Role of 5-HT2B receptors in cardiomyocyte apoptosis in noradrenaline-induced cardiomyopathy in rats

Clinical and Experimental Pharmacology and Physiology

Volumn 37, Issue 7, 2010, Pages

  Bai, Chong Feng ^a   Liu, Jin Cheng ^a   Zhao, Rong ^a   Cao, Wei ^b   Liu, Shui Bin ^b   Zhang, Xiao Nan ^b   Guo, Hong Ju ^b   Yang, Qi ^b   Yi, Ding Hua ^a   Zhao, Ming Gao ^a,b  

^a FOURTH MILITARY MEDICAL UNIVERSITY   (China)

^b FOURTH MILITARY MEDICAL UNIVERSITY   (China)

Author keywords

apoptosis; cardiac hypertrophy; myocardium; noradrenaline; serotonin

Indexed keywords

1 (1 METHYL 5 INDOLYL) 3 (3 METHYL 5 ISOTHIAZOLYL)UREA; 4,5,7A,8,9,10,11,11A OCTAHYDRO 10 METHYL 7H INDOLO[1,7 BC][2,6]NAPHTHYRIDINE; CASPASE 3; NORADRENALIN; PROTEIN BAX; PROTEIN BCL 2; SEROTONIN; SEROTONIN 2 ANTAGONIST; SEROTONIN 2B RECEPTOR; UNCLASSIFIED DRUG; 4,5,7A,8,9,10,11,11A-OCTOHYDRO-7H-10-METHYLINDOLOL(1,7BC)(2,6)-NAPTHYRIDINE; CALCIUM CHANNEL L TYPE; INDOLE DERIVATIVE; N-(1-METHYL-5-INDOLYL)-N'-(3-METHYL-5-ISOTHIAZOLYL)UREA; NAPHTHYRIDINE DERIVATIVE; UREA;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; APOPTOSIS; ARTICLE; CALCIUM CURRENT; CELL PROTECTION; CONTROLLED STUDY; HEART PROTECTION; HEART VENTRICLE HYPERTROPHY; HEART VENTRICLE REMODELING; NICK END LABELING; NONHUMAN; PATCH CLAMP; PROTEIN INDUCTION; RAT; ANALOGS AND DERIVATIVES; ANIMAL; CARDIOMEGALY; CARDIOMYOPATHY; DOWN REGULATION; DRUG EFFECTS; HEART MUSCLE CELL; METABOLISM; PATHOLOGY; PHYSIOLOGY; SPRAGUE DAWLEY RAT; UPREGULATION;

ANIMALS; APOPTOSIS; BCL-2-ASSOCIATED X PROTEIN; CALCIUM CHANNELS, L-TYPE; CARDIOMEGALY; CARDIOMYOPATHIES; CASPASE 3; DOWN-REGULATION; INDOLES; MYOCYTES, CARDIAC; NAPHTHYRIDINES; NOREPINEPHRINE; PROTO-ONCOGENE PROTEINS C-BCL-2; RATS; RATS, SPRAGUE-DAWLEY; RECEPTOR, SEROTONIN, 5-HT2B; SEROTONIN; UP-REGULATION; UREA; SEROTONIN 5-HT2 RECEPTOR ANTAGONISTS;

EID: 77953855506     PISSN: 03051870     EISSN: 14401681     Source Type: Journal    
DOI: 10.1111/j.1440-1681.2010.05388.x     Document Type: Article

References (34)

