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Volumn 16, Issue 4, 2014, Pages

Recent advances in understanding the pathogenesis of scleroderma- interstitial lung disease

Author keywords

Epigenetics; Fibroblast, TGF ; Genetics; Interstitial lung disease (ILD); Pathogenesis; Scleroderma; Systemic sclerosis (SSc); Thrombin; Wnt catenin pathway

Indexed keywords

BETA CATENIN; CONNECTIVE TISSUE GROWTH FACTOR; HLA DPB1 ANTIGEN; HLA DRB1 ANTIGEN; INTERLEUKIN 1 RECEPTOR ASSOCIATED KINASE 1; STAT4 PROTEIN; THROMBIN; TRANSCRIPTION FACTOR T BET; TRANSFORMING GROWTH FACTOR BETA; WNT PROTEIN; CTNNB1 PROTEIN, HUMAN; HLA D ANTIGEN;

EID: 84893674726     PISSN: 15233774     EISSN: 15346307     Source Type: Journal    
DOI: 10.1007/s11926-014-0411-1     Document Type: Article
Times cited : (52)

References (74)
  • 1
    • 84876542539 scopus 로고    scopus 로고
    • Amelioration of systemic fibrosis in mice by angiotensin II receptor blockade
    • 1:CAS:528:DC%2BC3sXms1Giu7c%3D 23335130 10.1002/art.37873
    • Marut W, Kavian N, Servettaz A, et al. Amelioration of systemic fibrosis in mice by angiotensin II receptor blockade. Arthritis Rheum. 2013;65:1367-77.
    • (2013) Arthritis Rheum , vol.65 , pp. 1367-1377
    • Marut, W.1    Kavian, N.2    Servettaz, A.3
  • 2
    • 0029957278 scopus 로고    scopus 로고
    • Pathogenesis of scleroderma. Collagen
    • 1:STN:280:DyaK2s%2Fot1entQ%3D%3D 10.1016/S0889-857X(05)70294-5
    • Jimenez SA, Hitraya E, Varga J. Pathogenesis of scleroderma. Collagen. Rheum Dis Clin N Am. 1996;22:647-74.
    • (1996) Rheum Dis Clin N Am , vol.22 , pp. 647-674
    • Jimenez, S.A.1    Hitraya, E.2    Varga, J.3
  • 3
    • 65849148248 scopus 로고    scopus 로고
    • Histopathology and bronchoalveolar lavage
    • 10.1093/rheumatology/ken272
    • Silver RM, Wells AU. Histopathology and bronchoalveolar lavage. Rheumatology. 2008;47:62-4.
    • (2008) Rheumatology , vol.47 , pp. 62-64
    • Silver, R.M.1    Wells, A.U.2
  • 4
    • 78650925648 scopus 로고    scopus 로고
    • Epithelium-specific deletion of TGF-β receptor type II protects mice from bleomycin-induced pulmonary fibrosis
    • 10.1172/JCI42090
    • Li M, Krishnaveni MS, Li C, et al. Epithelium-specific deletion of TGF-β receptor type II protects mice from bleomycin-induced pulmonary fibrosis. J Clin Invest. 2014;121(1):277-87.
    • (2014) J Clin Invest , vol.121 , Issue.1 , pp. 277-287
    • Li, M.1    Krishnaveni, M.S.2    Li, C.3
  • 5
    • 77958038345 scopus 로고    scopus 로고
    • Recent advances in pulmonary fibrosis: Implications for scleroderma
    • 1:CAS:528:DC%2BC3cXht1ahu7jE 20693906 10.1097/BOR.0b013e32833ddcc9
    • Homer RJ, Herzog EL. Recent advances in pulmonary fibrosis: implications for scleroderma. Curr Opin Rheumatol. 2010;22:683-9.
    • (2010) Curr Opin Rheumatol , vol.22 , pp. 683-689
    • Homer, R.J.1    Herzog, E.L.2
  • 6
    • 79952037889 scopus 로고    scopus 로고
    • Fibrosis in systemic sclerosis: Emerging concepts and implications for targeted therapy
    • 1:CAS:528:DC%2BC3MXisFejt74%3D 20863909 10.1016/j.autrev.2010.09.015 This summarizes the molecular and cellular pathways leading to SSc-fibrosis
    • Wei J, Bhattacharyya S, Tourtellotte WG, Varga J. Fibrosis in systemic sclerosis: emerging concepts and implications for targeted therapy. Autoimmun Rev. 2011;10:267-75. This summarizes the molecular and cellular pathways leading to SSc-fibrosis.
    • (2011) Autoimmun Rev , vol.10 , pp. 267-275
    • Wei, J.1    Bhattacharyya, S.2    Tourtellotte, W.G.3    Varga, J.4
  • 7
    • 84879298794 scopus 로고    scopus 로고
    • Scleroderma pathogenesis: A pivotal role for fibroblasts as effector cells
    • 23796020 10.1186/ar4230
    • Gilbane AJ, Denton CP, Holmes AM. Scleroderma pathogenesis: a pivotal role for fibroblasts as effector cells. Arthritis Res Ther. 2013;15:215.
    • (2013) Arthritis Res Ther , vol.15 , pp. 215
    • Gilbane, A.J.1    Denton, C.P.2    Holmes, A.M.3
  • 8
    • 34548411746 scopus 로고    scopus 로고
    • TGF-b-induced EMT: Mechanisms and implications for fibrotic lung disease
    • 10.1152/ajplung.00163.2007
    • Willis BC, Borok Z. TGF-b-induced EMT: mechanisms and implications for fibrotic lung disease. Am J Physiol Lung Cell Mol Physiol. 2007;293:525-34.
    • (2007) Am J Physiol Lung Cell Mol Physiol , vol.293 , pp. 525-534
    • Willis, B.C.1    Borok, Z.2
  • 9
    • 75649110071 scopus 로고    scopus 로고
    • Autoantibody profiles in systemic sclerosis: Predictive value for clinical evaluation and prognosis
    • 1:CAS:528:DC%2BC3cXjtVWgsrY%3D 20175839 10.1111/j.1346-8138.2009.00762.x
    • Hamaguchi Y. Autoantibody profiles in systemic sclerosis: predictive value for clinical evaluation and prognosis. J Dermatol. 2010;37:42-53.
