Citrus fruit and fabacea secondary metabolites potently and selectively block TRPM3

British Journal of Pharmacology

Volumn 168, Issue 8, 2013, Pages 1835-1850

  Straub, I ^a   Mohr, F ^b   Stab, J ^b   Konrad, M ^b   Philipp, S E ^c   Oberwinkler, J ^b   Schaefer, M ^a  

^a UNIVERSITY OF LEIPZIG   (Germany)

^b PHILIPPS UNIVERSITY MARBURG   (Germany)

^c SAARLAND UNIVERSITY   (Germany)

Author keywords

DRG neurones; flavonoids; TRP channels

Indexed keywords

ERIODICTYOL; FLAVANONE DERIVATIVE; HESPERETIN; NARINGENIN; NIFEDIPINE; ONONETIN; TRANSIENT RECEPTOR POTENTIAL CHANNEL AFFECTING AGENT; TRANSIENT RECEPTOR POTENTIAL CHANNEL M3; TRANSIENT RECEPTOR POTENTIAL CHANNEL M3 BLOCKING AGENT; UNCLASSIFIED DRUG; BENZOIN; CALCIUM; CALCIUM CHANNEL BLOCKING AGENT; DEOXYBENZOIN; HESPERIDIN; PREGNENOLONE; PREGNENOLONE SULFATE; TRANSIENT RECEPTOR POTENTIAL CHANNEL M; TRPM3 PROTEIN, MOUSE;

ANALGESIC ACTIVITY; ANIMAL CELL; ANIMAL TISSUE; ARTICLE; BIOPHYSICS; CITRUS FRUIT; CONCENTRATION RESPONSE; CONTROLLED STUDY; DRUG POTENCY; DRUG STRUCTURE; ELECTROPHYSIOLOGY; FABACEAE; FLUOROMETRY; HUMAN; HUMAN CELL; IC 50; MEDIAN EFFECTIVE CONCENTRATION; METABOLITE; MOUSE; NONHUMAN; NUCLEOTIDE SEQUENCE; PRIORITY JOURNAL; RAT; SPINAL GANGLION; ANALOGS AND DERIVATIVES; ANIMAL; ANTAGONISTS AND INHIBITORS; C57BL MOUSE; CALCIUM SIGNALING; CHEMISTRY; CITRUS; DRUG EFFECTS; DRUG SCREENING; GENETICS; HEK293 CELL LINE; ISOLATION AND PURIFICATION; MEMBRANE POTENTIAL; METABOLISM; SECONDARY METABOLISM; WISTAR RAT;

ANIMALS; BENZOIN; CALCIUM; CALCIUM CHANNEL BLOCKERS; CALCIUM SIGNALING; CITRUS; DRUG EVALUATION, PRECLINICAL; FABACEAE; FLAVANONES; GANGLIA, SPINAL; HEK293 CELLS; HESPERIDIN; HUMANS; MEMBRANE POTENTIALS; MICE; MICE, INBRED C57BL; PREGNENOLONE; RATS; RATS, WISTAR; SECONDARY METABOLISM; TRPM CATION CHANNELS;

EID: 84875474988     PISSN: 00071188     EISSN: 14765381     Source Type: Journal    
DOI: 10.1111/bph.12076     Document Type: Article

References (38)