1. Zhao MG, Mei QB, Zhang YF, Xing B, Li XQ, Cui Y. Inhibitory effects of serotonin on transient outward potassium current in rat ventricular myocytes. Acta Pharmacol. Sin. 2002 23: 617 622.
2. Zhao MG, Mei QB, Zhang YF et al. 5-Hydroxytryptamine enhances L-type calcium current in norepinephrine-induced hypertrophic ventricular myocytes. Acta Pharmacol. Sin. 2002 23: 523 528.
3. 2B receptor signaling in heart: Role of mitochondria in transition between hypertrophy and heart failure? Circulation 2003 108: 902 908.
4. 2 receptor blocker sarpogrelate prevents downregulation of antiapoptotic protein Bcl-2 and protects the heart against ischemia-reperfusion injury. Life Sci. 2006 79: 1749 1755.
5. 1A receptor antagonist pyrapyridolol against postischemic guinea-pig myocardial dysfunction and apoptosis through the mitochondrial permeability transition pore. Eur. J. Pharmacol. 2006 534: 165 177.
6. Mialet-Perez J, Bianchi P, Kunduzova O, Parini A. New insights on receptor-dependent and monoamine oxidase-dependent effects of serotonin in the heart. J. Neural Transm. 2007 114: 823 827.
7. 2B receptor in heart leads to abnormal mitochondrial function and cardiac hypertrophy. Circulation 2003 107: 3223 3229.
8. Monassier L, Laplante MA, Jaffre F, Bousquet P, Maroteaux L, de Champlain J. Serotonin 5-HT(2B) receptor blockade prevents reactive oxygen species-induced cardiac hypertrophy in mice. Hypertension 2008 52: 301 307.
9. Villeneuve C, Caudrillier A, Ordener C, Pizzinat N, Parini A, Mialet-Perez J. Dose-dependent activation of distinct hypertrophic pathways by serotonin in cardiac cells. Am. J. Physiol. Heart Circ. Physiol. 2009 297: H821 8.
10. 4 receptors is differentially regulated in hypertrophic and failing rat cardiac ventricle. J. Mol. Cell. Cardiol. 2007 43: 767 779.
11. Bianchi P, Pimentel DR, Murphy MP, Colucci WS, Parini A. A new hypertrophic mechanism of serotonin in cardiac myocytes: Receptor-independent ROS generation. FASEB J. 2005 19: 641 643.
12. Bianchi P, Kunduzova O, Masini E et al. Oxidative stress by monoamine oxidase mediates receptor-independent cardiomyocyte apoptosis by serotonin and postischemic myocardial injury. Circulation 2005 112: 3297 3305.
13. Jaffre F, Bonnin P, Callebert J et al. Serotonin and angiotensin receptors in cardiac fibroblasts coregulate adrenergic-dependent cardiac hypertrophy. Circ. Res. 2009 104: 113 123.
14. Anselmi A, Gaudino M, Baldi A et al. Role of apoptosis in pressure-overload cardiomyopathy. J. Cardiovasc. Med. 2008 9: 227 232.
15. Diwan A, Wansapura J, Syed FM, Matkovich SJ, Lorenz JN, Dorn II. GW. Nix-mediated apoptosis links myocardial fibrosis, cardiac remodeling, and hypertrophy decompensation. Circulation 2008 117: 396 404.
16. Nebigil CG, Etienne N, Messaddeq N, Maroteaux L. Serotonin is a novel survival factor of cardiomyocytes. Mitochondria as a target of 5-HT2B receptor signaling. FASEB J. 2003 17: 1373 1375.
17. Fu YC, Chi CS, Yin SC, Hwang B, Chiu YT, Hsu SL. Norepinephrine induces apoptosis in neonatal rat cardiomyocytes through a reactive oxygen species-TNF alpha-caspase signaling pathway. Cardiovasc. Res. 2004 62: 558 567.
18. Sorescu D, Griendling KK. Reactive oxygen species, mitochondria, and NAD(P)H oxidases in the development and progression of heart failure. Congest. Heart Fail. 2002 8: 132 140.
19. Kuster GM, Pimentel DR, Adachi T et al. Alpha-adrenergic receptor-stimulated hypertrophy in adult rat ventricular myocytes is mediated via thioredoxin-1-sensitive oxidative modification of thiols on Ras. Circulation 2005 111: 1192 1198.
20. Briest W, Holzl A, Rassler B et al. Cardiac remodeling after long term norepinephrine treatment in rats. Cardiovasc. Res. 2001 52: 265 273.
21. Schafer M, Ponicke K, Heinroth-Hoffmann I, Brodde OE, Piper HM, Schluter KD. Beta-adrenoceptor stimulation attenuates the hypertrophic effect of alpha-adrenoceptor stimulation in adult rat ventricular cardiomyocytes. J. Am. Coll. Cardiol. 2001 37: 300 307.
22. Cote F, Thevenot E, Fligny C et al. Disruption of the nonneuronal tph1 gene demonstrates the importance of peripheral serotonin in cardiac function. Proc. Natl Acad. Sci. USA 2003 100: 13525 13530.
23. Callebert J, Esteve JM, Herve P et al. Evidence for a control of plasma serotonin levels by 5-hydroxytryptamine (2B) receptors in mice. J. Pharmacol. Exp. Ther. 2006 317: 724 731.
24. Louhelainen M, Vahtola E, Kaheinen P et al. Effects of levosimendan on cardiac remodeling and cardiomyocyte apoptosis in hypertensive Dahl/Rapp rats. Br. J. Pharmacol. 2007 150: 851 861.
25. Gupta MK, Neelakantan TV, Sanghamitra M et al. An assessment of the role of reactive oxygen species and redox signaling in norepinephrine-induced apoptosis and hypertrophy of H9c2 cardiac myoblasts. Antioxid. Redox Signal. 2006 8: 1081 1093.
26. Haudek SB, Taffet GE, Schneider MD, Mann DL. TNF provokes cardiomyocyte apoptosis and cardiac remodeling through activation of multiple cell death pathways. J. Clin. Invest. 2007 117: 2692 2701.
27. Sun M, Chen M, Dawood F et al. Tumor necrosis factor-alpha mediates cardiac remodeling and ventricular dysfunction after pressure overload state. Circulation 2007 115: 1398 1407.
28. Brown L, Sernia C, Newling R, Fletcher P. Cardiac responses after norepinephrine-induced ventricular hypertrophy in rats. J. Cardiovasc. Pharmacol. 1992 20: 316 323.
29. 2+ signal integrators. Ann. NY Acad. Sci. 2008 1123: 64 8.
30. Pignier C, Levan-Petit I, Ancey C, Potreau D. Alpha-adrenoceptor stimulation induces hypertrophy and increases L-type calcium current density in neonatal rat ventricular cardiomyocytes in culture. Receptors Channels 2000 7: 173 187.
31. 2+/calmodulin-dependent protein kinase II in cardiac hypertrophy and heart failure. Cardiovasc. Res. 2004 63: 476 486.
32. Gustafsson AB, Gottlieb RA. Heart mitochondria: Gates of life and death. Cardiovasc. Res. 2008 77: 334 343.
33. 2-terminal kinase-dependent activation of the mitochondrial pathway. Circ. Res. 2003 92: 136 138.
34. 2B receptor in cardiac hypertrophy linked to sympathetic stimulation: Control of interleukin-6, interleukin-1beta, and tumor necrosis factor-alpha cytokine production by ventricular fibroblasts. Circulation 2004 110: 969 974.