Pharmacophore model refinement for 11β-hydroxysteroid dehydrogenase inhibitors: Search for modulators of intracellular glucocorticoid concentrations

Molecular Informatics

Volumn 33, Issue 1, 2014, Pages 15-25

  Vuorinen, Anna ^a   Nashev, Lyubomir G ^b   Odermatt, Alex ^b   Rollinger, Judith M ^a   Schuster, Daniela ^a  

^a UNIVERSITY OF INNSBRUCK   (Austria)

^b UNIVERSITY OF BASEL   (Switzerland)

Author keywords

11 Hydroxysteroid dehydrogenase; Enzyme inhibitor; Model refinement; Pharmacophore model; Virtual screening

Indexed keywords

INDIUM COMPOUNDS; PHARMACODYNAMICS; QUALITY CONTROL;

11Β-HYDROXYSTEROID DEHYDROGENASE; DRUG DISCOVERY; ENZYME INHIBITORS; GLUCOCORTICOIDS; HYDROXYSTEROID DEHYDROGENASE; INTRACELLULAR CONCENTRATION; METABOLIC SYNDROMES; MODEL REFINEMENT; PHARMACOPHORE MODELS; VIRTUAL SCREENING;

ENZYME ACTIVITY;

11BETA HYDROXYSTEROID DEHYDROGENASE; CEFDINIR; CEFTRIAXONE; CEPHAELINE; CYCLOSPORIN; DIGITOXIGENIN; DOBUTAMINE; ETACRYNIC ACID; FENOFIBRATE; FUROSEMIDE; GLUCOCORTICOID ANTAGONIST; GLYCEROL OLEATE; GOSSYPOL; HECOGENIN; IBUPROFEN; INDOMETACIN; IOPRONIC ACID; KETOCONAZOLE; LASALOCID; LIDOFLAZINE; NOVOBIOCIN; PHTHALYLSULFATHIAZOLE; RAPAMYCIN; RIFAMPICIN; SPIRONOLACTONE; TRITERPENOID;

ARTICLE; BINDING SITE; COMPARATIVE STUDY; COMPUTER MODEL; CONTROLLED STUDY; DRUG SCREENING; ENZYME ACTIVITY; ENZYME INHIBITION; HYDROGEN BOND; PHARMACOPHORE; PRIORITY JOURNAL; TOTAL QUALITY MANAGEMENT;

EID: 84893215166     PISSN: 18681743     EISSN: 18681751     Source Type: Journal    
DOI: 10.1002/minf.201300063     Document Type: Article

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