Burn plus lipopolysaccharide augments endoplasmic reticulum stress and NLRP3 inflammasome activation and reduces PGC-1α in liver

Shock

Volumn 41, Issue 2, 2014, Pages 138-144

  Diao, Li ^a,b   Marshall, Alexandra H ^a   Dai, Xiaojing ^a   Bogdanovic, Elena ^a   Abdullahi, Abdikarim ^a   Amini Nik, Saeid ^a   Jeschke, Marc G ^a,b  

^a UNIVERSITY OF TORONTO   (Canada)

^b UNIVERSITY OF TORONTO   (Canada)

Author keywords

ER stress; inflammasome; metabolism; sepsis; Thermal injury

Indexed keywords

ALANINE AMINOTRANSFERASE; ASPARTATE AMINOTRANSFERASE; BACTERIUM LIPOPOLYSACCHARIDE; CRYOPYRIN; CYCLIC AMP DEPENDENT PROTEIN KINASE; GLUCOSE; GLUCOSE REGULATED PROTEIN 78; GROWTH ARREST AND DNA DAMAGE INDUCIBLE PROTEIN 153; HYDROXYMETHYLGLUTARYL COENZYME A REDUCTASE KINASE; HYDROXYMETHYLGLUTARYL COENZYME A REDUCTASE KINASE ALPHA; INTERLEUKIN 1; PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR GAMMA COACTIVATOR 1ALPHA; PROTEIN DISULFIDE ISOMERASE; SIRTUIN 1; UNCLASSIFIED DRUG; X BOX BINDING PROTEIN 1;

ALANINE AMINOTRANSFERASE BLOOD LEVEL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; ASPARTATE AMINOTRANSFERASE BLOOD LEVEL; BODY SURFACE; BURN; CONTROLLED STUDY; DOWN REGULATION; ENDOPLASMIC RETICULUM STRESS; ENZYME INHIBITION; GENE EXPRESSION; GLUCOSE BLOOD LEVEL; GLUCOSE METABOLISM; HYPERMETABOLISM; IMMUNOHISTOCHEMISTRY; LIPID METABOLISM; LIVER INJURY; LIVER METABOLISM; MALE; NONHUMAN; PROTEIN ANALYSIS; PSEUDOMONAS AERUGINOSA; RAT; SCALD; SEPSIS; UNFOLDED PROTEIN RESPONSE; WEIGHT REDUCTION;

AMP-ACTIVATED PROTEIN KINASES; ANIMALS; BURNS; ENDOPLASMIC RETICULUM STRESS; INFLAMMASOMES; LIPOPOLYSACCHARIDES; LIVER; LIVER DISEASES; MALE; PSEUDOMONAS AERUGINOSA; RATS; RECEPTORS, CYTOPLASMIC AND NUCLEAR; SIRTUIN 1; TRANSCRIPTION FACTORS;

EID: 84893407988     PISSN: 10732322     EISSN: 15400514     Source Type: Journal    
DOI: 10.1097/SHK.0000000000000075     Document Type: Article

References (35)

