Protective effect of ginger (Zingiber officinale) on adriamycin - induced hepatotoxicity in albino rats

Journal of Medicinal Plants Research

Volumn 5, Issue 1, 2011, Pages 133-140

  Sakr, Saber A ^a   Mahran, Hoda A ^a   Lamfon, Hawazen A ^b  

^a Menoufia University   (Egypt)

^b UMM AL QURA UNIVERSITY   (Saudi Arabia)

Author keywords

Adriamycin; Ginger; Histology; Liver; Transaminases

Indexed keywords

ALANINE AMINOTRANSFERASE; ASPARTATE AMINOTRANSFERASE; DOXORUBICIN; GINGER EXTRACT; MALONALDEHYDE; SUPEROXIDE DISMUTASE;

ALANINE AMINOTRANSFERASE BLOOD LEVEL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTIOXIDANT ACTIVITY; ARTICLE; ASPARTATE AMINOTRANSFERASE BLOOD LEVEL; CELL INFILTRATION; CELL VACUOLE; CONTROLLED STUDY; LEUKOCYTE; LIPID PEROXIDATION; LIVER CELL; LIVER CONGESTION; LIVER FATTY DEGENERATION; LIVER PROTECTION; LIVER TOXICITY; MALE; NONHUMAN; RAT; WEIGHT REDUCTION;

ANIMALIA; RATTUS; ZINGIBER OFFICINALE;

EID: 79551701170     PISSN: 19960875     EISSN: 19960875     Source Type: Journal    
DOI: None     Document Type: Article

References (34)

