Panning phage antibody libraries on cells: Isolation of human Fab fragments against ovarian carcinoma using guided selection

Cancer Research

Volumn 58, Issue 5, 1998, Pages 991-996

  Figini, Mariangela ^a   Obici, Laura ^a,c   Mezzanzanica, Delia ^a   Griffiths, Andrew ^b   Colnaghi, Maria I ^a   Winter, Greg ^b   Canevari, Silvana ^a  

^a NATIONAL CANCER INSTITUTE   (Italy)

^b MRC LABORATORY OF MOLECULAR BIOLOGY   (United Kingdom)

^c FONDAZIONE IRCCS POLICLINICO SAN MATTEO   (Italy)

Author keywords

[No Author keywords available]

Indexed keywords

CANCER ANTIBODY; FOLATE BINDING PROTEIN; IMMUNOGLOBULIN F(AB) FRAGMENT; MONOCLONAL ANTIBODY; TUMOR ANTIGEN;

ARTICLE; CANCER IMMUNOTHERAPY; CELL SURFACE; CONTROLLED STUDY; DNA SEQUENCE; ENZYME LINKED IMMUNOSORBENT ASSAY; FLOW CYTOMETRY; HUMAN; HUMAN CELL; IMMUNOPRECIPITATION; NUCLEOTIDE SEQUENCE; OVARY CARCINOMA; PHAGE DISPLAY; PRIORITY JOURNAL;

AMINO ACID SEQUENCE; ANIMALS; ANTIBODIES, MONOCLONAL; ANTIBODIES, NEOPLASM; BACTERIOPHAGES; CARCINOMA; FEMALE; GENE LIBRARY; HUMANS; IMMUNOGLOBULIN FAB FRAGMENTS; MICE; MOLECULAR SEQUENCE DATA; OVARIAN NEOPLASMS; PEPTIDE LIBRARY;

EID: 0032031738     PISSN: 00085472     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (51)

