BMP signaling in the nephron progenitor niche

Pediatric Nephrology

Volumn 26, Issue 9, 2011, Pages 1491-1497

  Oxburgh, Leif ^a   Brown, Aaron C ^a   Fetting, Jennifer ^a   Hill, Beth ^a  

^a Maine Medical Center Research Institute   (United States)

Author keywords

BMP; Bone morphogenetic protein; Nephrogenesis; Nephrogenic zone; Nephron differentiation; Nephron progenitor cell

Indexed keywords

BONE MORPHOGENETIC PROTEIN; BONE MORPHOGENETIC PROTEIN 4; CROSSVEINLESS PROTEIN; MITOGEN ACTIVATED PROTEIN KINASE; OSTEOGENIC PROTEIN 1; PROTEIN; SMAD1 PROTEIN; SMAD4 PROTEIN; SMAD5 PROTEIN; SMAD8 PROTEIN; TRANSFORMING GROWTH FACTOR BETA ACTIVATED KINASE 1; UNCLASSIFIED DRUG; X LINKED INHIBITOR OF APOPTOSIS;

CELL PROLIFERATION; CELL SURVIVAL; CONFERENCE PAPER; GENE EXPRESSION; GENE INACTIVATION; IN SITU HYBRIDIZATION; KIDNEY DEVELOPMENT; NEPHRON PROGENITOR CELL; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN FUNCTION; PROTEIN PHOSPHORYLATION; SIGNAL TRANSDUCTION; STEM CELL; STEM CELL NICHE;

ANIMALS; BONE MORPHOGENETIC PROTEINS; GENE EXPRESSION REGULATION, DEVELOPMENTAL; HUMANS; NEPHRONS; SIGNAL TRANSDUCTION; STEM CELL NICHE; STEM CELLS;

EID: 80052300594     PISSN: 0931041X     EISSN: 1432198X     Source Type: Journal    
DOI: 10.1007/s00467-011-1819-8     Document Type: Conference Paper

References (63)

