Combined effects of smoking, anti-EBNA antibodies, and HLA-DRB1*1501 on multiple sclerosis risk

Neurology

Volumn 74, Issue 17, 2010, Pages 1365-1371

  Simon, K C ^a   Van Der Mei, I A F ^b   Munger, K L ^a   Ponsonby, A ^b   Dickinson, J ^b   Dwyer, T ^b   Sundstrom P ^c   Ascherio, A ^a,d  

^a HARVARD SCHOOL OF PUBLIC HEALTH   (United States)

^b UNIVERSITY OF TASMANIA   (Australia)

^c UMEÅ UNIVERSITY   (Sweden)

^d BRIGHAM AND WOMEN S HOSPITAL   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ANTIBODY; EPSTEIN BARR VIRUS ANTIBODY; EPSTEIN BARR VIRUS ANTIGEN; HLA DR ANTIGEN; UNCLASSIFIED DRUG;

ANTIBODY TITER; ARTICLE; CD4+ T LYMPHOCYTE; CONTROLLED STUDY; EPSTEIN BARR VIRUS; ETHNICITY; HUMAN; MAJOR CLINICAL STUDY; MULTIPLE SCLEROSIS; PRIORITY JOURNAL; RISK; SMOKING; STATISTICAL ANALYSIS;

EID: 77951728213     PISSN: 00283878     EISSN: 1526632X     Source Type: Journal    
DOI: 10.1212/WNL.0b013e3181dad57e     Document Type: Article

References (35)

