New promises for metformin: Advances in the understanding of its mechanisms of action;Les nouvelles promesses de la metformine

Medecine/Sciences

Volumn 30, Issue 1, 2014, Pages 82-92

  Foretz, Marc ^a,b,c   Viollet, Benoit ^a,b,c  

^a INSTITUT COCHIN   (France)

^b CNRS   (France)

^c UNIVERSITÉ PARIS DESCARTES   (France)

Author keywords

[No Author keywords available]

Indexed keywords

ANTIDIABETIC AGENT; ANTINEOPLASTIC AGENT; CARDIOTONIC AGENT; METFORMIN; NEUROPROTECTIVE AGENT;

ANIMAL; DRUG EFFECT; HISTORY; HUMAN; REVIEW; SIGNAL TRANSDUCTION;

ANIMALS; ANTINEOPLASTIC AGENTS; CARDIOTONIC AGENTS; HISTORY, 19TH CENTURY; HISTORY, 20TH CENTURY; HISTORY, MEDIEVAL; HUMANS; HYPOGLYCEMIC AGENTS; METFORMIN; NEUROPROTECTIVE AGENTS; SIGNAL TRANSDUCTION;

EID: 84893425402     PISSN: 07670974     EISSN: 19585381     Source Type: Journal    
DOI: 10.1051/medsci/20143001018     Document Type: Review

References (53)

