Altered pharmacokinetics of cimetidine caused by down-Regulation of renal rat organic cation transporter 2 (rOCT2) after liver ischemia-Reperfusion injury

Drug Metabolism and Pharmacokinetics

Volumn 28, Issue 6, 2013, Pages 504-509

  Ikemura, Kenji ^a,b   Nakagawa, Erika ^b   Kurata, Tomohiko ^b   Iwamoto, Takuya ^b,c   Okuda, Masahiro ^b,c  

^a KINJO GAKUIN UNIVERSITY   (Japan)

^b MIE UNIVERSITY GRADUATE SCHOOL OF MEDICINE   (Japan)

^c MIE UNIVERSITY HOSPITAL   (Japan)

Author keywords

Cimetidine; Kidney; Liver ischemia Reperfusion; Multidrug and toxin extrusion 1; Organic cation transporter 2; Oxidative stress; Trolox

Indexed keywords

CIMETIDINE; MULTIDRUG AND TOXIN EXTRUSION PROTEIN 1; ORGANIC CATION TRANSPORTER 2; TROLOX C;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; DISEASE DURATION; DOWN REGULATION; DRUG BLOOD LEVEL; DRUG CLEARANCE; DRUG EXCRETION; DRUG TISSUE LEVEL; KIDNEY CLEARANCE; KIDNEY TUBULE EXCRETION; LIVER ISCHEMIA; MALE; NONHUMAN; OXIDATIVE STRESS; PROTEIN METABOLISM; RAT; REPERFUSION INJURY; SHAM PROCEDURE;

ANIMALS; ANTIPORTERS; CHROMANS; CIMETIDINE; DOWN-REGULATION; LIVER; MALE; ORGANIC ANION TRANSPORTERS, SODIUM-INDEPENDENT; ORGANIC CATION TRANSPORT PROTEINS; RATS; RATS, WISTAR; REPERFUSION INJURY;

EID: 84893002090     PISSN: 13474367     EISSN: 18800920     Source Type: Journal    
DOI: 10.2133/dmpk.DMPK-13-RG-021     Document Type: Article

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