Serotonin inhibits apoptosis of pulmonary artery smooth muscle cell by pERK1/2 and PDK through 5-HT1B receptors and 5-HT transporters

Cardiovascular Pathology

Volumn 22, Issue 6, 2013, Pages 451-457

  Liu, Ya ^a   Tian, Hong Yan ^a   Yan, Xiao Li ^a   Fan, Fen Ling ^a   Wang, Wen Ping ^a   Han, Jun Li ^a   Zhang, Jun Bo ^a   Ma, Qiang ^a   Meng, Yan ^a   Wei, Feng ^a  

^a XI'AN JIAOTONG UNIVERSITY   (China)

Author keywords

Apoptosis; Pulmonary artery smooth muscle cell; Serotonin

Indexed keywords

2,3,6,7 TETRAHYDRO 1' METHYL 5 [[2' METHYL 4' (5 METHYL 1,2,4 OXADIAZOL 3 YL) 4 BIPHENYLYL]CARBONYL]SPIRO[FURO[2,3 F]INDOLE 3,4' PIPERIDINE]; 3 (1,2,5,6 TETRAHYDRO 4 PYRIDYL)PYRROLO[3,2 B]PYRIDIN 5 ONE; DICHLOROACETIC ACID; FLUOXETINE; LY 393558; MITOGEN ACTIVATED PROTEIN KINASE 1; MITOGEN ACTIVATED PROTEIN KINASE 3; PYRUVATE DEHYDROGENASE KINASE; SEROTONIN; SEROTONIN 1B ANTAGONIST; SEROTONIN 1B RECEPTOR; SEROTONIN TRANSPORTER; UNCLASSIFIED DRUG;

APOPTOSIS; ARTICLE; CELL PROLIFERATION; CONTROLLED STUDY; DRUG MECHANISM; HUMAN; HUMAN CELL; MITOCHONDRIAL MEMBRANE POTENTIAL; PRIORITY JOURNAL; PULMONARY ARTERY SMOOTH MUSCLE CELL; PULMONARY HYPERTENSION; SMOOTH MUSCLE FIBER;

APOPTOSIS; PULMONARY ARTERY SMOOTH MUSCLE CELL; SEROTONIN;

APOPTOSIS; CELL PROLIFERATION; CELLS, CULTURED; HUMANS; MEMBRANE POTENTIAL, MITOCHONDRIAL; MITOGEN-ACTIVATED PROTEIN KINASE 1; MITOGEN-ACTIVATED PROTEIN KINASE 3; MUSCLE, SMOOTH, VASCULAR; MYOCYTES, SMOOTH MUSCLE; PHOSPHORYLATION; PROTEIN-SERINE-THREONINE KINASES; PULMONARY ARTERY; RECEPTOR, SEROTONIN, 5-HT1B; SEROTONIN; SEROTONIN 5-HT1 RECEPTOR AGONISTS; SEROTONIN 5-HT1 RECEPTOR ANTAGONISTS; SEROTONIN PLASMA MEMBRANE TRANSPORT PROTEINS; SIGNAL TRANSDUCTION;

EID: 84893653078     PISSN: 10548807     EISSN: 18791336     Source Type: Journal    
DOI: 10.1016/j.carpath.2013.03.003     Document Type: Article

References (36)

