Oxytocin improves long-lasting spatial memory during motherhood through MAP kinase cascade

Nature Neuroscience

Volumn 6, Issue 4, 2003, Pages 384-390

  Tomizawa, Kazuhito ^a   Iga, Norichika ^a   Lu, Yun Fei ^c   Moriwaki, Akiyoshi ^a   Matsushita, Masayuki ^a   Li, Sheng Tian ^a   Miyamoto, Osamu ^b   Itano, Toshifumi ^b   Matsui, Hideki ^a,c  

^a OKAYAMA UNIVERSITY   (Japan)

^b KAGAWA UNIVERSITY   (Japan)

^c JAPAN SCIENCE AND TECHNOLOGY AGENCY   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

CYCLIC AMP RESPONSIVE ELEMENT BINDING PROTEIN; MITOGEN ACTIVATED PROTEIN KINASE; OXYTOCIN;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; FEMALE; HIPPOCAMPUS; HORMONE ACTION; LABOR; LACTATION; LEARNING; LONG TERM POTENTIATION; MEMORY; MOTHER; MOUSE; NONHUMAN; PHOSPHORYLATION; PRIORITY JOURNAL; SPATIAL MEMORY; SYNAPSE; TETANUS;

ANIMALS; CYCLIC AMP RESPONSE ELEMENT-BINDING PROTEIN; ELECTRIC STIMULATION; ENZYME INHIBITORS; HIPPOCAMPUS; INJECTIONS, INTRAVENTRICULAR; LACTATION; LEARNING; LONG-TERM POTENTIATION; MAP KINASE SIGNALING SYSTEM; MATERNAL BEHAVIOR; MEMORY; MICE; NEURAL PATHWAYS; NEURONS; ORGAN CULTURE TECHNIQUES; OXYTOCIN; PHOSPHORYLATION; SPACE PERCEPTION; UP-REGULATION;

EID: 0037381402     PISSN: 10976256     EISSN: None     Source Type: Journal    
DOI: 10.1038/nn1023     Document Type: Article

References (40)

