Association between the oxytocin receptor gene and amygdalar volume in healthy adults

Biological Psychiatry

Volumn 68, Issue 11, 2010, Pages 1066-1072

  Inoue, Hideyuki ^a   Yamasue, Hidenori ^a   Tochigi, Mamoru ^a   Abe, Osamu ^a   Liu, Xiaoxi ^a   Kawamura, Yoshiya ^a   Takei, Kunio ^b   Suga, Motomu ^a   Yamada, Haruyasu ^a,c   Rogers, Mark A ^a   Aoki, Shigeki ^a   Sasaki, Tsukasa ^b   Kasai, Kiyoto ^a  

^a UNIVERSITY OF TOKYO   (Japan)

^b UNIVERSITY OF TOKYO   (Japan)

^c JAPAN SCIENCE AND TECHNOLOGY AGENCY   (Japan)

Author keywords

Amygdala; Autism; MRI; OXTR; Oxytocin; Social dysfunction

Indexed keywords

OXYTOCIN RECEPTOR;

ADULT; ALLELE; AMYGDALOID NUCLEUS; ARTICLE; AUTISM; BRAIN REGION; BRAIN SIZE; CEREBROSPINAL FLUID; FEMALE; GENETIC ASSOCIATION; GENETIC SUSCEPTIBILITY; GRAY MATTER; HAPLOTYPE; HIPPOCAMPUS; HUMAN; JAPANESE; MAJOR CLINICAL STUDY; MALE; NEUROIMAGING; NUCLEAR MAGNETIC RESONANCE IMAGING; PRIORITY JOURNAL; SINGLE NUCLEOTIDE POLYMORPHISM; WHITE MATTER;

ADULT; AGE FACTORS; ALLELES; AMYGDALA; ANALYSIS OF VARIANCE; FEMALE; GENE FREQUENCY; GENETIC ASSOCIATION STUDIES; GENOTYPE; HAPLOTYPES; HUMANS; MAGNETIC RESONANCE IMAGING; MALE; MIDDLE AGED; ORGAN SIZE; POLYMORPHISM, SINGLE NUCLEOTIDE; RECEPTORS, OXYTOCIN;

EID: 78349309241     PISSN: 00063223     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.biopsych.2010.07.019     Document Type: Article

References (64)

