The potential role of epigenetic modifications in the heritability of multiple sclerosis

Multiple Sclerosis

Volumn 20, Issue 2, 2014, Pages 135-140

  Zhou, Yuan ^a   Simpson Jr , Steve ^a   Holloway, Adele F ^a   Charlesworth, Jac ^a   Van Der Mei, Ingrid ^a   Taylor, Bruce V ^a  

^a UNIVERSITY OF TASMANIA   (Australia)

Author keywords

DNA methylation; epigenetics; histone modification; microRNA; Multiple sclerosis

Indexed keywords

MICRORNA;

DEMYELINATION; DNA METHYLATION; EPIGENETICS; EPSTEIN BARR VIRUS INFECTION; GENE SILENCING; GENETIC VARIABILITY; HERITABILITY; HISTONE MODIFICATION; INFLAMMATION; MULTIPLE SCLEROSIS; NERVE DEGENERATION; PATHOGENESIS; POSTTRANSCRIPTIONAL GENE SILENCING; REMYELINIZATION; REVIEW; RISK FACTOR; SMOKING; VITAMIN D DEFICIENCY; 3' UNTRANSLATED REGION; CPG ISLAND; DNA MODIFICATION; ENVIRONMENTAL FACTOR; GENETIC ASSOCIATION; HUMAN; MOLECULAR PATHOLOGY; NONHUMAN;

DNA METHYLATION; EPIGENETICS; HISTONE MODIFICATION; MICRORNA; MULTIPLE SCLEROSIS;

EPIGENESIS, GENETIC; GENETIC PREDISPOSITION TO DISEASE; HUMANS; MULTIPLE SCLEROSIS;

EID: 84893591439     PISSN: 13524585     EISSN: 14770970     Source Type: Journal    
DOI: 10.1177/1352458514520911     Document Type: Review

References (47)

