Masked selection: A straightforward and flexible approach for the selection of binders against specific epitopes and differentially expressed proteins by phage display

Molecular and Cellular Proteomics

Volumn 13, Issue 2, 2014, Pages 653-665

  Even Desrumeaux, Klervi ^a,b,c,d   Nevoltris, Damien ^a,b,c,d   Noelle Lavaut, Marie ^a,b,c,d   Alim, Karima ^a,b,c,d   Borg, Jean Paul ^a,b,c,d   Audebert, Stephane ^a,b,c,d   Kerfelec, Brigitte ^a,b,c,d   Baty, Daniel ^a,b,c,d   Chames, Patrick ^a,b,c,d  

^a AIX MARSEILLE UNIVERSITY   (France)

^b INSTITUT PAOLI CALMETTES   (France)

^c AIX MARSEILLE UNIVERSITY   (France)

^d CNRS   (France)

Author keywords

[No Author keywords available]

Indexed keywords

CD71 ANTIGEN; CELL ADHESION MOLECULE; CELL SURFACE MARKER; CELL SURFACE RECEPTOR; CHEMOKINE RECEPTOR CXCR4; EPIDERMAL GROWTH FACTOR RECEPTOR 2; EPITHELIAL CELL ADHESION MOLECULE; EPITOPE; FC RECEPTOR; G PROTEIN COUPLED RECEPTOR; HYBRID PROTEIN; METABOTROPIC RECEPTOR 4; NANOBODY; PROTEIN; RECOMBINANT PROTEIN; TUMOR MARKER; TYROSINE KINASE RECEPTOR;

ANTIGEN BINDING; ARTICLE; BREAST CANCER; CELL LINE; CONTROLLED STUDY; FEMALE; GENETIC TRANSFECTION; HUMAN; HUMAN CELL; IMMUNOLOGICAL PROCEDURES; IMMUNOPRECIPITATION; MASKED SELECTION; MASS SPECTROMETRY; PHAGE DISPLAY; PRIORITY JOURNAL; PROTEIN EXPRESSION;

ANTIGENS; BREAST NEOPLASMS; CELL LINE, TUMOR; CELL SURFACE DISPLAY TECHNIQUES; EPITOPE MAPPING; EPITOPES; FEMALE; HEK293 CELLS; HELA CELLS; HT29 CELLS; HUMANS; IMMUNOPRECIPITATION; JURKAT CELLS; MCF-7 CELLS; PROTEIN BINDING; PROTEINS; PROTEOMICS;

EID: 84893209668     PISSN: 15359476     EISSN: 15359484     Source Type: Journal    
DOI: 10.1074/mcp.O112.025486     Document Type: Article

References (48)