    • (2010) J Dermatol , vol.37 , pp. 42-53
    • Hamaguchi, Y.1
  • 10
    • 84887451383 scopus 로고    scopus 로고
    • New insight on the Xq28 association with systemic sclerosis
    • 23444193 10.1136/annrheumdis-2012-202742
    • Carmona FD, Cénit MC, Diaz-Gallo LM, Broen JC, et al. New insight on the Xq28 association with systemic sclerosis. Ann Rheum Dis. 2013;72:2032-8.
    • (2013) Ann Rheum Dis , vol.72 , pp. 2032-2038
    • Carmona, F.D.1    Cénit, M.C.2    Diaz-Gallo, L.M.3    Broen, J.C.4
  • 11
    • 79952790398 scopus 로고    scopus 로고
    • MicroRNAs in idiopathic pulmonary fibrosis
    • 1:CAS:528:DC%2BC3MXjsV2nt7Y%3D 21420029 10.1016/j.trsl.2011.01.012
    • Pandit KV, Milosevic J, Kaminski N. MicroRNAs in idiopathic pulmonary fibrosis. Transl Res. 2011;157:191-9.
    • (2011) Transl Res , vol.157 , pp. 191-199
    • Pandit, K.V.1    Milosevic, J.2    Kaminski, N.3
  • 12
    • 33847361903 scopus 로고    scopus 로고
    • Infectious disease, the innate immune response, and fibrosis
    • 1:CAS:528:DC%2BD2sXis12hsbc%3D 1804377 17332880 10.1172/JCI30595
    • Meneghin A, Hogaboam CM. Infectious disease, the innate immune response, and fibrosis. J Clin Invest. 2007;117:530-8.
    • (2007) J Clin Invest , vol.117 , pp. 530-538
    • Meneghin, A.1    Hogaboam, C.M.2
  • 13
    • 47149109417 scopus 로고    scopus 로고
    • Oxidative stress and the pathogenesis of scleroderma: The Murrell's hypothesis revisited
    • 1:CAS:528:DC%2BD1cXosVCkt7o%3D 18548250 10.1007/s00281-008-0125-4
    • Gabrielli A, Svegliati S, Moroncini G, et al. Oxidative stress and the pathogenesis of scleroderma: the Murrell's hypothesis revisited. Semin Immunopathol. 2008;30:329-37.
    • (2008) Semin Immunopathol , vol.30 , pp. 329-337
    • Gabrielli, A.1    Svegliati, S.2    Moroncini, G.3
  • 14
    • 84863913123 scopus 로고    scopus 로고
    • New insights into the role of oxidative stress in scleroderma fibrosis
    • 1:CAS:528:DC%2BC38XhtVyis73K 3395898 22802906 10.2174/1874312901206010087
    • Gabrielli A, Svegliati S, Moroncini G, Amico D. New insights into the role of oxidative stress in scleroderma fibrosis. Open Rheumatol J. 2012;6:87-95.
    • (2012) Open Rheumatol J , vol.6 , pp. 87-95
    • Gabrielli, A.1    Svegliati, S.2    Moroncini, G.3    Amico, D.4
  • 15
    • 0141753083 scopus 로고    scopus 로고
    • The role of coagulation cascade proteases in lung repair and fibrosis
    • 10.1183/09031936.03.00001003
    • Chambers RC. The role of coagulation cascade proteases in lung repair and fibrosis. Eur Respir J. 2003;22:33-5.
    • (2003) Eur Respir J , vol.22 , pp. 33-35
    • Chambers, R.C.1
  • 16
    • 66149133635 scopus 로고    scopus 로고
    • Surfactant protein D and KL-6 as serum biomarkers of interstitial lung disease in patients with scleroderma
    • 1:CAS:528:DC%2BD1MXkvFemt7c%3D 19286849 10.3899/jrheum.080633
    • Hant FN, Ludwicka-Bradley A, Wang HJ, et al. Surfactant protein D and KL-6 as serum biomarkers of interstitial lung disease in patients with scleroderma. J Rheumatol. 2009;36:773-80.
    • (2009) J Rheumatol , vol.36 , pp. 773-780
    • Hant, F.N.1    Ludwicka-Bradley, A.2    Wang, H.J.3
  • 17
    • 67650999875 scopus 로고    scopus 로고
    • The basics of epithelial-mesenchymal transition
    • 1:CAS:528:DC%2BD1MXntVCjtr0%3D 2689101 19487818 10.1172/JCI39104
    • Kalluri R, Weinberg RA. The basics of epithelial-mesenchymal transition. J Clin Invest. 2009;119:1420-8.
    • (2009) J Clin Invest , vol.119 , pp. 1420-1428
    • Kalluri, R.1    Weinberg, R.A.2
  • 18
    • 84855511323 scopus 로고    scopus 로고
    • Multiple stromal populations contribute to pulmonary fibrosis without evidence for epithelial to mesenchymal transition
    • 10.1073/pnas.1117988108
    • Rocka JR, Barkauskasb CE, Cronceb MJ, et al. Multiple stromal populations contribute to pulmonary fibrosis without evidence for epithelial to mesenchymal transition. Proc Natl Acad Sci U S A. 2011;108:1475-83.
    • (2011) Proc Natl Acad Sci U S A , vol.108 , pp. 1475-1483
    • Rocka, J.R.1    Barkauskasb, C.E.2    Cronceb, M.J.3
  • 19
    • 33748375828 scopus 로고    scopus 로고
    • Alveolar epithelial cell mesenchymal transition develops in vivo during pulmonary fibrosis and is regulated by the extracellular matrix
    • 1:CAS:528:DC%2BD28Xptlels74%3D 1551904 16924102 10.1073/pnas.0605669103
    • Kim KK, Kugler MC, Wolters PJ, et al. Alveolar epithelial cell mesenchymal transition develops in vivo during pulmonary fibrosis and is regulated by the extracellular matrix. Proc Natl Acad Sci U S A. 2006;103:13180-5.