1. Abramoff MD, Magalhaes PJ, Ram SJ, (2004). Image processing with ImageJ. Biophotonics Int 11: 36-42.
2. Bailey DG, Dresser GK, Kreeft JH, Munoz C, Freeman DJ, Bend JR, (2000). Grapefruit-felodipine interaction: effect of unprocessed fruit and probable active ingredients[ast]. Clin Pharmacol Ther 68: 468-477.
3. Benavente-Garcia O, Castillo J, (2008). Update on uses and properties of citrus flavonoids: new findings in anticancer, cardiovascular, and anti-inflammatory activity. J Agric Food Chem 56: 6185-6205.
4. Breinholt VM, Offord EA, Brouwer C, Nielsen SE, Brosen K, Friedberg T, (2002). In vitro investigation of cytochrome P450-mediated metabolism of dietary flavonoids. Food Chem Toxicol 40: 609-616.
5. Cederroth CR, Nef S, (2009). Soy, phytoestrogens and metabolism: a review. Mol Cell Endocrinol 304: 30-42.
6. Edelstein A, Amodaj N, Hoover K, Vale R, Stuurman N, (2010). Computer Control of Microscopes Using -μManager. Curr Protoc Mol Biol 92: 14.20.1-14.20.17.
7. Erlund I, Meririnne E, Alfthan G, Aro A, (2001). Plasma kinetics and urinary excretion of the flavanones naringenin and hesperetin in humans after ingestion of orange juice and grapefruit juice. J Nutr 131: 235-241.
8. Felgines C, Texier O, Morand C, Manach C, Scalbert A, Régerat F, et al. (2000). Bioavailability of the flavanone naringenin and its glycosides in rats. Am J Physiol Gastrointest Liver Physiol 279: G1148-G1154.
9. Fuhr U, Kummert AL, (1995). The fate of naringin in humans: a key to grapefruit juice-drug interactions? Clin Pharmacol Ther 58: 365-373.
10. Grimm C, Kraft R, Schultz G, Harteneck C, (2005). Activation of the melastatin-related cation channel TRPM3 by d-erythro-sphingosine [corrected]. Mol Pharmacol 67: 798-805.
11. Hanley MJ, Cancalon P, Widmer WW, Greenblatt DJ, (2011). The effect of grapefruit juice on drug disposition. Expert Opin Drug Metab Toxicol 7: 267-286.
12. Harteneck C, Schultz G, (2007). TRPV4 and TRPM3 as volume-regulated cation channels. In:, Liedtke WB, Heller S, (eds). TRP Ion Channel Function in Sensory Transduction and Cellular Signaling Cascades. CRC Press: Boca Raton, FL.
13. Hellwig N, Plant TD, Janson W, Schafer M, Schultz G, Schaefer M, (2004). TRPV1 acts as proton channel to induce acidification in nociceptive neurons. J Biol Chem 279: 34553-34561.
14. Hill K, Schaefer M, (2009). Ultraviolet light and photosensitising agents activate TRPA1 via generation of oxidative stress. Cell Calcium 45: 155-164.
15. Hlasiwetz H, (1855). Ueber die Wurzel der Ononis spinosa. J Prakt Chem 65: 419-450.
16. Kilkenny C, Browne W, Cuthill IC, Emerson M, Altman DG, (2010). NC3Rs Reporting Guidelines Working Group. Br J Pharmacol 160: 1577-1579.
17. Klose C, Straub I, Riehle M, Ranta F, Krautwurst D, Ullrich S, et al. (2011). Fenamates as TRP channel blockers: mefenamic acid selectively blocks TRPM3. Br J Pharmacol 162: 1757-1769.
18. Lambert S, Drews A, Rizun O, Wagner TF, Lis A, Mannebach S, et al. (2011). Transient receptor potential melastatin 1 (TRPM1) is an ion-conducting plasma membrane channel inhibited by zinc ions. J Biol Chem 286: 12221-12233.
19. Leffler A, Fischer MJ, Rehner D, Kienel S, Kistner K, Sauer SK, et al. (2008). The vanilloid receptor TRPV1 is activated and sensitized by local anesthetics in rodent sensory neurons. J Clin Invest 118: 763-776.
20. Lenz JC, Reusch HP, Albrecht N, Schultz G, Schaefer M, (2002). Ca 2+-controlled competitive diacylglycerol binding of protein kinase C isoenzymes in living cells. J Cell Biol 159: 291-302.