1. Lassmann H, Brück W, Lucchinetti CF. The immunopathology of multiple sclerosis: An overview. Brain Pathol. 2007 ; 17: 210-218
2. Compston A, Coles A. Multiple sclerosis. Lancet. 2008 ; 372: 1502-1517
3. Malpass K. Multiple sclerosis: 'Outside-in' demyelination in MS. Nat Rev Neurol. 2012 ; 8: 61
4. Lucchinetti CF, Popescu BF, Bunyan RF, et al. Inflammatory cortical demyelination in early multiple sclerosis. N Engl J Med. 2011 ; 365: 2188-2197
5. Trapp BD, Peterson J, Ransohoff RM, et al. Axonal transection in the lesions of multiple sclerosis. N Engl J Med. 1998 ; 338: 278-285
6. Bjartmar C, Trapp BD. Axonal and neuronal degeneration in multiple sclerosis: Mechanisms and functional consequences. Curr Opin Neurol. 2001 ; 14: 271-278
7. Lincoln JA, Cook SD. An overview of gene-epigenetic-environmental contributions to MS causation. J Neurol Sci. 2009 ; 286: 54-57
8. Lin R, Charlesworth J, Stankovich J, et al. Identity-by-descent mapping to detect rare variants conferring susceptibility to multiple sclerosis. PLoS One. 2013 ; 8: e56379
9. Jaenisch R, Bird A. Epigenetic regulation of gene expression: How the genome integrates intrinsic and environmental signals. Nat Genet. 2003 ; 33: 245-254
10. Bird A. DNA methylation patterns and epigenetic memory. Genes Dev. 2002 ; 16: 6-21
11. Dieker J, Muller S. Epigenetic histone code and autoimmunity. Clin Rev Allergy Immunol. 2010 ; 39: 78-84
12. Baek D, Villen J, Shin C, et al. The impact of microRNAs on protein output. Nature. 2008 ; 455: 64-71
13. Kumagai C, Kalman B, Middleton FA, et al. Increased promoter methylation of the immune regulatory gene SHP-1 in leukocytes of multiple sclerosis subjects. J Neuroimmunol. 2012 ; 246: 51-57
14. Janson PC, Linton LB, Bergman EA, et al. Profiling of CD4+ T cells with epigenetic immune lineage analysis. J Immunol. 2011 ; 186: 92-102
15. Jadidi-Niaragh F, Mirshafiey A. Th17 cell, the new player of neuroinflammatory process in multiple sclerosis. Scand J Immunol. 2011 ; 74: 1-13
16. Lindberg RL, Hoffmann F, Mehling M, et al. Altered expression of miR-17-5p in CD4+ lymphocytes of relapsing-remitting multiple sclerosis patients. Eur J Immunol. 2010 ; 40: 888-898
17. Guerau-de-Arellano M, Smith KM, Godlewski J, et al. Micro-RNA dysregulation in multiple sclerosis favours pro-inflammatory T-cell-mediated autoimmunity. Brain. 2011 ; 134: 3578-3589
18. De Santis G, Ferracin M, Biondani A, et al. Altered miRNA expression in T regulatory cells in course of multiple sclerosis. J Neuroimmunol. 2010 ; 226: 165-171
19. Du C, Liu C, Kang J, et al. MicroRNA miR-326 regulates TH-17 differentiation and is associated with the pathogenesis of multiple sclerosis. Nat Immunol. 2009 ; 10: 1252-1259
20. Brück W. The pathology of multiple sclerosis is the result of focal inflammatory demyelination with axonal damage. J Neurol. 2005 ; 252: v3 - v9
21. Mastronardi FG, Noor A, Wood DD, et al. Peptidyl argininedeiminase 2 CpG island in multiple sclerosis white matter is hypomethylated. J Neurosci Res. 2007 ; 85: 2006-2016
22. Kim JK, Mastronardi FG, Wood DD, et al. Multiple sclerosis: An important role for post-translational modifications of myelin basic protein in pathogenesis. Mol Cell Proteomics. 2003 ; 2: 453-462
23. Mastronardi FG, Wood DD, Mei J, et al. Increased citrullination of histone H3 in multiple sclerosis brain and animal models of demyelination: A role for tumor necrosis factor-induced peptidylarginine deiminase 4 translocation. J Neurosci. 2006 ; 26: 11387-11396
24. Pedre X, Mastronardi F, Brück W, et al. Changed histone acetylation patterns in normal-appearing white matter and early multiple sclerosis lesions. J Neurosci. 2011 ; 31: 3435-3445
25. Junker A, Krumbholz M, Eisele S, et al. MicroRNA profiling of multiple sclerosis lesions identifies modulators of the regulatory protein CD47. Brain. 2009 ; 132: 3342-3352
26. Shin D, Shin JY, McManus MT, et al. Dicer ablation in oligodendrocytes provokes neuronal impairment in mice. Ann Neurol. 2009 ; 66: 843-857
27. Dugas JC, Cuellar TL, Scholze A, et al. Dicer1 and miR-219 are required for normal oligodendrocyte differentiation and myelination. Neuron. 2010 ; 65: 597-611
28. Zhao X, He X, Han X, et al. MicroRNA-mediated control of oligodendrocyte differentiation. Neuron. 2010 ; 65: 612-626
29. Noorbakhsh F, Ellestad KK, Maingat F, et al. Impaired neurosteroid synthesis in multiple sclerosis. Brain. 2011 ; 134: 2703-2721
30. Chestnut BA, Chang Q, Price A, et al. Epigenetic regulation of motor neuron cell death through DNA methylation. J Neurosci. 2011 ; 31: 16619-16636
31. Delecluse HJ, Feederle R, O'Sullivan B, et al. Epstein Barr virus-associated tumours: An update for the attention of the working pathologist. J Clin Pathol. 2007 ; 60: 1358-1364
32. Riley KJ, Rabinowitz GS, Yario TA, et al. EBV and human microRNAs co-target oncogenic and apoptotic viral and human genes during latency. Embo J. 2012 ; 31: 2207-2221
33. Waschbisch A, Atiya M, Linker RA, et al. Glatiramer acetate treatment normalizes deregulated microRNA expression in relapsing remitting multiple sclerosis. PLoS One. 2011 ; 6: e24604
34. Murugaiyan G, Beynon V, Mittal A, et al. Silencing microRNA-155 ameliorates experimental autoimmune encephalomyelitis. J Immunol. 2011 ; 187: 2213-2221
35. Kwong J, Lo KW, To KF, et al. Promoter hypermethylation of multiple genes in nasopharyngeal carcinoma. Clin Cancer Res. 2002 ; 8: 131-137
36. Ascherio A, Munger KL, Lunemann JD. The initiation and prevention of multiple sclerosis. Nat Rev Neurol. 2012 ; 8: 602-612
37. Smolders J, Peelen E, Thewissen M, et al. Safety and T cell modulating effects of high dose vitamin D3 supplementation in multiple sclerosis. PLoS One. 2010 ; 5: e15235
38. Joshi S, Pantalena LC, Liu XK, et al. 1,25-dihydroxyvitamin D(3) ameliorates Th17 autoimmunity via transcriptional modulation of interleukin-17A. Mol Cell Biol. 2011 ; 31: 3653-3669
39. Costenbader KH, Karlson EW. Cigarette smoking and autoimmune disease: What can we learn from epidemiology?. Lupus. 2006 ; 15: 737-745
40. Toledo-Rodriguez M, Lotfipour S, Leonard G, et al. Maternal smoking during pregnancy is associated with epigenetic modifications of the brain-derived neurotrophic factor-6 exon in adolescent offspring. Am J Med Genet B Neuropsychiatr Genet. 2010 ; 153B: 1350-1354
41. Maccani MA, Avissar-Whiting M, Banister CE, et al. Maternal cigarette smoking during pregnancy is associated with downregulation of miR-16, miR-21, and miR-146a in the placenta. Epigenetics. 2010 ; 5: 583-589
42. Simon KC, van der Mei IA, Munger KL, et al. Combined effects of smoking, anti-EBNA antibodies, and HLA-DRB1*1501 on multiple sclerosis risk. Neurology. 2010 ; 74: 1365-1371
43. Sundqvist E, Sundström P, Lindén M, et al. Epstein-Barr virus and multiple sclerosis: Interaction with HLA. Genes Immun. 2012 ; 13: 14-20
44. Fan DN, Tsang FH, Tam AH, et al. Histone lysine methyltransferase, suppressor of variegation 3-9 homolog 1, promotes hepatocellular carcinoma progression and is negatively regulated by microRNA-125b. Hepatology. 2013 ; 57: 637-647
45. Zhao S, Wang Y, Liang Y, et al. MicroRNA-126 regulates DNA methylation in CD4+ T cells and contributes to systemic lupus erythematosus by targeting DNA methyltransferase 1. Arthritis Rheum. 2011 ; 63: 1376-1386
46. Huang J, Wang Y, Guo Y, et al. Down-regulated microRNA-152 induces aberrant DNA methylation in hepatitis B virus-related hepatocellular carcinoma by targeting DNA methyltransferase 1. Hepatology. 2010 ; 52: 60-70
47. Scott GK, Mattie MD, Berger CE, et al. Rapid alteration of microRNA levels by histone deacetylase inhibition. Cancer Res. 2006 ; 66: 1277-1281