    • (2006) Proc Natl Acad Sci U S A , vol.103 , pp. 13180-13185
    • Kim, K.K.1    Kugler, M.C.2    Wolters, P.J.3
  • 20
    • 1342268310 scopus 로고    scopus 로고
    • Bone marrow-derived progenitor cells in pulmonary fibrosis
    • 1:CAS:528:DC%2BD2cXmsVyruw%3D%3D 310750 14722616 10.1172/JCI200418847
    • Hashimoto N, Jin H, Liu T, et al. Bone marrow-derived progenitor cells in pulmonary fibrosis. J Clin Invest. 2004;113:243-52.
    • (2004) J Clin Invest , vol.113 , pp. 243-252
    • Hashimoto, N.1    Jin, H.2    Liu, T.3
  • 21
    • 57149117863 scopus 로고    scopus 로고
    • Epithelial fibroblast triggering and interactions in pulmonary fibrosis
    • 10.1183/09059180.00010904
    • Noble PW. Epithelial fibroblast triggering and interactions in pulmonary fibrosis. Eur Respir Rev. 2008;17:123-9.
    • (2008) Eur Respir Rev , vol.17 , pp. 123-129
    • Noble, P.W.1
  • 22
    • 33847171545 scopus 로고    scopus 로고
    • Combinatorial activation of FAK and AKT by transforming growth factor-β1 confers an anoikis-resistant phenotype to myofibroblasts
    • 1:CAS:528:DC%2BD2sXit1Grtr4%3D 1820832 17113264 10.1016/j.cellsig.2006. 10.001
    • Horowitz JC, Rogers DS, Sharma V, et al. Combinatorial activation of FAK and AKT by transforming growth factor-β1 confers an anoikis-resistant phenotype to myofibroblasts. Cell Signal. 2007;19:761-71.
    • (2007) Cell Signal , vol.19 , pp. 761-771
    • Horowitz, J.C.1    Rogers, D.S.2    Sharma, V.3
  • 23
    • 0033258047 scopus 로고    scopus 로고
    • Inhibition of myofibroblasts apoptosis by transforming growth factor β1
    • 1:CAS:528:DC%2BD3cXhslemtg%3D%3D 10572062 10.1165/ajrcmb.21.6.3720
    • Zhang H-Y, Phan SH. Inhibition of myofibroblasts apoptosis by transforming growth factor β1. Am J Respir Cell Mol Biol. 1999;21:658-65.
    • (1999) Am J Respir Cell Mol Biol , vol.21 , pp. 658-665
    • Zhang, H.-Y.1    Phan, S.H.2
  • 24
    • 0141860791 scopus 로고    scopus 로고
    • Inverse effects of interleukin-6 on apoptosis of fibroblasts from pulmonary fibrosis and normal lungs
    • 1:CAS:528:DC%2BD3sXnvFOks7w%3D 12714376 10.1165/rcmb.2002-0262OC
    • Moodley YP, Misso NL, Scaffidi AK, et al. Inverse effects of interleukin-6 on apoptosis of fibroblasts from pulmonary fibrosis and normal lungs. Am J Respir Cell Mol Biol. 2003;29:490-8.
    • (2003) Am J Respir Cell Mol Biol , vol.29 , pp. 490-498
    • Moodley, Y.P.1    Misso, N.L.2    Scaffidi, A.K.3
  • 25
    • 84883187248 scopus 로고    scopus 로고
    • X-linked inhibitor of apoptosis regulates lung fibroblast resistance to Fas-mediated apoptosis
    • 1:CAS:528:DC%2BC3sXhtFajs73J 23492187 10.1165/rcmb.2012-0224OC
    • Ajayi IO, Sisson TH, Higgins PD, et al. X-linked inhibitor of apoptosis regulates lung fibroblast resistance to Fas-mediated apoptosis. Am J Respir Cell Mol Biol. 2013;49:86-95.
    • (2013) Am J Respir Cell Mol Biol , vol.49 , pp. 86-95
    • Ajayi, I.O.1    Sisson, T.H.2    Higgins, P.D.3
  • 26
    • 84879379272 scopus 로고    scopus 로고
    • Histone modifications are responsible for decreased Fas expression and apoptosis resistance in fibrotic lung fibroblasts
    • 10.1038/cddis.2013.146 10.1038/cddis.2013.146
    • Huang SK, Scruggs AM, Donaghy J, et al. Histone modifications are responsible for decreased Fas expression and apoptosis resistance in fibrotic lung fibroblasts. Cell Death Dis. 2013;4:621. doi: 10.1038/cddis.2013.146.
    • (2013) Cell Death Dis , vol.4 , pp. 621
    • Huang, S.K.1    Scruggs, A.M.2    Donaghy, J.3
  • 27
    • 9644310524 scopus 로고    scopus 로고
    • Differential regulation of apoptotic cell death in senescent human cells
    • 1:CAS:528:DC%2BD2cXhtVCltLfO 15582287 10.1016/j.exger.2004.05.010
    • Hampel B, Malisan F, Niederegger H, et al. Differential regulation of apoptotic cell death in senescent human cells. Exp Gerontol. 2004;39:1713-21.
    • (2004) Exp Gerontol , vol.39 , pp. 1713-1721
    • Hampel, B.1    Malisan, F.2    Niederegger, H.3
  • 28
    • 0142219250 scopus 로고    scopus 로고
    • Transforming growth factor (TGF)-β1-producing regulatory T cells induce Smad-mediated interleukin 10 secretion that facilitates coordinated immunoregulatory activity and amelioration of TGF-β1-mediated fibrosis
    • 1:CAS:528:DC%2BD3sXosVGqt7s%3D 2194234 14557415 10.1084/jem.20030917
    • Kitani A, Fuss I, Nakamura K, et al. Transforming growth factor (TGF)-β1-producing regulatory T cells induce Smad-mediated interleukin 10 secretion that facilitates coordinated immunoregulatory activity and amelioration of TGF-β1-mediated fibrosis. J Exp Med. 2003;198:1179-88.