21. Majeed Y, Bahnasi Y, Seymour VA, Wilson LA, Milligan CJ, Agarwal AK, et al. (2011). Rapid and contrasting effects of rosiglitazone on transient receptor potential TRPM3 and TRPC5 channels. Mol Pharmacol 79: 1023-1030.
22. Manach C, Scalbert A, Morand C, Rémésy C, Jiménez L, (2004). Polyphenols: food sources and bioavailability. Am J Clin Nutr 79: 727-747.
23. McGrath J, Drummond G, McLachlan E, Kilkenny C, Wainwright C, (2010). Guidelines for reporting experiments involving animals: the ARRIVE guidelines. Br J Pharmacol 160: 1573-1576.
24. Nadler MJS, Hermosura MC, Inabe K, Perraud AL, Zhu Q, Stokes AJ, et al. (2001). LTRPC7 is a MgATP-regulated divalent cation channel required for cell viability. Nature 411: 590-595.
25. Naylor J, Li J, Milligan CJ, Zeng F, Sukumar P, Hou B, et al. (2010). Pregnenolone sulphate- and cholesterol-regulated TRPM3 channels coupled to vascular smooth muscle secretion and contraction. Circ Res 106: 1507-1515.
26. Ng LT, Ko HH, Lu TM, (2009). Potential antioxidants and tyrosinase inhibitors from synthetic polyphenolic deoxybenzoins. Bioorg Med Chem 17: 4360-4366.
27. Norenberg W, Hempel C, Urban N, Sobottka H, Illes P, Schaefer M, (2011). Clemastine potentiates the human P2X7 receptor by sensitizing it to lower ATP concentrations. J Biol Chem 286: 11067-11081.
28. Oberwinkler J, Lis A, Giehl KM, Flockerzi V, Philipp SE, (2005). Alternative splicing switches the divalent cation selectivity of TRPM3 channels. J Biol Chem 280: 22540-22548.
29. Ortiz-Andrade RR, Sánchez-Salgado JC, Navarrete-Vázquez G, Webster SP, Binnie M, García-Jiménez S, et al. (2008). Antidiabetic and toxicological evaluations of naringenin in normoglycaemic and NIDDM rat models and its implications on extra-pancreatic glucose regulation. Diabetes Obes Metab 10: 1097-1104.
30. Rossato MF, Trevisan G, Walker CI, Klafke JZ, de, Oliveira AP, Villarinho JG, et al. (2011). Eriodictyol: a flavonoid antagonist of the TRPV1 receptor with antioxidant activity. Biochem Pharmacol 81: 544-551.
31. Shulman M, Cohen M, Soto-Gutierrez A, Yagi H, Wang H, Goldwasser J, et al. (2011). Enhancement of naringenin bioavailability by complexation with hydroxypropoyl-β-cyclodextrin. PLoS ONE 6: e18033.
32. Urban N, Hill K, Wang L, Kuebler WM, Schaefer M, (2012). Novel pharmacological TRPC inhibitors block hypoxia-induced vasoconstriction. Cell Calcium 51: 194-206.
33. Vriens J, Nilius B, Vennekens R, (2008). Herbal compounds and toxins modulating TRP channels. Curr Neuropharmacol 6: 79-96.
34. Vriens J, Owsianik G, Hofmann T, Philipp SE, Stab J, Chen X, et al. (2011). TRPM3 is a nociceptor channel involved in the detection of noxious heat. Neuron 70: 482-494.
35. Wagner TF, Loch S, Lambert S, Straub I, Mannebach S, Mathar I, et al. (2008). Transient receptor potential M3 channels are ionotropic steroid receptors in pancreatic beta cells. Nat Cell Biol 10: 1421-1430.
36. Wagner TF, Drews A, Loch S, Mohr F, Philipp SE, Lambert S, et al. (2010). TRPM3 channels provide a regulated influx pathway for zinc in pancreatic beta cells. Pflugers Arch 460: 755-765.
37. Xu SZ, Zeng F, Boulay G, Grimm C, Harteneck C, Beech DJ, (2005). Block of TRPC5 channels by 2-aminoethoxydiphenyl borate: a differential, extracellular and voltage-dependent effect. Br J Pharmacol 145: 405-414.
38. Zamudio-Bulcock PA, Everett J, Harteneck C, Valenzuela CF, (2011). Activation of steroid-sensitive TRPM3 channels potentiates glutamatergic transmission at cerebellar Purkinje neurons from developing rats. J Neurochem 119: 474-485.