Fermenting next generation glycosylated therapeutics

ACS Chemical Biology

Volumn 6, Issue 1, 2011, Pages 14-17

  Chen, Xi ^a  

^a UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

GLYCOSYLTRANSFERASE; GLYCOSYLTRANSFERASE OLED; MONOSACCHARIDE; NUCLEOSIDE; UNCLASSIFIED DRUG;

ENZYME ACTIVITY; ESCHERICHIA COLI; FERMENTATION; IN VITRO STUDY; IN VIVO STUDY; NONHUMAN; PRIORITY JOURNAL; REVIEW;

BIOLOGICAL PRODUCTS; BIOSYNTHETIC PATHWAYS; CATALYSIS; ESCHERICHIA COLI; FERMENTATION; GLYCOSIDES; GLYCOSYLATION; GLYCOSYLTRANSFERASES;

ESCHERICHIA COLI;

EID: 79251498607     PISSN: 15548929     EISSN: 15548937     Source Type: Journal    
DOI: 10.1021/cb100375y     Document Type: Review

References (10)

1. Williams, G. J., Yang, J., Zhang, C., and Thorson, J. S. (2010) Recombinant E. coli prototype strains for in vivo glycorandomization, ACS Chem. Biol. DOI: 10.1021/cb100267k.
2. Gantt, R. W., Goff, R. D., Williams, G. J., and Thorson, J. S. (2008) Probing the aglycon promiscuity of an engineered glycosyltransferase Angew. Chem., Int. Ed. 47, 8889-8892
3. Hancock, S. M., Rich, J. R., Caines, M. E., Strynadka, N. C., and Withers, S. G. (2009) Designer enzymes for glycosphingolipid synthesis by directed evolution Nat. Chem. Biol. 5, 508-514
4. Yang, G., Rich, J. R., Gilbert, M., Wakarchuk, W. W., Feng, Y., and Withers, S. G. (2010) Fluorescence activated cell sorting as a general ultra-high-throughput screening method for directed evolution of glycosyltransferases J. Am. Chem. Soc. 132, 10570-10577
5. Yang, J., Fu, X., Liao, J., Liu, L., and Thorson, J. S. (2005) Structure-based engineering of E. coli galactokinase as a first step toward in vivo glycorandomization Chem. Biol. 12, 657-664
6. Barton, W. A., Biggins, J. B., Jiang, J., Thorson, J. S., and Nikolov, D. B. (2002) Expanding pyrimidine diphosphosugar libraries via structure-based nucleotidylyltransferase engineering Proc. Natl. Acad. Sci. U.S.A. 99, 13397-13402
7. Chen, X., Liu, Z., Zhang, J., Zhang, W., Kowal, P., and Wang, P. G. (2002) Reassembled biosynthetic pathway for large-scale carbohydrate synthesis: alpha-Gal epitope producing superbug ChemBioChem 3, 47-53
8. Yi, W., Liu, X., Li, Y., Li, J., Xia, C., Zhou, G., Zhang, W., Zhao, W., Chen, X., and Wang, P. G. (2009) Remodeling bacterial polysaccharides by metabolic pathway engineering Proc. Natl. Acad. Sci. U.S.A. 106, 4207-4212
9. Melancon, C. E., 3rd, Yu, W. L., and Liu, H. W. (2005) TDP-mycaminose biosynthetic pathway revised and conversion of desosamine pathway to mycaminose pathway with one gene J. Am. Chem. Soc. 127, 12240-12241
10. Salas, J. A. and Mendez, C. (2005) Biosynthesis pathways for deoxysugars in antibiotic-producing actinomycetes: isolation, characterization and generation of novel glycosylated derivatives J. Mol. Microbiol. Biotechnol. 9, 77-85