1. AT Dudley KM Lyons EJ Robertson 1995 A requirement for bone morphogenetic protein-7 during development of the mammalian kidney and eye Genes Dev 9 2795 2807 7590254 10.1101/gad.9.22.2795 1:CAS:528:DyaK2MXpslOmsbc%3D
2. G Luo C Hofmann ALJJ Bronckers M Sohocki A Bradley G Karsenty 1995 BMP-7 is an inducer of nephrogenesis, and is also required for eye development and skeletal patterning Genes Dev 9 2808 2820 7590255 10.1101/gad.9.22.2808 1:CAS:528:DyaK2MXpslOmtr4%3D
3. T Obara-Ishihara J Kuhlman L Niswander D Herzlinger 1999 The surface ectoderm is essential for nephric duct formation in intermediate mesoderm Development 126 1103 1108 10021330 1:CAS:528:DyaK1MXisFWms7k%3D (Pubitemid 29182107)
4. O Michos A Goncalves J Lopez-Rios E Tiecke F Naillat K Beier A Galli S Vainio R Zeller 2007 Reduction of BMP4 activity by gremlin 1 enables ureteric bud outgrowth and GDNF/WNT11 feedback signalling during kidney branching morphogenesis Development 134 2397 2405 17522159 10.1242/dev.02861 1:CAS:528:DC%2BD2sXosVKrt7Y%3D (Pubitemid 47074134)
5. A Brenner-Anantharam C Cebrian R Guillaume R Hurtado TT Sun D Herzlinger 2007 Tailbud-derived mesenchyme promotes urinary tract segmentation via BMP4 signaling Development 134 1967 1975 17442697 10.1242/dev.004234 1:CAS:528:DC%2BD2sXmvFagu7s%3D (Pubitemid 46939241)
6. KT Bush H Sakurai DL Steer MO Leonard RV Sampogna TN Meyer C Schwesinger J Qiao SK Nigam 2004 TGF-[beta] superfamily members modulate growth, branching, shaping, and patterning of the ureteric bud Dev Biol 266 285 298 14738877 10.1016/j.ydbio.2003.10.023 1:CAS:528:DC%2BD2cXltF2rtA%3D%3D (Pubitemid 38102239)
7. IR Gupta M Macias-Silva S Kim X Zhou TD Piscione C Whiteside JL Wrana ND Rosenblum 2000 BMP-2/ALK3 and HGF signal in parallel to regulate renal collecting duct morphogenesis J Cell Sci 113 Pt 2 269 278 10633078 1:CAS:528:DC%2BD3cXht1yntLo%3D (Pubitemid 30088972)
8. S Hartwig D Bridgewater V Di Giovanni J Cain Y Mishina ND Rosenblum 2008 BMP receptor ALK3 controls collecting system development J Am Soc Nephrol 19 117 124 18178801 10.1681/ASN.2007010080 1:CAS:528:DC%2BD1cXhs12hur0%3D
9. Y Miyazaki K Oshima A Fogo BL Hogan I Ichikawa 2000 Bone morphogenetic protein 4 regulates the budding site and elongation of the mouse ureter J Clin Invest 105 863 873 10749566 10.1172/JCI8256 1:CAS:528:DC%2BD3cXit1ynsr0%3D (Pubitemid 30203059)
10. AT Dudley RE Godin EJ Robertson 1999 Interaction between FGF and BMP signaling pathways regulates development of metanephric mesenchyme Genes Dev 13 1601 1613 10385628 10.1101/gad.13.12.1601 1:CAS:528:DyaK1MXktlOhsbs%3D (Pubitemid 29297927)
11. M Ikeya K Fukushima M Kawada S Onishi Y Furuta S Yonemura T Kitamura T Nosaka Y Sasai 2010 Cv2, functioning as a pro-BMP factor via twisted gastrulation, is required for early development of nephron precursors Dev Biol 337 405 414 19914233 10.1016/j.ydbio.2009.11.013 1:CAS:528:DC%2BC3cXosVCq
12. U Blank A Brown DC Adams MJ Karolak L Oxburgh 2009 BMP7 promotes proliferation of nephron progenitor cells via a JNK-dependent mechanism Development 136 3557 3566 19793891 10.1242/dev.036335 1:CAS:528: DC%2BD1MXhsFWhurfJ
