Plant lectins as carriers for oral drugs: Is wheat germ agglutinin a suitable candidate?

Toxicology and Applied Pharmacology

Volumn 207, Issue 2, 2005, Pages 170-178

  Dalla Pellegrina, Chiara ^a   Rizzi, Corrado ^a   Mosconi, Silvia ^a   Zoccatelli, Gianni ^a   Peruffo, Angelo ^a   Chignola, Roberto ^a  

^a UNIVERSITY OF VERONA   (Italy)

Author keywords

Caco2 cells; Drug carrier; Drug safety; Gastrointestinal epithelium; Permeability; Trans epithelial electrical resistance; Wheat germ agglutinin

Indexed keywords

DRUG; DRUG CARRIER; PLANT LECTIN; WHEAT GERM AGGLUTININ;

ARTICLE; CELL STRAIN CACO 2; CELL VIABILITY; DRUG BINDING; DRUG PENETRATION; EPITHELIUM CELL; GASTROINTESTINAL TRACT; HUMAN; HUMAN CELL; INTESTINE EPITHELIUM; INTESTINE EPITHELIUM CELL; PERMEABILITY;

CACO-2 CELLS; CELL POLARITY; CELL SURVIVAL; DRUG CARRIERS; HUMANS; MANNITOL; PERMEABILITY; WHEAT GERM AGGLUTININS;

TRITICUM AESTIVUM;

EID: 23644450774     PISSN: 0041008X     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.taap.2005.01.001     Document Type: Article

References (26)

