Oxytocin modulates neural circuitry for social cognition and fear in humans

Journal of Neuroscience

Volumn 25, Issue 49, 2005, Pages 11489-11493

  Kirsch, Peter ^a   Esslinger, Christine ^a   Chen, Qiang ^b   Mier, Daniela ^a   Lis, Stefanie ^a   Siddhanti, Sarina ^b   Gruppe, Harald ^a   Mattay, Venkata S ^b   Gallhofer, Bernd ^a   Meyer Lindenberg, Andreas ^b,c  

^a JUSTUS LIEBIG UNIVERSITY   (Germany)

^b NATIONAL INSTITUTE OF MENTAL HEALTH   (United States)

^c NATIONAL INSTITUTES OF HEALTH   (United States)

Author keywords

Amygdala; Fear; fMRI; Human; Oxytocin; Social cognition

Indexed keywords

OXYTOCIN;

ADULT; AMYGDALOID NUCLEUS; ARTICLE; BRAIN FUNCTION; BRAIN REGION; BRAIN STEM; COGNITION; CONTROLLED STUDY; FEAR; FUNCTIONAL MAGNETIC RESONANCE IMAGING; HUMAN; HUMAN EXPERIMENT; MALE; METHODOLOGY; NEUROMODULATION; NORMAL HUMAN; PRIORITY JOURNAL; VISUAL STIMULATION;

ADOLESCENT; ADULT; COGNITION; DOUBLE-BLIND METHOD; FEAR; HUMANS; MAGNETIC RESONANCE IMAGING; MALE; NERVE NET; OXYTOCIN; PHOTIC STIMULATION; PSYCHOMOTOR PERFORMANCE; SOCIAL BEHAVIOR;

EID: 30544438866     PISSN: 02706474     EISSN: 02706474     Source Type: Journal    
DOI: 10.1523/JNEUROSCI.3984-05.2005     Document Type: Article

References (39)