13. K Georgas B Rumballe MT Valerius HS Chiu RD Thiagarajan E Lesieur BJ Aronow EW Brunskill AN Combes D Tang D Taylor SM Grimmond SS Potter AP McMahon MH Little 2009 Analysis of early nephron patterning reveals a role for distal RV proliferation in fusion to the ureteric tip via a cap mesenchyme-derived connecting segment Dev Biol 332 273 286 19501082 10.1016/j.ydbio.2009.05.578 1:CAS:528:DC%2BD1MXptVehu7k%3D
14. CM Bracken K Mizeracka KA McLaughlin 2008 Patterning the embryonic kidney: BMP signaling mediates the differentiation of the pronephric tubules and duct in Xenopus laevis Dev Dyn 237 132 144 18069689 10.1002/dvdy.21387 1:CAS:528:DC%2BD1cXhvFGksr4%3D
15. I Kazama Z Mahoney JH Miner D Graf AN Economides JA Kreidberg 2008 Podocyte-derived BMP7 is critical for nephron development J Am Soc Nephrol 19 2181 2191 18923055 10.1681/ASN.2007111212 1:CAS:528:DC%2BD1cXhsVaitrvL
16. H Ueda Y Miyazaki T Matsusaka Y Utsunomiya T Kawamura T Hosoya I Ichikawa 2008 Bmp in podocytes is essential for normal glomerular capillary formation J Am Soc Nephrol 19 685 694 18272846 10.1681/ASN.2006090983 1:CAS:528: DC%2BD1cXkvFOhsL8%3D
17. JE Cain S Hartwig JF Bertram ND Rosenblum 2008 Bone morphogenetic protein signaling in the developing kidney: present and future Differentiation 76 831 842 18331343 10.1111/j.1432-0436.2008.00265.x 1:CAS:528:DC%2BD1cXht1GksLjN
18. P Simic S Vukicevic 2005 Bone morphogenetic proteins in development and homeostasis of kidney Cytokine Growth Factor Rev 16 299 308 15923134 10.1016/j.cytogfr.2005.02.010 1:CAS:528:DC%2BD2MXlsl2rtLk%3D (Pubitemid 40910319)
19. RE Godin EJ Robertson AT Dudley 1999 Role of BMP family members during kidney development Int J Dev Biol 43 405 411 10535316 1:CAS:528: DyaK1MXnslWqtbs%3D
20. LA Cullen-McEwen J Drago JF Bertram 2001 Nephron endowment in glial cell line-derived neurotrophic factor (GDNF) heterozygous mice Kidney Int 60 31 36 11422733 10.1046/j.1523-1755.2001.00767.x 1:CAS:528:DC%2BD3MXltlKntLk%3D (Pubitemid 32587536)
21. HA Hartman HL Lai LT Patterson 2007 Cessation of renal morphogenesis in mice Dev Biol 310 379 387 17826763 10.1016/j.ydbio.2007.08.021 1:CAS:528:DC%2BD2sXhtFSksrvJ (Pubitemid 47496040)
22. J Yu TJ Carroll AP McMahon 2002 Sonic hedgehog regulates proliferation and differentiation of mesenchymal cells in the mouse metanephric kidney Development 129 5301 5312 12399320 1:CAS:528:DC%2BD38XpsFGjurY%3D (Pubitemid 35460691)
23. L Oxburgh GC Chu SK Michael EJ Robertson 2004 TGFb superfamily signals are required for morphogenesis of the kidney mesenchyme progenitor population Development 131 4593 4605 15342483 10.1242/dev.01324 1:CAS:528: DC%2BD2cXovVehtbs%3D (Pubitemid 39409699)
24. S Boyle A Misfeldt KJ Chandler KK Deal EM Southard-Smith DP Mortlock HS Baldwin M de Caestecker 2008 Fate mapping using Cited1-CreERT2 mice demonstrates that the cap mesenchyme contains self-renewing progenitor cells and gives rise exclusively to nephronic epithelia Dev Biol 313 234 245 18061157 10.1016/j.ydbio.2007.10.014 1:CAS:528:DC%2BD1cXhsVKquw%3D%3D (Pubitemid 350298313)
25. BD Humphreys SL Lin A Kobayashi TE Hudson BT Nowlin JV Bonventre MT Valerius AP McMahon JS Duffield 2010 Fate tracing reveals the pericyte and not epithelial origin of myofibroblasts in kidney fibrosis Am J Pathol 176 85 97 20008127 10.2353/ajpath.2010.090517 1:CAS:528:DC%2BC3cXhs12rtr8%3D
26. A Kobayashi MT Valerius JW Mugford TJ Carroll M Self G Oliver AP McMahon 2008 Six2 defines and regulates a multipotent self-renewing nephron progenitor population throughout mammalian kidney development Cell Stem Cell 3 169 181 18682239 10.1016/j.stem.2008.05.020 1:CAS:528:DC%2BD1cXhtVegtr%2FM