1. Ajith TA, Nivitha V, Usha S (2007). Zingiber officinale Roscoe alone and in combination with alpha-tocopherol protect the kidney against cisplatin-induced acute renal failure. Food Chem. Toxicol., 45(6): 921-927.
2. Alberts DS, Salmon SE (1975). Adriamycin (NSC 123127) in the treatment of alkylator-resistant multiple myeloma: a pilot study. Cancer Chemother. Rep., 59(2Pt1): 345-350.
3. Amin A, Hamza AA (2006). Effects of Rosell and ginger on cisplatininduced reproductive toxicity in rats. Asian J. Androl., 8(5): 607-612.
4. Ansari MN, Bhandari U, Pillai KK (2006). Ethanolic Zingiber officinale R. extract pretreatment alleviates isoproterenol-induced oxidative myocardial necrosis in rats. Indian J. Exp. Biol., 44(11): 892-897
5. Bachur NR, Gordon SL, Gee MW (1978). A general mechanism for microsomal activation of quinone anticancer agents to free radicals. Cancer Res., 38(6): 1745-1750.
6. Bertazzoli C, Chieli T, Solcia E (1971). Different incidence of breast carcinomas or fibroadenomas in daunomycin or adriamycin treated rats. Experientia., 27(10): 1209-1210.
7. Bhandari U, Sharma JN, Zafar R (1998), The protective action of ethanolic ginger (Zingiber officinale) extract in cholesterol fed rabbits. J. Ethanopharmacol., 61(2):167-171.
8. Deepa PR, Varalakshmi P. (2003). Protective effect of low molecular weight heparin on oxidative injury and cellular abnormalities in adriamycin-induced cardiac and hepatic toxicity. Chemico. Biol. Interact., 146(2): 201-210.
9. DiMarco A, Gaetani M, Scarpinato B (1969). Adriamycin(NSC-123,127). A new antibiotic with antitumour activity. Cancer Chemother. Rep., 53(1): 33-37.
10. El-Mofty MM, Khudoley VV, Sakr SA, Osman SI, Toulan BA (1991). Adriamycin-induced neoplastic lesions in the Egyptian toad Bufo regularis. Oncology., 48(2): 171-174.
11. El-Sayyad HI, Ismail MF, Shalaby FM, Abou-El-Magd RF, Gaur RL, Fernando A, Raj MH, Ouhtit A (2009). Histopathological effects of cisplatin, doxorubicin and 5-flurouracil (5-FU) on the liver of male albino rats Int. J. Biol. Sci., 5(5): 466-473
12. Fisher-Rasmussen W, Kjaer SK, Dahl C, Asping U (1991). Ginger treatment of Hyperemesis gravidarm. Eur. J. Obstet. Gynecol. Rep. Biol., 38(1):19-24.
13. Gilani AH, Rahman AU (2005), Trends in ethnopharmocology. J. Ethnopharmacol., 100(1-2): 43-49.
14. Gokcimen A, Cim A, Tola HT, Bayram D, Kocak A, Ozgüner F, Ayata A (2007). Protective effect of N-acetylcysteine, caffeic acid and vitamin E on doxorubicin hepatotoxicity. Hum. Exp. Toxicol., 26(6): 519-525.
15. Gujral S, Bhumra H, Swaroop M (1978). Effect of ginger (Zingebar officinate Roscoe) Oleoresin on serum and hepatic cholesterol levels in cholesterol fed rats. Nutr. Reports Intl., 17(2): 183-189.
16. Injac R, Perse M, Obermajer N, Djordjevic-Milic V, Prijatelj M, Djordjevic A, Cerar A, Strukelj B. (2008). Potential hepatoprotective effects of fullerenol C60(OH)24 in doxorubicin-induced hepatotoxicity in rats with mammary carcinomas. Biomaterials., 29(24-25): 3451-3460.
17. Kalender Y, Yel M., Kalender S (2005). Doxorubicin hepatotoxicity and hepatic free radical metabolism in rats. The effects of vitamin E and catechin. Toxicology, 209(1): 39-45.
18. Kamtchouing P, Mbongue Fandio GY, Dimo T, Jatsa HB (2002). Evaluation of androgenic activity of Zingiber officinale and Pentadiplandra brazzeana in male rats. Asian J. Androl., 4(4):299-301.
19. Lee V, Randhawa AK, Singal PK (1991). Adriamycin-induced myocardial dysfunction in vitro is mediated by free radicals. Am. J. Physiol., 26(4Pt2): H989-H995.
20. Leo MA, Lieber CS (1983). Hepatic fibrosis after long-term administration of ethanol and moderate vitamin A supplementation in the rat. Hepatology., 3(1): 1-11.
21. Llesuy SF, Arnaiz SL (1990). Hepatotoxicity of mitoxantrone and doxorubicin. Toxicology., 63(2): 187-198.
22. Mascolo N, Jain R, Tain SC, Capasso FJ (1989). Ethnopharmacologic investigation of ginger (Zingiber officinale). J. Ethanoharmacol., 27 (1-2): 129-140.
23. Minami M, Matsumoto S, Horiuchi H (2010). Cardiovascular side-effects of modern cancer therapy. Circ. J., 74(9): 1779-1786.
24. National Rsearch Council (1985). Guide for use and care of laboratory animals, Publication no. 85-23, Washington, NIH.
25. Ogawa T (1985). Studies on endoscopic local injection of an anticancer agent into experimental canine stomach cancer. Kitakant Med. J., 35: 463-476.
26. Ohkawa H, Ohishi N, Yagi K (1979). Assay for lipid peroxidase in animal tissue by thiobarbituric acid reaction. Anal. Biochem., 95(2): 351-358.
27. Rest RF, Spitznagel JK (1977). Subcellular distribution of superoxide dismutases in human neutrophils. Influence of myeloperoxide measurement of superoxide dismutase activity. Biochem. J., 166(2): 145-153.
28. Saad SY, Najjar TA, AL-Rikabi AC (2001). The preventive role of deferoxamine against acute doxorubicin-induced cardiac, renal and hepatic toxicity in rats. Pharmacol. Res., 43(3): 211-218.
29. Sakr SA (2007). Ameliorative effect of ginger (Zingiber officinale) on mancozeb fungicide induced liver injury in albino rats. Australian J. Basic Appl. Sci., 1(14): 650-656.
30. Sharma JN, Srivastava KC, Gan EK (1994). Suppressive effects of eugenol and ginger oil on arthritic rats. Pharmacol., 49(5): 314-318.
31. +, ATPase and Helicobacter pylori growth by phenolic antioxidants of Zingiber officinale. Mol. Nutr. Food Res., 51(3): 324-332
32. Sternberg SS, Philips FS, Cronin AP (1972). Renal tumours and other lesions in rats following a single intravenous injection of daunomycin. Cancer Res., 32(5): 1029-1036.
33. Wang JJ, Cortes E, Sink LF, Holland JF (1971). Therapeutic effect and toxicity of adriamycin in patients with nepotistic diseases. Cancer, 28(4): 837-843
34. Yemitan OK, Izegbu MC (2006). Protective effects of Zingiber offcinale (zingiberaceae) against carbon tetrachloride and acetaminopheninduced hepatotoxucity in rats. Phytother. Res., 20(11): 997-1002.