Inhibition of human neutrophil elastase by pentacyclic triterpenes

PLoS ONE

Volumn 8, Issue 12, 2013, Pages

  Feng, Li ^a   Liu, Xiaoyu ^b   Zhu, Weiliang ^c   Guo, Fujiang ^a   Wu, Yingchun ^a   Wang, Rui ^a   Chen, Kaixian ^a,c   Huang, Cheng ^a   Li, Yiming ^a  

^a SHANGHAI UNIVERSITY OF TRADITIONAL CHINESE MEDICINE   (China)

^b SECOND MILITARY MEDICAL UNIVERSITY   (China)

^c SHANGHAI INSTITUTE OF MATERIA MEDICA   (China)

Author keywords

[No Author keywords available]

Indexed keywords

ASTRAGALOSIDE IV; BETULIC ACID; CIGARETTE SMOKE; GLYCYRRHETINIC ACID; GLYCYRRHIZIC ACID; LEUKOCYTE ELASTASE; LUPEOL; OLEANOLIC ACID; PENTACYCLIC TRITERPENE; SIVELESTAT; URSOLIC ACID; ASTRAGALOSIDE A; ENZYME INHIBITOR; GLYCINE; SAPONIN; SULFONAMIDE; TRITERPENE;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANTIINFLAMMATORY ACTIVITY; ARTICLE; COMPETITIVE INHIBITION; CONTROLLED STUDY; DRUG MECHANISM; DRUG POTENCY; DRUG SCREENING; DRUG STRUCTURE; ENZYME ACTIVITY; ENZYME INHIBITION; ENZYME INHIBITION ASSAY; FEMALE; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; HUMAN; HUMAN CELL; IC 50; IN VITRO STUDY; IN VIVO STUDY; INHIBITION KINETICS; MASS SPECTROMETRY; MOLECULAR DOCKING; MOUSE; MOUSE MODEL; NONHUMAN; NUCLEAR MAGNETIC RESONANCE SPECTROSCOPY; PNEUMONIA; ANALOGS AND DERIVATIVES; ANIMAL; ANTAGONISTS AND INHIBITORS; BAGG ALBINO MOUSE; CHEMISTRY; DISEASE MODEL; KINETICS; METABOLISM; PROTON NUCLEAR MAGNETIC RESONANCE; SMOKING;

ANIMALS; DISEASE MODELS, ANIMAL; ENZYME INHIBITORS; FEMALE; GLYCINE; HUMANS; KINETICS; LEUKOCYTE ELASTASE; MICE, INBRED BALB C; MOLECULAR DOCKING SIMULATION; PENTACYCLIC TRITERPENES; PNEUMONIA; PROTON MAGNETIC RESONANCE SPECTROSCOPY; SAPONINS; SMOKING; SULFONAMIDES; TRITERPENES;

EID: 84893387587     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0082794     Document Type: Article

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