27. JW Mugford P Sipila JA McMahon AP McMahon 2008 Osr1 expression demarcates a multi-potent population of intermediate mesoderm that undergoes progressive restriction to an Osr1-dependent nephron progenitor compartment within the mammalian kidney Dev Biol 324 88 98 18835385 10.1016/j.ydbio.2008.09.010 1:CAS:528:DC%2BD1cXhsVSjs7fL
28. QC Vega CA Worby MS Lechner JE Dixon GR Dressler 1996 Glial cell line-derived neurotrophic factor activates the receptor tyrosine kinase RET and promotes kidney morphogenesis Proc Natl Acad Sci USA 93 10657 10661 8855235 10.1073/pnas.93.20.10657 1:CAS:528:DyaK28XmtVOltrY%3D (Pubitemid 26333044)
29. A Schuchardt V D'Agati L Larsson-Blomberg F Costantini V Pachnis 1994 Defects in the kidney and enteric nervous system of mice lacking the tyrosine kinase receptor Ret Nature 367 380 383 8114940 10.1038/367380a0 1:CAS:528:DyaK2cXhvVOqtr0%3D
30. K Sainio P Suvanto J Davies J Wartiovaara K Wartiovaara M Saarma U Arumae X Meng M Lindahl V Pachnis H Sariola 1997 Glial-cell-line-derived neurotrophic factor is required for bud initiation from ureteric epithelium Development 124 4077 4087 9374404 1:CAS:528:DyaK2sXnt12gsb4%3D (Pubitemid 27484268)
31. JG Pichel L Shen HZ Sheng AC Granholm J Drago A Grinberg EJ Lee SP Huang M Saarma BJ Hoffer H Sariola H Westphal 1996 Defects in enteric innervation and kidney development in mice lacking GDNF Nature 382 73 76 8657307 10.1038/382073a0 1:CAS:528:DyaK28XjvFKjsro%3D (Pubitemid 26243360)
32. TJ Carroll JS Park S Hayashi A Majumdar AP McMahon 2005 Wnt9b plays a central role in the regulation of mesenchymal to epithelial transitions underlying organogenesis of the Mammalian urogenital system Dev Cell 9 283 292 16054034 10.1016/j.devcel.2005.05.016 1:CAS:528:DC%2BD2MXovFSgs70%3D (Pubitemid 41051746)
33. C Rosselot L Spraggon I Chia E Batourina P Riccio B Lu K Niederreither P Dolle G Duester P Chambon F Costantini T Gilbert A Molotkov C Mendelsohn 2010 Non-cell-autonomous retinoid signaling is crucial for renal development Development 137 283 292 20040494 10.1242/dev.040287 1:CAS:528: DC%2BC3cXislWnsr8%3D
34. E Batourina S Gim N Bello M Shy M Clagett-Dame S Srinivas F Costantini C Mendelsohn 2001 Vitamin A controls epithelial/mesenchymal interactions through ret expression Nat Genet 27 74 78 11138002 1:CAS:528:DC%2BD3MXis1ykug%3D%3D (Pubitemid 32044522)
35. H Chang CW Brown MM Matzuk 2002 Genetic analysis of the mammalian transforming growth factor-beta superfamily Endocr Rev 23 787 823 12466190 10.1210/er.2002-0003 1:CAS:528:DC%2BD38XpvVSntLc%3D (Pubitemid 35454589)
36. P ten Dijke H Yamashita TK Sampath AH Reddi M Estevez DL Riddle H Ichijo CH Heldin K Miyazono 1994 Identification of type I receptors for osteogenic protein-1 and bone morphogenetic protein-4 J Biol Chem 269 16985 16988 8006002 (Pubitemid 24204009)
37. M Macias-Silva PA Hoodless SJ Tang M Buchwald JL Wrana 1998 Specific activation of Smad1 signaling pathways by the BMP7 type I receptor, ALK2 J Biol Chem 273 25628 25636 9748228 10.1074/jbc.273.40.25628 1:CAS:528: DyaK1cXms1egs7c%3D (Pubitemid 28475783)
