First line of defense: The role of the intestinal epithelium as an active component of the mucosal immune system

Journal of Gastroenterology

Volumn 35, Issue 11, 2000, Pages 805-814

  Pitman, R S ^a   Blumberg, R S ^a  

^a BRIGHAM AND WOMEN S HOSPITAL   (United States)

Author keywords

Epithelial immune cell interactions; Intestinal epithelium; Mucosal immunity

Indexed keywords

ALTERNATIVE COMPLEMENT PATHWAY C3 C5 CONVERTASE; CD4 ANTIGEN; CD47 ANTIGEN; CD8 ANTIGEN; CD86 ANTIGEN; CECROPIN; COMPLEMENT COMPONENT C3; COMPLEMENT COMPONENT C4; CYTOKINE RECEPTOR; DEFENSIN; EPIDERMAL GROWTH FACTOR; FIBROBLAST GROWTH FACTOR; IMMUNOGLOBULIN A; IMMUNOGLOBULIN M; INTERCELLULAR ADHESION MOLECULE 1; INTERLEUKIN 10; INTERLEUKIN 7; INTESTINAL TREFOIL FACTOR; LYMPHOCYTE FUNCTION ASSOCIATED ANTIGEN 3; MAJOR HISTOCOMPATIBILITY ANTIGEN; MONOCYTE CHEMOTACTIC PROTEIN 1; MUCIN; PROSTAGLANDIN; SCATTER FACTOR; SECRETORY IMMUNOGLOBULIN; T LYMPHOCYTE RECEPTOR; UVOMORULIN;

ANIMAL CELL; ANIMAL TISSUE; ANTIGEN PRESENTATION; BACTERIAL INFECTION; CELL ADHESION; CELL SECRETION; CELL STRUCTURE; COLON MUCOSA; CONTROLLED STUDY; CYTOKINE RELEASE; DEFENSE MECHANISM; HUMAN; HUMAN CELL; IMMUNE RESPONSE; INTESTINE EPITHELIUM CELL; INTESTINE INFECTION; LYMPHOCYTE ACTIVATION; LYMPHOCYTE SUBPOPULATION; MICROFILAMENT; MOUSE; MUCOSAL IMMUNITY; NONHUMAN; PRIORITY JOURNAL; PROSTAGLANDIN RELEASE; REVIEW; T LYMPHOCYTE; TISSUE REPAIR;

ANTIGEN PRESENTATION; CHEMOKINES; CYTOKINES; EPITHELIAL CELLS; HUMANS; IMMUNITY, MUCOSAL; INTESTINAL MUCOSA; RECEPTORS, CYTOKINE;

EID: 0033669635     PISSN: 09441174     EISSN: None     Source Type: Journal    
DOI: 10.1007/s005350070017     Document Type: Review

References (121)