1. Argiolas, A. & Gessa, G.L. Central functions of oxytocin. Neurosci. Biobehav. Rev. 15, 217-231 (1991).
2. Gainer, H. & Wray, S. Lactation and its hormonal control, in The Physiology of Reproduction (eds. Knobil, E. & Neill, J.D.) 1099-1129 (Raven, New York, 1994).
3. Perdersen, C.A. & Prange, A.J. Jr. Induction of maternal behavior in virgin rats after intracerebroventricular administration of oxytocin. Proc. Natl. Acad. Sci. USA 76, 6661-6665 (1988).
4. Ferguson, J.N. et al. Social amnesia in mice lacking the oxytocin gene. Nat. Genet. 25, 284-288 (2000).
5. Ferguson, J.N., Aldag, J.M., Insel, T.R. & Young, L.J. Oxytocin in the medial amygdala is essential for social recognition in the mouse. J. Neurosci. 21, 8278-8285 (2001).
6. Kinsley, C.H. et al. Motherhood improves learning and memory. Nature 402, 137-138 (1999).
7. Schulkin, J. Hormonal regulation of food selection, in The Neuroendocrine Regulation of Behavior (ed. Schulkin, J.) 123-130 (Cambridge Univ. Press, London, 1999).
8. Fahrbach, S.E., Morrell, J.I. & Pfaff, D.W. Possible role for endogenous oxytocin in estrogen-facilitated maternal behavior in rats. Neuroendocrinology 40, 526-532 (1985).
9. Pedersen, C.A., Caldwell, J.D., Walker, C., Ayers G.H. & Mason, G.A. Oxytocin activates the postpartum onset of rat maternal behavior in the ventral tegmental and medial oreoptic areas. Behav. Neurosci. 108, 1163-1171 (1994).
10. Vaccari, C., Lolait, S.J. & Ostrowski, N.L. Comparative distribution of vasopressin VIb and oxytocin receptor messenger ribonucleic acids in brain. Endocrinology 139, 5015-5033 (1998).
11. Krémarik, P., Freund-Mercier, M.J. & Stoeckel, M.E. Histoautoradiographic detection of oxytocin- and vasopressin-binding sites in the telencephalon of the rat. J. Comp. Neurol. 333, 343-359 (1993).
12. Breton, C. & Zingg, H.H. Expression and region-specific regulation of the oxytocin receptor gene in rat brain. Endocrinology 138, 1857-1862 (1997).
13. Insel, T.R. Oxytocin - a neuropeptide for affiliation: evidence from behavioral, receptor autoradiographic and comparative studies. Psychoneuroendocrinology 17, 3-35 (1992).
14. Bale, T.L., Davis, A.M., Auger, A.P., Dorsa, D.M. & McCarthy, M.M. CNS region-specific oxytocin receptor expression: importance in regulation of anxiety and sex behavior. J. Neurosci. 21, 2546-2552 (2001).
15. Bale, T.L. & Dorsa, D.M. Sex differences in and effects of estrogen on oxytocin receptor messenger ribonucleic acid expression in the ventromedial hypothalamus. Endocrinology 136, 27-32 (1995).
16. Zucker, R.S. Short-term synaptic plasticity. Annu. Rev. Neurosci. 12, 13-31 (1989).
17. Huang, Y.Y., Nguyen, P.V., Able, T. & Kandel, K.R. Long-lasting forms of synaptic potentiation in the mammalian hippocampus. Learn. Mem. 3, 74-85 (1996).
18. Lee, H.-K., Barbarosie, M., Kameyama, K., Bear, M.F. & Huganir, R.L. Regulation of distinct AMPA receptor phosphorylation sites during bidirectional synaptic plasticity. Nature 405, 955-959 (2000).
19. Nguyen, P.V., Able, T. & Kandel, E.R. Requirement of a critical period of transcription for induction of a late phase of LTP. Science 265, 1104-1107 (1994).
20. Gass, P. et al. Deficits in memory tasks of mice with CREB mutations depend on gene dosage. Learn. Mem. 5, 274-288 (1998).
21. Nguyen, P.V. & Kandel, E.R. Brief theta-burst stimulation induces a transcription-dependent late phase of LTP requiring camp in area CA1 of the mouse hippocampus. Learn. Mem. 4, 230-243 (1997).
22. 2+ stimulation of CREB-dependent transcription and ERK nuclear translocation. Neuron 21, 869-883 (1998).
23. Matsushita, M. et al. A high-efficiency protein transduction system demonstrating the role of PKA in long-lasting long-term potentiation. J. Neurosci. 21, 6000-6007 (2001).
24. Able, T. et al. Genetic demonstration of a role for PKA in the late phase of LTP and in hippocampus-based long-term memory. Cell 88, 615-626 (1997).
25. Olton, D.S. Memory functions and the hippocampus, in Neurobiology of the Hippocampus (ed. Seifert, W.) 335-374 (Academic, San Diego, 1983).
26. Barnes, C.A. Spatial learning and memory processes: the search for their neurobiological mechanisms in the rat. Trends Neurosci. 11, 163-169 (1988).
27. Shapiro, M.L. & O'Connor, C. N-methyl-D-aspartate receptor antagonist MK-801 and spatial memory representation: working memory is impaired in an unfamiliar environment but not in a familiar environment. Behav. Neurosci. 106, 604-612 (1992).
28. Shapiro, M.L. & Eichenbaum, H. Hippocampus as a memory map: synaptic plasticity and memory encoding by hippocampal neurons. Hippocampus 9, 365-384 (1999).
29. Steele, R.J. & Morris, R.G.M. Delay-dependent impairment of a matching-to-place task with chronic and intrahippocampal infusion of the NMDA-antagonist D-AP5. Hippocampus 9, 118-136 (1999).
30. Borroni, A.M., Fichtenholtz, H., Woodside, B.L. & Teyler, T.J. Role of voltage-dependent calcium channel long-term potentiation (LTP) and NMDA LTP in spatial memory. J. Neurosci. 20, 9272-9276 (2000).
31. Guerra-Araiza, C., Cerbon, M.A., Morimoto, S. & Camacho-Arroyo, I. Progesterone receptor isoforms expression pattern in the rat brain during the estrous cycle. Life Sci. 66, 1743-1752 (2000).
32. Grattan, D.R. Behavioural significance of prolactin signaling in the central nervous system during pregnancy and lactation. Reproduction 123, 497-506 (2002).
33. Pi, X. & Voogt, J.L. Sex difference and estrous cycle: expression of prolactin receptor mRNA in rat brain. Mol. Brain Res. 103, 130-139 (2002).
34. Jirikowski, G.F., Caldwell, J.D., Haussler, H.U. & Pedersen, C.A. Mating alters topography and content of oxytocin immunoreactivity in male mouse brain. Cell Tissue Res. 266, 399-403 (1991).
35. Kubota, Y. et al. Structure and expression of the mouse oxytocin receptor gene. Mol. Cell. Endocrinol. 124, 25-32 (1996).
36. Durham, D.A., Banks, W.A. & Kastin, A.J. Carrier-mediated transport of labeled oxytocin from brain to blood. Neuroendocrinology 53, 447-452 (1991).
37. Diaz-Cabiale, Z. et al. Systemic oxytocin treatment modulates α2-adrenoceptors in telencephalic and diencephalic regions of the rat. Brain Res. 887, 421-425 (2000).
38. Tomizawa, K. et al. Cdk5/p35 regulates neurotransmitter release through phosphorylation and downregulation of P/Q-type voltage-dependent calcium channel activity. J. Neurosci. 22, 2590-2597 (2002).
39. nck5a) in the rat brain. Neuroscience 74, 519-529 (1996).
40. Masaki, T., Yoshimatsu, H., Chiba, S., Watanabe, T. & Sakata, T. Central infusion of histamine reduces fat accumulation and upregulates UCP family in leptin-resistant obese mice. Diabetes 50, 376-384 (2001).