Repeated antidepressant therapy increases cyclic GMP signaling in rat hippocampus

Neuroscience Letters

Volumn 466, Issue 3, 2009, Pages 149-153

  Reierson, Gillian W ^a   Mastronardi, Claudio A ^b   Licinio, Julio ^b   Wong, Ma Li ^b  

^a UNIVERSITY OF MIAMI MILLER SCHOOL OF MEDICINE   (United States)

^b Biology and Environment   (Australia)

Author keywords

Antidepressant; Cyclic; Hippocampus; Nucleotides; Phosphodiesterase; Rat

Indexed keywords

AMITRIPTYLINE; ANTIDEPRESSANT AGENT; CYCLIC GMP; FLUOXETINE; PHOSPHODIESTERASE;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; DRUG EFFECT; DRUG EFFICACY; DRUG MECHANISM; GENE EXPRESSION; HIPPOCAMPUS; MALE; NONHUMAN; NUCLEOTIDE SEQUENCE; PRIORITY JOURNAL; PROTEIN EXPRESSION; RAT; SIGNAL TRANSDUCTION; TREATMENT DURATION;

ADENYLATE CYCLASE; AMITRIPTYLINE; ANIMALS; ANTIDEPRESSIVE AGENTS; CYCLIC AMP; CYCLIC GMP; DOSE-RESPONSE RELATIONSHIP, DRUG; FLUOXETINE; HIPPOCAMPUS; ISOENZYMES; MALE; PHOSPHORIC DIESTER HYDROLASES; RATS; RATS, SPRAGUE-DAWLEY; SIGNAL TRANSDUCTION;

EID: 70350347177     PISSN: 03043940     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.neulet.2009.09.047     Document Type: Article

References (29)

