Enteric polymers as acidifiers for the pH-independent sustained delivery of a weakly basic drug salt from coated pellets

European Journal of Pharmaceutics and Biopharmaceutics

Volumn 78, Issue 3, 2011, Pages 447-454

  Körber, Martin ^a   Ciper, Mesut ^a   Hoffart, Valerie ^a   Pearnchob, Nantharat ^a   Walther, Mathias ^b   MacRae, Ross J ^b   Bodmeier, Roland ^a  

^a FREIE UNIVERSITÄT BERLIN   (Germany)

^b PFIZER GLOBAL RESEARCH AND DEVELOPMENT   (United Kingdom)

Author keywords

Coating; Controlled drug release; Enteric; Ethylcellulose; Eudragit L; Microenvironmental pH; Multiparticulates; Non enteric; Pellets; Polymer blend; Weakly basic drug

Indexed keywords

CARBOXYLIC ACID; ETHYL CELLULOSE; EUDRAGIT; HYDROXYPROPYLCELLULOSE;

ACIDIFICATION; ARTICLE; DRUG COATING; DRUG PELLET; DRUG SOLUBILITY; PH; SUSTAINED DRUG RELEASE;

ASPARTIC ACID; CELLULOSE; DELAYED-ACTION PREPARATIONS; DRUG COMPOUNDING; DRUG DELIVERY SYSTEMS; DRUG IMPLANTS; EXCIPIENTS; HYDROGEN-ION CONCENTRATION; MESYLATES; POLYMERS; POLYMETHACRYLIC ACIDS; SOLUBILITY; TABLETS, ENTERIC-COATED;

EID: 79960600320     PISSN: 09396411     EISSN: 18733441     Source Type: Journal    
DOI: 10.1016/j.ejpb.2011.03.018     Document Type: Article

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