38. DW Walsh C Godson DP Brazil F Martin 2010 Extracellular BMP-antagonist regulation in development and disease: tied up in knots Trends Cell Biol 20 244 256 20188563 10.1016/j.tcb.2010.01.008 1:CAS:528:DC%2BC3cXlsFWqu7Y%3D
39. J Larrain D Bachiller B Lu E Agius S Piccolo EM De Roberts 2000 BMP-binding modules in chordin: a model for signalling regulation in the extracellular space Development 127 821 830 10648240 1:CAS:528: DC%2BD3cXkt1aku7g%3D (Pubitemid 30129028)
40. J Larrain M Oelgeschlager NI Ketpura B Reversade L Zakin EM De Roberts 2001 Proteolytic cleavage of chordin as a switch for the dual activities of twisted gastrulation in BMP signaling Development 128 4439 4447 11714670 1:CAS:528:DC%2BD3MXptVGlurw%3D (Pubitemid 33130425)
41. F Rentzsch J Zhang C Kramer W Sebald M Hammerschmidt 2006 Crossveinless 2 is an essential positive feedback regulator of Bmp signaling during zebrafish gastrulation Development 133 801 811 16439480 10.1242/dev.02250 1:CAS:528:DC%2BD28XjtlKgu7s%3D
42. AL Ambrosio VF Taelman HX Lee CA Metzinger C Coffinier EM De Robertis 2008 Crossveinless-2 is a BMP feedback inhibitor that binds chordin/BMP to regulate Xenopus embryonic patterning Dev Cell 15 248 260 18694564 10.1016/j.devcel.2008.06.013 1:CAS:528:DC%2BD1cXhtVehtL%2FI
43. G Lagna A Hata A Hemmati-Brivanlou J Massagué 1996 Partnership between DPC4 and SMAD proteins in TGF-beta signalling pathways Nature 383 832 836 8893010 10.1038/383832a0 1:CAS:528:DyaK28Xms1Sisrg%3D (Pubitemid 26372668)
44. S Faure P de Santa Barbara DJ Roberts M Whitman 2002 Endogenous patterns of BMP signaling during early chick development Dev Biol 244 44 65 11900458 10.1006/dbio.2002.0579 1:CAS:528:DC%2BD38XitVajuro%3D (Pubitemid 34271140)
45. H Shibuya K Yamaguchi K Shirakabe A Tonegawa Y Gotoh N Ueno K Irie E Nishida K Matsumoto 1996 TAB1: an activator of the TAK1 MAPKKK in TGF-beta signal transduction Science 272 1179 1182 8638164 10.1126/science.272.5265.1179 1:CAS:528:DyaK28XjtF2ns74%3D
46. K Yamaguchi S Nagai J Ninomiya-Tsuji M Nishita K Tamai K Irie N Ueno E Nishida H Shibuya K Matsumoto 1999 XIAP, a cellular member of the inhibitor of apoptosis protein family, links the receptors to TAB1-TAK1 in the BMP signaling pathway EMBO J 18 179 187 9878061 10.1093/emboj/18.1.179 1:CAS:528: DyaK1MXntV2hsA%3D%3D (Pubitemid 29005034)
47. K Yamaguchi K Shirakabe H Shibuya K Irie I Oishi N Ueno T Taniguchi E Nishida K Matsumoto 1995 Identification of a member of the MAPKKK family as a potential mediator of TGF-beta signal transduction Science 270 2008 2011 8533096 10.1126/science.270.5244.2008 1:CAS:528:DyaK28XltlSl (Pubitemid 26097194)
48. JH Shim MB Greenblatt M Xie MD Schneider W Zou B Zhai S Gygi LH Glimcher 2009 TAK1 is an essential regulator of BMP signalling in cartilage EMBO J 28 2028 2041 19536134 10.1038/emboj.2009.162 1:CAS:528:DC%2BD1MXnsVagurc%3D
49. X Xu J Han Y Ito P Bringas C Deng Y Chai 2008 Ectodermal Smad4 and p38 MAPK are functionally redundant in mediating TGF-beta/BMP signaling during tooth and palate development Dev Cell 15 322 329 18694570 10.1016/j.devcel.2008.06. 004 1:CAS:528:DC%2BD1cXhtVehtL%2FE
50. AT Dudley EJ Robertson 1997 Overlapping expression domains of bone morphogenetic protein family members potentially account for limited tissue defects in BMP7 deficient embryos Dev Dyn 208 349 362 9056639 10.1002/(SICI)1097-0177(199703)208:3<349::AID-AJA6>3.0.CO;2-I 1:CAS:528:DyaK2sXit1Gqt7Y%3D (Pubitemid 27114288)
