Nephron number in patients with primary hypertension

New England Journal of Medicine

Volumn 348, Issue 2, 2003, Pages 101-108

  Keller, Gunhild ^a   Zimmer, Gisela ^a   Mall, Gerhard ^b   Ritz, Eberhard ^a   Amann, Kerstin ^c  

^a UNIVERSITY OF HEIDELBERG   (Germany)

^b Hospital of Darmstadt   (Germany)

^c UNIVERSITY OF ERLANGEN NUREMBERG   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

ACCIDENT; ADULT; ARTICLE; BLOOD PRESSURE; BLOOD VOLUME; BODY HEIGHT; BODY WEIGHT; CLINICAL ARTICLE; CONTROLLED STUDY; DISEASE COURSE; FEMALE; GLOMERULUS; HEART LEFT VENTRICLE HYPERTROPHY; HUMAN; HYPERTENSION; HYPOTHESIS; MALE; NEPHRON; PRIORITY JOURNAL; STEREOLOGY;

ADULT; CASE-CONTROL STUDIES; CELL COUNT; FEMALE; HUMANS; HYPERTENSION; HYPERTROPHY, LEFT VENTRICULAR; IMAGE PROCESSING, COMPUTER-ASSISTED; IMAGING, THREE-DIMENSIONAL; KIDNEY GLOMERULUS; MALE; MIDDLE AGED; NEPHRONS; ORGAN SIZE; REFERENCE VALUES;

EID: 0037426760     PISSN: 00284793     EISSN: None     Source Type: Journal    
DOI: 10.1056/NEJMoa020549     Document Type: Article

References (26)

1. Bianchi G, Fox U, Di Francesco GF, Giovanetti AM, Pagetti D. Blood pressure changes produced by kidney cross-transplantation between spontaneously hypertensive rats and normotensive rats. Clin Sci Mol Med 1974;47:435-48.
2. Dahl LK, Heine M, Thompson K. Genetic influence of the kidneys on blood pressure: Evidence from chronic renal homografts in rats with opposite predispositions to hypertension. Circ Res 1974;40:94-101.
3. Rettig R, Folberth C, Stauss H, Kopf D, Waldherr R, Unger T. Role of the kidney in primary hypertension: A renal transplantation study in rats. Am J Physiol 1990;258:F606-F611.
4. Strandgaard S, Hansen U. Hypertension in renal allograft recipients may be conveyed by cadaveric kidneys from donors with subarachnoid haemorrhage. Br Med J (Clin Res Ed) 1986;292:1041-4.
5. Curtis JJ, Luke RG, Dustan HP, et al. Remission of essential hypertension after renal transplantation. N Engl J Med 1983;309:1009-15.
6. Brenner BM, Chertow GM. Congenital oligonephropathy and the etiology of adult hypertension and progressive renal injury. Am J Kidney Dis 1994;23:171-5.
7. Fassi A, Sangalli F, Maffi R. et al. Progressive glomerular injury in the MWF rat is predicted by inborn nephron deficit. J Am Soc Nephrol 1998;9:1399-406.
8. Hakim RM, Goldszer RC, Brenner BM. Hypertension and proteinuria: Long-term sequelae of uninephrectomy in humans. Kidney Int 1984;25:930-6.
9. Pesce CM, Schmidt C, Fogo A, et al. Glomerular size and the incidence of renal disease in African Americans and Caucasians. J Nephrol 1994;7:355-8.
10. Schmidt K, Pesce C, Liu Q, et al. Large glomerular size in Pima Indians: Lack of change with diabetic nephropathy. J Am Soc Nephrol 1992;3:229-35.
11. Brenner BM, Garcia DL, Anderson S. Glomeruli and blood pressure: Less of one, more the other? Am J Hypertens 1988;1:335-47.
12. Gundersen HJG. Stereology of arbitrary particles: A review of unbiased number and size estimators and the presentation of some new ones, in memory of William R. Thompson. J Microsc 1986;143:3-45.
13. Gundersen HJ, Bagger P, Bendtsen TF, et al. The new stereological tools: Disector, fractionator, nucleator and point sampled intercepts and their use in pathological research and diagnosis. APMIS 1988;96:857-81.
14. Nyengaard JR, Bendtsen TF. Glomerular number and size in relation to age, kidney weight, and body surface in normal man. Anat Rec 1992;232:194-201.
15. Merlet-Benichou C, Gilbert T, Vilar J, Moreau E, Freund N, Lelievre-Pegorier M. Nephron number: Variability is the rule: Causes and consequences. Lab Invest 1999;79:515-27.
16. McLachlan MSF, Guthrie JC, Anderson CK, Fulker MJ. Vascular and glomerular changes in the ageing kidney. Am J Pathol 1977;121:65-78.
17. Neugarten J, Kasiske B, Silbiger S, Nyengaard JR. Effects of gender on renal structure and the progression of chronic renal disease. J Am Soc Nephrol 2000;11: 72A. abstract.
18. Merlet-Benichou C, Leroy B, Gilbert T, Lelievre-Pegorier M. Retard de croissance intra-uterine et deficit en nephrons. Med Sci 1993;9:777-80.
19. Gurnani A, Nadim NK, Luyckx VA, et al. Estimating glomerular number in male and female offspring of rats subjected to gestational dietary protein restriction: A comparison using an unbiased stereological technique and the maceration technique. J Am Soc Nephrol 2000;11:390A. abstract.
20. Bertram JF, Hughson MD, Hoy WE, Cass A, Johnson K. Glomerular number, glomerular volume and kidney weight in forensic autopsies: A multiracial study. J Am Soc Nephrol 2001;12:724A. abstract.
21. Skov K, Nyengaard J, Korsgaard N, Mulvany MJ. Number and size of renal glomeruli in spontaneously hypertensive rats. J Hypertens 1994;12:1373-6.
22. Barker DJP, Osmond C, Golding J, Kuh D, Wadsworth ME. Growth in utero, blood pressure in childhood and adult life, and mortality from cardiovascular disease. BMJ 1989;298:564-7.
23. Gennser G, Rymark P, Isberg PE. Low birth weight and risk of high blood pressure in adulthood. Br Med J (Clin Res Ed) 1988;296:1498-500.
24. Yiu V, Buka S, Zurakowski D, McCormick M, Brenner B, Jabs K. Relationship between birthweight and blood pressure in childhood. Am J Kidney Dis 1999;33:253-60.
25. Vehaskari MV, Aviles DH, Manning J. Prenatal programming of adult hypertension in the rat. Kidney Int 2001;59:238-45.
26. Spencer J, Wang Z, Hoy W. Low birth weight and reduced renal volume in Aboriginal children. Am J Kidney Dis 2001;37:915-20.