Dexamethasone protects auditory hair cells against TNFα-initiated apoptosis via activation of PI3K/Akt and NFκB signaling

Hearing Research

Volumn 255, Issue 1-2, 2009, Pages 22-32

  Haake, Scott M ^a   Dinh, Christine T ^a   Chen, Shibing ^a   Eshraghi, Adrien A ^a   Van De Water, Thomas R ^a  

^a UNIVERSITY OF MIAMI EAR INSTITUTE   (United States)

Author keywords

Apoptosis; Auditory hair cells; Dexamethasone; Nuclear factor kappa B; Organ of Corti explants; Otoprotection; Tumor necrosis factor alpha

Indexed keywords

2 MORPHOLINO 8 PHENYLCHROMONE; CASPASE INHIBITOR; DEXAMETHASONE; FLUORESCEIN ISOTHIOCYANATE; GLUCOCORTICOID RECEPTOR; I KAPPA B; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; MIFEPRISTONE; PHALLOIDIN; PHOSPHATIDYLINOSITOL 3 KINASE; PROTEIN KINASE B; RECOMBINANT TUMOR NECROSIS FACTOR ALPHA;

ANIMAL CELL; ANIMAL TISSUE; APOPTOSIS; ARTICLE; CELL COUNT; CELL LABELING; CELL PROTECTION; CELL SURVIVAL; CONCENTRATION RESPONSE; CONTROLLED STUDY; CORTI ORGAN; DRUG EFFICACY; DRUG MECHANISM; ENZYME ACTIVATION; EXPLANT; HAIR CELL; IN VITRO STUDY; NONHUMAN; OTOTOXICITY; PRIORITY JOURNAL; RAT; SIGNAL TRANSDUCTION;

ANIMALS; APOPTOSIS; BENZYL COMPOUNDS; CASPASES; DEXAMETHASONE; DOSE-RESPONSE RELATIONSHIP, DRUG; HAIR CELLS, AUDITORY; HYDROCARBONS, FLUORINATED; NF-KAPPA B; PHOSPHATIDYLINOSITOL 3-KINASES; PROTO-ONCOGENE PROTEINS C-AKT; RATS; RATS, SPRAGUE-DAWLEY; RECEPTORS, GLUCOCORTICOID; SIGNAL TRANSDUCTION; TUMOR NECROSIS FACTOR-ALPHA;

EID: 67849118625     PISSN: 03785955     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.heares.2009.05.003     Document Type: Article

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