The effect of acid pH modifiers on the release characteristics of weakly basic drug from hydrophlilic-lipophilic matrices

AAPS PharmSciTech

Volumn 14, Issue 4, 2013, Pages 1341-1348

  Dvořáčková, Kateřina ^a   Doležel, Petr ^a   Mašková, Eliška ^a   Muselík, Jan ^a   Kejdušová, Martina ^a   Vetchý, David ^a  

^a UNIVERSITY OF VETERINARY AND PHARMACEUTICAL SCIENCES   (Czech Republic)

Author keywords

Gel layer; Matrix tablets; PH modifiers; PH independent drug release; Statistical evaluation

Indexed keywords

CITRIC ACID; FUMARIC ACID; GLYCOL; HYDROXYPROPYLMETHYLCELLULOSE; ITACONIC ACID; MONTANGLYCOL; UNCLASSIFIED DRUG; VERAPAMIL;

ARTICLE; CONCENTRATION (PARAMETERS); CONTROLLED STUDY; DRUG RELEASE; DRUG SOLUBILITY; ELECTRODE; HYDROPHILICITY; LIPOPHILICITY; MATRIX TABLET; MICROENVIRONMENT; PARTICLE SIZE; PH; PKA; PRIORITY JOURNAL;

ALGORITHMS; CALCIUM CHANNEL BLOCKERS; DRUG DESIGN; ELECTRODES; FACTOR ANALYSIS, STATISTICAL; GELS; HYDROGEN-ION CONCENTRATION; KINETICS; METHYLCELLULOSE; PARTICLE SIZE; PHARMACEUTICAL PREPARATIONS; SOLUBILITY; TABLETS; VERAPAMIL;

EID: 84893658907     PISSN: None     EISSN: 15309932     Source Type: Journal    
DOI: 10.1208/s12249-013-0019-1     Document Type: Article

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