1. M.C. Chen, J. Goliger, N. Bunnett, and A.H. Soll Apical and basolateral EGF receptors regulate gastric mucosal paracellular permeability Am. J. Physiol.: Gastrointest. Liver Physiol. 280 2001 G264 G272
2. M. Ciarlet, S.E. Crawford, and M.K. Estes Differential infection of polarized epithelial cell lines by sialic acid-dependent and sialic acid-independent rotavirus strains J. Virol. 75 2001 11834 11850
3. C. Dalla Pellegrina, A. Matucci, G. Zoccatelli, C. Rizzi, S. Vincenzi, G. Veneri, G. Andrighetto, A.D.B. Peruffo, and R. Chignola Studies on the joint cytotoxicity of wheat germ agglutinin and monensin Toxicol. In Vitro 18 2004 821 827
4. J.M. Daniel, and A.B. Reynolds Tyrosine phosphorylation and cadherin/catenin function Bioessays 19 1997 883 891
5. F. Gabor, A. Schwarzbauer, and M. Wirth Lectin-mediated drug delivery: binding and uptake of BSA-WGA conjugates using the Caco-2 model Int. J. Pharm. 237 2002 227 239
6. F. Gabor, E. Bogner, A. Weissenboeck, and M. Wirth The lectin-cell interaction and its implications to intestinal lectin-mediated drug delivery Adv. Drug. Deliv. Rev. 56 2004 459 480
7. H. Haas, F.H. Falcone, G. Schramm, K. Haisch, B.F. Gibbs, J. Klauche, M. Poppelmann, W.M. Becker, H.J. Gabius, and M. Schlaak Dietary lectins can induce in vitro release of IL-4 and IL-13 from human basophils Eur. J. Immunol. 29 1999 918 927
8. D.C. Kilpatrick Lectins in immunology A. Pusztai S. Bardocz Lectins: biomedical perspectives 1995 Taylor and Francis Basingstroke 155 182
9. H. Lecoeur, L.M. De Oliveira-Pinto, and M.L. Gougeon Multiparametric flow cytometric analysis of biochemical and functional events associated with apoptosis and oncosis using 7-aminoactinomycin D assay J. Immunol. Methods 265 2002 81 96
10. N. Lochner, F. Pittner, M. Wirth, and F. Gabor Wheat germ agglutinin binds to the epidermal growth factor receptor of artificial Caco-2 membranes as detected by silver nanoparticle enhanced fluorescence Pharm. Res. 20 2003 833 839
11. A. Matucci, G. Veneri, C. Dalla Pellegrina, G. Zoccatelli, S. Vincenzi, R. Chignola, A.D.B. Peruffo, and C. Rizzi Temperature-dependent decay of wheat germ agglutinin activity and its implications for food processing and analysis Food Control 15 2004 391 395
12. E. Muraille, B. Pjak, J. Urbain, and O. Leo Carbohydrate-bearing cell surface receptors involved in innate immunity: interleukin-12 induction by mitogenic and nonmitogenic lectins Cell. Immunol. 191 1999 1 9
13. N. Pantzar, S. Lundin, L. Wester, and B.R. Westrom Bidirectional small-intestinal permeability in the rat to some common marker molecules in vitro Scand. J. Gastroenterol. 29 1994 703 709
14. A. Pusztai Transport of proteins through the membranes of the adult gastrointestinal tract: a potential for drug delivery? Adv. Drug Deliv. Rev. 3 1989 215 228
15. A. Pusztai Lectin-targeting of microparticles to different parts of the gastrointestinal tract Proc. Int. Symp. Controlled Release Bioact. Mater. 22 1995 161 162
16. A. Pusztai, S.W.B. Ewen, G. Grant, D.S. Brown, J.C. Stewart, W.J. Peumans, E.J.M. Van Damme, and S. Bardocz Antinutritive effects of wheat germ agglutinin and other N-acetylglucosamine-specific lectins Br. J. Nutr. 70 1993 313 321
17. G.J. Russell-Jones Oral vaccination with lectins and lectin-like molecules D.T. O'Hagan Novel delivery systems for oral vaccines 1994 CRC Press Boca Raton 225 240
18. G.J. Russell-Jones, J. Lindner, and H. De Azipurua The use of lectins for oral delivery Proc. Int. Symp. Controlled Release Bioact. Mater. 19 1992 40 41
19. G.J. Russell-Jones, H. Veitch, and L. Arthur Lectin-mediated transport of nanoparticles across Caco-2 and OK cells Int. J. Pharm. 190 1999 165 174
20. J.M. Staddon, K. Herrencknecht, C. Smales, and L.L. Rubin Evidence that tyrosine phosphorylation may increase tight junction permeability J. Cell Sci. 108 1995 609 619
21. E.J.M. Van Damme, W.J. Peumans, A. Pusztai, and S. Bardocz Handbook of plant lectins: properties and biomedical applications 1998 John Wiley and Sons West Sussex
22. S. Vincenzi, G. Zoccatelli, F. Perbellini, C. Rizzi, R. Chignola, A. Curioni, and A.D.B. Peruffo Quantitative determination of dietary lectin activities by enzyme-linked immunosorbent assay using specific glycoproteins immobilized on microtiter plates J. Agric. Food Chem. 50 2002 6266 6270
23. M. Wirth, A. Fuchs, M. Wolf, B. Ertl, and F. Gabor Lectin-mediated drug targeting: preparation, binding characteristics, and antiproliferative activity of wheat germ agglutinin conjugated doxorubicin on Caco-2 cells Pharm. Res. 15 1998 1031 1037
24. M. Wirth, C. Kneuer, C.M. Lehr, and F. Gabor Lectin-mediated drug delivery: discrimination between cytoadhesion and cytoinvasion and evidence for lysosomal accumulation of wheat germ agglutinin in the Caco-2 model J. Drug Targeting 10 2002 439 448
25. Y. Yatomi, Y. Ozaki, Y. Koike, K. Satoh, and S. Kume Wheat germ agglutinin-induced intracellular calcium mobilization in human platelets: suppression by staurosporine and resistance to cyclic AMP inhibition Biochem. Biophys. Res. Commun. 191 1993 453 458
26. G. Zoccatelli, C. Dalla Pellegrina, S. Vincenzi, C. Rizzi, R. Chignola, and A.D.B. Peruffo Egg-matrix for large-scale single-step affinity purification of plant lectins with different carbohydrate specificities Protein Expression Purif. 27 2003 182 185