1. Maeda, M., and Firtel, R. A. Activation of the mitogen-activated protein kinase ERK2 by the chemoattractant folic acid in dictyostelium. J. Biol. Chem., 272: 23690-23695, 1997.
2. Reithmuller, G., Schneider-Gadicke, E., and Johnson, J. P. Monoclonal antibodies in cancer therapy. Curr. Opin. Immunol., 5: 732-739, 1993.
3. Khazaeli, M. B., Conry, R. M., and LoBuglio, A. F. Human immune response to monoclonal antibodies. J. Immunother., 15: 42-52, 1994.
4. De Kruif, J., Van der Vuurst de Vries, L., Cilenti, L., Boel, E., Van Ewijk, W., and Logtenberg, T. New perspectives on recombinant human antibodies. Immunol. Today, 17: 453-455, 1996.
5. Chester, K. A., and Hawkins, R. E. Clinical issues in antibody design. Trends Biotechnol., 13: 294-300, 1995.
6. Jain, R. K. Physiological barriers to delivery of monoclonal antibodies and other macromolecules in tumors. Cancer Res., 50 (Suppl 3): 814s-819s, 1990.
7. Marks, J. D., Hoogenboom, H. R., Bonnert, T. P., McCafferty, J., Griffiths, A. D., and Winter, G. By-passing immunization: human antibodies from V-gene libraries displayed on phage. J. Mol. Biol., 222: 581-597, 1991.
8. Hoogenboom, H. R., and Winter, G. Bypassing immunization: human antibodies from synthetic repertoires of germ line VH-gene segments rearranged in vitro. J. Mol. Biol., 227: 381-388, 1992.
9. Nissim, A., Hoogenboom, H. R., Tomlinson, I. M., Flynn, G., Midgley, C., Lane, D., and Winter, G. Antibody fragments from a "single pot" phage display library as immunochemical reagents. EMBO J., 13: 692-698, 1994.
10. Hoogenboom, H. R., Griffiths, A. D., Johnson, K. S., Chiswell, D. J., Hudson, P., and Winter, G. Multi-subunit proteins on the surface of filamentous phage: methodologies for displaying antibody (Fab) heavy and light chains. Nucleic Acids Res., 19: 4133-4137, 1991.
11. Marks, J. D., Ouwehand, W. H., Bye, J. M., Finnern, R., Gorick, B. D., Voak, D., Thorpe, S., Hughes-Jones, N. C., and Winter, G. Human antibody fragments specific for human blood group antigens from a phage display library. Bio/Technology, 11: 1145-1149, 1993.
12. De Kruif, J., Terstappen, L., Boel, E., and Logtenberg, T. Rapid selection of cell subpopulation-specific human monoclonal antibodies from a synthetic phage antibody library. Proc. Natl. Acad. Sci. USA, 92: 3938-3942, 1995.
13. Cai, X., and Garen, A. Anti-melanoma antibodies from melanoma patients immunized with genetically modified autologous tumor cells: selection of specific antibodies from single-chain Fv fusion phage libraries. Proc. Natl. Acad. Sci. USA, 92: 6537-6541, 1995.
14. Miotti, S., Canevari, S., Ménard, S., Mezzanzanica, D., Porro, G., Pupa, S. M., Regazzoni, M., Tagliabue, E., and Colnaghi, M. I. Characterization of human ovarian carcinoma-associated antigens defined by novel monoclonal antibodies with tumor-restricted specificity. Int. J. Cancer, 39: 297-303, 1987.
15. Luhrs, C. A. A human membrane-associated folate binding protein is anchored by a glycosyl-phosphatidylinositol tail. J. Biol. Chem., 264: 21446-21449, 1989.
16. Lacey, S. W., Sanders, J. M., Rothberg, K. G., Anderson, R. G. W., and Kamen, B. A. Complementary DNA for the folate binding protein correctly predicts anchoring to the membrane by glycosyl-phosphatidylinositol. J. Clin. Invest., 84: 715-720, 1989.
17. Alberti, S., Miotti, S., Fornaro, M., Mantovani, L., Walter, S., Canevari, S., Ménard, S., and Colnaghi, M. I. The Ca-MOv18 molecule, a cell-surface marker of human ovarian carcinomas, is anchored to the cell membrane by phosphatidylinositol. Biochem. Biophys. Res. Commun., 171: 1051-1055, 1990.
18. Toffoli, G., Cernigoi, C., Russo, A., Gallo, A., Bagnoli, M., and Boiocchi, M. Overexpression of folate binding protein in ovarian cancers. Int. J. Cancer, 74: 193-198, 1997.
19. Ross, J. F., Chaudhuri, P. K., and Ratnam, M. Differential regulation of folate receptor isoforms in normal and malignant tissues in vivo and in established cell lines: physiologic and clinical implications. Cancer (Phila.), 73: 2432-2443, 1994.
20. Veggian, R., Fasolato, S., Ménard, S., Minucci, D., Pizzetti, P., Regazzoni, M., Tagliabue, E., and Colnaghi, M. I. Immunohistochemical reactivity of a monoclonal antibody prepared against human ovarian carcinoma on normal and pathological female genital tissues. Tumori, 75: 510-513, 1989.
21. Boerman, O. C., Van Niekerk, C. C., Makkink, K., Hanselaar, T. G. J. M., Kenemans, P., and Poels, L. G. Comparative immunohistochemical study of four monoclonal antibodies directed against ovarian carcinoma-associated antigens. Int. J. Gynecol. Pathol., 10: 15-25, 1991.
22. Mantovani, L. T., Miotti, S., Ménard, S., Canevari, S., Raspagliesi, F., Bottini, C., Bottero, F., and Colnaghi, M. I. Folate binding protein distribution in normal tissues and biological fluids from ovarian carcinoma patients as detected by the monoclonal antibodies MOv18 and MOv19. Eur. J. Cancer. 30A: 363-369, 1994.
23. Canevari, S., Stoter, G., Arienti, F., Bolis, G., Colnaghi, M. I., Di Re, E., Eggermont, A. M. M., Goey, S. H., Gratama, J. W., Lamers, C. H. J., Nooy, M. A., Parmiani, G., Raspagliesi, F., Ravagnani, F., Scarfone, G., Trimbos, J. B., Wamaar, S. O., and Bolhuis, R. L. H. Regression of advanced ovarian carcinoma by intraperitoneal treatment with autologous T-lymphocytes retargeted by a bispecific monoclonal antibody. J. Natl. Cancer Inst., 87: 1463-1469, 1995.