1. Y. Takayanagi, M. Yoshida, I.F. Bielsky, H.E. Ross, M. Kawamata, and T. Onaka Pervasive social deficits, but normal parturition, in oxytocin receptor-deficient mice Proc Natl Acad Sci U S A 102 2005 16096 16101
2. D. Jin, H.X. Liu, H. Hirai, T. Torashima, T. Nagai, and O. Lopatina CD38 is critical for social behaviour by regulating oxytocin secretion Nature 446 2007 41 45
3. I.D. Neumann Brain oxytocin: A key regulator of emotional and social behaviours in both females and males J Neuroendocrinol 20 2008 858 865
4. J.N. Ferguson, J.M. Aldag, T.R. Insel, and L.J. Young Oxytocin in the medial amygdala is essential for social recognition in the mouse J Neurosci 21 2001 8278 8285
5. E. Choleris, S.R. Little, J.A. Mong, S.V. Puram, R. Langer, and D.W. Pfaff Microparticle-based delivery of oxytocin receptor antisense DNA in the medial amygdala blocks social recognition in female mice Proc Natl Acad Sci U S A 104 2007 4670 4675
6. T.L. Bale, A.M. Davis, A.P. Auger, D.M. Dorsa, and M.M. McCarthy CNS region-specific oxytocin receptor expression: Importance in regulation of anxiety and sex behavior J Neurosci 21 2001 2546 2552
7. D. Huber, P. Veinante, and R. Stoop Vasopressin and oxytocin excite distinct neuronal populations in the central amygdala Science 308 2005 245 248
8. T.R. Insel, and L.E. Shapiro Oxytocin receptor distribution reflects social organization in monogamous and polygamous voles Proc Natl Acad Sci U S A 89 1992 5981 5985
9. A.K. Beery, E.A. Lacey, and D.D. Francis Oxytocin and vasopressin receptor distributions in a solitary and a social species of tuco-tuco (Ctenomys haigi and Ctenomys sociabilis) J Comp Neurol 507 2008 1847 1859
10. P. Campbell, A.G. Ophir, and S.M. Phelps Central vasopressin and oxytocin receptor distributions in two species of singing mice J Comp Neurol 516 2009 321 333
11. M. Heinrichs, T. Baumgartner, C. Kirschbaum, and U. Ehlert Social support and oxytocin interact to suppress cortisol and subjective responses to psychosocial stress Biol Psychiatry 54 2003 1389 1398
12. M. Kosfeld, M. Heinrichs, P.J. Zak, U. Fischbacher, and E. Fehr Oxytocin increases trust in humans Nature 435 2005 673 676
13. A.J. Guastella, P.B. Mitchell, and M.R. Dadds Oxytocin increases gaze to the eye region of human faces Biol Psychiatry 63 2008 3 5
14. A.J. Guastella, P.B. Mitchell, and F. Mathews Oxytocin enhances the encoding of positive social memories in humans Biol Psychiatry 64 2008 256 258
15. G. Domes, M. Heinrichs, A. Michel, C. Berger, and S.C. Herpertz Oxytocin improves "mind-reading" in humans Biol Psychiatry 61 2007 731 733
16. P. Kirsch, C. Esslinger, Q. Chen, D. Mier, S. Lis, and S. Siddhanti Oxytocin modulates neural circuitry for social cognition and fear in humans J Neurosci 25 2005 11489 11493
17. G. Domes, M. Heinrichs, J. Glascher, C. Buchel, D.F. Braus, and S.C. Herpertz Oxytocin attenuates amygdala responses to emotional faces regardless of valence Biol Psychiatry 62 2007 1187 1190
18. T. Baumgartner, M. Heinrichs, A. Vonlanthen, U. Fischbacher, and E. Fehr Oxytocin shapes the neural circuitry of trust and trust adaptation in humans Neuron 58 2008 639 650
19. P. Petrovic, R. Kalisch, T. Singer, and R.J. Dolan Oxytocin attenuates affective evaluations of conditioned faces and amygdala activity J Neurosci 28 2008 6607 6615
20. H. Yamasue, H. Kuwabara, Y. Kawakubo, and K. Kasai Oxytocin, sexually dimorphic features of the social brain, and autism Psychiatry Clin Neurosci 63 2009 129 140
21. E. Hollander, S. Novotny, M. Hanratty, R. Yaffe, C.M. DeCaria, B.R. Aronowitz, and S. Mosovich Oxytocin infusion reduces repetitive behaviors in adults with autistic and Asperger's disorders Neuropsychopharmacology 28 2003 193 198
22. E. Hollander, J. Bartz, W. Chaplin, A. Phillips, J. Sumner, and L. Soorya Oxytocin increases retention of social cognition in autism Biol Psychiatry 61 2007 498 503
23. A.J. Guastella, S.L. Einfeld, K.M. Gray, N.J. Rinehart, B.J. Tonge, T.J. Lambert, and I.B. Hickie Intranasal oxytocin improves emotion recognition for youth with autism spectrum disorders Biol Psychiatry 67 2010 692 694