1. Bailey C, Campbell I. Metformin: the gold standard. A scientific handbook. Chichester, UK : Wiley, 2007 : 288 p.
2. Sterne J. Du nouveau dans les antidiabétiques. La NN diméthylamino guanyl guanidine (NNDG). Maroc Med 1957 ; 36 : 1295-1296.
3. UKPDS. Effect of intensive blood-glucose control with metformin on complications in overweight patients with type 2 diabetes (UKPDS 34). Lancet 1998 ; 352 : 854-865.
4. Stades AM, Heikens JT, Erkelens DW, et al. Metformin and lactic acidosis: cause or coincidence? A review of case reports. J Intern Med 2004 ; 255 : 179-187.
5. Lee A, Morley JE. Metformin decreases food consumption and induces weight loss in subjects with obesity with type II non-insulin-dependent diabetes. Obes Res 1998 ; 6 : 47-53.
6. Lin HZ, Yang SQ, Chuckaree C, et al. Metformin reverses fatty liver disease in obese, leptin-deficient mice. Nat Med 2000 ; 6 : 998-1003.
7. Marchesini G, Brizi M, Bianchi G, et al. Metformin in non-alcoholic steatohepatitis. Lancet 2001 ; 358 : 893-894.
8. Foretz M, Viollet B. Mécanisme d'action hépatique de la metformine dans le diabète de type 2. Med Mal Metab 2009 ; 3 : 48-54.
9. Foretz M, Viollet B. Mécanisme d'inhibition de la production hépatique de glucose par la metformine. Med Sci (Paris) 2010 ; 26 : 663-666.
10. Knowler WC, Barrett-Connor E, Fowler SE, et al. Reduction in the incidence of type 2 diabetes with lifestyle intervention or metformin. N Engl J Med 2002 ; 346 : 393-403.
11. Rowan JA, Hague WM, Gao W, et al. Metformin versus insulin for the treatment of gestational diabetes. N Engl J Med 2008 ; 358 : 2003-2015.
12. Lord JM, Flight IH, Norman RJ. Metformin in polycystic ovary syndrome: systematic review and meta-analysis. Br Med J 2003 ; 327 : 951-953.
13. Shu Y, Sheardown SA, Brown C, et al. Effect of genetic variation in the organic cation transporter 1 (OCT1) on metformin action. J Clin Invest 2007 ; 117 : 1422-1431.
14. Argaud D, Roth H, Wiernsperger N, Leverve XM. Metformin decreases gluconeogenesis by enhancing the pyruvate kinase flux in isolated rat hepatocytes. Eur J Biochem 1993 ; 213 : 1341-1348.
15. El-Mir MY, Nogueira V, Fontaine E, et al. Dimethylbiguanide inhibits cell respiration via an indirect effect targeted on the respiratory chain complex I. J Biol Chem 2000 ; 275 : 223-228.
16. Owen MR, Doran E, Halestrap AP. Evidence that metformin exerts its antidiabetic effects through inhibition of complex 1 of the mitochondrial respiratory chain. Biochem J 2000 ; 348 : 607-614.
17. Logie L, Harthill J, Patel K, et al. Cellular responses to the metal-binding properties of metformin. Diabetes 2012 ; 61 : 1423-1433.
18. Zhou G, Myers R, Li Y, et al. Role of AMP-activated protein kinase in mechanism of metformin action. J Clin Invest 2001 ; 108 : 1167-1174.
19. Foretz M, Taleux N, Guigas B, et al. Régulation du métabolisme énergétique par l'AMPK. Med Sci (Paris) 2006 ; 22 : 381-388.
20. Foretz M, Viollet B. Regulation of hepatic metabolism by AMPK. J Hepatol 2011 ; 54 : 827-829.
21. Shaw RJ, Lamia KA, Vasquez D, et al. The kinase LKB1 mediates glucose homeostasis in liver and therapeutic effects of metformin. Science 2005 ; 310 : 1642-1646.
22. Foretz M, Hebrard S, Leclerc J, et al. Metformin inhibits hepatic gluconeogenesis in mice independently of the LKB1/AMPK pathway via a decrease in hepatic energy state. J Clin Invest 2010 ; 120 : 2355-2369.
23. Miller RA, Chu Q, Xie J, et al. Biguanides suppress hepatic glucagon signalling by decreasing production of cyclic AMP. Nature 2013 ; 494 : 256-260.
24. Yin M, van der Horst IC, van Melle JP, et al. Metformin improves cardiac function in a nondiabetic rat model of post-MI heart failure. Am J Physiol Heart Circ Physiol 2011 ; 301 : H459-H468.
25. Gundewar S, Calvert JW, Jha S, et al. Activation of AMP-activated protein kinase by metformin improves left ventricular function and survival in heart failure. Circ Res 2009 ; 104 : 403-411.
26. MacDonald MR, Eurich DT, Majumdar SR, et al. Treatment of type 2 diabetes and outcomes in patients with heart failure: a nested case-control study from the U.K. General practice research database. Diabetes care 2010 ; 33 : 1213-1218.
27. Xie Z, Lau K, Eby B, et al. Improvement of cardiac functions by chronic metformin treatment is associated with enhanced cardiac autophagy in diabetic OVE26 mice. Diabetes 2011 ; 60 : 1770-1778.
28. Evans JM, Donnelly LA, Emslie-Smith AM, et al. Metformin and reduced risk of cancer in diabetic patients. Br Med J 2005 ; 330 : 1304-1305.