51. RE Godin NT Takaesu EJ Robertson AT Dudley 1998 Regulation of BMP7 expression during kidney development Development 125 3473 3482 9693150 1:CAS:528:DyaK1cXmtlyhsbk%3D (Pubitemid 28458346)
52. G Martinez KL Loveland AT Clark M Dziadek JF Bertram 2001 Expression of bone morphogenetic protein receptors in the developing mouse metanephros Exp Nephrol 9 372 379 11701996 10.1159/000052635 1:CAS:528:DC%2BD3MXotFeru7Y%3D (Pubitemid 33035999)
53. P Vrljicak D Myburgh AK Ryan MA van Rooijen CL Mummery IR Gupta 2004 Smad expression during kidney development Am J Physiol Renal Physiol 286 F625 F633 14656760 10.1152/ajprenal.00152.2003 1:CAS:528:DC%2BD2cXjtlKrsbc%3D
54. EW Brunskill BJ Aronow K Georgas B Rumballe MT Valerius J Aronow V Kaimal AG Jegga S Grimmond AP McMahon LT Patterson MH Little SS Potter 2008 Atlas of gene expression in the developing kidney at microanatomic resolution Dev Cell 15 781 791 19000842 10.1016/j.devcel.2008.09.007 1:CAS:528:DC%2BD1cXhsVSms7jL
55. JL Jadrich MB O'Connor E Coucouvanis 2003 Expression of TAK1, a mediator of TGF-beta and BMP signaling, during mouse embryonic development Gene Expr Patterns 3 131 134 12711537 10.1016/S1567-133X(03)00012-7 1:CAS:528: DC%2BD3sXjtFersrw%3D (Pubitemid 36503659)
56. RS Levinson E Batourina C Choi M Vorontchikhina J Kitajewski CL Mendelsohn 2005 Foxd1-dependent signals control cellularity in the renal capsule, a structure required for normal renal development Development 132 529 539 15634693 10.1242/dev.01604 1:CAS:528:DC%2BD2MXhvVeltbc%3D (Pubitemid 40277693)
57. U Blank ML Seto DC Adams DM Wojchowski MJ Karolak L Oxburgh 2008 An in vivo reporter of BMP signaling in organogenesis reveals targets in the developing kidney BMC Dev Biol 8 86 18801194 10.1186/1471-213X-8-86
58. L Oxburgh EJ Robertson 2002 Dynamic regulation of Smad expression during mesenchyme to epithelium transition in the metanephric kidney Mech Dev 112 207 211 11850197 10.1016/S0925-4773(01)00648-7 1:CAS:528:DC%2BD38Xht1agtbo%3D (Pubitemid 34163239)
59. LF Jackson TH Qiu SW Sunnarborg A Chang C Zhang C Patterson DC Lee 2003 Defective valvulogenesis in HB-EGF and TACE-null mice is associated with aberrant BMP signaling EMBO J 22 2704 2716 12773386 10.1093/emboj/cdg264 1:CAS:528:DC%2BD3sXkt1Wrt7k%3D (Pubitemid 36712367)
60. L Oxburgh AT Dudley RE Godin CH Koonce A Islam DC Anderson EK Bikoff EJ Robertson 2005 BMP4 substitutes for loss of BMP7 during kidney development Dev Biol 286 637 646 16154126 10.1016/j.ydbio.2005.08.024 1:CAS:528: DC%2BD2MXhtFWntbrP (Pubitemid 41443299)
61. GJ Wang A Brenner-Anantharam ED Vaughan D Herzlinger 2009 Antagonism of BMP4 signaling disrupts smooth muscle investment of the ureter and ureteropelvic junction J Urol 181 401 407 19010499 10.1016/j.juro.2008.08.117 1:CAS:528:DC%2BD1MXht1ent7w%3D
62. M Ikeya M Kawada H Kiyonari N Sasai K Nakao Y Furuta Y Sasai 2006 Essential pro-Bmp roles of Crossveinless 2 in mouse organogenesis Development 133 4463 4473 17035289 10.1242/dev.02647 1:CAS:528:DC%2BD2sXjs1Wj (Pubitemid 46017821)
63. BD Humphreys MT Valerius A Kobayashi JW Mugford S Soeung JS Duffield AP McMahon JV Bonventre 2008 Intrinsic epithelial cells repair the kidney after injury Cell Stem Cell 2 284 291 18371453 10.1016/j.stem.2008.01.014 1:CAS:528:DC%2BD1cXjslegtrk%3D (Pubitemid 351298594)