Mechanism of maprotiline-induced apoptosis: Role of [Ca2+]i, ERK, JNK and caspase-3 signaling pathways

Toxicology

Volumn 304, Issue , 2013, Pages 1-12

  Jan, Chung Ren ^a   Su, Jian An ^b,c   Teng, Chih Chuan ^c,d   Sheu, Meei Ling ^e,f   Lin, Paul Yann ^b   Chi, Miao Ching ^c   Chang, Chia Hao ^c   Liao, Wayne C ^c   Kuo, Chun Chi ^g   Chou, Chiang Ting ^c  

^a KAOHSIUNG VETERANS GENERAL HOSPITAL   (Taiwan)

^b CHANG GUNG MEMORIAL HOSPITAL   (Taiwan)

^c CHANG GUNG UNIVERSITY OF SCIENCE AND TECHNOLOGY   (Taiwan)

^d NATIONAL CHENG KUNG UNIVERSITY   (Taiwan)

^e NATIONAL CHUNG HSING UNIVERSITY   (Taiwan)

^f TAICHUNG VETERANS GENERAL HOSPITAL   (Taiwan)

^g TZU HUI INSTITUTE OF TECHNOLOGY   (Taiwan)

Author keywords

Apoptosis; Calcium; JNK; Maprotiline; Neuro 2a cells

Indexed keywords

CALCIUM ION; CASPASE 3; ETHYLENE GLYCOL 1,2 BIS(2 AMINOPHENYL) ETHER N,N,N',N' TETRAACETIC ACID; MAPROTILINE; MITOGEN ACTIVATED PROTEIN KINASE; STRESS ACTIVATED PROTEIN KINASE;

ANTINEOPLASTIC ACTIVITY; APOPTOSIS; ARTICLE; CALCIUM CELL LEVEL; CALCIUM MOBILIZATION; CELL VIABILITY; CONCENTRATION RESPONSE; CONTROLLED STUDY; DRUG CYTOTOXICITY; ENDOPLASMIC RETICULUM; ENZYME ACTIVATION; ENZYME INACTIVATION; ENZYME PHOSPHORYLATION; HUMAN; HUMAN CELL; INTRACELLULAR SIGNALING; NEUROBLASTOMA CELL; PRIORITY JOURNAL;

ADRENERGIC UPTAKE INHIBITORS; ANIMALS; ANTIDEPRESSIVE AGENTS, SECOND-GENERATION; APOPTOSIS; CALCIUM; CALCIUM SIGNALING; CASPASE 3; CELL LINE, TUMOR; CELL SURVIVAL; DOSE-RESPONSE RELATIONSHIP, DRUG; EGTAZIC ACID; ENDOPLASMIC RETICULUM; EXTRACELLULAR SIGNAL-REGULATED MAP KINASES; JNK MITOGEN-ACTIVATED PROTEIN KINASES; MAPROTILINE; MICE; NEUROBLASTOMA; PHOSPHORYLATION; SIGNAL TRANSDUCTION; TIME FACTORS;

EID: 84871599178     PISSN: 0300483X     EISSN: 18793185     Source Type: Journal    
DOI: 10.1016/j.tox.2012.11.013     Document Type: Article

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