Role of coagulation cascade proteases in lung repair and fibrosis

European Respiratory Journal, Supplement

Volumn 22, Issue 44, 2003, Pages

  Chambers, R C ^a  

^a UNIVERSITY COLLEGE LONDON   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

BLEOMYCIN; BLOOD CLOTTING FACTOR 10; BLOOD CLOTTING FACTOR 10A; BLOOD CLOTTING FACTOR 11; BLOOD CLOTTING FACTOR 7; BLOOD CLOTTING FACTOR 9A; FIBRIN; FIBRINOGEN; G PROTEIN COUPLED RECEPTOR; PLASMINOGEN ACTIVATOR INHIBITOR 1; PROTEINASE; PROTEINASE ACTIVATED RECEPTOR 1; PROTHROMBIN; THROMBIN; THROMBOPLASTIN; BLOOD CLOTTING FACTOR;

BLOOD CLOTTING; CONFERENCE PAPER; HUMAN; INFLAMMATION; LUNG FIBROBLAST; LUNG FIBROSIS; LUNG INJURY; NONHUMAN; PRIORITY JOURNAL; PROTEIN DEGRADATION; RESPIRATORY DISTRESS SYNDROME; ANIMAL; ENZYME ACTIVATION; ENZYMOLOGY; METABOLISM; MOUSE; PATHOPHYSIOLOGY; PHYSIOLOGY; REGENERATION; REVIEW; SENSITIVITY AND SPECIFICITY; SIGNAL TRANSDUCTION;

ANIMALS; BLOOD COAGULATION; BLOOD COAGULATION FACTORS; ENDOPEPTIDASES; ENZYME ACTIVATION; HUMANS; MAP KINASE SIGNALING SYSTEM; MICE; PLASMINOGEN ACTIVATOR INHIBITOR 1; PULMONARY FIBROSIS; REGENERATION; SENSITIVITY AND SPECIFICITY; SIGNAL TRANSDUCTION;

EID: 0141753083     PISSN: 09041850     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Conference Paper

References (21)

1. Howell DC, Laurent GJ, Chambers RC. Role of thrombin and its major cellular receptor, protease-activated receptor-1, in pulmonary fibrosis. Biochem Soc Trans 2002; 30: 211-216.
2. Chambers RC, Laurent GJ. Coagulation cascade proteases and tissue fibrosis. Biochem Soc Trans 2002; 30: 194-200.
3. Imokawa S, Sato A, Hayakawa H, Kotani M, Urano T, Takada A. Tissue factor expression and fibrin deposition in the lungs of patients with idiopathic pulmonary fibrosis and systemic sclerosis. Am J Respir Crit Care Med 1997; 156: 631-636.
4. Idell S, James KK, Levin EG, et al. Local abnormalities in coagulation and fibrinolytic pathways predispose to alveolar fibrin deposition in the adult respiratory distress syndrome. J Clin Invest 1989; 84: 695-705.
5. Hernandez Rodriguez NA, Cambrey AD, Harrison NK, et al. Role of thrombin in pulmonary fibrosis. Lancet 1995; 346: 1071-1073.
6. Dik WA, Zimmermann LJ, Naber BA, Janssen DJ, Van Kaam AH, Versnel MA. Thrombin contributes to bronchoalveolar lavage fluid mitogenicity in lung disease of the premature infant. Pediatr Pulmonol 2003; 35: 34-41.
7. Gabazza EC, Taguchi O, Tamaki S, et al. Thrombin in the airways of asthmatic patients. Lung 1999; 177: 253-262.
8. Peyrol S, Cordier JF, Grimaud JA. Intra-alveolar fibrosis of idiopathic bronchiolitis obliterans-organizing pneumonia. Cell-matrix patterns. Am J Pathol 1990; 137: 155-170.
9. Eitzman DT, McCoy RD, Zheng X, et al. Bleomycin-induced pulmonary fibrosis in transgenic mice that either lack or overexpress the murine plasminogen activator inhibitor-1 gene. J Clin Invest 1996; 97: 232-237.
10. Hattori N, Degen JL, Sisson TH, et al. Bleomycin-induced pulmonary fibrosis in fibrinogen-null mice. J Clin Invest 2000; 106: 1341-1350.
11. Wilberding JA, Ploplis VA, McLennan L, et al. Development of pulmonary fibrosis in fibrinogen-deficient mice. Ann NY Acad Sci 2001; 936: 542-548.
12. Vu TK, Hung DT, Wheaton VI, Coughlin SR. Molecular cloning of a functional thrombin receptor reveals a novel proteolytic mechanism of receptor activation. Cell 1991; 64: 1057-1068.
13. Chen LB, Buchanan JM. Mitogenic activity of blood components. I. Thrombin and prothrombin. Proc Natl Acad Sci USA 1975; 72: 131-135.
14. Chambers RC, Dabbagh K, McAnulty RJ, Gray AJ, Blanc Brude OP, Laurent GJ. Thrombin stimulates fibroblast procollagen production via proteolytic activation of protease-activated receptor I. Biochem J 1998; 333: 121-127.
15. Bogatkevich GS, Tourkina E, Silver RM, Ludwicka-Bradley A. Thrombin differentiates normal lung fibroblasts to a myofibroblast phenotype via the proteolytically activated receptor-1 and a protein kinase C-dependent pathway. J Biol Chem 2001; 276: 45184-45192.
16. Ohba T, McDonald JK, Silver RM, Strange C, LeRoy EC, Ludwicka A. Scleroderma bronchoalveolar lavage fluid contains thrombin, a mediator of human lung fibroblast proliferation via induction of platelet-derived growth factor α-receptor. Am J Respir Cell Mol Biol 1994; 10: 405-412.
17. Chambers RC, Leoni P, Blanc-Brude OP, Wembridge DE, Laurent GJ. Thrombin is a potent inducer of connective tissue growth factor production via proteolytic activation of protease-activated receptor-1. J Biol Chem 2000; 275: 35584-35591.
18. Howell DC, Goldsack NR, Marshall RP, et al. Direct thrombin inhibition reduces lung collagen, accumulation, and connective tissue growth factor mRNA levels in bleomycin-induced pulmonary fibrosis. Am J Pathol 2001; 159: 1383-1395.
19. Yasui H, Gabazza EC, Tamaki S, et al. Intratracheal administration of activated protein C inhibits bleomycin-induced lung fibrosis in the mouse. Am J Respir Crit Care Med 2001; 163: 1660-1668.
20. Bernard GR, Vincent JL, Laterre PF, et al. Efficacy and safety of recombinant human activated protein C for severe sepsis. N Engl J Med 2001; 344: 699-709.
21. Derian CK, Damiano BP, Addo MF, et al. Blockade of the thrombin receptor protease-activated receptor-1 with a small-molecule antagonist prevents thrombus formation and vascular occlusion in nonhuman primates. J Pharmacol Exp Ther 2003; 304: 855-861.