29. Beck E, Scheen AJ. Quels bénéfices antitumoraux attendre de la metformine ? Ann Endocrinol (Paris) 2013 ; 74 : 137-147.
30. Memmott RM, Mercado JR, Maier CR, et al. Metformin prevents tobacco carcinogen-induced lung tumorigenesis. Cancer Prev Res 2010 ; 3 : 1066-1076.
31. Viollet B, Foretz M. Metformine et cancer. Du diabète au cancer : de nouvelles perspectives thérapeutiques pour la metformine. Med Mal Metab 2011 ; 5 : 29-37.
32. Zakikhani M, Dowling R, Fantus IG, et al. Metformin is an AMP kinase-dependent growth inhibitor for breast cancer cells. Cancer Res 2006 ; 66 : 10269-10273.
33. Ben Sahra I, Laurent K, Loubat A, et al. The antidiabetic drug metformin exerts an antitumoral effect in vitro and in vivo through a decrease of cyclin D1 level. Oncogene 2008 ; 27 : 3576-3586.
34. Huang X, Wullschleger S, Shpiro N, et al. Important role of the LKB1-AMPK pathway in suppressing tumorigenesis in PTEN-deficient mice. Biochem J 2008 ; 412 : 211-221.
35. Ben Sahra I, Regazzetti C, Robert G, et al. Metformin, independent of AMPK, induces mTOR inhibition and cell-cycle arrest through REDD1. Cancer Res 2011 ; 71 : 4366-4372.
36. Buzzai M, Jones RG, Amaravadi RK, et al. Systemic treatment with the antidiabetic drug metformin selectively impairs p53-deficient tumor cell growth. Cancer Res 2007 ; 67 : 6745-6752.
37. Pearce EL, Walsh MC, Cejas PJ, et al. Enhancing CD8 T-cell memory by modulating fatty acid metabolism. Nature 2009 ; 460 : 103-107.
38. Algire C, Moiseeva O, Deschenes-Simard X, et al. Metformin reduces endogenous reactive oxygen species and associated DNA damage. Cancer Prev Res 2012 ; 5 : 536-543.
39. Del Barco S, Vazquez-Martin A, Cufi S, et al. Metformin: multi-faceted protection against cancer. Oncotarget 2011 ; 2 : 896-917.
40. Cerezo M, Tichet M, Abbe P, et al. Metformin blocks melanoma invasion and metastasis development in a AMPK/p53-dependent manner. Mol Cancer Ther 2013 ; 12 : 1605-1615.
41. Jiralerspong S, Palla SL, Giordano SH, et al. Metformin and pathologic complete responses to neoadjuvant chemotherapy in diabetic patients with breast cancer. J Clin Oncol 2009 ; 27 : 3297-3302.
42. Hirsch HA, Iliopoulos D, Tsichlis PN, Struhl K. Metformin selectively targets cancer stem cells, and acts together with chemotherapy to block tumor growth and prolong remission. Cancer Res 2009 ; 69 : 7507-7511.
43. Hwang YP, Jeong HG. Metformin blocks migration and invasion of tumour cells by inhibition of matrix metalloproteinase-9 activation through a calcium and protein kinase Calpha-dependent pathway: phorbol-12-myristate-13-acetate- induced/extracellular signal-regulated kinase/activator protein-1. Br J Pharmacol 2010 ; 160 : 1195-1211.
44. Shackelford DB, Abt E, Gerken L, et al. LKB1 inactivation dictates therapeutic response of non-small cell lung cancer to the metabolism drug phenformin. Cancer Cell 2013 ; 23 : 143-158.
45. Kickstein E, Krauss S, Thornhill P, et al. Biguanide metformin acts on tau phosphorylation via mTOR/protein phosphatase 2A (PP2A) signaling. Proc Natl Acad Sci USA 2010 ; 107 : 21830-21835.
46. Paintlia AS, Paintlia MK, Mohan S, et al. AMP-activated protein kinase signaling protects oligodendrocytes that restore central nervous system functions in an experimental autoimmune encephalomyelitis model. Am J Pathol 2013 ; 183 : 526-541.
47. Ma TC, Buescher JL, Oatis B, et al. Metformin therapy in a transgenic mouse model of Huntington's disease. Neurosci Lett 2007 ; 411 : 98-103.
48. Wang J, Gallagher D, DeVito LM, et al. Metformin activates an atypical PKC-CBP pathway to promote neurogenesis and enhance spatial memory formation. Cell Stem Cell 2012 ; 11 : 23-35.
49. Anisimov VN, Berstein LM, Popovich IG, et al. If started early in life, metformin treatment increases life span and postpones tumors in female SHR mice. Aging (Albany NY) 2011 ; 3 : 148-157.
50. Onken B, Driscoll M. Metformin induces a dietary restriction-like state, the oxidative stress response to extend C. elegans Healthspan via AMPK, LKB1, SKN-1. PLoS One 2010 ; 5 : e8758.
51. Cabreiro F, Au C, Leung KY, et al. Metformin retards aging in C. elegans by altering microbial folate and methionine metabolism. Cell 2013 ; 153 : 228-239.
52. Razungles J, Jalaguier S, Cavaillès V, Teyssier C. L'effet Warburg : de la théorie du cancer aux applications thérapeutiques en cancérologie. Med Sci (Paris) 2013 ; 29 : 1026-1033.
53. Julien LA, Roux PP. mTOR, the mammalian target of rapamycin. Med Sci (Paris) 2010 ; 26 : 1056-1060.