Forms and functions of human SDR enzymes

Chemico-Biological Interactions

Volumn 130-132, Issue , 2001, Pages 699-705

  Oppermann, Udo C T ^a   Filling, Charlotta ^a   Jörnvall, Hans ^a  

^a KAROLINSKA INSTITUTE   (Sweden)

Author keywords

Human genome project; Hydroxysteroid dehydrogenases; Short chain dehydrogenases reductases

Indexed keywords

OXIDOREDUCTASE;

CONFERENCE PAPER; ENZYME ANALYSIS; ENZYME METABOLISM; HORMONE METABOLISM; HUMAN; OPEN READING FRAME; SEQUENCE ANALYSIS; SEQUENCE HOMOLOGY;

ALCOHOL DEHYDROGENASE; AMINO ACID MOTIFS; AMINO ACID SEQUENCE; CATALYTIC DOMAIN; CHROMOSOME MAPPING; CONSERVED SEQUENCE; DATABASES, FACTUAL; DISEASE; HUMANS; OPEN READING FRAMES; PROTEIN FOLDING; XENOBIOTICS;

EID: 0035969860     PISSN: 00092797     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0009-2797(00)00301-X     Document Type: Conference Paper

References (20)

1. Alcohol and polyol dehydrogenases are both divided into two protein types, and structural properties cross-relate the different enzyme activities within each type
2. Characteristics of short-chain alcohol dehydrogenases and related enzymes
3. Short-chain dehydrogenases/reductases (SDR)
4. A super-family of medium-chain dehydrogenases/reductases (MDR). Sub-lines including zeta-crystallin, alcohol and polyoldehydrogenases, quinone oxidoreductase enoyl reductases, VAT-1 and other proteins
5. Structure-function relationships of SDR hydroxysteroid dehydrogenases
6. Three-dimensional structure of holo 3α,20β-hydroxysteroid dehydrogenase, a member of a short-chain dehydrogenase family
7. The refined crystal structure of Drosophila lebanonensis alcohol dehydrogenase at 1.9 A resolution
8. 17β-hydroxysteroid dehydrogenase (HSD)/17-ketosteroid reductase (KSR) family; nomenclature and main characteristics of the 17HSD/KSR enzymes
9. Basic local alignment search tool
10. SDR and MDR: Completed genome sequences show these protein families to be large, of old origin, and of complex nature
11. Human UDP-galactose 4′ epimerase (GALE) gene and identification of five missense mutations in patients with epimerase-deficiency galactosemia
12. Dihydropteridine reductase deficiency: Physical structure of the QDPR gene, identification of two new mutations and genotype-phenotype correlations
13. Intrinsic alcohol dehydrogenase and hydroxysteroid dehydrogenase activities of human mitochondrial short-chain L-3-hydroxyacyl-CoA dehydrogenase
14. Molecular and structural aspects of xenobiotic carbonyl metabolizing enzymes. Role of reductases and dehydrogenases in xenobiotic phase I reactions
15. Role of type-1 11β-hydroxysteroid dehydrogenase in detoxification processes
16. Expression of human and rat carbonyl reductase in E. coli. Comparison of the recombinant enzymes
17. Families of retinoid dehydrogenases regulating vitamin A function. Production of visual pigment and retinoic acid
18. Identification of novel human genes evolutionarily conserved in caenorhabditis elegans by comparative proteomics
19. A nuclear protein, synthesized in growth-arrested human hepatoblastoma cells, is a novel member of the short-chain alcohol dehydrogenase family
20. FVT-1, a novel human transcription unit affected by variant translocation t(2;18)(p11;q21) of follicular lymphoma