Structural requirements of steroidal agonists of transient receptor potential melastatin 3 (TRPM3) cation channels

British Journal of Pharmacology

Volumn 171, Issue 4, 2014, Pages 1019-1032

  Drews, A ^a,d   Mohr, F ^b   Rizun, O ^b   Wagner, T F J ^a,e   Dembla, S ^a,b   Rudolph, S ^a   Lambert, S ^a   Konrad, M ^b   Philipp, S E ^a   Behrendt, M ^b   Marchais Oberwinkler, S ^b   Covey, D F ^c   Oberwinkler, J ^b  

^a SAARLAND UNIVERSITY   (Germany)

^b PHILIPPS UNIVERSITY MARBURG   (Germany)

^c WASHINGTON UNIVERSITY   (United States)

^d UNIVERSITY OF CAMBRIDGE   (United Kingdom)

^e SCRIPPS RESEARCH INSTITUTE   (United States)

Author keywords

cation membrane channel; ClC 3; dihydropyridine; enantiomer; neurosteroid; PAORAC; pregnenolone sulphate; proton Activated outwardly rectifying anion channel; transient receptor potential; transient receptor potential melastatin

Indexed keywords

1,4 DIHYDROPYRIDINE; ANION CHANNEL; EPIALLOPREGNANOLONE SULFATE; NIFEDIPINE; PREGNENOLONE DERIVATIVE; PREGNENOLONE SULFATE; PROTON ACTIVATED OUTWARDLY RECTIFYING ANION CHANNEL; TRANSIENT RECEPTOR POTENTIAL CHANNEL M3; UNCLASSIFIED DRUG;

ANIMAL CELL; ARTICLE; CALCIUM CELL LEVEL; CELL STRAIN HEK293; CONCENTRATION (PARAMETERS); CONTROLLED STUDY; ENANTIOMER; ENZYME ACTIVATION; ENZYME INACTIVATION; ENZYME INHIBITION; HUMAN; MOUSE; NONHUMAN; NUCLEOTIDE BINDING SITE; NUCLEOTIDE SEQUENCE; PRIORITY JOURNAL; STRUCTURE ACTIVITY RELATION; WHOLE CELL PATCH CLAMP;

CATION MEMBRANE CHANNEL; CLC-3; DIHYDROPYRIDINE; ENANTIOMER; NEUROSTEROID; PAORAC; PREGNENOLONE SULPHATE; PROTON-ACTIVATED OUTWARDLY RECTIFYING ANION CHANNEL; TRANSIENT RECEPTOR POTENTIAL; TRANSIENT RECEPTOR POTENTIAL MELASTATIN;

ANIMALS; BASE SEQUENCE; BINDING SITES; HEK293 CELLS; HUMANS; MICE; MOLECULAR SEQUENCE DATA; NIFEDIPINE; PREGNENOLONE; TRPM CATION CHANNELS;

EID: 84893120983     PISSN: 00071188     EISSN: 14765381     Source Type: Journal    
DOI: 10.1111/bph.12521     Document Type: Article

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