    • (2003) J Exp Med , vol.198 , pp. 1179-1188
    • Kitani, A.1    Fuss, I.2    Nakamura, K.3
  • 29
    • 0035020567 scopus 로고    scopus 로고
    • Fibrosis of the lung and other tissues: New concepts in pathogenesis and treatment
    • 1:CAS:528:DC%2BD3MXkslOgsLw%3D 11358425 10.1006/clim.2001.5008
    • Sime PJ, O'Reilly KMA. Fibrosis of the lung and other tissues: new concepts in pathogenesis and treatment. Clin Immunol. 2001;99:308-19.
    • (2001) Clin Immunol , vol.99 , pp. 308-319
    • Sime, P.J.1    O'Reilly, K.M.A.2
  • 30
    • 0024730940 scopus 로고
    • Macrophage production of transforming growth factor beta and fibroblast collagen synthesis in chronic pulmonary inflammation
    • 10.1084/jem.170.3.727
    • Khalil N, Bereznay O, Sporn M, Greenberg AH. Macrophage production of transforming growth factor beta and fibroblast collagen synthesis in chronic pulmonary inflammation. J Exp Med. 1989;70:727-37.
    • (1989) J Exp Med , vol.70 , pp. 727-737
    • Khalil, N.1    Bereznay, O.2    Sporn, M.3    Greenberg, A.H.4
  • 31
    • 0031944290 scopus 로고    scopus 로고
    • Regulation of immune responses by TGF-β
    • 1:CAS:528:DyaK1cXislyhsrk%3D 9597127 10.1146/annurev.immunol.16.1.137
    • Letterio JJ, Roberts AB. Regulation of immune responses by TGF-β. Annu Rev Immunol. 1998;16:137-61.
    • (1998) Annu Rev Immunol , vol.16 , pp. 137-161
    • Letterio, J.J.1    Roberts, A.B.2
  • 32
    • 48749132865 scopus 로고    scopus 로고
    • Thrombin induces fibroblast CCL2/JE production and release via coupling of PAR1 to Galphaq and cooperation between ERK1/2 and Rho kinase signaling pathways
    • 1:CAS:528:DC%2BD1cXntV2rt7k%3D 2397294 18353977 10.1091/mbc.E07-07-0720
    • Deng X, Mercer PF, Scotton CJ, Gilchrist A, Chambers RC. Thrombin induces fibroblast CCL2/JE production and release via coupling of PAR1 to Galphaq and cooperation between ERK1/2 and Rho kinase signaling pathways. Mol Biol Cell. 2008;19:2520-33.
    • (2008) Mol Biol Cell , vol.19 , pp. 2520-2533
    • Deng, X.1    Mercer, P.F.2    Scotton, C.J.3    Gilchrist, A.4    Chambers, R.C.5
  • 33
    • 84896542956 scopus 로고    scopus 로고
    • Inhibition of thrombin as a novel strategy in the treatment of scleroderma-associated interstitial lung disease
    • Edited by Radstake T. InTech
    • Bogatkevich GS, Highland KB, Akter T, et al. Inhibition of thrombin as a novel strategy in the treatment of scleroderma-associated interstitial lung disease. Edited by Radstake T. InTech. Croatia 2012:131-48. This paper provides evidence for a promising therapeutic strategy: use of thrombin inhibitor in the treatment of murine lung fibrosis.
    • (2012) Croatia , pp. 131-148
    • Bogatkevich, G.S.1    Highland, K.B.2    Akter, T.3
  • 34
    • 0028418608 scopus 로고
    • Scleroderma bronchoalveolar lavage fluid contains thrombin, a mediator of human lung fibroblast proliferation via induction of platelet-derived growth factor alpha-receptor
    • 1:CAS:528:DyaK2cXktlahtb4%3D 7510986 10.1165/ajrcmb.10.4.7510986
    • Ohba T, McDonald JK, Silver RM, et al. Scleroderma bronchoalveolar lavage fluid contains thrombin, a mediator of human lung fibroblast proliferation via induction of platelet-derived growth factor alpha-receptor. Am J Respir Cell Mol Biol. 1994;10:405-12.
    • (1994) Am J Respir Cell Mol Biol , vol.10 , pp. 405-412
    • Ohba, T.1    McDonald, J.K.2    Silver, R.M.3
  • 35
    • 0028835189 scopus 로고
    • Role of thrombin in pulmonary fibrosis
    • 7564789 10.1016/S0140-6736(95)91744-6
    • Hernández-Rodríguez NA, Cambrey AD, Harrison NK, et al. Role of thrombin in pulmonary fibrosis. Lancet. 1995;346:1071-3.
    • (1995) Lancet , vol.346 , pp. 1071-1073
    • Hernández-Rodríguez, N.A.1    Cambrey, A.D.2    Harrison, N.K.3
  • 36
    • 17844399243 scopus 로고    scopus 로고
    • Absence of protease-activated receptor-1 signaling affords protection from bleomycin-induced lung inflammation and fibrosis
    • 1:CAS:528:DC%2BD2MXksFGmtLo%3D 1606391 15855637 10.1016/S0002-9440(10) 62354-1
    • Howell DCJ, Johns RH, Lasky JA, et al. Absence of protease-activated receptor-1 signaling affords protection from bleomycin-induced lung inflammation and fibrosis. Am J Pathol. 2005;166:1353-65.
    • (2005) Am J Pathol , vol.166 , pp. 1353-1365
    • Howell, D.C.J.1    Johns, R.H.2    Lasky, J.A.3
  • 37
    • 11144278561 scopus 로고    scopus 로고
    • Distinct PKC isoforms mediate cell survival and DNA synthesis in thrombin-induced myofibroblasts
    • 10.1152/ajplung.00448.2003
    • Bogatkevich GS, Gustilo E, Oates J, et al. Distinct PKC isoforms mediate cell survival and DNA synthesis in thrombin-induced myofibroblasts. Am J Physiol Lung Cell Mol Physiol. 2005;288:190-201.
