Enhanced production of 24S-hydroxycholesterol is not sufficient to drive liver X receptor target genes in vivo

Journal of Internal Medicine

Volumn 270, Issue 4, 2011, Pages 377-387

  Shafaati, M ^a   Olin, M ^a   Bavner A ^a   Pettersson, H ^a   Rozell, B ^b   Meaney, S ^c   Parini, P ^a   Bjorkhem I ^a  

^a Division of Clinical Chemistry   (Sweden)

^b KAROLINSKA UNIVERSITY HOSPITAL   (Sweden)

^c DUBLIN INSTITUTE OF TECHNOLOGY   (Ireland)

Author keywords

Cholesterol homeostasis; CNS; CYP46A1; LXR agonist; Oxysterols

Indexed keywords

24 HYDROXYCHOLESTEROL; CHOLESTEROL DERIVATIVE; CYTOCHROME P450; CYTOCHROME P450 46A1; HUMAN CHOLESTEROL 24 HYDROXYLASE; LIVER X RECEPTOR; LIVER X RECEPTOR AGONIST; OXYGENASE; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BRAIN LEVEL; CHOLESTEROL BILE LEVEL; CHOLESTEROL BLOOD LEVEL; CHOLESTEROL SYNTHESIS; CONTROLLED STUDY; FECES LEVEL; FEMALE; GENE ACTIVATION; GENE CONTROL; GENE EXPRESSION PROFILING; IN VIVO STUDY; MALE; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; REGULATORY MECHANISM; TRANSGENIC MOUSE;

ANIMALS; BRAIN; FEMALE; GENE EXPRESSION PROFILING; GENE EXPRESSION REGULATION, ENZYMOLOGIC; HUMANS; HYDROXYCHOLESTEROLS; LIVER; MALE; MICE; MICE, TRANSGENIC; ORPHAN NUCLEAR RECEPTORS; POLYMERASE CHAIN REACTION; STEROID HYDROXYLASES;

EID: 80052965098     PISSN: 09546820     EISSN: 13652796     Source Type: Journal    
DOI: 10.1111/j.1365-2796.2011.02389.x     Document Type: Article

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