1. Quantitative cultures of the mucosal-associated bacteria in the mechanically prepared colon and rectum
2. Anaerobic bacteria, the colon and colitis
3. Epithelia: Biologic principles of organization
4. The function of intermediate filaments in cell shape and cytoskeletal integrity
5. Polarity of epithelial and neuronal cells
6. Tight junctions: Closing in on the seal
7. Structure and biological activity of basement membrane proteins
8. Hepatocyte growth factor/scatter factor effects on epithelia. Regulation of intercellular junctions in transformed and nontransformed cell lines, basolateral polarization of c-met receptor in transformed and natural epithelia, and induction of rapid wound repair in a transformed model epithelium
9. Cytokine modulation of intestinal epithelial cell restitution: Central role of transforming growth factor beta
10. Trefoil peptides promote epithelial migration through a transforming growth factor beta-independent pathway
11. Epithelium in inflammatory bowel disease: Trefoil peptides at the interface
12. Trefoil peptide protection of intestinal epithelial barrier function: Cooperative interaction with mucin glycoprotein
13. Oral trefoil peptides protect against ethanol- and indomethacin-induced gastric injury in rats
14. Human intestinal goblet cell mucin
15. Mucin genes and the proteins they encode: Structure, diversity, and regulation
16. Functional protective role for mucin glycosylated repetitive domains
17. Binding of pig small intestinal mucin glycopeptides to fimbriated enterotoxigenic Escherichia coli
18. Inhibition of Helicobacter pylori colonization by sulfated gastric mucin
19. Intestinal mucin inhibits adhesion of human enteropathogenic Escherichia coli to HEp-2 cells
20. Differential stimulation of intestinal mucin secretion by cholera toxin and carbachol
21. Lipopolysaccharide from Escherichia coli stimulates mucin secretion by cultured dog gallbladder epithelia cells
22. The T84 human colonic adenocarcinoma cell line produces mucin in culture and releases it in response to various secretagogues
23. Differential cytokine regulation of complement C3, C4, and factor B synthesis in human intestinal epithelial cell line, Caco-2
24. Developmental regulation of cryptdin, a corticostatin/defensin precursor mRNA in mouse small intestinal crypt epithelium
25. Cryptdins: Antimicrobial defensins of the murine small intestine
26. Expression and regulation of the human beta-defensins hBD-1 and hBD-2 in intestinal epithelium
27. Antibacterial peptides from pig intestine: Isolation of a mammalian cecropin
28. Amino acid sequence of PR-39. Isolation from pig intestine of a new member of the family of prolinearginine-rich antibacterial peptides
29. Mechanisms of action on Escherichia coli of cecropin P1 and PR-39, two antibacterial peptides from pig intestine
30. Synthesis and antibacterial action of cecropin and proline-arginine-rich peptides from pig intestine
31. Paneth cells and innate immunity in the crypt microenvironment
32. Inhibitory effects of bovine lactoferrin on the adherence of enterotoxigenic Escherichia coli to host cells
33. Selective transport of IgA. Cellular and molecular aspects
34. Structure and function of the polymeric immunoglobulin receptor in epithelial cells
35. The immune system
36. Intra-epithelial lymphocytes. Evidence for regional specialization and extrathymic T cell maturation in the human gut epithelium
37. Oligoclonal expansion and CD1 recognition by human intestinal intraepithelial lymphocytes
38. Human intestinal intraepithelial lymphocytes are derived from a limited number of T cell clones that utilize multiple V beta T cell receptor genes
39. Oligoclonality of human intestinal intraepithelial T cells
40. Infection of human epithelial cells with invasive bacteria upregulates apical intercellular adhesion molecule-1 (ICAM-1) expression and neutrophil adhesion
41. Expression and regulation of adhesion molecules ICAM-1 (CD54) and LFA-3 (CD58) in human intestinal epithelial cell lines
42. E-cadherin expression in intestinal epithelium
43. Expression of a candidate cadherin in T lymphocytes
44. Characterization of a 180-kDa intestinal epithelial cell membrane glycoprotein, gp180. A candidate molecule mediating T cell-epithelial cell interactions
45. Human intestinal epithelial cell-induced CD8+ T cell activation is mediated through CD8 and the activation of CD8-associated p56lck
46. Regulation of human intestinal intraepithelial lymphocyte cytolytic function by biliary glycoprotein (CD66a)
47. Expression and polarization of intercellular adhesion molecule-1 on human intestinal epithelia: Consequences for CD11b/CD18-mediated interactions with neutrophils
48. Expression of B7-1 and B7-2 costimulatory molecules by human gastric epithelial cells: Potential role in CD4+ T cell activation during Helicobacter pylori infection
49. Proliferative responses of human intraepithelial lymphocytes to various T-cell stimuli
50. Polarized expression and function of the costimulatory molecule CD58 on human intestinal epithelial cells
51. Enhancement of CD3-induced activation of human intestinal intraepithelial lymphocytes by stimulation of the beta 7-containing integrin defined by HML-1 monoclonal antibody
52. Epithelial cells bearing class II molecules stimulate allogeneic human colonic intraepithelial lymphocytes
53. Functional expression of costimulatory molecule CD86 on epithelial cells in the inflamed colonic mucosa
54. Phenotype and cytokine profile of intraepithelial lymphocytes in human small and large intestine
55. The central role of chemokines (chemotactic cytokines) in the immunopathogenesis of ulcerative colitis and Crohn's disease
56. Chemokines in the inflammatory bowel diseases
57. Differential cytokine expression by human intestinal epithelial cell lines: Regulated expression of interleukin 8
58. Epithelial cells secrete the chemokine interleukin-8 in response to bacterial entry
59. Surface attachment of Salmonella typhimurium to intestinal epithelia imprints the subepithelial matrix with gradients chemotactic for neurtrophils
60. Yersinia enterocolitica-Induced interleukin-8 secretion by human intestinal epithelial cells depends on cell differentiation