24. Crippa, F., Buraggi, G. L., Di Re, E., Gasparini, M., Seregni, E., Canevari, S., Gadina, M., Presti, M., Marini, A., and Seccamani, E. Radioimmunoscintigraphy of ovarian cancer with the MOv18 monoclonal antibody. Eur. J. Cancer, 27: 724-729, 1991.
25. 131I-MOv18: clinical results in patients with minimal residual disease of ovarian cancer. Eur. J. Cancer, 31A: 686-690, 1995.
26. Figini, M., Marks, J. D., Winter, G., and Griffiths, A. D. In vitro assembly of repertoires of antibody chains on the surface of phage by renaturation. J. Mol. Biol., 239: 68-78, 1994.
27. Jespers, L. S., Roberts, A., Mahler, S. M., Winter, G., and Hoogenboom, H. R. Guiding the selection of human antibodies from phage display repertoires to a single epitope of an antigen. BioTechnology, 12: 899-903, 1994.
28. Marks, J. D., Griffiths, A. D., Malmqvist, M., Clackson, T., Bye, J. M., and Winter, G. By-passing immunization: building high affinity human antibodies by chain shuffling. BioTechnology, 10: 779-783, 1992.
29. Bénard, J., De Silva, J., De Blois, M. C., Boyer, P., Duvilland, P., Chiric, E., and Riou, G. Characterization of a human ovarian adenocarcinoma line, IGROV1, in tissue culture and in nude mice. Cancer Res., 45: 4970-4979, 1985.
30. Coney, L. R., Tomassetti, A., Carayannopoulos, L., Frasca, V., Kamen, B. A., Colnaghi, M. I., and Zurawski, V. R. Cloning of a tumor-associated antigen: MOv18 and MOv19 antibodies recognize a folate-binding protein. Cancer Res., 51: 6125-6132, 1991.
31. Munro, S., and Pelham, H. R. B. An Hsp-like protein in the ER: identity with the 78kd glucose regulated protein and immunoglobulin heavy chain binding protein. Cell, 46: 291-300, 1986.
32. Clackson, T., Hoogenboom, H. R., Griffiths, A. D., and Winter, G. Making antibody fragments using phage display libraries. Nature (Lond.), 352: 624-628, 1991.
33. Gibson, T. J. Studies on the Epstein-Barr virus genome (Thesis). Cambridge, UK: University of Cambridge, 1984.
34. Miller, J. H. Experiments in Molecula Genetics. Cold Spring Harbor, NY: Cold Springs Harbor Laboratory, 1972.
35. Griffiths, A. D., Williams, S. C., and Hartley, O. Isolation of high affinity human antibodies directly from large synthetic repertoires. EMBO J., 13: 3245-3260, 1994.
36. De Bellis, D., and Schwartz, I. Regulated expression of foreign genes fused to lac: control by glucose levels in growth medium. Nucleic Acids Res., 18: 1311, 1990.
37. Breitling, F., Dübel, S., Seehaus, T., Klewinghaus, I., and Little, M. A surface expression vector for antibody screening. Gene (Amst.), 104: 147-153, 1991.
38. Casalini, P., Mezzanzanica, D., Valota, O., Adobati, E., Tomassetti, A., Colnaghi, M. I., and Canevari, S. Undirectional potentiation of binding between two anti-FBP MAbs: evaluation of the involved mechanisms. J. Cell. Biochem., 58: 47-55, 1995.
39. Scatchard, G. The attractions of protein for small molecules and ions. Ann. NY Acad. Sci., 51: 660, 1949.
40. Sanger, F., Nicklen, S., and Coulson, A. R. DNA sequencing with chain-terminating inhibitors. Proc. Natl. Acad. Sci. USA, 74: 5463-5467, 1977.
41. Tomlinson, I. M. V Base Sequence Directory. Cambridge, UK: Medical Research Council Centre for Protein Engineering.
42. Williams, S. C., and Winter, G. Cloning and sequencing of human immunoglobulin variable lambda gene segments. Eur. J. Immunol., 23: 1456-1461, 1993.
43. Mariani-Costantini, R., Colnaghi, M. I., Leoni, F., Ménard, S., Cerasoli, S., and Rilke, F. Immunohistochemical reactivities of a monoclonal antibody prepared against human breast carcinoma. Virchows Arch. A Pathol. Anat. Hist., 402: 389-404, 1984.
44. Griffiths, A. D., Malmqvist, M., Marks, J. D., Bye, J. M., Embleton, M. J., McCafferty, J., Baier, M., Holliger, K. P., Gorick, B. D., Hughes-Jones, N. C., Hoogenboom, H. R., and Winter, G. Human anti-self antibodies with high specificity from phage display libraries. EMBO J., 12: 725-734, 1993.
45. Chothia, C., and Lesk, A. M. Canonical structures for the hypervariable regions of immunoglobulins. J. Mol. Biol., 196: 901-917, 1987.
46. Hawkins, R. E., Russell, S. J., and Winter, G. Selection of phage antibodies by binding affinity: mimicking affinity maturation. J. Mol. Biol., 226: 889-896, 1992.
47. Low, N., Holliger, P., and Winter, G. Mimicking somatic hypermutation: affinity maturation of antibodies displayed on bacteriophage using a bacterial mutator strain. J. Mol. Biol., 260: 359-368, 1996.
48. Jain, R. K. Vascular and interstitial barriers to delivery of therapeutic agents in tumors. Cancer Metastasis Rev., 9: 253-266, 1990.
49. Milenic, D. E., Yokota, T., Filpula, D. R., Finkelman, M. A. J., Dodd, S. W., Wood, J. F., Whitlow, M., Snoy, P., and Schlom, J. Construction, binding properties, metabolism, and tumor targeting of a single-chain Fv derived from the pancarcinoma monoclonal antibody CC49. Cancer Res., 51: 6363-6371, 1991.
50. Chothia, C., Lesk, A. M., Tramontano, A., Levitt, M., Smith-Gill, S. J., Air, G., Sheriff, S., Padlan, E. A., Davies, D., Tulip, W. R., Colman, P. M., Spinelli, S., Alzari, P. M., and Poljak, R. J. Conformations of immunoglobulin hypervariable regions. Nature (Lond.), 342: 877-883, 1989.
51. Chothia, C., Lesk, A. M., Gherardi, E., Tomlinson, I. M., Walter, G., Marks, J. D., Llewelyn, M. B., and Winter, G. Structural repertoire of the human VH segments. J. Mol. Biol., 227: 799-817, 1992.