Weighing nanoparticles in solution at the attogram scale

Proceedings of the National Academy of Sciences of the United States of America

Volumn 111, Issue 4, 2014, Pages 1310-1315

  Olcum, Selim ^a,b   Cermak, Nathan ^c   Wasserman, Steven C ^a   Christine, Kathleen S ^d,e   Atsumi, Hiroshi ^f   Payer, Kris R ^g   Shen, Wenjiang ^h   Lee, Jungchul ⁱ   Belcher, Angela M ^a,b,f   Bhatia, Sangeeta N ^b,d,e,j,k   Manalis, Scott R ^a,b,c,l  

^a Departments of Biological Engineering   (United States)

^b KOCH INSTITUTE FOR INTEGRATIVE CANCER RESEARCH   (United States)

^c Computational and Systems Biology Initiative ^*  (United States)

^d HARVARD MIT DIVISION OF HEALTH SCIENCES AND TECHNOLOGY   (United States)

^e Institute for Medical Engineering and Science   (United States)

^f Materials Science and Engineering   (United States)

^g Massachusetts Institute of Technology Cambridge   (United States)

^h Innovative Micro Technology   (United States)

ⁱ Sogang University   (South Korea)

^j Departments of Electrical Engineering and Computer Science   (United States)

^k HOWARD HUGHES MEDICAL INSTITUTE   (United States)

^l Dep of Mechanical Engineering   (United States)

more..

Author keywords

[No Author keywords available]

Indexed keywords

DNA; NANOPARTICLE;

ACCURACY; ARTICLE; DNA STRUCTURE; EXOSOME; MOLECULAR MECHANICS; MOLECULAR WEIGHT; NANOCHEMISTRY; PRIORITY JOURNAL;

MECHANICAL OSCILLATORS; MICROFLUIDICS; NANOPARTICLE CHARACTERIZATION; NEMS;

EXOSOMES; GOLD; LIMIT OF DETECTION; METAL NANOPARTICLES; MOLECULAR WEIGHT; REPRODUCIBILITY OF RESULTS; SOLUTIONS;

EID: 84893411232     PISSN: 00278424     EISSN: 10916490     Source Type: Journal    
DOI: 10.1073/pnas.1318602111     Document Type: Article

References (41)

