Cis-isomerism and other chemical requirements of steroidal agonists and partial agonists acting at TRPM3 channels

British Journal of Pharmacology

Volumn 161, Issue 2, 2010, Pages 430-441

  Majeed, Y ^a   Agarwal, A K ^b   Naylor, J ^a   Seymour, V A L ^a   Jiang, S ^a   Muraki, K ^a,c   Fishwick, C W G ^b   Beech, D J ^a  

^a Chapel Allerton Hospital   (United Kingdom)

^b UNIVERSITY OF LEEDS   (United Kingdom)

^c AICHI GAKUIN UNIVERSITY   (Japan)

Author keywords

Cationic channel; pregnenolone; stereo isomerism; steroid; sulphation; transient receptor potential

Indexed keywords

3BETA HYDROXY 5BETA PREGNAN 20 ONE; CALCIUM; CORTICOSTERONE 21 ACETATE; EPIANDROSTERONE; ESTRADIOL; PRASTERONE; PRASTERONE SULFATE; PREGNENOLONE; PROGESTERONE; TRANSIENT RECEPTOR POTENTIAL CHANNEL M3;

ARTICLE; BINDING SITE; CALCIUM CELL LEVEL; CALCIUM TRANSPORT; CELL STRAIN HEK293; CHEMICAL BOND; CHEMICAL STRUCTURE; CIS TRANS ISOMERISM; COMPUTER MODEL; CONTROLLED STUDY; DRUG EFFICACY; DRUG POTENCY; EMBRYO; GENE OVEREXPRESSION; HUMAN; HUMAN CELL; NUCLEOTIDE SEQUENCE; PATCH CLAMP; PRIORITY JOURNAL; RECEPTOR SENSITIVITY; STEREOCHEMISTRY; STRUCTURE ACTIVITY RELATION; WHOLE CELL;

ANIMALS; CALCIUM; CELL LINE; HUMANS; MICE; PATCH-CLAMP TECHNIQUES; PREGNENOLONE; STEREOISOMERISM; STRUCTURE-ACTIVITY RELATIONSHIP; TRANSFECTION; TRPM CATION CHANNELS;

EID: 77956033189     PISSN: 00071188     EISSN: 14765381     Source Type: Journal    
DOI: 10.1111/j.1476-5381.2010.00892.x     Document Type: Article

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