Effects of furanodiene on 95-d lung cancer cells: Apoptosis, autophagy and g1 phase cell cycle arrest

American Journal of Chinese Medicine

Volumn 42, Issue 1, 2014, Pages 243-255

  Xu, Wen Shan ^a   Li, Ting ^a   Wu, Guo Sheng ^a   Dang, Yuan Ye ^a   Hao, Wen Hui ^a   Chen, Xiu Ping ^a   Lu, Jin Jian ^a   Wang, Yi Tao ^a  

^a University of Macau   (Macao)

Author keywords

Apoptosis; Autophagy; Cell Cycle; Furanodiene; Metastasis

Indexed keywords

ANTINEOPLASTIC AGENT; CASPASE 7; CYCLIN D1; CYCLIN DEPENDENT KINASE 6; FURANODIENE; MATRIGEL; P21 ACTIVATED KINASE; PROTEIN BCL 2; PROTEIN P27; SURVIVIN; TERPENOID; UNCLASSIFIED DRUG;

ANALYTIC METHOD; ANTIPROLIFERATIVE ACTIVITY; APOPTOSIS; ARTICLE; AUTOPHAGY; CANCER CELL CULTURE; CELL ADHESION; CELL CYCLE; CELL CYCLE ASSAY; CELL CYCLE PROGRESSION; CELL INFILTRATION; CELL MIGRATION; CELL PROLIFERATION; CELL STRUCTURE; CELL VIABILITY; CHINESE MEDICINE; DOWN REGULATION; DRUG EFFECT; DRUG MECHANISM; G1 PHASE CELL CYCLE CHECKPOINT; HERBAL MEDICINE; HUMAN; HUMAN CELL; LIGHT CHAIN; LUNG CANCER; LUNG CANCER CELL; MTT ASSAY; NONHUMAN; PROTEIN CLEAVAGE; RHIZOMA CURCUMAE; TRANSWELL ANALYSIS; UPREGULATION; WESTERN BLOTTING; WOUND HEALING;

ANTINEOPLASTIC AGENTS, PHYTOGENIC; APOPTOSIS; AUTOPHAGY; CASPASE 7; CURCUMA; DOSE-RESPONSE RELATIONSHIP, DRUG; FURANS; G1 PHASE CELL CYCLE CHECKPOINTS; HETEROCYCLIC COMPOUNDS, 2-RING; HUMANS; INHIBITOR OF APOPTOSIS PROTEINS; LUNG NEOPLASMS; NEOPLASM METASTASIS; POLY(ADP-RIBOSE) POLYMERASES; PROTO-ONCOGENE PROTEINS C-BCL-2; RHIZOME; TUMOR CELLS, CULTURED;

EID: 84893444719     PISSN: 0192415X     EISSN: None     Source Type: Journal    
DOI: 10.1142/S0192415X14500165     Document Type: Article

References (40)

