HIF-2α suppresses p53 to enhance the stemness and regenerative potential of human embryonic stem cells

Stem Cells

Volumn 30, Issue 8, 2012, Pages 1685-1695

  Das, Bikul ^a,b   Bayat Mokhtari, Reza ^b   Tsui, Micky ^b   Lotfi, Shamim ^b   Tsuchida, Rika ^c   Felsher, Dean W ^a   Yeger, Herman ^b  

^a STANFORD UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b HOSPITAL FOR SICK CHILDREN   (Canada)

^c TOKYO MEDICAL AND DENTAL UNIVERSITY   (Japan)

Author keywords

Altruism; Embryonic stem cells; Hypoxia; Neoplastic stem cell biology; Oxidative stress; Reprogramming; Self renewal

Indexed keywords

FIBROBLAST GROWTH FACTOR 2; HYPOXIA INDUCIBLE FACTOR 2ALPHA; OCTAMER TRANSCRIPTION FACTOR 4; PROTEIN BCL 2; PROTEIN MDM2; PROTEIN P53; TRANSCRIPTION FACTOR NANOG;

ARTICLE; CELL PROTECTION; CONTROLLED STUDY; EMBRYO; EMBRYONIC STEM CELL; HUMAN; HUMAN CELL; OXIDATIVE STRESS; PHENOTYPE; PROTEIN ANALYSIS; PROTEIN FUNCTION;

ANIMALS; BASIC HELIX-LOOP-HELIX TRANSCRIPTION FACTORS; CELL DIFFERENTIATION; CELL HYPOXIA; CELL SURVIVAL; EMBRYONIC STEM CELLS; HUMANS; MICE; MICE, INBRED NOD; MICE, SCID; OXIDATIVE STRESS; RATS; RNA, SMALL INTERFERING; TUMOR SUPPRESSOR PROTEIN P53; UP-REGULATION;

EID: 84864370555     PISSN: 10665099     EISSN: None     Source Type: Journal    
DOI: 10.1002/stem.1142     Document Type: Article

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