24. Y. Shao, C.M. Wolpert, K.L. Raiford, M.M. Menold, S.L. Donnelly, and S.A. Ravan Genomic screen and follow-up analysis for autistic disorder Am J Med Genet 114 2002 99 105
25. J.L. McCauley, C. Li, L. Jiang, L.M. Olson, G. Crockett, and K. Gainer Genome-wide and ordered-subset linkage analyses provide support for autism loci on 17q and 19p with evidence of phenotypic and interlocus genetic correlates BMC Med Genet 6 2005 1
26. M.B. Lauritsen, T.D. Als, H.A. Dahl, T.J. Flint, A.G. Wang, and M. Vang A genome-wide search for alleles and haplotypes associated with autism and related pervasive developmental disorders on the Faroe Islands Mol Psychiatry 11 2006 37 46
27. T. Ylisaukko-Oja, M. Alarcon, R.M. Cantor, M. Auranen, R. Vanhala, and E. Kempas Search for autism loci by combined analysis of autism genetic resource exchange and Finnish families Ann Neurol 59 2006 145 155
28. S. Wu, M. Jia, Y. Ruan, J. Liu, Y. Guo, and M. Shuang Positive association of the oxytocin receptor gene (OXTR) with autism in the Chinese Han population Biol Psychiatry 58 2005 74 77
29. S. Jacob, C.W. Brune, C.S. Carter, B.L. Leventhal, C. Lord, and E.H. Cook Jr Association of the oxytocin receptor gene (OXTR) in Caucasian children and adolescents with autism Neurosci Lett 417 2007 6 9
30. E. Lerer, S. Levi, S. Salomon, A. Darvasi, N. Yirmiya, and R.P. Ebstein Association between the oxytocin receptor (OXTR) gene and autism: Relationship to Vineland Adaptive Behavior Scales and cognition Mol Psychiatry 13 2008 980 988
31. C.M. Yrigollen, S.S. Han, A. Kochetkova, T. Babitz, J.T. Chang, and F.R. Volkmar Genes controlling affiliative behavior as candidate genes for autism Biol Psychiatry 63 2008 911 916
32. A.K. Wermter, I. Kamp-Becker, P. Hesse, G. Schulte-Korne, K. Strauch, and H. Remschmidt Evidence for the involvement of genetic variation in the oxytocin receptor gene (OXTR) in the etiology of autistic disorders on high-functioning level Am J Med Genet B Neuropsychiatr Genet 153B 2009 629 639
33. H.D. Critchley, E.M. Daly, E.T. Bullmore, S.C. Williams, T. Van Amelsvoort, and D.M. Robertson The functional neuroanatomy of social behaviour: Changes in cerebral blood flow when people with autistic disorder process facial expressions Brain 123 2000 2203 2212
34. N.M. Kleinhans, L.C. Johnson, T. Richards, R. Mahurin, J. Greenson, G. Dawson, and E. Aylward Reduced neural habituation in the amygdala and social impairments in autism spectrum disorders Am J Psychiatry 166 2009 467 475
35. B.F. Sparks, S.D. Friedman, D.W. Shaw, E.H. Aylward, D. Echelard, and A.A. Artru Brain structural abnormalities in young children with autism spectrum disorder Neurology 59 2002 184 192
36. M.R. Herbert, D.A. Ziegler, C.K. Deutsch, L.M. O'Brien, N. Lange, and A. Bakardjiev Dissociations of cerebral cortex, subcortical and cerebral white matter volumes in autistic boys Brain 126 2003 1182 1192
37. J. Munson, G. Dawson, R. Abbott, S. Faja, S.J. Webb, and S.D. Friedman Amygdalar volume and behavioral development in autism Arch Gen Psychiatry 63 2006 686 693
38. M.W. Mosconi, H. Cody-Hazlett, M.D. Poe, G. Gerig, R. Gimpel-Smith, and J. Piven Longitudinal study of amygdala volume and joint attention in 2 to 4-year-old children with autism Arch Gen Psychiatry 66 2009 509 516
39. C.M. Schumann, J. Hamstra, B.L. Goodlin-Jones, L.J. Lotspeich, H. Kwon, and M.H. Buonocore The amygdala is enlarged in children but not adolescents with autism; the hippocampus is enlarged at all ages J Neurosci 24 2004 6392 6401
40. C.M. Schumann, C.C. Barnes, C. Lord, and E. Courchesne Amygdala enlargement in toddlers with autism related to severity of social and communication impairments Biol Psychiatry 66 2009 942 949
41. B.A. Corbett, V. Carmean, S. Ravizza, C. Wendelken, M.L. Henry, C. Carter, and S.M. Rivera A functional and structural study of emotion and face processing in children with autism Psychiatry Res 173 2009 196 205
42. E.H. Aylward, N.J. Minshew, G. Goldstein, N.A. Honeycutt, A.M. Augustine, and K.O. Yates MRI volumes of amygdala and hippocampus in non-mentally retarded autistic adolescents and adults Neurology 53 1999 2145 2150