1. Blokland A., Schreiber R., and Prickaerts J. Improving memory: a role for phosphodiesterases. Curr. Pharm. Des. 12 (2006) 2511-2523
2. Bon C.L., and Garthwaite J. Exogenous nitric oxide causes potentiation of hippocampal synaptic transmission during low-frequency stimulation via the endogenous nitric oxide-cGMP pathway. Eur. J. Neurosci. 14 (2001) 585-594
3. Brady L.S., Gold P.W., Herkenham M., Lynn A.B., and Whitfield Jr. H.J. The antidepressants fluoxetine, idazoxan and phenelzine alter corticotropin-releasing hormone and tyrosine hydroxylase mRNA levels in rat brain: therapeutic implications. Brain Res. 572 (1992) 117-125
4. Brink C.B., Clapton J.D., Eagar B.E., and Harvey B.H. Appearance of antidepressant-like effect by sildenafil in rats after central muscarinic receptor blockade: evidence from behavioural and neuro-receptor studies. J. Neural. Transm. 115 (2008) 117-125
5. Culmsee C., Gerling N., Landshamer S., Rickerts B., Duchstein H.J., Umezawa K., Klumpp S., and Krieglstein J. Nitric oxide donors induce neurotrophin-like survival signaling and protect neurons against apoptosis. Mole. Pharmacol. 68 (2005) 1006-1017
6. Devan B.D., Sierra-Mercado Jr. D., Jimenez M., Bowker J.L., Duffy K.B., Spangler E.L., and Ingram D.K. Phosphodiesterase inhibition by sildenafil citrate attenuates the learning impairment induced by blockade of cholinergic muscarinic receptors in rats. Pharmacol., Biochem., Behav. 79 (2004) 691-699
7. Esposito K., Reierson G.W., Rong Luo H., Sheng Wu G., Licinio J., and Wong M.L. Phosphodiesterase genes and antidepressant treatment response: A review. Annals Med. (2008) 1-9
8. Hanoune J., Pouille Y., Tzavara E., Shen T., Lipskaya L., Miyamoto N., Suzuki Y., and Defer N. Adenylyl cyclases: structure, regulation and function in an enzyme superfamily. Mole. Cell. Endocrinol. 128 (1997) 179-194
9. Heiberg I.L., Wegener G., and Rosenberg R. Reduction of cGMP and nitric oxide has antidepressant-like effects in the forced swimming test in rats. Behav. Brain Res. 134 (2002) 479-484
10. Kurt M., Bilge S.S., Aksoz E., Kukula O., Celik S., and Kesim Y. Effect of sildenafil on anxiety in the plus-maze test in mice. Pol. J. Pharmacol. 56 (2004) 353-357
11. Manier D.H., Shelton R.C., and Sulser F. Noradrenergic antidepressants: does chronic treatment increase or decrease nuclear CREB-P?. J. Neural. Transm. 109 (2002) 91-99
12. Matsuoka I., Suzuki Y., Defer N., Nakanishi H., and Hanoune J. Differential expression of type I, II, and V adenylyl cyclase gene in the postnatal developing rat brain. J. Neurochem. 68 (1997) 498-506
13. Menniti F.S., Faraci W.S., and Schmidt C.J. Phosphodiesterases in the CNS: targets for drug development. Nat. Rev. Drug. Discov. 5 (2006) 660-670
14. Mergia E., Russwurm M., Zoidl G., and Koesling D. Major occurrence of the new alpha2beta1 isoform of NO-sensitive guanylyl cyclase in brain. Cell Signal 15 (2003) 189-195
15. Muller M.J., and Benkert O. Lower self-reported depression in patients with erectile dysfunction after treatment with sildenafil. J. Affect. Disord. 66 (2001) 255-261
16. Nair A., and Vaidya V.A. Cyclic AMP response element binding protein and brain-derived neurotrophic factor: molecules that modulate our mood?. J. Biosci. 31 (2006) 423-434
17. Pelligrino D.A., and Wang Q. Cyclic nucleotide crosstalk and the regulation of cerebral vasodilation. Progress Neurobiol. 56 (1998) 1-18
18. Prickaerts J., Sik A., van Staveren W.C., Koopmans G., Steinbusch H.W., van der Staay F.J., de Vente J., and Blokland A. Phosphodiesterase type 5 inhibition improves early memory consolidation of object information. Neurochem. Int. 45 (2004) 915-928
19. Prickaerts J., van Staveren W.C., Sik A., Markerink-van Ittersum M., Niewohner U., van der Staay F.J., Blokland A., and de Vente J. Effects of two selective phosphodiesterase type 5 inhibitors, sildenafil and vardenafil, on object recognition memory and hippocampal cyclic GMP levels in the rat. Neuroscience 113 (2002) 351-361
20. Reierson G.W., Mastronardi C.A., Licinio J., and Wong M.L. Chronic imipramine downregulates cyclic AMP signaling in rat hippocampus. Neuroreport 20 (2009) 307-311
21. Reneerkens O.A., Rutten K., Steinbusch H.W., Blokland A., and Prickaerts J. Selective phosphodiesterase inhibitors: a promising target for cognition enhancement. Psychopharmacology (2008)
22. Rose G.M., Hopper A., De Vivo M., and Tehim A. Phosphodiesterase inhibitors for cognitive enhancement. Curr. Pharm. Des. 11 (2005) 3329-3334
23. Schneider H.H. Brain cAMP response to phosphodiesterase inhibitors in rats killed by microwave irradiation or decapitation. Biochem. Pharmacol. 33 (1984) 1690-1693
24. Tanis K.Q., and Duman R.S. Intracellular signaling pathways pave roads to recovery for mood disorders. Annals Med. 39 (2007) 531-544
25. Tignol J., Furlan P.M., Gomez-Beneyto M., Opsomer R., Schreiber W., Sweeney M., and Wohlhuter C. Efficacy of sildenafil citrate (Viagra) for the treatment of erectile dysfunction in men in remission from depression. Int. Clin. Psychopharmacol. 19 (2004) 191-199
26. Trivedi M.H., Rush A.J., Wisniewski S.R., Nierenberg A.A., Warden D., Ritz L., Norquist G., Howland R.H., Lebowitz B., McGrath P.J., Shores-Wilson K., Biggs M.M., Balasubramani G.K., and Fava M. Evaluation of outcomes with citalopram for depression using measurement-based care in STAR*D: implications for clinical practice. Am. J. Psychiatry 163 (2006) 28-40
27. Volke V., Wegener G., and Vasar E. Augmentation of the NO-cGMP cascade induces anxiogenic-like effect in mice. J. Physiol. Pharmacol. 54 (2003) 653-660
28. Wang H., and Edens N.K. mRNA expression and antilipolytic role of phosphodiesterase 4 in rat adipocytes in vitro. J. Lipid Res. 48 (2007) 1099-1107
29. Yau J.L., Olsson T., Morris R.G., Meaney M.J., and Seckl J.R. Glucocorticoids, hippocampal corticosteroid receptor gene expression and antidepressant treatment: relationship with spatial learning in young and aged rats. Neuroscience 66 (1995) 571-581