    • (2005) Am J Physiol Lung Cell Mol Physiol , vol.288 , pp. 190-201
    • Bogatkevich, G.S.1    Gustilo, E.2    Oates, J.3
  • 38
    • 0035976915 scopus 로고    scopus 로고
    • Thrombin differentiates normal lung fibroblast to a myofibroblast phenotype via proteolytically activated receptor-1 and protein kinase C-dependent pathway
    • 1:CAS:528:DC%2BD3MXovFensLs%3D 11579091 10.1074/jbc.M106441200
    • Bogatkevich GS, Tourkina E, Silver RM, Ludwicka-Bradley A. Thrombin differentiates normal lung fibroblast to a myofibroblast phenotype via proteolytically activated receptor-1 and protein kinase C-dependent pathway. J Biol Chem. 2001;276:45184-92.
    • (2001) J Biol Chem , vol.276 , pp. 45184-45192
    • Bogatkevich, G.S.1    Tourkina, E.2    Silver, R.M.3    Ludwicka-Bradley, A.4
  • 39
    • 0027419442 scopus 로고
    • A alpha and B beta chains of fibrinogen stimulate proliferation of human fibroblasts
    • 1:CAS:528:DyaK3sXktVGrs7g%3D 8505369
    • Gray AJ, Bishop JE, Reeves JT, Laurent GJ. A alpha and B beta chains of fibrinogen stimulate proliferation of human fibroblasts. J Cell Sci. 1993;104:409-13.
    • (1993) J Cell Sci , vol.104 , pp. 409-413
    • Gray, A.J.1    Bishop, J.E.2    Reeves, J.T.3    Laurent, G.J.4
  • 40
    • 0031044094 scopus 로고    scopus 로고
    • Alpha-Thrombin induces transforming growth factor-beta1 mRNA and protein in cultured vascular smooth muscle cells via a proteolytically activated receptor
    • 1:CAS:528:DyaK2sXhvV2ls78%3D 9075824
    • Bachhuber BG, Sarembock IJ, Gimple LW, Owens GK. alpha-Thrombin induces transforming growth factor-beta1 mRNA and protein in cultured vascular smooth muscle cells via a proteolytically activated receptor. J Vasc Res. 1997;34:41-8.
    • (1997) J Vasc Res , vol.34 , pp. 41-48
    • Bachhuber, B.G.1    Sarembock, I.J.2    Gimple, L.W.3    Owens, G.K.4
  • 41
    • 0034634622 scopus 로고    scopus 로고
    • Thrombin is a potent inducer of connective tissue growth factor production via proteolytic activation of protease-activated receptor-1
    • 1:CAS:528:DC%2BD3cXotFehsr0%3D 10952976 10.1074/jbc.M003188200
    • Chambers RC, Leoni P, Blanc-Brude OP, Wembridge DE, Laurent GJ. Thrombin is a potent inducer of connective tissue growth factor production via proteolytic activation of protease-activated receptor-1. J Biol Chem. 2000;275:35584-91.
    • (2000) J Biol Chem , vol.275 , pp. 35584-35591
    • Chambers, R.C.1    Leoni, P.2    Blanc-Brude, O.P.3    Wembridge, D.E.4    Laurent, G.J.5
  • 42
    • 34547399674 scopus 로고    scopus 로고
    • Scleroderma lung fibroblasts: Contractility and connective tissue growth factor
    • Edited by Gabbiani G, Chaponnier C, Desmouliere A. Texas: Landes
    • Bogatkevich GS, Ludwicka-Bradley A, Nietert PJ, Silver RM. Scleroderma lung fibroblasts: contractility and connective tissue growth factor. Edited by Gabbiani G, Chaponnier C, Desmouliere A. Texas: Landes. Bioscience 2006:25-31.
    • (2006) Bioscience , pp. 25-31
    • Bogatkevich, G.S.1    Ludwicka-Bradley, A.2    Nietert, P.J.3    Silver, R.M.4
  • 43
    • 0034974631 scopus 로고    scopus 로고
    • Depletion of protein kinase Cε in normal and scleroderma lung fibroblasts has opposite effects on tenascin expression
    • 1:CAS:528:DC%2BD38XpsFE%3D 11407697 10.1002/1529-0131(200106)44: 6<1370: AID-ART230>3.0.CO;2-2
    • Tourkina E, Hoffman S, Fenton JW, Lipsitz S, et al. Depletion of protein kinase Cε in normal and scleroderma lung fibroblasts has opposite effects on tenascin expression. Arthritis Rheum. 2001;44:1370-81.
    • (2001) Arthritis Rheum , vol.44 , pp. 1370-1381
    • Tourkina, E.1    Hoffman, S.2    Fenton, J.W.3    Lipsitz, S.4
  • 44
    • 0032126368 scopus 로고    scopus 로고
    • Thrombin stimulates fibroblast procollagen production via proteolytic activation of protease-activated receptor 1
    • 1:CAS:528:DyaK1cXkslyisb0%3D 1219564 9639571
    • Chambers RC, Dabbagh K, McAnulty RJ, et al. Thrombin stimulates fibroblast procollagen production via proteolytic activation of protease-activated receptor 1. Biochem J. 1998;333:121-7.
    • (1998) Biochem J , vol.333 , pp. 121-127
    • Chambers, R.C.1    Dabbagh, K.2    McAnulty, R.J.3
  • 45
    • 0030051502 scopus 로고    scopus 로고
    • Thrombin stimulation of matrix fibronectin
    • 1:CAS:528:DyaK28Xit1Cmtg%3D%3D 8557759 10.1002/(SICI)1097-4652(199601) 166:1<112: AID-JCP13>3.0.CO;2-H
    • Armstrong MT, Fenton 2nd JW, Andersen TT, Armstrong PB. Thrombin stimulation of matrix fibronectin. J Cell Physiol. 1996;166:112-20.
    • (1996) J Cell Physiol , vol.166 , pp. 112-120
    • Armstrong, M.T.1    Fenton II, J.W.2    Andersen, T.T.3    Armstrong, P.B.4
  • 46
    • 0036549805 scopus 로고    scopus 로고
    • Role of thrombin and its major cellular receptor, protease-activated receptor-1, in pulmonary fibrosis
    • 1:CAS:528:DC%2BD38XjvVKhu7Y%3D 12023853 10.1042/BST0300211
    • Howell DC, Laurent GJ, Chambers RC. Role of thrombin and its major cellular receptor, protease-activated receptor-1, in pulmonary fibrosis. Biochem Soc Trans. 2002;30:211-6.
