Stromal-epithelial crosstalk regulates kidney progenitor cell differentiation

Nature Cell Biology

Volumn 15, Issue 9, 2013, Pages 1035-1044

  Das, Amrita ^a,b   Tanigawa, Shunsuke ^c   Karner, Courtney M ^a,b,d   Xin, Mei ^b   Lum, Lawrence ^b   Chen, Chuo ^a   Olson, Eric N ^b   Perantoni, Alan O ^c   Carroll, Thomas J ^a,b  

^a UNIVERSITY OF TEXAS SOUTHWESTERN MEDICAL CENTER   (United States)

^b UNIVERSITY OF TEXAS SOUTHWESTERN MEDICAL CENTER   (United States)

^c NATIONAL CANCER INSTITUTE   (United States)

^d WASHINGTON UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

BETA CATENIN; CADHERIN; CYTOKERATIN 2; FAT4 PROTEIN; TRANSCRIPTION FACTOR PAX2; TRANSCRIPTION FACTOR YAP1; UNCLASSIFIED DRUG; UVOMORULIN; WNT9B PROTEIN;

ANIMAL CELL; ANIMAL TISSUE; ARTICLE; CELL DIFFERENTIATION; CELL FATE; CELL RENEWAL; CELL SURVIVAL; CONTROLLED STUDY; EMBRYO; EPITHELIUM CELL; FIBROBLAST; KIDNEY FUNCTION; KIDNEY SIZE; KIDNEY STEM CELL; MOLECULAR INTERACTION; NEPHRON; NONHUMAN; PRIORITY JOURNAL; SIGNAL TRANSDUCTION; STEM CELL; STROMA CELL; URETER;

CADHERINS; CELL COMMUNICATION; CELL DIFFERENTIATION; EPITHELIAL CELLS; FIBROBLASTS; GENE EXPRESSION REGULATION; HUMANS; KIDNEY; ORGAN SIZE; SIGNAL TRANSDUCTION; STEM CELLS; STROMAL CELLS; TUMOR SUPPRESSOR PROTEINS; WNT PROTEINS;

EID: 84883741356     PISSN: 14657392     EISSN: 14764679     Source Type: Journal    
DOI: 10.1038/ncb2828     Document Type: Article

References (33)

