What is the role for the inflammasome in burn injury and sepsis?

Shock

Volumn 37, Issue 1, 2012, Pages 124-125

  Gentile, Lori F ^a   Moldawer, Lyle L ^a  

^a UNIVERSITY OF FLORIDA COLLEGE OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

INFLAMMASOME; INTERLEUKIN 1 RECEPTOR BLOCKING AGENT; INTERLEUKIN 10; INTERLEUKIN 18; INTERLEUKIN 1BETA; INTERLEUKIN 1BETA CONVERTING ENZYME; INTERLEUKIN 1BETA CONVERTING ENZYME INHIBITOR; NUCLEOTIDE BINDING OLIGOMERIZATION DOMAIN LIKE RECEPTOR; TOLL LIKE RECEPTOR;

APOPTOSIS; BURN; CELL SURFACE; CYTOKINE PRODUCTION; DENDRITIC CELL; EDITORIAL; ENDOSOME; GOUT; HUMAN; INNATE IMMUNITY; MACROPHAGE; MUCKLE WELLS SYNDROME; NATURAL KILLER CELL; NONHUMAN; PROTECTION; RHEUMATOID ARTHRITIS; SEPSIS; SYSTEMIC LUPUS ERYTHEMATOSUS;

ANIMALS; BURNS; CASPASE 1; INFLAMMASOMES; LYMPHOCYTES; MALE; SPLEEN;

EID: 83655183626     PISSN: 10732322     EISSN: 15400514     Source Type: Journal    
DOI: 10.1097/SHK.0b013e31823b7643     Document Type: Editorial

References (10)

1. Lamkanfi M: Emerging inflammasome effector mechanisms. Nat Rev Immunol 11(3):213-220, 2011.
2. Vande Walle L, Lamkanfi M: Inflammasomes: caspase-1-activating platforms with critical roles in host defense. Front Microbiol 2:3, 2011.
3. Tschopp J, Schroder K: NLRP3 inflammasome activation: the convergence of multiple signalling pathways on ROS production? Nat Rev Immunol 10(3): 210-215, 2010.
4. Osuka A, Hanschen M, Stoecklein V, Lederer JA: A protective role for inflammasome activation following injury. Shock 37(1):47-55, 2011.
5. Li P, Allen H, Banerjee S, Franklin S, Herzog L, Johnston C, McDowell J, Paskind M, Rodman L, Salfeld J, et al: Mice deficient in IL-1 betaYconverting enzyme are defective in production of mature IL-1 beta and resistant to endotoxic shock. Cell 80(3):401-411, 1995.
6. Sarkar A, Hall MW, Exline M, Hart J, Knatz N, Gatson NT, Wewers MD: Caspase-1 regulates Escherichia coli sepsis and splenic B cell apoptosis independently of interleukin-1beta and interleukin-18. Am J Respir Crit Care Med 174(9):1003-1010, 2006. (Pubitemid 44684449)
7. Giamarellos-Bourboulis EJ, van de Veerdonk FL, Mouktaroudi M, Raftogiannis M, Antonopoulou A, Joosten LA, Pickkers P, Savva A, Georgitsi M, van der Meer JW, et al: Inhibition of caspase-1 activation in Gram-negative sepsis and experimental endotoxemia. Crit Care 15(1):R27, 2011.
8. van der Poll T, Marchant A, Buurman WA, Berman L, Keogh CV, Lazarus DD, Nguyen L, GoldmanM,Moldawer LL, Lowry SF: Endogenous IL-10 protects mice from death during septic peritonitis. J Immunol 155(11):5397-5401, 1995. (Pubitemid 3015364)
9. Kelly JL, O'Suilleabhain CB, Soberg CC, Mannick JA, Lederer JA: Severe injury triggers antigen-specific T-helper cell dysfunction. Shock 12(1):39-45, 1999.
10. KaraoǧlanA, Kaya E, Akdemir O, Saǧmanligil A, Bilguvar K, Cirakoǧlu B, Sahan E, Erdoǧan N, Barut AE, Colak A: Neuroprotective effects of Ac.YVAD.cmk on experimental spinal cord injury in rats. Surg Neurol 69(6):561-567, 2008.