1. Kohler, G., and Milstein, C. (1975) Continuous cultures of fused cells secreting antibody of predefined specificity. Nature 256, 495-497
2. McCafferty, J., Griffiths, A. D., Winter, G., and Chiswell, D. J. (1990) Phage antibodies: filamentous phage displaying antibody variable domains. Nature 348, 552-554
3. Weiner, L. M. (2006) Fully human therapeutic monoclonal antibodies. J. Immunother. 29, 1-9
4. Hoogenboom, H. R. (2005) Selecting and screening recombinant antibody libraries. Nat. Biotechnol. 23, 1105-1116
5. Ngai, P. K., Ackermann, F., Wendt, H., Savoca, R., and Bosshard, H. R. (1993) Protein A antibody-capture ELISA (PACE): an ELISA format to avoid denaturation of surface-adsorbed antigens. J. Immunol. Methods 158, 267-276
6. Siva, A. C., Kirkland, R. E., Lin, B., Maruyama, T., McWhirter, J., Yantiri- Wernimont, F., Bowdish, K. S., and Xin, H. (2008) Selection of anticancer antibodies from combinatorial libraries by whole-cell panning and stringent subtraction with human blood cells. J. Immunol. Methods 330, 109-119
7. Even-Desrumeaux, K., Fourquet, P., Secq, V., Baty, D., and Chames, P. (2012) Single-domain antibodies: a versatile and rich source of binders for breast cancer diagnostic approaches. Mol. Biosyst. 8, 2385-2394
8. Veggiani, G., Ossolengo, G., Aliprandi, M., Cavallaro, U., and de Marco, A. (2011) Single-domain antibodies that compete with the natural ligand fibroblast growth factor block the internalization of the fibroblast growth factor receptor 1. Biochem. Biophys. Res. Commun. 408, 692-696
9. Stefan, N., Martin-Killias, P., Wyss-Stoeckle, S., Honegger, A., Zangemeister- Wittke, U., and Pluckthun, A. (2011) DARPins recognizing the tumorassociated antigen EpCAM selected by phage and ribosome display and engineered for multivalency. J. Mol. Biol. 413, 826-843
10. Liew, P. X., Ge, F., Gullo, C., Teoh, G. K., and Hwang, W. Y. (2009) Use of phage display to isolate specific human monoclonal antibody fragments against a potential target for multiple myeloma. Ann. Acad. Med. Singapore 38, 621-629
11. Omidfar, K., Rasaee, M. J., Modjtahedi, H., Forouzandeh, M., Taghikhani, M., and Golmakani, N. (2004) Production of a novel camel single-domain antibody specific for the type III mutant EGFR. Tumour Biol. 25, 296-305
12. Mazuet, C., Lerouge, D., Poul, M. A., and Blin, N. (2006) Breast carcinoma specific antibody selection combining phage display and immunomagnetic cell sorting. Biochem. Biophys. Res. Commun. 348, 550-559
13. Nielsen, U. B., and Marks, J. D. (2000) Internalizing antibodies and targeted cancer therapy: direct selection from phage display libraries. Pharm. Sci. Technolo. Today 3, 282-291
14. Behar, G., Chames, P., Teulon, I., Cornillon, A., Alshoukr, F., Roquet, F., Pugniere, M., Teillaud, J. L., Gruaz-Guyon, A., Pelegrin, A., and Baty, D. (2009) Llama single-domain antibodies directed against nonconventional epitopes of tumor-associated carcinoembryonic antigen absent from nonspecific cross-reacting antigen. FEBS J. 276, 3881-3893
15. Roovers, R. C., van der Linden, E., de Bruine, A. P., Arends, J. W., and Hoogenboom, H. R. (2001) Identification of colon tumour-associated antigens by phage antibody selections on primary colorectal carcinoma. Eur. J. Cancer 37, 542-549
16. Jensen, K. B., Jensen, O. N., Ravn, P., Clark, B. F., and Kristensen, P. (2003) Identification of keratinocyte-specific markers using phage display and mass spectrometry. Mol. Cell. Proteomics 2, 61-69
17. Geuijen, C. A., Bijl, N., Smit, R. C., Cox, F., Throsby, M., Visser, T. J., Jongeneelen, M. A., Bakker, A. B., Kruisbeek, A. M., Goudsmit, J., and de Kruif, J. (2005) A proteomic approach to tumour target identification using phage display, affinity purification and mass spectrometry. Eur. J. Cancer 41, 178-187
