Nonclassical antifolates, part 5. Benzodiazepine analogs as a new class of DHFR inhibitors: Synthesis, antitumor testing and molecular modeling study

European Journal of Medicinal Chemistry

Volumn 74, Issue , 2014, Pages 234-245

  El Subbagh, Hussein I ^a   Hassan, Ghada S ^b   El Messery, Shahenda M ^b   Al Rashood, Sarah T ^c   Al Omary, Fatmah A M ^c   Abulfadl, Yasmin S ^a   Shabayek, Marwa I ^a  

^a FUTURE UNIVERSITY IN EGYPT   (Egypt)

^b University of Mansoura   (Egypt)

^c KING SAUD UNIVERSITY   (Saudi Arabia)

Author keywords

DHFR inhibition; Dibenzo b,e 1,4 diazepines; Molecular modeling study; Synthesis; Tetrahydro quinazolines

Indexed keywords

ANTINEOPLASTIC AGENT; BENZODIAZEPINE DERIVATIVE; CHALCONE; DIHYDROFOLATE REDUCTASE INHIBITOR; FLUOROURACIL; FOLIC ACID ANTAGONIST; METHOTREXATE; METHYL GROUP; NITROGEN; TETRAHYDROQUINAZOLINE DERIVATIVE;

ANTINEOPLASTIC ACTIVITY; ARTICLE; BRAIN CANCER; BREAST CANCER; CANCER CELL CULTURE; CANCER INHIBITION; COLON CANCER; COMPUTER MODEL; CONTROLLED STUDY; DRUG POTENCY; DRUG SYNTHESIS; ENZYME INHIBITION; HUMAN; HUMAN CELL; IC 50; IN VITRO STUDY; KIDNEY CANCER; LC 50; LUNG NON SMALL CELL CANCER; MELANOMA; MOLECULAR MODEL; OVARY CANCER; PHARMACOPHORE; PROSTATE CANCER; STRUCTURE ACTIVITY RELATION;

DHFR INHIBITION; DIBENZO[B,E][1,4]DIAZEPINES; MOLECULAR MODELING STUDY; SYNTHESIS; TETRAHYDRO-QUINAZOLINES;

BENZODIAZEPINES; ENZYME INHIBITORS; FOLIC ACID ANTAGONISTS; MODELS, MOLECULAR; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 84893191074     PISSN: 02235234     EISSN: 17683254     Source Type: Journal    
DOI: 10.1016/j.ejmech.2014.01.004     Document Type: Article

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