Guided selection of a pan carcinoma specific antibody reveals similar binding characteristics yet structural divergence between the original antibody and its human equivalent

Journal of Molecular Biology

Volumn 296, Issue 3, 2000, Pages 833-849

  Beiboer, Sigrid H W ^a   Reurs, Anneke ^a   Roovers, Rob C ^a   Arends, Jan Willem ^a,b   Whitelegg, Nick R ^c   Rees, Anthony R ^c   Hoogenboom, Hennie R ^a  

^a MAASTRICHT UNIVERSITY   (Netherlands)

^b MAASTRICHT UNIVERSITY MEDICAL CENTER   (Netherlands)

^c University of Bath   (United Kingdom)

Author keywords

Epithelial glycoprotein 2; Human antibody; Humanisation; Phage selection; Tumour targeting

Indexed keywords

ANTIBODY; EPITOPE; GLYCOPROTEIN; IMMUNOGLOBULIN HEAVY CHAIN; IMMUNOGLOBULIN LIGHT CHAIN;

AMINO ACID SEQUENCE; ANIMAL CELL; ANTIBODY SPECIFICITY; ANTIBODY STRUCTURE; ANTIGEN BINDING; ANTIGEN EXPRESSION; ARTICLE; BINDING AFFINITY; CANCER IMMUNOTHERAPY; CARCINOMA; CONTROLLED STUDY; GENE MUTATION; GENE TARGETING; HUMAN; MOLECULAR CLONING; NONHUMAN; NUCLEOTIDE SEQUENCE; PRIORITY JOURNAL; SEQUENCE ANALYSIS;

EID: 0034711956     PISSN: 00222836     EISSN: None     Source Type: Journal    
DOI: 10.1006/jmbi.2000.3512     Document Type: Article

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