18. Rozan, C., Cornillon, A., Petiard, C., Chartier, M., Behar, G., Boix, C., Kerfelec, B., Robert, B., Pelegrin, A., Chames, P., Teillaud, J. L., and Baty, D. (2013) Single-Domain Antibody-Based and Linker-Free Bispecific Antibodies Targeting FcgammaRIII Induce Potent Antitumor Activity without Recruiting Regulatory T Cells. Mol. Cancer Ther. 12, 1481-1491
19. Even-Desrumeaux, K., Baty, D., and Chames, P. (2010) Strong and oriented immobilization of single domain antibodies from crude bacterial lysates for high-throughput compatible cost-effective antibody array generation. Mol. Biosyst. 6, 2241-2248
20. Alvarez-Rueda, N., Behar, G., Ferre, V., Pugniere, M., Roquet, F., Gastinel, L., Jacquot, C., Aubry, J., Baty, D., Barbet, J., and Birkle, S. (2007) Generation of llama single-domain antibodies against methotrexate, a prototypical hapten. Mol. Immunol. 44, 1680-1690
21. Shevchenko, A., Wilm, M., Vorm, O., and Mann, M. (1996) Mass spectrometric sequencing of proteins silver-stained polyacrylamide gels. Anal. Chem. 68, 850-858
22. Belotti, E., Puvirajesinghe, T. M., Audebert, S., Baudelet, E., Camoin, L., Pierres, M., Lasvaux, L., Ferracci, G., Montcouquiol, M., and Borg, J. P. (2012) Molecular characterisation of endogenous Vangl2/Vangl1 heteromeric protein complexes. PLoS One 7, e46213
23. Muyldermans, S. (2001) Single domain camel antibodies: current status. J. Biotechnol. 74, 277-302
24. Harmsen, M. M., and De Haard, H. J. (2007) Properties, production, and applications of camelid single-domain antibody fragments. Appl. Microbiol. Biotechnol. 77, 13-22
25. Cho, H. S., Mason, K., Ramyar, K. X., Stanley, A. M., Gabelli, S. B., Denney, D. W., Jr., and Leahy, D. J. (2003) Structure of the extracellular region of HER2 alone and in complex with the Herceptin Fab. Nature 421, 756-760
26. Bessis, A. S., Bertrand, H. O., Galvez, T., De Colle, C., Pin, J. P., and Acher, F. (2000) Three-dimensional model of the extracellular domain of the type 4a metabotropic glutamate receptor: new insights into the activation process. Protein Sci. 9, 2200-2209
27. Wu, B., Chien, E. Y., Mol, C. D., Fenalti, G., Liu, W., Katritch, V., Abagyan, R., Brooun, A., Wells, P., Bi, F. C., Hamel, D. J., Kuhn, P., Handel, T. M., Cherezov, V., and Stevens, R. C. (2010) Structures of the CXCR4 chemokine GPCR with small-molecule and cyclic peptide antagonists. Science 330, 1066-1071
28. Degorce, F., Card, A., Soh, S., Trinquet, E., Knapik, G. P., and Xie, B. (2009) HTRF: A technology tailored for drug discovery - a review of theoretical aspects and recent applications. Curr. Chem. Genomics 3, 22-32
29. Beiboer, S. H., Reurs, A., Roovers, R. C., Arends, J. W., Whitelegg, N. R., Rees, A. R., and Hoogenboom, H. R. (2000) Guided selection of a pan carcinoma specific antibody reveals similar binding characteristics yet structural divergence between the original murine antibody and its human equivalent. J. Mol. Biol. 296, 833-849
30. Figini, M., Obici, L., Mezzanzanica, D., Griffiths, A., Colnaghi, M. I., Winter, G., and Canevari, S. (1998) Panning phage antibody libraries on cells: isolation of human Fab fragments against ovarian carcinoma using guided selection. Cancer Res. 58, 991-996
31. Simon, M., Stefan, N., Pluckthun, A., and Zangemeister-Wittke, U. (2013) Epithelial cell adhesion molecule-targeted drug delivery for cancer therapy. Expert Opin. Drug Delivery 10, 451-468
32. Gastl, G., Spizzo, G., Obrist, P., Dunser, M., and Mikuz, G. (2000) Ep-CAM overexpression in breast cancer as a predictor of survival. Lancet 356, 1981-1982