1. Goyal R, Papamatheakis DG, Loftin M, Vrancken K, Dawson AS, Osman NJ, et al. Long-term maternal hypoxia: the role of extracellular Ca2+ entry during serotonin-mediated contractility in fetal ovine pulmonary arteries[J]. Reprod Sci 2011;18:948-62.
2. McLaughlin VV, Davis M, Cornwell W. Pulmonary arterial hypertension[J]. Curr Probl Cardiol 2011;36:461-517.
3. Humbert M, Morrell NW, Archer SL, Stenmark KR, MacLean MR, Lang IM, et al. Cellular and molecular pathobiology of pulmonary arterial hypertension[J]. J Am Coll Cardiol 2004;43:13S-24S.
4. Yeager ME, Belchenko DD, Nguyen CM, Colvin KL, Ivy DD, Stenmark KR. Endothelin-1, the unfolded protein response, and persistent inflammation role of pulmonary artery smooth muscle cells[J]. Am J Respir Cell Mol Biol 2012;46:14-22.
5. Zhang S, Fantozzi I, Tigno DD, Yi ES, Platoshyn O, Thistlethwaite PA, et al. Bone morphogenetic proteins induce apoptosis in human pulmonary vascular smooth muscle cells[J]. Am J Physiol Lung Cell Mol Physiol 2003;285:L740-54.
6. Gurbanov E, Xiao S. The key role of apoptosis in the pathogenesis and treatment of pulmonary hypertension[J]. Eur J Cardiothorac Surg 2006;30:499-507.
7. Lambert CM, Roy M, Robitaille GA, Richard DE, Bonnet S. HIF-1 inhibition decreases systemic vascular remodelling diseases by promoting apoptosis through a hexokinase 2-dependent mechanism[J]. Cardiovasc Res 2010;88:196-204.
8. Xia S, Tai X, Wang Y, An X, Qian G, Dong J, et al. Involvement of gax gene in hypoxia-induced pulmonary hypertension, proliferation, and apoptosis of arterial smooth muscle cells[J]. Am J Respir Cell Mol Biol 2011;44:66-73.
9. Nakamura K, Akagi S, Ogawa A, Kusano KF, Matsubara H, Miura D, et al. Proapoptotic effects of imatinib on PDGF-stimulated pulmonary artery smooth muscle cells from patients with idiopathic pulmonary arterial hypertension[J]. Int J Cardiol 2011.
10. Long L, MacLean MR, Jeffery TK, Morecroft I, Yang X, Rudarakanchana N, et al. Serotonin increases susceptibility to pulmonary hypertension in BMPR2-deficient mice[J]. Circ Res 2006;98:818-27.
11. MacLean MR, Dempsie Y. Serotonin and pulmonary hypertension-from bench to bedside?[J]. Curr Opin Pharmacol 2009;9:281-6.
12. MacLean MR. Pulmonary hypertension and the serotonin hypothesis: where are we now?[J]. Int J Clin Pract 2007;61:27-31.
13. Han DD, Wang Y, Zhang XH, Liu JR, Wang HL. Fluoxetine protects against monocrotaline-induced pulmonary arterial remodeling by inhibition of hypoxiainducible factor-1alpha and vascular endothelial growth factor[J]. Can J Physiol Pharmacol 2012;90:445-54.
14. Wang Y, Han DD, Wang HM, Liu M, Zhang XH, Wang HL. Downregulation of osteopontin is associated with fluoxetine amelioration of monocrotaline-induced pulmonary inflammation and vascular remodelling[J]. Clin Exp Pharmacol Physiol 2011;38:365-72.
15. Morecroft I, Pang L, Baranowska M, Nilsen M, Loughlin L, Dempsie Y, et al. In vivo effects of a combined 5-HT (1B) receptor/SERT antagonist in experimental pulmonary hypertension[J]. Cardiovasc Res 2010;85:593-603.
16. Chung H-H, Dai Z-K, Wu B-N, Yeh J-L, Chai C-Y, Chu K-S, et al. KMUP-1 inhibits pulmonary artery proliferation by targeting serotonin receptors/transporter and NO synthase, inactivating RhoA and suppressing AKT/ERK phosphorylation[J]. Vascul Pharmacol 2010;53:239-49.
17. Li M, Liu Y, Dutt P, Fanburg BL, Toksoz D. Inhibition of serotonin-induced mitogenesis, migration, and ERK MAPK nuclear translocation in vascular smooth muscle cells by atorvastatin[J]. Am J Physiol Lung Cell Mol Physiol 2007;293:L463-71.
18. Soga F, Katoh N, Inoue T, Kishimoto S. Serotonin activates human monocytes and prevents apoptosis[J]. J Invest Dermatol 2007;127:1947-55.
