ClC-3 is a candidate of the channel proteins mediating acid-activated chloride currents in nasopharyngeal carcinoma cells

American Journal of Physiology - Cell Physiology

Volumn 303, Issue 1, 2012, Pages

  Wang, Liwei ^a   Ma, Wenbo ^a   Zhu, Linyan ^a   Ye, Dong ^a   Li, Yuan ^a   Liu, Shanwen ^a   Li, Huarong ^a   Zuo, Wanhong ^a   Li, Bingxue ^a   Ye, Wencai ^b   Chen, Lixin ^a  

^a MEDICAL COLLEGE OF JINAN UNIVERSITY   (China)

^b JINAN UNIVERSITY   (China)

Author keywords

Acidification; Chloride channels; Extracellular pH; Tumor cells

Indexed keywords

4,4'DIISOTHIOCYANATOSTILBENE 2,2' DISULFONIC ACID DISODIUM SALT HYDRATE; ANION CHANNEL; BENZOIC ACID DERIVATIVE; BROMIDE ION; CHLORIDE ION; GLUCONIC ACID; HYPERTONIC SOLUTION; IODIDE ION; PROTEIN CHLORIDE CHANNEL 3; SMALL INTERFERING RNA; TAMOXIFEN; UNCLASSIFIED DRUG;

ACIDIFICATION; ARTICLE; CARCINOMA CELL; CHLORIDE CURRENT; CONTROLLED STUDY; GENE SILENCING; HUMAN; HUMAN CELL; HUMAN TISSUE; NASOPHARYNX CARCINOMA; PH; PRIORITY JOURNAL; PROTEIN EXPRESSION;

4,4'-DIISOTHIOCYANOSTILBENE-2,2'-DISULFONIC ACID; CELL LINE, TUMOR; CHLORIDE CHANNELS; CHLORIDES; HUMANS; MEMBRANE POTENTIALS; NASOPHARYNGEAL NEOPLASMS; NITROBENZOATES; PATCH-CLAMP TECHNIQUES; RNA INTERFERENCE; RNA, SMALL INTERFERING; TAMOXIFEN;

EID: 84863504002     PISSN: 03636143     EISSN: 15221563     Source Type: Journal    
DOI: 10.1152/ajpcell.00145.2011     Document Type: Article

References (31)