1. Alt, J.R., A.B. Gladden and J.A. Diehl. p21(Cip1) Promotes cyclin D1 nuclear accumulation via direct inhibition of nuclear export. J. Biol. Chem. 277: 8517-8523, 2002.
2. Boulares, A.H., A.G. Yakovlev, V. Ivanova, B.A. Stoica, G. Wang, S. Iyer and M. Smulson. Role of poly(ADP-ribose) polymerase (PARP) cleavage in apoptosis. Caspase 3-resistant PARP mutant increases rates of apoptosis in transfected cells. J. Biol. Chem. 274: 22932-22940, 1999.
3. Chaffer, C.L. and R.A. Weinberg. A perspective on cancer cell metastasis. Science 331: 1559-1564, 2011.
4. Chen, N. and V. Karantza-Wadsworth. Role and regulation of autophagy in cancer. Biochim. Biophys. Acta 1793: 1516-1523, 2009.
5. Colitti, M. BCL-2 family of proteins and mammary cellular fate. Anat. Histol. Embryol. 41: 237-247, 2012.
6. Corcelle, E.A., P. Puustinen and M. Jaattela. Apoptosis and autophagy: targeting autophagy signalling in cancer cells-'trick or treats'? FEBS J. 276: 6084-6096, 2009.
7. Cotter, T.G. Apoptosis and cancer: the genesis of a research field. Nat. Rev. Cancer 9: 501-507, 2009.
8. Dohi, T., E. Beltrami, N.R. Wall, J. Plescia and D.C. Altieri. Mitochondrial survivin inhibits apoptosis and promotes tumorigenesis. J. Clin. Invest. 114: 1117-1127, 2004.
9. Fidler, I.J. Critical factors in the biology of human cancer metastasis: twenty-eighth G.H.A. Clowes memorial award lecture. Cancer Res. 50: 6130-6138, 1990.
10. Hippert, M.M., P.S. O'Toole and A. Thorburn. Autophagy in cancer: good, bad, or both? Cancer Res. 66: 9349-9351, 2006.
11. Hood, J.D. and D.A. Cheresh. Role of integrins in cell invasion and migration. Nat. Rev. Cancer 2: 91-100, 2002.
12. Hoyer-Hansen, M., L. Bastholm, I.S. Mathiasen, F. Elling and M. Jaattela. Vitamin D analog EB1089 triggers dramatic lysosomal changes and Beclin 1-mediated autophagic cell death. Cell Death Differ. 12: 1297-1309, 2005.
13. Hwang, J.M., W.J. Ting, H.C. Wu, Y.J. Chen, F.J. Tsai, P.Y. Chen, C.Y. Liu, L.C. Chou, S.C. Kuo and C.Y. Huang. KHC-4 anti-cancer effects on human PC3 prostate cancer cell line. Am. J. Chin. Med. 40: 1063-1071, 2012.
14. Kamei, T., T. Matozaki and Y. Takai. Mechanisms of cell adhesion and migration [in Japanese]. Gan To Kagaku Ryoho 26: 1359-1366, 1999.
15. Kondo, Y., T. Kanzawa, R. Sawaya and S. Kondo. The role of autophagy in cancer development and response to therapy. Nat. Rev. Cancer 5: 726-734, 2005.
16. Lu, J.J., Y.Y. Dang, M. Huang, W.S. Xu, X.P. Chen and Y.T. Wang. Anti-cancer properties of terpenoids isolated from Rhizoma Curcumae-a review. J. Ethnopharmacol. 143: 406-411, 2012.
17. Ma, E., X. Wang, Y. Li, X. Sun, W. Tai, T. Li and T. Guo. Induction of apoptosis by furanodiene in HL60 leukemia cells through activation of TNFR1 signaling pathway. Cancer Lett. 271: 158-166, 2008.
18. Mizushima, N. Methods for monitoring autophagy. Int. J. Biochem. Cell Biol. 36: 2491-2502, 2004.
19. Mizushima, N. and T. Yoshimori. How to interpret LC3 immunoblotting. Autophagy 3: 542-545, 2007.
20. Olsson, M. and B. Zhivotovsky. Caspases and cancer. Cell Death Differ. 18: 1441-1449, 2011.
21. Park, M.T. and S.J. Lee. Cell cycle and cancer. J. Biochem. Mol. Biol. 36: 60-65, 2003.
22. Polyak, K., J.Y. Kato, M.J. Solomon, C.J. Sherr, J. Massague, J.M. Roberts and A. Koff. p27Kip1, a cyclin-Cdk inhibitor, links transforming growth factor-beta and contact inhibition to cell cycle arrest. Genes Dev. 8: 9-22, 1994.
23. Sandal, T. Molecular aspects of the mammalian cell cycle and cancer. Oncologist 7: 73-81, 2002.