    • (2002) Biochem Soc Trans , vol.30 , pp. 211-216
    • Howell, D.C.1    Laurent, G.J.2    Chambers, R.C.3
  • 47
    • 40349098060 scopus 로고    scopus 로고
    • Procoagulant signalling mechanisms in lung inflammation and fibrosis: Novel opportunities for pharmacological intervention?
    • 10.1038/sj.bjp.0707603
    • Chambers RC. Procoagulant signalling mechanisms in lung inflammation and fibrosis: novel opportunities for pharmacological intervention? Br J Pharmacol. 2008;153:367-78.
    • (2008) Br J Pharmacol , vol.153 , pp. 367-378
    • Chambers, R.C.1
  • 48
    • 70350539686 scopus 로고    scopus 로고
    • Dabigatran, a direct thrombin inhibitor, blocks differentiation of normal fibroblasts to a myofibroblast phenotype and demonstrates anti-fibrotic effects on scleroderma lung fibroblasts
    • 1:CAS:528:DC%2BD1MXhsFentLzE 2837365 19877031 10.1002/art.24935
    • Bogatkevich GS, Ludwicka-Bradley A, Silver RM. Dabigatran, a direct thrombin inhibitor, blocks differentiation of normal fibroblasts to a myofibroblast phenotype and demonstrates anti-fibrotic effects on scleroderma lung fibroblasts. Arthritis Rheum. 2009;60:3455-64.
    • (2009) Arthritis Rheum , vol.60 , pp. 3455-3464
    • Bogatkevich, G.S.1    Ludwicka-Bradley, A.2    Silver, R.M.3
  • 49
    • 79955558187 scopus 로고    scopus 로고
    • Antiinflammatory and antifibrotic effects of the oral direct thrombin inhibitor dabigatran etexilate in a murine model of interstitial lung disease
    • 1:CAS:528:DC%2BC3MXltlGht74%3D 3086970 21312187 10.1002/art.30255
    • Bogatkevich GS, Ludwicka-Bradley A, Nietert PJ, et al. Antiinflammatory and antifibrotic effects of the oral direct thrombin inhibitor dabigatran etexilate in a murine model of interstitial lung disease. Arthritis Rheum. 2011;63:1416-25.
    • (2011) Arthritis Rheum , vol.63 , pp. 1416-1425
    • Bogatkevich, G.S.1    Ludwicka-Bradley, A.2    Nietert, P.J.3
  • 50
    • 65249088418 scopus 로고    scopus 로고
    • WNT1-inducible signaling protein-1 mediates pulmonary fibrosis in mice and is upregulated in humans with idiopathic pulmonary fibrosis
    • 2662540 19287097
    • Königshoff M, Kramer M, Balsara N, Wilhelm J, et al. WNT1-inducible signaling protein-1 mediates pulmonary fibrosis in mice and is upregulated in humans with idiopathic pulmonary fibrosis. J Clin Invest. 2009;119:772-87.
    • (2009) J Clin Invest , vol.119 , pp. 772-787
    • Königshoff, M.1    Kramer, M.2    Balsara, N.3    Wilhelm, J.4
  • 51
    • 0242500879 scopus 로고    scopus 로고
    • Aberrant Wnt/beta-catenin pathway activation in idiopathic pulmonary fibrosis
    • 1:CAS:528:DC%2BD3sXjsl2murs%3D 1851206 12707032 10.1016/S0002-9440(10) 64282-4
    • Chilosi M, Poletti V, Zamò A, et al. Aberrant Wnt/beta-catenin pathway activation in idiopathic pulmonary fibrosis. Am J Pathol. 2003;162:1495-502.
    • (2003) Am J Pathol , vol.162 , pp. 1495-1502
    • Chilosi, M.1    Poletti, V.2    Zamò, A.3
  • 52
    • 33747339465 scopus 로고    scopus 로고
    • Wnt signaling: Multiple pathways, multiple receptors, and multiple transcription factors
    • 1:CAS:528:DC%2BD28XnvVSquro%3D 16793760 10.1074/jbc.R600015200
    • Gordon MD, Nusse R. Wnt signaling: multiple pathways, multiple receptors, and multiple transcription factors. J Biol Chem. 2006;281:22429-33.
    • (2006) J Biol Chem , vol.281 , pp. 22429-22433
    • Gordon, M.D.1    Nusse, R.2
  • 53
    • 2542485410 scopus 로고    scopus 로고
    • Endothelin-1 promotes myofibroblast induction through the ETA receptor via a rac/phosphoinositide 3-kinase/Akt-dependent pathway and is essential for the enhanced contractile phenotype of fibrotic fibroblasts
    • 420095 15047866 10.1091/mbc.E03-12-0902
    • Shi-Wen X, Chen Y, Denton CP, et al. Endothelin-1 promotes myofibroblast induction through the ETA receptor via a rac/phosphoinositide 3-kinase/Akt-dependent pathway and is essential for the enhanced contractile phenotype of fibrotic fibroblasts. Mol Biol Cell. 2004;15:2707-19.
    • (2004) Mol Biol Cell , vol.15 , pp. 2707-2719
    • Shi-Wen, X.1    Chen, Y.2    Denton, C.P.3
  • 54
    • 80051664850 scopus 로고    scopus 로고
    • Elevated MMP-7 levels in patients with systemic sclerosis: Correlation with pulmonary involvement
    • 1:CAS:528:DC%2BC3MXht1WmtrjL 21707759 10.1111/j.1600-0625.2011.01321.x
    • Moinzadeh P, Krieg T, Hellmich M, et al. Elevated MMP-7 levels in patients with systemic sclerosis: correlation with pulmonary involvement. Exp Dermatol. 2011;20:770-3.
    • (2011) Exp Dermatol , vol.20 , pp. 770-773
    • Moinzadeh, P.1    Krieg, T.2    Hellmich, M.3
  • 55
    • 79958036406 scopus 로고    scopus 로고
    • Canonical Wnt signaling induces skin fibrosis and subcutaneous lipoatrophy, a novel mouse model for scleroderma
    • 1:CAS:528:DC%2BC3MXmslOku7c%3D 3124699 21370225 10.1002/art.30312
    • Wei J, Melichian D, Komura K, et al. Canonical Wnt signaling induces skin fibrosis and subcutaneous lipoatrophy, a novel mouse model for scleroderma. Arthritis Rheum. 2011;63:1707-17.