1. +current in hair cells. Neurochem Res 33: 1435-1441, 2008.
2. Auzanneau C, Thoreau V, Kitzis A, Becq F. A novel voltage-dependent chloride current activated by extracellular acidic pH in cultured rat Sertoli cells. J Biol Chem 278: 19230-19236, 2003.
3. Chen L, Wang L, Zhu L, Nie S, Zhang J, Zhong P, Cai B, Luo H, Jacob TJ. Cell cycle-dependent expression of volume-activated chloride currents in nasopharyngeal carcinoma cells. Am J Physiol Cell Physiol 283: C1313-C1323, 2002.
4. -currents and regulatory volume decrease in the cell cycle and proliferation in nasopharyngeal carcinoma cells. Cell Prolif 40: 253-267, 2007.
5. Diewald L, Rupp J, Dreger M, Hucho F, Gillen C, Nawrath H. Activation by acidic pH of CLC-7 expressed in oocytes from Xenopus laevis. Biochem Biophys Res Commun 291: 421-424, 2002.
6. Du CY, El Harchi A, McPate MJ, Orchard CH, Hancox JC. Enhanced inhibitory effect of acidosis on hERG potassium channels that incorporate the hERG1b isoform. Biochem Biophys Res Commun 405: 222-227, 2011.
7. Duan D, Winter C, Cowley S, Hume JR, Horowitz B. Molecular identification of a volume-regulated chloride channel. Nature 390: 417-421, 1997.
8. Friedrich T, Breiderhoff T, Jentsch TJ. Mutational analysis demonstrates that ClC-4 and ClC-5 directly mediate plasma membrane currents. J Biol Chem 274: 896-902, 1999.
9. -channel in cell volume regulation, proliferation and apoptosis in vascular smooth muscle cells. Trends Pharmacol Sci 27: 290-296, 2006.
10. He QF, Wang LW, Mao JW, Sun XR, Li P, Zhong P, Nie SH, Jacob T, Chen LX. Activation of chloride current and decrease of cell volume by ATP in nasopharyngeal carcinoma cells. Sheng Li Xue Bao 56: 691-696, 2004.
11. Hughes BA, Swaminathan A. Modulation of the Kir7.1 potassium channel by extracellular and intracellular pH. Am J Physiol Cell Physiol 294: C423-C431, 2008.
12. +channels in vascular smooth muscle cells. Anesth Analg 105: 1714-1719, 2007.
13. -channel from human skeletal muscles. Am J Physiol Cell Physiol 277: C948-C954, 1999.
14. Kwan DC, Fedida D, Kehl SJ. Single channel analysis reveals different modes of Kv1.5 gating behavior regulated by changes of external pH. Biophys J 90: 1212-1222, 2006.
15. +channel by intracellular and extracellular pH in bovine aortic endothelial cells. Korean J Physiol Pharmacol 6: 255-260, 2002.
16. Makara JK, Petheo GL, Toth A, Spat A. pH-sensitive inwardly rectifying chloride current in cultured rat cortical astrocytes. Glia 34: 52-58, 2001.
17. Mao J, Chen L, Xu B, Wang L, Wang W, Li M, Zheng M, Li H, Guo J, Li W, Jacob TJ. Volume-activated chloride channels contribute to cell-cycle-dependent regulation of HeLa cell migration. Biochem Pharmacol 77: 159-168, 2009.
18. Mao J, Xu B, Li H, Chen L, Jin X, Zhu J, Wang W, Zhu L, Zuo W, Chen W, Wang L. Lack of association between stretch-activated and volume-activated Cl currents in hepatocellular carcinoma cells. J Cell Physiol 226: 1176-1185, 2011.
19. -channels. Gen Pharmacol 27: 1131-1140, 1996.
20. swell. Am J Physiol Cell Physiol 287: C1426-C1435, 2004.
21. Petheo GL, Molnar Z, Roka A, Makara JK, Spat A. A pH-sensitive chloride current in the chemoreceptor cell of rat carotid body. J Physiol 535: 95-106, 2001.
22. Raghunand N, He X, van Sluis R, Mahoney B, Baggett B, Taylor CW, Paine-Murrieta G, Roe D, Bhujwalla ZM, Gillies RJ. Enhancement of chemotherapy by manipulation of tumour pH. Br J Cancer 80: 1005-1011, 1999.
23. Rofstad EK, Mathiesen B, Kindem K, Galappathi K. Acidic extracellular pH promotes experimental metastasis of human melanoma cells in athymic nude mice. Cancer Res 66: 6699-6707, 2006.
24. Goodchild SJ, Lamy C, Seutin V, Marrion NV. Inhibition of KCa2.2 and KCa2.3 channel currents by protonation of outer pore histidine residues. J Gen Physiol 134: 295-308, 2009.
25. Sandoz G, Douguet D, Chatelain F, Lazdunski M, Lesage F. Extracellular acidification exerts opposite actions on TREK1 and TREK2 potassium channels via a single conserved histidine residue. Proc Natl Acad Sci USA 106: 14628-14633, 2009.
26. Schnizler K, Saeger B, Pfeffer C, Gerbaulet A, Ebbinghaus-Kintscher U, Methfessel C, Franken EM, Raming K, Wetzel CH, Saras A, Pusch H, Hatt H, Gisselmann G. A novel chloride channel in Drosophila melanogaster is inhibited by protons. J Biol Chem 280: 16254-16262, 2005.
27. Teicher BA, Song CW, Griffin R, Park HJ. Influence of tumor pH on therapeutic response. In: Cancer Drug Resistance. Totowa, NJ: Humana, 2006, p. 21-42.
28. Wang L, Chen L, Jacob TJ. The role of ClC-3 in volume-activated chloride currents and volume regulation in bovine epithelial cells demonstrated by antisense inhibition. J Physiol 524: 63-75, 2000.
29. Yang L, Ye D, Ye W, Jiao C, Zhu L, Mao J, Jacob TJ, Wang L, Chen L. ClC-3 is a main component of background chloride channels activated under isotonic conditions by autocrine ATP in nasopharyngeal carcinoma cells. J Cell Physiol 226: 2516-2526, 2011.
30. Zhu G, Chanchevalap S, Cui N, Jiang C. Effects of intra-and extracellular acidifications on single channel Kir2.3 currents. J Physiol 516: 699-710, 1999.
31. Zhu L, Yang H, Zuo W, Yang L, Zhang H, Ye W, Mao J, Chen L, Wang L. Differential expression and roles of volume-activated chloride channels in control of growth of normal and cancerous nasopharyngeal epithelial cells. Biochem Pharmacol 83: 324-334, 2012.