43. D.C. Rojas, J.A. Smith, T.L. Benkers, S.L. Camou, M.L. Reite, and S.J. Rogers Hippocampus and amygdala volumes in parents of children with autistic disorder Am J Psychiatry 161 2004 2038 2044
44. B.M. Nacewicz, K.M. Dalton, T. Johnstone, M.T. Long, E.M. McAuliff, and T.R. Oakes Amygdala volume and nonverbal social impairment in adolescent and adult males with autism Arch Gen Psychiatry 63 2006 1417 1428
45. K.M. Dalton, B.M. Nacewicz, A.L. Alexander, and R.J. Davidson Gaze-fixation, brain activation, and amygdala volume in unaffected siblings of individuals with autism Biol Psychiatry 61 2007 512 520
46. H. Yamasue, M. Ishijima, O. Abe, T. Sasaki, H. Yamada, and M. Suga Neuroanatomy in monozygotic twins with Asperger disorder discordant for comorbid depression Neurology 65 2005 491 492
47. M.B. First, R.L. Spitzer, M. Gibbon, and J.B.W. Williams Structured Clinical Interview for DSM-IV Axis I Disorders, Non-Patient Edition 1997 Biometrics Research Department, New York State Psychiatric Institute New York (Japanese translation: Kitamura T, Okano T (2003): Tokyo: Nihon Hyoron-sha publishers)
48. R.C. Oldfield The assessment and analysis of handedness: The Edinburgh inventory Neuropsychologia 9 1971 97 113
49. A.B. Hollingshead Two Factor Index of Social Position 1957 Yale University, Department of Sociology New Haven, Connecticut
50. H. Yamasue, K. Kasai, A. Iwanami, T. Ohtani, H. Yamada, and O. Abe Voxel-based analysis of MRI reveals anterior cingulate gray-matter volume reduction in posttraumatic stress disorder due to terrorism Proc Natl Acad Sci U S A 100 2003 9039 9043
51. H. Yamasue, C. Kakiuchi, M. Tochigi, H. Inoue, M. Suga, and O. Abe Association between mitochondrial DNA 10398A>G polymorphism and the volume of amygdala Genes Brain Behav 7 2008 698 704
52. C.D. Good, I. Johnsrude, J. Ashburner, R.N. Henson, K.J. Friston, and R.S. Frackowiak Cerebral asymmetry and the effects of sex and handedness on brain structure: A voxel-based morphometric analysis of 465 normal adult human brains Neuroimage 14 2001 685 700
53. H. Yamasue, A. Iwanami, Y. Hirayasu, H. Yamada, O. Abe, and N. Kuroki Localized volume reduction in prefrontal, temporolimbic, and paralimbic regions in schizophrenia: An MRI parcellation study Psychiatry Res 131 2004 195 207
54. X. Liu, Y. Kawamura, T. Shimada, T. Otowa, S. Koishi, and T. Sugiyama Association of the oxytocin receptor (OXTR) gene polymorphisms with autism spectrum disorder (ASD) in the Japanese population J Hum Genet 55 2010 137 141
55. C.S. Carter Sex differences in oxytocin and vasopressin: Implications for autism spectrum disorders? Behav Brain Res 176 2007 170 186
56. H. Yamasue, O. Abe, M. Suga, H. Yamada, M.A. Rogers, and S. Aoki Sex-linked neuroanatomical basis of human altruistic cooperativeness Cereb Cortex 18 2008 2331 2340
57. S. Purcell, B. Neale, K. Todd-Brown, L. Thomas, M.A. Ferreira, and D. Bender PLINK: A tool set for whole-genome association and population-based linkage analyses Am J Hum Genet 81 2007 559 575
58. A.P. Dempster, N.M. Laird, and D.B. Rubin Maximum likelihood from incomplete data via the EM algorithm J R Stat Soc B Stat Methodol 39 1977 1 38
59. F. Dudbridge Likelihood-based association analysis for nuclear families and unrelated subjects with missing genotype data Hum Hered 66 2008 87 98
60. W.J. Gauderman Sample size requirements for matched case-control studies of gene-environment interaction Stat Med 21 2002 35 50
61. T.R. Insel Oxytocina neuropeptide for affiliation: Evidence from behavioral, receptor autoradiographic, and comparative studies Psychoneuroendocrinology 17 1992 3 35
62. E. Choleris, N. Devidze, M. Kavaliers, and D.W. Pfaff Steroidal/neuropeptide interactions in hypothalamus and amygdala related to social anxiety Prog Brain Res 170 2008 291 303
63. E. Tribollet, M. Dubois-Dauphin, J.J. Dreifuss, C. Barberis, and S. Jard Oxytocin receptors in the central nervous system Distribution, development, and species differences Ann N Y Acad Sci 652 1992 29 38
64. F. Loup, E. Tribollet, M. Dubois-Dauphin, and J.J. Dreifuss Localization of high-affinity binding sites for oxytocin and vasopressin in the human brain An autoradiographic study Brain Res 555 1991 220 232