1. Grobstein, C. Inductive interaction in the development of the mouse metanephros. J. Exp. Zool. 130, 319-340 (1955).
2. Grobstein, C. Inductive epithlio-mesenchymal interaction in cultured organ rudiments of the mouse metanephros. Science 118, 52-55 (1953).
3. Carroll, T. J., Park, J. S., Hayashi, S., Majumdar, A. & McMahon, A. P. Wnt9b plays a central role in the regulation of mesenchymal to epithelial transitions underlying organogenesis of the mammalian urogenital system. Dev. Cell 9, 283-292 (2005).
4. Karner, C. M. et al. Canonical Wnt9b signaling balances progenitor cell expansion and differentiation during kidney development. Development 138, 1247-1257 (2011).
5. Hatini, V., Huh, S. O., Herzlinger, D., Soares, V. C. & Lai, E. Essential role of stromal mesenchyme in kidney morphogenesis revealed by targeted disruption of Winged Helix transcription factor BF-2. Genes Dev. 10, 1467-1478 (1996).
6. Levinson, R. S. et al. Foxd1-dependent signals control cellularity in the renal capsule, a structure required for normal renal development. Development 132, 529-539 (2005).
7. Voehringer, D., Liang, H. E. & Locksley, R. M. Homeostasis and effector function of lymphopenia-induced ̀memory-like' T cells in constitutively T cell-depleted mice. J. Immunol. 180, 4742-4753 (2008).
8. Yu, J. et al. A Wnt7b-dependent pathway regulates the orientation of epithelial cell division and establishes the cortico-medullary axis of the mammalian kidney. Development 136, 161-171 (2009).
9. Yoshino, K. et al. Secreted Frizzled-related proteins can regulate metanephric development. Mech. Dev. 102, 45-55 (2001).
10. Lescher, B., Haenig, B. & Kispert, A. sFRP-2 is a target of the Wnt-4 signaling pathway in the developing metanephric kidney. Dev. Dyn. 213, 440-451 (1998).
11. Karner, C. M. et al. Tankyrase is necessary for canonical Wnt signaling during kidney development. Dev. Dyn. 239, 2014-2023 (2010).
12. Chen, B. et al. Small molecule-mediated disruption of Wnt-dependent signaling in tissue regeneration and cancer. Nat. Chem. Biol. 5, 100-107 (2009).
13. Heallen, T. et al. Hippo pathway inhibits Wnt signaling to restrain cardiomyocyte proliferation and heart size. Science 332, 458-461 (2011).
14. Varelas, X. et al. The Hippo pathway regulates Wnt/-catenin signaling. Dev. Cell 18, 579-591 (2010).
15. Imajo, M., Miyatake, K., Iimura, A., Miyamoto, A. & Nishida, E. A molecular mechanism that links Hippo signalling to the inhibition of Wnt/-catenin signalling. EMBO J. 31, 1109-1122 (2012).
16. Xin, M. et al. Regulation of insulin-like growth factor signaling by Yap governs cardiomyocyte proliferation and embryonic heart size. Sci. Signal. 4, ra70 (2011).
17. Reddy, B. V. & Irvine, K. D. The Fat and Warts signaling pathways: new insights into their regulation, mechanism and conservation. Development 135, 2827-2838 (2008).
18. Zhang, J., Smolen, G. A. & Haber, D. A. Negative regulation of YAP by LATS1 underscores evolutionary conservation of the Drosophila Hippo pathway. Cancer Res. 68, 2789-2794 (2008).
19. Halder, G. & Johnson, R. L. Hippo signaling: growth control and beyond. Development 138, 9-22 (2011).
20. Lu, L. et al. Hippo signaling is a potent in vivo growth and tumor suppressor pathway in the mammalian liver. Proc. Natl Acad. Sci. USA 107, 1437-1442 (2010).
21. Tanigawa, S. et al. Wnt4 induces nephronic tubules in metanephric mesenchyme by a non-canonical mechanism. Dev. Biol. 352, 58-69 (2011).
22. Blank, U., Brown, A., Adams, D. C., Karolak, M. J. & Oxburgh, L. BMP7 promotes proliferation of nephron progenitor cells via a JNK-dependent mechanism. Development 136, 3557-3566 (2009).
23. Willecke, M. et al. The fat cadherin acts through the hippo tumor-suppressor pathway to regulate tissue size. Curr. Biol. 16, 2090-2100 (2006).
24. Rock, R., Schrauth, S. & Gessler, M. Expression of mouse dchs1, fjx1, and fat-j suggests conservation of the planar cell polarity pathway identi-ed in Drosophila. Dev. Dyn. 234, 747-755 (2005).
25. Mao, Y. et al. Characterization of a Dchs1 mutant mouse reveals requirements for Dchs1-Fat4 signaling during mammalian development. Development 138, 947-957 (2011).
26. Saburi, S. et al. Loss of Fat4 disrupts PCP signaling and oriented cell division and leads to cystic kidney disease. Nat. Genet. 40, 1010-1015 (2008).
27. Karner, C. M. et al. Wnt9b signaling regulates planar cell polarity and kidney tubule morphogenesis. Nat. Genet. 41, 793-799 (2009).
28. Yallowitz, A. R., Hrycaj, S. M., Short, K. M., Smyth, I. M. & Wellik, D. M. Hox10 genes function in kidney development in the differentiation and integration of the cortical stroma. PLoS One 6, e23410 (2011).
29. Mendelsohn, C., Batourina, E., Fung, S., Gilbert, T. & Dodd, J. Stromal cells mediate retinoid-dependent functions essential for renal development. Development 126, 1139-1148 (1999).
30. Tufro, A., Norwood, V. F., Carey, R. M. & Gomez, R. A. Vascular endothelial growth factor induces nephrogenesis and vasculogenesis. J. Am. Soc. Nephrol. 10, 2125-2134 (1999).
31. Brunskill, E. W., Lai, H. L., Jamison, D. C., Potter, S. S. & Patterson, L. T. Microarrays and RNA-Seq identify molecular mechanisms driving the end of nephron production. BMC Dev. Biol. 11, 15 (2011).
32. Hoch, R. V. & Soriano, P. Context-speci-c requirements for Fgfr1 signaling through Frs2 and Frs3 during mouse development. Development 133, 663-673 (2006).
33. Rodriguez, C. I. et al. High-ef-ciency deleter mice show that FLPe is an alternative to Cre-loxP. Nat. Genet. 25, 139-140 (2000).