33. Schmidt, M., Hasenclever, D., Schaeffer, M., Boehm, D., Cotarelo, C., Steiner, E., Lebrecht, A., Siggelkow, W., Weikel, W., Schiffer-Petry, I., Gebhard, S., Pilch, H., Gehrmann, M., Lehr, H. A., Koelbl, H., Hengstler, J. G., and Schuler, M. (2008) Prognostic effect of epithelial cell adhesion molecule overexpression in untreated node-negative breast cancer. Clin. Cancer Res. 14, 5849-5855
34. Allard, W. J., Matera, J., Miller, M. C., Repollet, M., Connelly, M. C., Rao, C., Tibbe, A. G., Uhr, J. W., and Terstappen, L. W. (2004) Tumor cells circulate in the peripheral blood of all major carcinomas but not in healthy subjects or patients with nonmalignant diseases. Clin. Cancer Res. 10, 6897-6904
35. Pantel, K., Brakenhoff, R. H., and Brandt, B. (2008) Detection, clinical relevance and specific biological properties of disseminating tumour cells. Nat. Rev. Cancer 8, 329-340
36. Daniels, T. R., Delgado, T., Rodriguez, J. A., Helguera, G., and Penichet, M. L. (2006) The transferrin receptor part I: Biology and targeting with cytotoxic antibodies for the treatment of cancer. Clin. Immunol. 121, 144-158
37. Yang, D. C., Wang, F., Elliott, R. L., and Head, J. F. (2001) Expression of transferrin receptor and ferritin H-chain mRNA are associated with clinical and histopathological prognostic indicators in breast cancer. Anticancer Res. 21, 541-549
38. Jian, J., Yang, Q., and Huang, X. (2011) Src regulates Tyr(20) phosphorylation of transferrin receptor-1 and potentiates breast cancer cell survival. J. Biol. Chem. 286, 35708-35715
39. Lehmann, J. M., Holzmann, B., Breitbart, E. W., Schmiegelow, P., Riethmuller, G., and Johnson, J. P. (1987) Discrimination between benign and malignant cells of melanocytic lineage by two novel antigens, a glycoprotein with a molecular weight of 113,000 and a protein with a molecular weight of 76,000. Cancer Res. 47, 841-845
40. Bidlingmaier, S., He, J., Wang, Y., An, F., Feng, J., Barbone, D., Gao, D., Franc, B., Broaddus, V. C., and Liu, B. (2009) Identification of MCAM/ CD146 as the target antigen of a human monoclonal antibody that recognizes both epithelioid and sarcomatoid types of mesothelioma. Cancer Res. 69, 1570-1577
41. Zigler, M., Villares, G. J., Dobroff, A. S., Wang, H., Huang, L., Braeuer, R. R., Kamiya, T., Melnikova, V. O., Song, R., Friedman, R., Alani, R. M., and Bar-Eli, M. (2011) Expression of Id-1 is regulated by MCAM/MUC18: a missing link in melanoma progression. Cancer Res. 71, 3494-3504
42. Zeng, G. F., Cai, S. X., and Wu, G. J. (2011) Up-regulation of METCAM/ MUC18 promotes motility, invasion, and tumorigenesis of human breast cancer cells. BMC Cancer 11, 113
43. Camby, I., Le Mercier, M., Lefranc, F., and Kiss, R. Galectin-1: a small protein with major functions. Glycobiology 16, 137R-157R, 2006
44. Watson, A. P., Evans, R. L., and Egland, K. A. (2013) Multiple functions of sushi domain containing 2 (SUSD2) in breast tumorigenesis. Mol. Cancer Res. 11, 74-85
45. Siolas, D., and Hannon, G. J. (2013) Patient-Derived Tumor Xenografts: Transforming Clinical Samples into Mouse Models. Cancer Res. 73, 5315-5319
46. Stumpp, M. T., and Amstutz, P. (2007) DARPins: a true alternative to antibodies. Curr. Opin. Drug Discov. Devel. 10, 153-159
47. Gebauer, M., and Skerra, A. (2009) Engineered protein scaffolds as nextgeneration antibody therapeutics. Curr. Opin. Chem. Biol. 13, 245-255
48. Zahnd, C., Amstutz, P., and Pluckthun, A. (2007) Ribosome display: selecting and evolving proteins in vitro that specifically bind to a target. Nat. Methods 4, 269-279