    • (2011) Arthritis Rheum , vol.63 , pp. 1707-1717
    • Wei, J.1    Melichian, D.2    Komura, K.3
  • 56
    • 84876805135 scopus 로고    scopus 로고
    • TCDD inhibition of canonical Wnt signaling disrupts prostatic bud formation in mouse urogenital sinus
    • 23429912 10.1093/toxsci/kft027
    • Schneider AJ, Vezina CM, Richard E, et al. TCDD inhibition of canonical Wnt signaling disrupts prostatic bud formation in mouse urogenital sinus. Toxicol Sci. 2013;133:42-53.
    • (2013) Toxicol Sci , vol.133 , pp. 42-53
    • Schneider, A.J.1    Vezina, C.M.2    Richard, E.3
  • 57
    • 0034965980 scopus 로고    scopus 로고
    • Familial occurrence frequencies and relative risks for systemic sclerosis (scleroderma) in three United States cohorts
    • 1:STN:280:DC%2BD3MzksVOnsA%3D%3D 11407695 10.1002/1529-0131(200106)44: 6<1359: AID-ART228>3.0.CO;2-S
    • Arnett FC, Cho M, Chatterjee S, et al. Familial occurrence frequencies and relative risks for systemic sclerosis (scleroderma) in three United States cohorts. Arthritis Rheum. 2001;44:1359-62.
    • (2001) Arthritis Rheum , vol.44 , pp. 1359-1362
    • Arnett, F.C.1    Cho, M.2    Chatterjee, S.3
  • 58
    • 80052639950 scopus 로고    scopus 로고
    • Systemic sclerosis - An update
    • 10.1309/LM9OB5BZ4OSNVGVF
    • Haustein U-F. Systemic sclerosis - an update. Lab Med. 2011;42:562-72.
    • (2011) Lab Med , vol.42 , pp. 562-572
    • Haustein, U.-F.1
  • 59
    • 0030905217 scopus 로고    scopus 로고
    • Racial differences in scleroderma among women in Michigan
    • 1:STN:280:DyaK2s3ksVejuw%3D%3D 9125258 10.1002/art.1780400421
    • Laing TJ, Gillespie BW, Toth MB, et al. Racial differences in scleroderma among women in Michigan. Arthritis Rheum. 1997;40:734-42.
    • (1997) Arthritis Rheum , vol.40 , pp. 734-742
    • Laing, T.J.1    Gillespie, B.W.2    Toth, M.B.3
  • 60
    • 84867032498 scopus 로고    scopus 로고
    • Racial differences between blacks and whites with systemic sclerosis
    • 3756312 22955018 10.1097/BOR.0b013e328356d9dc This article provides evidence of correlation between race-dependent predisposition to fibrosis and biological variable factors
    • Silver RM, Bogatkevich G, Tourkina E, et al. Racial differences between blacks and whites with systemic sclerosis. Curr Opin Rheumatol. 2012;24:642-8. This article provides evidence of correlation between race-dependent predisposition to fibrosis and biological variable factors.
    • (2012) Curr Opin Rheumatol , vol.24 , pp. 642-648
    • Silver, R.M.1    Bogatkevich, G.2    Tourkina, E.3
  • 61
    • 34547492358 scopus 로고    scopus 로고
    • Impairment of the antifibrotic effect of hepatocyte growth factor in lung fibroblasts from African Americans: Possible role in systemic sclerosis
    • 1:CAS:528:DC%2BD2sXovFSgu7s%3D 17599773 10.1002/art.22713
    • Bogatkevich GS, Ludwicka-Bradley A, Highland KB, et al. Impairment of the antifibrotic effect of hepatocyte growth factor in lung fibroblasts from African Americans: possible role in systemic sclerosis. Arthritis Rheum. 2007;56:2432-42.
    • (2007) Arthritis Rheum , vol.56 , pp. 2432-2442
    • Bogatkevich, G.S.1    Ludwicka-Bradley, A.2    Highland, K.B.3
  • 62
    • 84880272365 scopus 로고    scopus 로고
    • Race and association with disease manifestations and mortality in scleroderma: A 20-year experience at the Johns Hopkins Scleroderma Center and review of the literature
    • 10.1097/MD.0b013e31829be125
    • Gelber AC, Manno RL, Shah AA, et al. Race and association with disease manifestations and mortality in scleroderma: a 20-year experience at the Johns Hopkins Scleroderma Center and review of the literature. Medicine (Baltimore). 2013;92:191-205.
    • (2013) Medicine (Baltimore) , vol.92 , pp. 191-205
    • Gelber, A.C.1    Manno, R.L.2    Shah, A.A.3
  • 63
    • 84865648979 scopus 로고    scopus 로고
    • A clinical and serologic comparison of African American and Caucasian patients with systemic sclerosis
    • 1:CAS:528:DC%2BC38Xht1GrsbjI 3557827 22576620 10.1002/art.34482
    • Steen V, Domsic RT, Lucas M, et al. A clinical and serologic comparison of African American and Caucasian patients with systemic sclerosis. Arthritis Rheum. 2012;64:2986-94.
    • (2012) Arthritis Rheum , vol.64 , pp. 2986-2994
    • Steen, V.1    Domsic, R.T.2    Lucas, M.3
  • 64
    • 84863964211 scopus 로고    scopus 로고
    • The PPARγ agonist rosiglitazone is antifibrotic for scleroderma lung fibroblasts: Mechanisms of action and differential racial effects
    • 10.1155/2012/545172 3206324 22135743 10.1155/2012/545172 This article provides functional evidence of race-based transcriptional factor over-activation and promising treatment for SSc-ILD on that basis
    • Bogatkevich GS, Highland KB, Akter T, Silver RM. The PPARγ agonist rosiglitazone is antifibrotic for scleroderma lung fibroblasts: mechanisms of action and differential racial effects. Pulm Med. 2012;2012:545172. doi: 10.1155/2012/545172. This article provides functional evidence of race-based transcriptional factor over-activation and promising treatment for SSc-ILD on that basis.
