation in a single microliter plate: Its use for evaluation of antioxidants. Anal. Biochem., 208: 10-15.
12. Zimmerman, H.J. and J.B. Henry, 1984. Clinical Enzymology. In: Clinical Diagnosis and Management by Laboratory Methods, Henry, J.B. (Ed.). W.B. Sanders Publishers, Philadelphia, pp: 251-282.