1. Hirtz D, Thurman DJ, Gwinn-Hardy K, et al. How common are the "common" neurologic disorders? Neurology 2007;68:326-337. (Pubitemid 46188246)
2. Compston A. Genetic susceptibility to multiple sclerosis. In: Compston A, ed. McAlpine's Multiple Sclerosis. 3rd Edition. New York: Churchill Livingstone; 1998:101-142.
3. Ascherio A, Munger KL. Environmental risk factors for multiple sclerosis: part I: the role of infection. Ann Neurol 2007;61:288-299. (Pubitemid 46676728)
4. Ascherio A, Munger KL. Environmental risk factors for multiple sclerosis: part II: noninfectious factors. Ann Neu-rol 2007;61:504-513. (Pubitemid 47068132)
5. De Jager PL, Simon KC, Munger KL, et al. Integrating risk factors: HLA-DRB1*1501 and Epstein-Barr virus in multiple sclerosis. Neurology 2008;70:1113-1118. (Pubitemid 351464768)
6. Sundstrom P, Nystrom L, Jidell E, Hallmans G. EBNA-1 reactivity and HLA DRB1*1501 as statistically independent risk factors for multiple sclerosis: a case-control study. Mult Scler 2008;14:1120-1122.
7. Ascherio A, Zhang SM, Hernan MA, et al. Hepatitis B vaccination and the risk of multiple sclerosis. N Engl J Med 2001;344:327-332. (Pubitemid 32107640)
8. van der Mei IAF, Ponsonby AL, Dwyer T, et al. Past exposure to sun, skin phenotype and risk of multiple sclerosis: a case-control study. BMJ 2003;327:316-321. (Pubitemid 36966618)
9. Ponsonby AL, van der Mei I, Dwyer T, et al. Exposure to infant siblings during early life and risk of multiple sclerosis. JAMA 2005;293:463-469.
10. Sundstrom P, Juto P, Wadell G, et al. An altered immune response to Epstein-Barr virus in multiple sclerosis: a prospective study. Neurology 2004;62:2277-2282. (Pubitemid 38787787)
11. Sundstrom P, Nystrom L, Hallmans G. Smoke exposure increases the risk for multiple sclerosis. Eur J Neurol 2008; 15:579-583. (Pubitemid 351677503)
12. Ascherio A, Munger KL, Lennette ET, et al. Epstein-Barr virus antibodies and risk of multiple sclerosis: a prospective study. JAMA 2001;286:3083-3088. (Pubitemid 34016522)
13. Lennette ET, Rymo L, Yadav M, et al. Disease-related differences in antibody patterns against EBV-encoded nuclear antigens EBNA 1, EBNA 2 and EBNA 6. Eur J Cancer 1993;29A:1584-1589. (Pubitemid 23251802)
14. DerSimonian R, Laird N. Meta-analysis in clinical trials. Control Clin Trials 1986;7:177-188. (Pubitemid 17189972)
15. Glaser SL, Keegan TH, Clarke CA, et al. Smoking and Hodgkin lymphoma risk in women United States. Cancer Causes Control 2004;15:387-397.
16. Hjalgrim H, Ekstrom-Smedby K, Rostgaard K, et al. Cigarette smoking and risk of Hodgkin lymphoma: a population-based case-control study. Cancer Epidemiol Biomarkers Prev 2007;16:1561-1566. (Pubitemid 47294819)
17. Chang ET, Zheng T, Lennette ET, et al. Heterogeneity of risk factors and antibody profiles in Epstein-Barr virus genome-positive and-negative Hodgkin lymphoma. J Infect Dis 2004;189:2271-2281. (Pubitemid 38757200)
18. Hawkes CH. Smoking is a risk factor for multiple sclerosis: a metaanalysis. Mult Scler 2007;13:610-615. (Pubitemid 46939526)
19. Hoshino S, Yoshida M, Inoue K, et al. Cigarette smoke extract induces endothelial cell injury via JNK pathway. Biochem Biophys Res Commun 2005;329:58-63. (Pubitemid 40255420)
20. Eliopoulos AG, Young LS. Activation of the cJun N-terminal kinase (JNK) pathway by the Epstein-Barr virus-encoded latent membrane protein 1 (LMP1). Oncogene 1998;16:1731-1742.
21. Kieser A, Kilger E, Gires O, et al. Epstein-Barr virus latent membrane protein-1 triggers AP-1 activity via the c-Jun N-terminal kinase cascade. Embo J 1997;16:6478-6485. (Pubitemid 27483273)
22. Heusch WL, Maneckjee R. Signalling pathways involved in nicotine regulation of apoptosis of human lung cancer cells. Carcinogenesis 1998;19:551-556. (Pubitemid 28376796)
23. Satoh T, Hoshikawa Y, Satoh Y, et al. The interaction of mitogen-activated protein kinases to Epstein-Barr virus activation in Akata cells. Virus Genes 1999;18:57-64. (Pubitemid 29137491)
24. Roberts ML, Cooper NR. Activation of a ras-MAPK-dependent pathway by Epstein-Barr virus latent membrane protein 1 is essential for cellular transformation. Virology 1998;240:93-99. (Pubitemid 28394127)
25. Shen Y, Rattan V, Sultana C, Kalra VK. Cigarette smoke condensate-induced adhesion molecule expression and transendothelial migration of monocytes. Am J Physiol 1996;270:H1624-H1633. (Pubitemid 26177044)
26. Baumann M, Mischak H, Dammeier S, et al. Activation of the Epstein-Barr virus transcription factor BZLF1 by 12-O-tetradecanoylphorbol-13-acetate-induced phosphorylation. J Virol 1998;72:8105-8114. (Pubitemid 28421805)
27. Zhang S, Day IN, Ye S. Microarray analysis of nicotine-induced changes in gene expression in endothelial cells. Physiol Genomics 2001;5:187-192. (Pubitemid 33675216)
28. Adamson AL, Kenney S. The Epstein-Barr virus BZLF1 protein interacts physically and functionally with the his-tone acetylase CREB-binding protein. J Virol 1999;73: 6551-6558. (Pubitemid 29327836)
29. Jacobsen M, Cepok S, Quak E, et al. Oligoclonal expansion of memory CD8+ T cells in cerebrospinal fluid from multiple sclerosis patients. Brain 2002;125:538-550. (Pubitemid 34194409)
30. Cepok S, Zhou D, Srivastava R, et al. Identification of Epstein-Barr virus proteins as putative targets of the immune response in multiple sclerosis. J Clin Invest 2005; 115:1352-1360. (Pubitemid 40629055)
31. Jilek S, Schluep M, Rossetti AO, et al. CSF enrichment of highly differentiated CD8+ T cells in early multiple sclerosis. Clin Immunol 2007;123:105-113. (Pubitemid 46401506)
32. Jilek S, Schluep M, Meylan P, et al. Strong EBV-specific CD8+ T-cell response in patients with early multiple sclerosis. Brain 2008;131:1712-1721. (Pubitemid 351957461)
33. RickinsonAB, Kieff E. Epstein-Barr Virus. In: Knipe DM, Howley PM, Griffin DE, et al., eds. Fields Virology. Vol.2. 5th ed. Philadelphia: Wolters Kluwer Health/Lippincott Williams & Wilkins; 2007:2655-2700.
34. Arcavi L, Benowitz NL. Cigarette smoking and infection. Arch Intern Med 2004;164:2206-2216. (Pubitemid 39452980)
35. Henle W, Henle G, Andersson J, et al. Antibody responses to Epstein-Barr virus-determined nuclear antigen (EBNA)-1 and EBNA-2 in acute and chronic Epstein-Barr virus infection. Proc Natl Acad Sci USA 1987;84:570-574. (Pubitemid 17006237)