    • (2012) Pulm Med , vol.2012 , pp. 545172
    • Bogatkevich, G.S.1    Highland, K.B.2    Akter, T.3    Silver, R.M.4
  • 65
    • 0028916660 scopus 로고
    • Association of HLA-DR5 (DR11) with systemic sclerosis (scleroderma) in Mexican patients
    • 7774089
    • Vargas-Alarcón G, Granados J, Ibañez de Kasep G, et al. Association of HLA-DR5 (DR11) with systemic sclerosis (scleroderma) in Mexican patients. Clin Exp Rheumatol. 1995;13:11-6.
    • (1995) Clin Exp Rheumatol , vol.13 , pp. 11-16
    • Vargas-Alarcón, G.1    Granados, J.2    Ibañez De Kasep, G.3
  • 66
    • 0029199990 scopus 로고
    • HLA and autoimmunity in scleroderma (systemic sclerosis)
    • 1:STN:280:DyaK2MznvVOitQ%3D%3D 7650416 10.3109/08830189509056707
    • Arnett FC. HLA and autoimmunity in scleroderma (systemic sclerosis). Int Rev Immunol. 1995;12:107-28.
    • (1995) Int Rev Immunol , vol.12 , pp. 107-128
    • Arnett, F.C.1
  • 67
    • 0027724487 scopus 로고
    • Molecular genetics of systemic sclerosis
    • 1:STN:280:DyaK2c7mt1Slsg%3D%3D 8117538 10.1097/00002281-199305060-00010
    • Reveille JD. Molecular genetics of systemic sclerosis. Curr Opin Rheumatol. 1993;5:753-9.
    • (1993) Curr Opin Rheumatol , vol.5 , pp. 753-759
    • Reveille, J.D.1
  • 68
    • 0029841856 scopus 로고    scopus 로고
    • Association of TAP1 and TAP2 with systemic sclerosis in Japanese
    • 1:STN:280:DyaK2s%2FntVOhtQ%3D%3D 8913653
    • Takeuchi F, Kuwata S, Nakano K, et al. Association of TAP1 and TAP2 with systemic sclerosis in Japanese. Clin Exp Rheumatol. 1996;14:513-21.
    • (1996) Clin Exp Rheumatol , vol.14 , pp. 513-521
    • Takeuchi, F.1    Kuwata, S.2    Nakano, K.3
  • 69
    • 84875953107 scopus 로고    scopus 로고
    • Systemic sclerosis: Genetics and epigenetics
    • 1:CAS:528:DC%2BC3sXisVyjsL0%3D 23415078 10.1016/j.jaut.2013.01.012
    • Luo Y, Wang Y, Wang Q, Xiao R, Lu Q. Systemic sclerosis: genetics and epigenetics. J Autoimmun. 2013;41:161-7.
    • (2013) J Autoimmun , vol.41 , pp. 161-167
    • Luo, Y.1    Wang, Y.2    Wang, Q.3    Xiao, R.4    Lu, Q.5
  • 70
    • 0028239510 scopus 로고
    • Severe systemic sclerosis with anti-topoisomerase i antibodies is associated with an HLA-DRw11 allele
    • 1:STN:280:DyaK2M%2FhtlCntw%3D%3D 7928439 10.1016/0198-8859(94)90054-X
    • Morel PA, Chang HJ, Wilson JW, et al. Severe systemic sclerosis with anti-topoisomerase I antibodies is associated with an HLA-DRw11 allele. Hum Immunol. 1994;40:101-10.
    • (1994) Hum Immunol , vol.40 , pp. 101-110
    • Morel, P.A.1    Chang, H.J.2    Wilson, J.W.3
  • 71
    • 79960421272 scopus 로고    scopus 로고
    • The genetics of systemic sclerosis: An update
    • Romano E, Manetti M, Guiducci S, et al. The genetics of systemic sclerosis: an update. Clin Exp Rheumatol. 2011;29:75-86.
    • (2011) Clin Exp Rheumatol , vol.29 , pp. 75-86
    • Romano, E.1    Manetti, M.2    Guiducci, S.3
  • 72
    • 33745918328 scopus 로고    scopus 로고
    • Association between enhanced type i collagen expression and epigenetic repression of the FLI1 gene in scleroderma fibroblasts
    • 1:CAS:528:DC%2BD28XnslKhu7s%3D 16802366 10.1002/art.21948
    • Wang Y, Fan PS, Kahaleh B. Association between enhanced type I collagen expression and epigenetic repression of the FLI1 gene in scleroderma fibroblasts. Arthritis Rheum. 2006;54:2271-9.
    • (2006) Arthritis Rheum , vol.54 , pp. 2271-2279
    • Wang, Y.1    Fan, P.S.2    Kahaleh, B.3
  • 73
    • 84875979967 scopus 로고    scopus 로고
    • The downregulation of microRNA let-7a contributes to the excessive expression of type i collagen in systemic and localized scleroderma
    • 1:CAS:528:DC%2BC3sXlsVCls70%3D 10.4049/jimmunol.1200822
    • Makino K, Jinnin M, Hirano A, et al. The downregulation of microRNA let-7a contributes to the excessive expression of type I collagen in systemic and localized scleroderma. Immunology. 2013;190:3905-15.
    • (2013) Immunology , vol.190 , pp. 3905-3915
    • Makino, K.1    Jinnin, M.2    Hirano, A.3
  • 74
    • 77955373730 scopus 로고    scopus 로고
    • MiR-21 mediates fibrogenic activation of pulmonary fibroblasts and lung fibrosis
    • 1:CAS:528:DC%2BC3cXhtVejt7nL 2916139 20643828 10.1084/jem.20100035
    • Liu G, Friggeri A, Yang Y, et al. miR-21 mediates fibrogenic activation of pulmonary fibroblasts and lung fibrosis. J Exp Med. 2010;207:1589-97.
    • (2010) J Exp Med , vol.207 , pp. 1589-1597
    • Liu, G.1    Friggeri, A.2    Yang, Y.3


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