61. A distinct array of pro-inflammatory cytokines is expressed in human colon epithelial cells in response to bacterial invasion
62. Expression of interleukin 8 and CD54 by human gastric epitthelium after Helicobacter pylori infection in vitro
63. Helicobacter pylori induces an array of pro-inflammatory cytokines in human gastric epithelial cells: Quantification of mRNA for interleukin-8, chemoattractant protein-1 and tumour necrosis factor-alpha
64. Mucosal cytokines
65. Colonic epithelial cell lines as a source of interleukin-8: Stimulation by inflammatory cytokines and bacterial lipopolysaccharide
66. Intestinal epithelial cells both express and respond to interleukin 15
67. Functional interleukin-2 receptors on intestinal epithelial cells
68. Transforming growth factor beta regulation of migration in wounded rat intestinal epithelial monolayers
69. Transforming growth factor beta 1 increases IgA isotype switching at the clonal level
70. Cholera toxin enhances alloantigen presentation by cultured intestinal epithelial cells
71. Ligation of intestinal epithelial CD1d induces bioactive IL-10: Critical role of the cytoplasmic tail in autocrine signaling
72. Interleukin 10 and transforming growth factor beta cooperate to induce anti-CD40-activated naive human B cells to secrete immunoglobulin A
73. Interleukin-10
74. Interleukin 10 prevents cytokine-induced disruption of T84 monolayer barrier integrity and limits chloride secretion
75. An interleukin-7 internet for intestinal intraepithelial T cell development: Knockout of ligand or receptor reveals differences in the immunodeficient state
76. Interleukin-7 receptor alpha is essential for the development of gamma delta + T cells, but not natural killer cells
77. Interleukin 7 receptor-deficient mice lack gammadelta T cells
78. Interleukin 2-independent interleukin 7 activity enhances cytotoxic immune response of HIV-1-infected individuals
79. IL-7 stimulates protective immunity in mice against the intracellular pathogen, Toxoplasma gondii
80. Interleukin 7 is produced by human intestinal epithelial cells and regulates the proliferation of intestinal mucosal lymphocytes
81. Interactions between stem cell factor and c-Kit are required for intestinal immune system homeostasis
82. A role for stem cell factor (SCF): C-kit interaction(s) in the intestinal tract response to Salmonella typhimurium infection
83. Local hormone networks and intestinal T cell homeostasis
84. Primary colonic epithelial cell culture of the rabbit producing prostaglandins
85. Regulation by prostaglandin E2 of interleukin release by T lymphocytes in mucosa
86. Human intestinal epithelial cells express functional cytokine receptors sharing the common gamma c chain of the interleukin 2 receptor
87. Identification and characterization of the rat intestinal epithelia cell (IEC-18) interleukin-1 receptor
88. The effect of cytokine stimulation on IL-1 receptor mRNA expression by intestinal epithelial cells
89. Interferon-gamma enhances expression of secretory component, the epithelial receptor for polymeric immunoglobulins
90. Tumor necrosis factor-alpha up-regulates expression of secretory component, the epithelial receptor for polymeric Ig
91. Synergistic effect of IL-4 and IFN-gamma on the expression of polymeric Ig receptor (secretory component) and IgA binding by human epithelial cells
92. Intraepithelial lymphocytes modulate Ia expression by intestinal epithelial cells
93. Characterisation and quantification of mucosal cytokine that induces epithelial histocompatibility locus antigen-DR expression in inflammatory bowel disease
94. Antigen-presenting cells; epithelial cells
95. Antigen presentation by epithelial cells of the rat small intestine. I. Kinetics, antigen specificity and blocking by anti-Ia antisera
96. Antigen presentation by epithelial cells of the rat small intestine. II. Selective induction of suppressor T cells
97. Murine enterocytes can present soluble antigen to specific class II-restricted CD4+ T cells
98. Expression of class II molecules on intestinal epithelial cells in humans. Differences between normal and inflammatory bowel disease
99. Expression of HLA-DR antigens on epithelium associated with lymphoid tissue in the human gastrointestinal tract
100. HLA-DR-like antigens in the epithelium of the human small intestine
101. Rat intestinal epithelial cells present major histocompatibility complex allopeptides to primed T cells
102. Evidence for function of Ia molecules on gut epithelial cells in man
103. Highly polarized HLA class II antigen processing and presentation by human intestinal epithelial cells
104. Intestinal epithelial cells use two distinct pathways for HLA class II antigen processing
105. Tissue distribution of the nonpolymorphic major histocompatibility complex class I-like molecule, CD1d
106. Expression of a nonpolymorphic MHC class I-like molecule, CD1D, by human intestinal epithelial cells
107. Expression of murine CD1 on gastrointestinal epithelium
108. The CD1 system: Antigen-presenting molecules for T cell recognition of lipids and glycolipids
109. Antigen-presenting function of mouse CD1: One molecule with two different kinds of antigenic ligands
110. Peptide binding and presentation by mouse CD1
111. Crystal structure of mouse CD1: An MHC-like fold with a large hydrophobic binding groove
112. Beta 2-microglobulin-independent MHC class Ib molecule expressed by human intestinal epithelium
113. Biochemical characterization of CD1d expression in the absence of beta2-microglobulin
114. CD1 recognition by mouse NK1+ T lymphocytes
115. CD1d is involved in T cell-intestinal epithelial cell interactions
116. The glycolipid, α-galactosylceramide protects against murine DSS colitis in a CD1d and NK1.1+ T-cell restricted manner
117. The expression of Fc receptors for immunoglobulin G in human rectal epithelium
118. Bidirectional FcRn-dependent IgG transport in a polarized human intestinal epithelial cell line
119. A major histocompatibility complex class I-like Fc receptor cloned from human placenta: Possible role in transfer of immunoglobulin G from mother to fetus
120. Bidirectional FcRn-dependent IgG transport in a polarized human intestinal epithelial cell line
121. Class II MHC antigen (Ia)-bearing dendritic cells in the epithelium of the rat intestine