1. Peer D, et al. (2007) Nanocarriers as an emerging platform for cancer therapy. Nat Nanotechnol 2(12):751-760.
2. Morachis JM, Mahmoud EA, Almutairi A (2012) Physical and chemical strategies for therapeutic delivery by using polymeric nanoparticles. Pharmacol Rev 64(3):505-519.
3. Chi EY, Krishnan S, Randolph TW, Carpenter JF (2003) Physical stability of proteins in aqueous solution: Mechanism and driving forces in nonnative protein aggregation. Pharm Res 20(9):1325-1336.
4. Sauerborn M, Brinks V, Jiskoot W, Schellekens H (2010) Immunological mechanism underlying the immune response to recombinant human protein therapeutics. Trends Pharmacol Sci 31(2):53-59.
5. Théry C, Ostrowski M, Segura E (2009) Membrane vesicles as conveyors of immune responses. Nat Rev Immunol 9(8):581-593.
6. Anderson W, Kozak D, Coleman VA, Jämting AK, Trau M (2013) A comparative study of submicron particle sizing platforms: Accuracy, precision and resolution analysis of polydisperse particle size distributions. J Colloid Interface Sci 405:322-330.
7. Lange H (1995) Comparative test of methods to determine particle size and particle size distribution in the submicron range. Part Part Syst Charact 12(3):148-157.
8. Mahl D, Diendorf J, Meyer-Zaika W, Epple M (2011) Possibilities and limitations of different analytical methods for the size determination of a bimodal dispersion of metallic nanoparticles. Colloids Surf Physicochem Eng Asp 377(1-3):386-392.
9. Fraikin J-L, Teesalu T, McKenney CM, Ruoslahti E, Cleland AN (2011) A highthroughput label-free nanoparticle analyser. Nat Nanotechnol 6(5):308-313.
10. Roberts GS, et al. (2010) Tunable nano/micropores for particle detection and discrimination: Scanning ion occlusion spectroscopy. Small 6(23):2653-2658.
11. Chaste J, et al. (2012) A nanomechanical mass sensor with yoctogram resolution. Nat Nanotechnol 7(5):301-304.
12. Jensen K, Kim K, Zettl A (2008) An atomic-resolution nanomechanical mass sensor. Nat Nanotechnol 3(9):533-537.
13. Naik AK, Hanay MS, Hiebert WK, Feng XL, Roukes ML (2009) Towards single-molecule nanomechanical mass spectrometry. Nat Nanotechnol 4(7):445-450.
14. Hanay MS, et al. (2012) Single-protein nanomechanical mass spectrometry in real time. Nat Nanotechnol 7(9):602-608.
15. Burg TP, et al. (2007) Weighing of biomolecules, single cells and single nanoparticles in fluid. Nature 446(7139):1066-1069.
16. Barton RA, et al. (2010) Fabrication of a nanomechanical mass sensor containing a nanofluidic channel. Nano Lett 10(6):2058-2063.
17. Lee J, Shen W, Payer K, Burg TP, Manalis SR (2010) Toward attogram mass measurements in solution with suspended nanochannel resonators. Nano Lett 10(7): 2537-2542.
18. Yang YT, Callegari C, Feng XL, Ekinci KL, Roukes ML (2006) Zeptogram-scale nanomechanical mass sensing. Nano Lett 6(4):583-586.
19. Ekinci KL, Roukes ML (2005) Electromechanical transducers at the nanoscale: Actuation and sensing of motion in nanoelectromechanical systems (NEMS). Small 1(8-9): 786-797.
20. Feng XL, White CJ, Hajimiri A, Roukes ML (2008) A self-sustaining ultrahigh-frequency nanoelectromechanical oscillator. Nat Nanotechnol 3(6):342-346.
21. Arlett JL, Roukes ML (2010) Ultimate and practical limits of fluid-based mass detection with suspended microchannel resonators. J Appl Phys 108(8):084701.
22. Théry C, Zitvogel L, Amigorena S (2002) Exosomes: Composition, biogenesis and function. Nat Rev Immunol 2(8):569-579.
23. Ekinci KL, Yang YT, Roukes ML (2004) Ultimate limits to inertial mass sensing based upon nanoelectromechanical systems. J Appl Phys 95(5):2682-2689.
24. Greywall DS, Yurke B, Busch PA, Pargellis AN, Willett RL (1994) Evading amplifier noise in nonlinear oscillators. Phys Rev Lett 72(19):2992-2995.
25. Rutman J, Walls FL (1991) Characterization of frequency stability in precision frequency sources. Proc IEEE 79(6):952-960.
26. Leeson D (1966) A simple model of feedback oscillator noise spectrum. Proc IEEE 54(2): 329-330.
27. Rubiola E (2009) Phase Noise and Frequency Stability in Oscillators (Cambridge Univ Press, Cambridge, UK).
28. Albrecht TR, Grütter P, Horne D, Rugar D (1991) Frequency modulation detection using high-Q cantilevers for enhanced force microscope sensitivity. J Appl Phys 69(2): 668-673.
29. Cleland AN, Roukes ML (2002) Noise processes in nanomechanical resonators. J Appl Phys 92(5):2758-2769.
30. Dohn S, Svendsen W, Boisen A, Hansen O (2007) Mass and position determination of attached particles on cantilever based mass sensors. Rev Sci Instrum 78(10): 103303-103333.
31. Hippenstiel RD (2002) Detection Theory: Applications and Digital Signal Processing (CRC, Boca Raton, FL).
32. Skog J, et al. (2008) Glioblastoma microvesicles transport RNA and proteins that promote tumour growth and provide diagnostic biomarkers. Nat Cell Biol 10(12): 1470-1476.
33. Peinado H, et al. (2012) Melanoma exosomes educate bone marrow progenitor cells toward a pro-metastatic phenotype through MET. Nat Med 18(6):883-891.
34. Hui EE, Bhatia SN (2007) Micromechanical control of cell-cell interactions. Proc Natl Acad Sci USA 104(14):5722-5726.
35. Khetani SR, Bhatia SN (2008) Microscale culture of human liver cells for drug development. Nat Biotechnol 26(1):120-126.
36. van der Pol E, et al. (2010) Optical and non-optical methods for detection and characterization of microparticles and exosomes. J Thromb Haemost 8(12):2596-2607.
37. Douglas SM, Bachelet I, Church GM (2012) A logic-gated nanorobot for targeted transport of molecular payloads. Science 335(6070):831-834.
38. Simons M, Raposo G (2009) Exosomes-vesicular carriers for intercellular communication. Curr Opin Cell Biol 21(4):575-581.
39. Hajimiri A, Lee TH (1999) The Design of Low Noise Oscillators (Kluwer Academic, Boston).
40. Barnes J, et al. (1971) Characterization of frequency stability. IEEE Trans Instrum Meas 20(2):105-120.
41. Sharma J, et al. (2008) Toward reliable gold nanoparticle patterning on self-assembled DNA nanoscaffold. J Am Chem Soc 130(25):7820-7821.