1. Rex S: Burn injuries. Curr Opin Crit Care 18:671-676, 2012
2. Wafaisade A, Lefering R, Bouillon B, Sakka SG, Thamm OC, Paffrath T, Neugebauer E, Maegele M, Trauma Registry of the German Society for Trauma Surgery: Epidemiology and risk factors of sepsis after multiple trauma: An analysis of 29,829 patients from the Trauma Registry of the German Society for Trauma Surgery. Crit Care Med 39:621-628, 2011
3. Osborn TM, Tracy JK, Dunne JR, Pasquale M, Napolitano LM: Epidemiology of sepsis in patients with traumatic injury. Crit Care Med 32:2234-2240, 2004
4. Jeschke MG, Micak RP, Finnerty CC, Herndon DN: Changes in liver function and size after a severe thermal injury. Shock 28:172-177, 2007
5. Jeschke MG: The hepatic response to thermal injury: Is the liver important for postburn outcomes? Mol Med 15:337-351, 2009
6. Croner RS, Hohenberger W, Jeschke MG: Hepatic gene expression during endotoxemia. J Surg Res 154:126-134, 2009
7. Finnerty CC, Herndon DN, Chinkes DL, Jeschke MG: Serum cytokine differences in severely burned children with and without sepsis. Shock 27:4-9, 2007
8. Paterson HM, Murphy TJ, Purcell EJ, Shelley O, Kriynovich SJ, Lien E, Mannick JA, Lederer JA: Injury primes the innate immune system for enhanced Toll-like receptor reactivity. J Immunol 171:1473-1483, 2003
9. Gross O, Thomas CJ, Guarda G, Tschopp J: The inflammasome: An integrated view. Immunol Rev 243:136-151, 2011
10. Jeschke MG, Finnerty CC, Herndon DN, Song J, Boehning D, Tompkins RG, Baker HV, Gauglitz GG: Severe injury is associated with insulin resistance, endoplasmic reticulum stress response, and unfolded protein response. Ann Surg 255: 370-378, 2012
11. Osuka A, Hanschen M, Stoecklein V, Lederer JA: A protective role for inflammasome activation following injury. Shock 37:47-55, 2012
12. Gentile LF, Moldawer LL: What is the role for the inflammasome in burn injury and sepsis? Shock 37:124-125, 2012
13. Herndon DN, Wilmore DW, Mason AD Jr: Development and analysis of a small animal model simulating the human postburn hypermetabolic response. J Surg Res 25:394-403, 1978
14. JeschkeMG, Kraft R, Song J, Gauglitz GG, Cox RA, Brooks NC, Finnerty CC, Kulp GA, Herndon DN, Boehning D: Insulin protects against hepatic damage postburn. Mol Med 17:516-522, 2011
15. Hiyama Y, Marshall AH, Kraft R, Qa'aty N, Arno A, Herndon DN, Jeschke MG: Effects of metformin on burn-induced hepatic endoplasmic reticulum stress in male rats. Mol Med 19:1-6, 2013
16. Okamoto M, Takemori H, Katoh Y: Salt-inducible kinase in steroidogenesis and adipogenesis. Trends Endocrinol Metab 15:21-26, 2004
17. Mauvoisin D, Mounier C: Hormonal and nutritional regulation of SCD1 gene expression. Biochimie 93:78-86, 2011
18. Scarpulla RC: Metabolic control of mitochondrial biogenesis through the PGC-1 family regulatory network. Biochim Biophys Acta 1813:1269-1278, 2011
19. Jeschke MG, Gauglitz GG, Kulp GA, Finnerty CC, Williams FN, Kraft R, SumanOE,Mlcak RP, Herndon DN: Long-term persistence of the pathophysiologic response to severe burn injury. PLoS One 6:e21245, 2011
20. Bolder U, Jeschke MG, Landmann L, Wolf F, de Sousa C, Schlitt HJ, Przkora R: Heat stress enhances recovery of hepatocyte bile acid and organic anion transporters in endotoxemic rats by multiple mechanisms. Cell Stress Chaperones 11:89-100, 2006
21. Cheung AM, Jeschke MG: What's new in Shock, December 2011? Shock 36:529-531, 2011
22. Mathews RJ, Robinson JI, Battellino M, Wong C, Taylor JC, Biologics in Rheumatoid Arthritis Genetics Genomics Study Syndicate, Eyre S, Churchman SM, Wilson AG, Isaacs JD, Hyrich K, et al.: Evidence of NLRP3-inflammasome activation in rheumatoid arthritis (RA); genetic variants within the NLRP3-inflammasome complex in relation to susceptibility to RA and response to anti-TNF treatment. Ann Rheum Dis. Nov 11. doi: 10.1136/annrheumdis-2013-203276. [Epub ahead of print], 2013
23. Rotta Detto Loria J, Rohmann K, Droemann D, Kujath P, Rupp J, Goldmann T, Dalhoff K: Haemophilus influenzae infection upregulates the NLRP3 inflammasome and leads to caspase-1Ydependent secretion of interleukin-1betaVa possible pathway of exacerbations in COPD. PLoS One 8:e66818, 2013
24. Weber A, Wasiliew P, Kracht M: Interleukin-1 (IL-1) pathway. Sci Signal 3:cm1, 2010
25. Choi AM, Nakahira K: Dampening insulin signaling by an NLRP3 Fmetaflammasome-. Nat Immunol 12:379-380, 2011
26. Khazen W, M'Bika JP, Tomkiewicz C, Benelli C, Chany C, Achour A, Forest C: Expression of macrophage-selective markers in human and rodent adipocytes. FEBS Lett 579:5631-5634, 2005
27. Menu P, Mayor A, Zhou R, Tardivel A, Ichijo H, Mori K, Tschopp J: ER stress activates the NLRP3 inflammasome via an UPR-independent pathway. Cell Death Dis 3:e261, 2012
28. Gauglitz GG, Halder S, Boehning DF, Kulp GA, Herndon DN, Barral JM, Jeschke MG: Post-burn hepatic insulin resistance is associated with endoplasmic reticulum (ER) stress. Shock 33:299-305, 2010
29. Stefan N, Peter A, Cegan A, Staiger H, Machann J, Schick F, Claussen CD, Fritsche A, Häring HU, Schleicher E: Low hepatic stearoyl-CoA desaturase 1 activity is associated with fatty liver and insulin resistance in obese humans. Diabetologia 51:648-656, 2008
30. Shen T, Liu Y, Schneider MF: Localization and regulation of the N terminal splice variant of PGC-1alpha in adult skeletal muscle fibers. J Biomed Biotechnol 2012:989263, 2012
31. Marshall AH, Brooks NC, Hiyama Y, Qa'aty N, Al-Mousawi A, Finnerty CC, Jeschke MG: Hepatic apoptosis postburn is mediated by c-Jun N-terminal kinase 2. Shock 39:183-188, 2013
32. Jeschke MG, Gauglitz GG, Song J, Kulp GA, Finnerty CC, Cox RA, Barral JM, Herndon DN, Boehning D: Calcium and ER stress mediate hepatic apoptosis after burn injury. J Cell Mol Med 13:1857-1865, 2009
33. Chang JS, Huypens P, Zhang Y, Black C, Kralli A, Gettys TW: Regulation of NTYPGC-1alpha subcellular localization and function by protein kinase AYdependent modulation of nuclear export by CRM1. J Biol Chem 285: 18039-18050, 2010
34. Canto C, Auwerx J: PGC-1alpha, SIRT1 and AMPK, an energy sensing network that controls energy expenditure. Curr Opin Lipidol 20:98-105, 2009
35. Haemmerle G, Moustafa T, Woelkart G, Buttner S, Schmidt A, van de Weijer T, Hesselink M, Jaeger D, Kienesberger PC, Zierler K, et al.: ATGL-mediated fat catabolism regulates cardiac mitochondrial function via PPAR-alpha and PGC-1. Nat Med 17:1076-1085, 2011