Desipramine-induced apoptosis in human PC3 prostate cancer cells: Activation of JNK kinase and caspase-3 pathways and a protective role of [Ca2+]i elevation

Toxicology

Volumn 250, Issue 1, 2008, Pages 9-14

  Chang, Hong Chiang ^a   Huang, Chorng Chih ^b   Huang, Chun Jen ^c,d   Cheng, Jin Shiung ^e   Liu, Shiuh In ^f   Tsai, Jeng Yu ^f   Chang, Hong Tai ^f   Huang, Jong Khing ^f   Chou, Chiang Ting ^f   Jan, Chung Ren ^f  

^a NATIONAL TAIWAN UNIVERSITY   (Taiwan)

^b TZU HUI INSTITUTE OF TECHNOLOGY   (Taiwan)

^c KAOHSIUNG MEDICAL UNIVERSITY   (Taiwan)

^d KAOHSIUNG MEDICAL UNIVERSITY HOSPITAL   (Taiwan)

^e Yongkang Veterans Hospital   (Taiwan)

^f KAOHSIUNG VETERANS GENERAL HOSPITAL   (Taiwan)

Author keywords

Apoptosis; Caspase 3; Desipramine; MAPKs; PC3 cells; Prostate

Indexed keywords

ANTHRA[1,9 CD]PYRAZOL 6(2H) ONE; CALCIUM; CASPASE 3; DESIPRAMINE; MITOGEN ACTIVATED PROTEIN KINASE P38; STRESS ACTIVATED PROTEIN KINASE;

APOPTOSIS; ARTICLE; CANCER CELL; CELL VIABILITY; CONTROLLED STUDY; DRUG ACTIVITY; HUMAN; HUMAN CELL; IMMUNOBLOTTING; PRIORITY JOURNAL; PROSTATE CANCER; PROTEIN PHOSPHORYLATION;

ANTIDEPRESSIVE AGENTS, TRICYCLIC; APOPTOSIS; CALCIUM; CASPASE 3; CELL LINE, TUMOR; CELL SURVIVAL; CYTOSOL; DESIPRAMINE; DOSE-RESPONSE RELATIONSHIP, DRUG; HUMANS; IMMUNOBLOTTING; JNK MITOGEN-ACTIVATED PROTEIN KINASES; MALE; PHOSPHORYLATION; PROSTATIC NEOPLASMS;

EID: 47849107996     PISSN: 0300483X     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.tox.2008.05.010     Document Type: Article

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