1. Adolphs R (2003) Cognitive neuroscience of human social behaviour. Nat Rev Neurosci 4:165-178.
2. Adolphs R, Tranel D, Damasio AR (1998) The human amygdala in social judgment. Nature 393:470-474.
3. Adolphs R, Gosselin F, Buchanan TW, Tranel D, Schyns P, Damasio AR (2005) A mechanism for impaired fear recognition after amygdala damage. Nature 433:68-72.
4. Amaral DG (2003) The amygdala, social behavior, and danger detection. Ann NY Acad Sci 1000:337-347.
5. Blair RJ (2003) Neurobiological basis of psychopathy. Br J Psychiatry 182:5-7.
6. Born J, Lange T, Kern W, McGregor GP, Bickel U, Fehm HL (2002) Sniffing neuropeptides: a transnasal approach to the human brain. Nat Neurosci 5:514-516.
7. Bosch OJ, Meddle SL, Beiderbeck DI, Douglas AJ, Neumann ID (2005) Brain oxytocin correlates with maternal aggression: link to anxiety. J Neurosci 25:6807-6815.
8. Bradley MM, Lang PJ (1994) Measuring emotion: the Self-Assessment Manikin and the Semantic Differential. J Behav Ther Exp Psychiatry 25:49-59.
9. Buijs RM, De Vries GJ, Van Leeuwen FW, Swaab DF (1983) Vasopressin and oxytocin: distribution and putative functions in the brain. Prog Brain Res 60:115-122.
10. Dalton KM, Nacewicz BM, Johnstone T, Schaefer HS, Gernsbacher MA, Goldsmith HH, Alexander AL, Davidson RJ (2005) Gaze fixation and the neural circuitry of face processing in autism. Nat Neurosci 8:519-526.
11. Ferguson JN, Aldag JM, Insel TR, Young LJ (2001) Oxytocin in the medial amygdala is essential for social recognition in the mouse. J Neurosci 21:8278-8285.
12. Friston KJ, Frith CD, Liddle PF, Frackowiak RS (1993) Functional connectivity: the principal-component analysis of large (PET) data sets. J Cereb Blood Flow Metab 13:5-14.
13. Green L, Fein D, Modahl C, Feinstein C, Waterhouse L, Morris M (2001) Oxytocin and autistic disorder: alterations in peptide forms. Biol Psychiatry 50:609-613.
14. Hariri AR, Tessitore A, Mattay VS, Fera F, Weinberger DR (2002) The amygdala response to emotional stimuli: a comparison of faces and scenes. NeuroImage 17:317-323.
15. Heinrichs M, Baumgartner T, Kirschbaum C, Ehlert U (2003) Social support and oxytocin interact to suppress cortisol and subjective responses to psychosocial stress. Biol Psychiatry 54:1389-1398.
16. Huber D, Veinante P, Stoop R (2005) Vasopressin and oxytocin excite distinct neuronal populations in the central amygdala. Science 308:245-248.
17. Ibragimov R (1990) Influence of neurohypophyseal peptides on the formation of active avoidance conditioned reflex behavior. Neurosci Behav Physiol 20:189-193.
18. Insel TR, Fernald RD (2004) How the brain processes social information: searching for the social brain. Annu Rev Neurosci 27:697-722.
19. Jezova D, Skultetyova I, Tokarev DI, Bakos P, Vigas M (1995) Vasopressin and oxytocin in stress. Ann NY Acad Sci 771:192-203.
20. Johnstone T, Somerville LH, Alexander AL, Oakes TR, Davidson RJ, Kalin NH, Whalen PJ (2005) Stability of amygdala BOLD response to fearful faces over multiple scan sessions. NeuroImage 25:1112-1123.
21. Kiehl KA, Smith AM, Hare RD, Mendrek A, Forster BB, Brink J, Liddle PF (2001) Limbic abnormalities in affective processing by criminal psychopaths as revealed by functional magnetic resonance imaging. Biol Psychiatry 50:677-684.
22. Kosfeld M, Heinrichs M, Zak PJ, Fischbacher U, Fehr E (2005) Oxytocin increases trust in humans. Nature 435:673-676.
23. LeDoux JE (2000) Emotion circuits in the brain. Annu Rev Neurosci 23:155-184.
24. LeDoux JE, Iwata J, Cicchetti P, Reis DJ (1988) Different projections of the central amygdaloid nucleus mediate autonomic and behavioral correlates of conditioned fear. J Neurosci 8:2517-2529.
25. Loup F, Tribollet E, Dubois-Dauphin M, Dreifuss JJ (1991) Localization of high-affinity binding sites for oxytocin and vasopressin in the human brain. An autoradiographic study. Brain Res 555:220-232.
26. McCarthy MM, McDonald CH, Brooks PJ, Goldman D (1996) An anxiolytic action of oxytocin is enhanced by estrogen in the mouse. Physiol Behav 60:1209-1215.
27. Meyer-Lindenberg A, Hariri AR, Munoz KE, Mervis CB, Mattay VS, Morris CA, Berman KF (2005) Neural correlates of genetically abnormal social cognition in Williams syndrome. Nat Neurosci 8:991-993.
28. Pezawas L, Meyer-Lindenberg A, Drabant EM, Verchinski BA, Munoz KE, Kolachana BS, Egan MF, Mattay VS, Hariri AR, Weinberger DR (2005) 5-HTTLPR polymorphism impacts human cingulate-amygdala interactions: a genetic susceptibility mechanism for depression. Nat Neurosci 8:828-834.
29. Phelps EA, Delgado MR, Nearing KI, LeDoux JE (2004) Extinction learning in humans: role of the amygdala and vmPFC. Neuron 43:897-905.
30. Pitman RK, Orr SP, Lasko NB (1993) Effects of intranasal vasopressin and oxytocin on physiologic responding during personal combat imagery in Vietnam veterans with posttraumatic stress disorder. Psychiatry Res 48:107-117.
31. Prather MD, Lavenex P, Mauldin-Jourdain ML, Mason WA, Capitanio JP, Mendoza SP, Amaral DG (2001) Increased social fear and decreased fear of objects in monkeys with neonatal amygdala lesions. Neuroscience 106:653-658.
32. Ragnauth AK, Devidze N, Moy V, Finley K, Goodwillie A, Kow LM, Muglia LJ, Pfaff DW (2005) Female oxytocin gene-knockout mice, in a semi-natural environment, display exaggerated aggressive behavior. Genes Brain Behav 4:229-239.
33. Spielberger CD (1988) State Trait Anger Expression Inventory (STAXI), research edition. Odessa, FL: Psychological Assessment Resources.
34. Stein MB, Goldin PR, Sareen J, Zorrilla LT, Brown GG (2002) Increased amygdala activation to angry and contemptuous faces in generalized social phobia. Arch Gen Psychiatry 59:1027-1034.
35. Steyer R, Schwenkmezger P, Notz P, Eid M (1994) Testtheoretische Analysen des mehrdimensionalen Befindlichkeitsfragebogens (MDBF). Diagnostica 40:320-328.
36. Whalen PJ, Rauch SL, Etcoff NL, McInerney SC, Lee MB, Jenike MA (1998) Masked presentations of emotional facial expressions modulate amygdala activity without explicit knowledge. J Neurosci 18:411-418.
37. Winslow JT, Insel TR (1991) Social status in pairs of male squirrel monkeys determines the behavioral response to central oxytocin administration. J Neurosci 11:2032-2038.
38. Winslow JT, Insel TR (2004) Neuroendocrine basis of social recognition. Curr Opin Neurobiol 14:248-253.
39. Winston JS, Strange BA, O'Doherty J, Dolan RJ (2002) Automatic and intentional brain responses during evaluation of trustworthiness of faces. Nat Neurosci 5:277-283.