19. Nebigil CG, Etienne N, Messaddeq N, Maroteaux L. Serotonin is a novel survival factor of cardiomyocytes: mitochondria as a target of 5-HT2B receptor signaling[J]. FASEB J 2003;17:1373-5.
20. Rasola A, Sciacovelli M, Chiara F, Pantic B, Brusilow WS, Bernardi P. Activation of mitochondrial ERK protects cancer cells from death through inhibition of the permeability transition[J]. Proc Natl Acad Sci U S A 2010;107:726-31.
21. Monick MM, Powers LS, Barrett CW, Hinde S, Ashare A, Groskreutz DJ, et al. Constitutive ERK MAPK activity regulates macrophage ATP production and mitochondrial integrity[J]. J Immunol 2008;180:7485-96.
22. Sarafian TA, Kouyoumjian S, Khoshaghideh F, Tashkin DP, Roth MD. Delta 9-Tetrahydrocannabinol disrupts mitochondrial function and cell energetics[J]. Am J Physiol Lung Cell Mol Physiol 2003;284:L298-306.
23. Sanchez-Alcazar JA, Khodjakov A, Schneider E. Anticancer drugs induce increased mitochondrial cytochrome c expression that precedes cell death[J]. Cancer Res 2001;61:1038-44.
24. Dromparis P, Sutendra G, Michelakis ED. The role of mitochondria in pulmonary vascular remodeling[J]. J Mol Med (Berl) 2010;88:1003-10.
25. Nebigil CG, Jaffre F, Messaddeq N, Hickel P, Monassier L, Launay JM, et al. Overexpression of the serotonin 5-HT2B receptor in heart leads to abnormal mitochondrial function and cardiac hypertrophy[J]. Circulation 2003;107:3223-9.
26. Rajesh KG, Suzuki R, Maeda H, Murio Y, Sasaguri S. 5-HT2 receptor blocker sarpogrelate prevents downregulation of antiapoptotic protein Bcl-2 and protects the heart against ischemia-reperfusion injury[J]. Life Sci 2006;79:1749-55.
27. Bai CF, Liu JC, Zhao R, Cao W, Liu SB, Zhang XN, et al. Role of 5-HT 2B receptors in cardiomyocyte apoptosis in noradrenaline-induced cardiomyopathy in rats[J]. Clin Exp Pharmacol Physiol 2010;37:e145-51.
28. Leone AM, Errico M, Lin SL, Cowen DS, Lione AM. Activation of extracellular signalregulated kinase (ERK) and Akt by human serotonin 5-HT (1B) receptors in transfected BE (2)-C neuroblastoma cells is inhibited by RGS4[J]. J Neurochem 2000;75:934-8.
29. Fumagalli F, Molteni R, Calabrese F, Frasca A, Racagni G, Riva MA. Chronic fluoxetine administration inhibits extracellular signal-regulated kinase 1/2 phosphorylation in rat brain[J]. J Neurochem 2005;93:1551-60.
30. Cloez-Tayarani I, Kayyali US, Fanburg BL, Cavaillon JM. 5-HT activates ERK MAP kinase in cultured-human peripheral blood mononuclear cells via 5-HT1A receptors[J]. Life Sci 2004;76:429-43.
31. Lawrie A, Spiekerkoetter E, Martinez EC, Ambartsumian N, Sheward WJ, MacLean MR, et al. Interdependent serotonin transporter and receptor pathways regulate S100A4/Mts1, a gene associated with pulmonary vascular disease[J]. Circ Res 2005;97:227-35.
32. McMurtry MS, Bonnet S, Wu X, Dyck JR, Haromy A, Hashimoto K, et al. Dichloroacetate prevents and reverses pulmonary hypertension by inducing pulmonary artery smooth muscle cell apoptosis[J]. Circ Res 2004;95:830-40.
33. He K, Aizenman E. ERK signaling leads to mitochondrial dysfunction in extracellular zinc-induced neurotoxicity[J]. J Neurochem 2010;114:452-61.
34. Gupta SC, Reuter S, Phromnoi K, Park B, Hema PS, Nair M, et al. Nimbolide sensitizes human colon cancer cells to TRAIL through reactive oxygen species- and ERK-dependent up-regulation of death receptors, p53, and Bax[J]. J Biol Chem 2011;286:1134-46.
35. Subramanian M, Shaha C. Up-regulation of bcl-2 through ERK phosphorylation is associated with human macrophage survival in an estrogen microenvironment[J]. J Immunol 2007;179:2330-8.
36. Ostrakhovitch EA, Cherian MG. Inhibition of extracellular signal regulated kinase (ERK) leads to apoptosis inducing factor (AIF) mediated apoptosis in epithelial breast cancer cells: The lack of effect of ERK in p53 mediated copper induced apoptosis[J]. J Cell Biochem 2005;95:1120-34.