24. Shimizu, S., T. Kanaseki, N. Mizushima, T. Mizuta, S. Arakawa-Kobayashi, C.B. Thompson and Y. Tsujimoto. Role of Bcl-2 family proteins in a non-apoptotic programmed cell death dependent on autophagy genes. Nat. Cell Biol. 6: 1221-1228, 2004.
25. Sun, X.Y., Y.P. Zheng, D.H. Lin, H. Zhang, F. Zhao and C.S. Yuan. Potential anti-cancer activities of Furanodiene, a Sesquiterpene from Curcuma wenyujin. Am. J. Chin. Med. 37: 589-596, 2009.
26. Tanida, I., T. Ueno and E. Kominami. LC3 and Autophagy. Methods Mol. Biol. 445: 77-88, 2008.
27. Tanida, I. and S. Waguri. Measurement of autophagy in cells and tissues. Methods Mol. Biol. 648: 193-214, 2010.
28. Thompson, E.W., D.F. Newgreen and D. Tarin. Carcinoma invasion and metastasis: a role for epithelial-mesenchymal transition? Cancer Res. 65: 5991-5995, 2005.
29. Wang, Y., X.Y. Liu, X.G. Wang, F.N. Li, J.G. Li and W.H. Cao. Furanodiene blocks NF-kBdependent MMP-9 and VEGF activation and inhibits cellular invasiveness and angiogenesis of breast cancer cells in vitro and in vivo. Biomed. Res. 23: 7, 2012.
30. Wang, S., Z. Zhong, J. Wan, W. Tan, G. Wu, M. Chen and Y. Wang. Oridonin induces apoptosis, inhibits migration and invasion on highly-metastatic human breast cancer cells. Am. J. Chin. Med. 41: 177-196, 2013.
31. Wilson, E.N., M.L. Bristol, X. Di, W.A. Maltese, K. Koterba, M.J. Beckman and D.A. Gewirtz. A switch between cytoprotective and cytotoxic autophagy in the radiosensitization of breast tumor cells by chloroquine and vitamin D. Horm. Cancer 2: 272-285, 2011.
32. Wong, R.S. Apoptosis in cancer: from pathogenesis to treatment. J. Exp. Clin. Cancer Res. 30: 87, 2011.
33. Wu, G., Z. Qian, J. Guo, D. Hu, J. Bao, J. Xie, W. Xu, J. Lu, X. Chen and Y. Wang. Ganoderma lucidum extract induces G1 cell cycle arrest, and apoptosis in human breast cancer cells. Am. J. Chin. Med. 40: 631-642, 2012.
34. Xiao, Y., F.Q. Yang, S.P. Li, J.L. Gao, G. Hu, S.C. Lao, E.L. Conceicao, K.P. Fung, Y.T. Wang and S.M. Lee. Furanodiene induces G2/M cell cycle arrest and apoptosis through MAPK signaling and mitochondria-caspase pathway in human hepatocellular carcinoma cells. Cancer Biol. Ther. 6: 1044-1050, 2007.
35. Xu, W.S., Y.Y. Dang, J.J. Guo, G.S. Wu, J.J. Lu, X.P. Chen and Y.T. Wang. Furanodiene induces endoplasmic reticulum stress and presents antiproliferative activities in lung cancer cells. Evid. Based Complement. Alternat. Med. 2012: 426521, 2012.
36. Xu, Z., G. Wu, X. Wei, X. Chen, Y. Wang and L. Chen. Celastrol induced DNA damage, cell cycle arrest, and apoptosis in human rheumatoid fibroblast-like synovial cells. Am. J. Chin. Med. 41: 615-628, 2013.
37. Yang, F.Q., Y.T. Wang and S.P. Li. Simultaneous determination of 11 characteristic components in three species of Curcuma rhizomes using pressurized liquid extraction and high-performance liquid chromatography. J. Chromatogr. A 1134: 226-231, 2006.
38. Yoon, J.J., Y.J. Lee, S.M. Lee, S.N. Jin, D.G. Kang and H.S. Lee. Poria cocos inhibits high glucoseinduced proliferation of rat mesangial cells. Am. J. Chin. Med. 41: 71-83, 2013.
39. Zhong, Z., Y. Dang, X. Yuan, W. Guo, Y. Li, W. Tan, J. Cui, J. Lu, Q. Zhang, X. Chen and Y. Wang. Furanodiene, a natural product, inhibits breast cancer growth both in vitro and in vivo. Cell Physiol. Biochem. 30: 778-790, 2012a.
40. Zhong, Z.F., P.M. Hoi, G.S. Wu, Z.T. Xu, W. Tan, X.P. Chen, L. Cui, T. Wu and Y.T. Wang. Antiangiogenic effect of furanodiene on HUVECs in vitro and on zebrafish in vivo. J. Ethnopharmacol. 141: 721-727, 2012b.